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WorksheetsImmunogenetics Quiz - Week 6
Total questions: 25
Worksheet time: 25mins
Which problem is one of the most common issues encountered when using CRISPR for gene editing?
Only works on bacteria
Always creates exact edits
Off-target mutations in the genome
Cannot be used in embryos
When multiple CRISPR cuts occur simultaneously, what dangerous outcome can happen?
Programmed cell death
Chromosomal translocations
Telomere shortening
Protein misfolding
Which of the following best defines immunogenetics?
The study of protein folding
The study of how genetic variation affects immune responses
The study of antibiotics
The study of cancer signaling pathways
In sickle cell CRISPR therapy, which mutation is corrected?
Adenine to Guanine
Glutamate to Valine
Valine to Glutamate
Cytosine to Uracil
What gene deletion provides some people immunity to HIV?
CFTR
CCR5 delta
PD-L1
HLA-B27
Natural Killer (NK) cells use which genetic tool to recognize foreign cells?
Immunoglobulin heavy chains
Random mutagenesis
Receptor genes encoded in the genome
CRISPR RNA guides
What is the role of Toll-like Receptors (TLRs)?
Detect foreign bacterial or viral patterns
Repair DNA mutations
Regulate synapse pruning
Allow viral entry into cells
What genetic process creates the diversity in B-cell receptors and antibodies?
VDJ recombination
Transcription
Translation
RNA interference
In B-cell receptor gene recombination, which segments are used for light chains?
V, D, and J
D and J only
V and J
V only
Why does class switching occur in B-cells?
To increase viral resistance
To switch from IgM to other antibody types (IgG, IgA, etc.)
To create more B cells
To eliminate autoreactive clones
What is one key function of Major Histocompatibility Complex (MHC) proteins?
Code for antibodies
Present antigens to T-cells
Trigger complement system directly
Repair DNA mismatches
HLA diversity plays a major role in:
How easily individuals catch colds
Variation in innate skin barriers
Individual variation in immune responses
Eye color differences
What makes the female immune system genetically stronger than the male immune system?
More mitochondria
Hormonal differences
X-chromosome contains many immune genes
Greater numbers of T-cells
Which cells are primarily responsible for generating antibodies?
T-cells
Macrophages
Natural Killer Cells
B-cells
Why are antibodies so specific to a particular pathogen?
Receptor editing during infection
Antigen-driven random hypermutation and selection
Viral integration into B-cell DNA
CRISPR inserted new genes
What happens to B-cells that do not generate strong binding antibodies during selection?
They clone themselves
They undergo apoptosis (cell death)
They class switch automatically
They attack normal body cells
Which type of immunity involves pre-existing genetic variation present at birth?
Adaptive immunity
Innate immunity
Acquired immunity
Secondary immunity
In the animal kingdom, bright coloring (like in peacocks) may correlate with:
Intelligence
Fertility genes
Immune system gene strength
Nervous system function
What happens in autoimmune diseases like Type 1 diabetes?
Immune system ignores infections
Immune system attacks its own healthy tissues
B-cells hypermutate
Viral infections destroy insulin directly
In CAR T-cell therapy, how is the T-cell genetically altered?
Inserting synthetic cancer-killing receptors via plasmid DNA
Full genome editing with CRISPR
Infecting with bacteria
Using microRNA regulation
CRISPR-Cas9 is a genetic modification technique that edits parts of the genome of an organism. Using this technique scientists can add, remove, or modify sections of the DNA sequence.
How can scientists use this technique to control gene expression?
By activating or deactivating specific genes
By calculating the number of genes different organisms produce
By identifying how closely related one individual is to another
By determining the number of chromosomes in an organism
siRNA and CRISPR are similar because they both give scientists the ability to
Count the number of genes in the human genome
Mass Analyze Genes in Any Species
Manipulate Gene Expression in targeted genes
Find and Kill the effects of Cytotoxic Reagents in Various Cell Populations in Quick and Easy Way
Skin is a part of our immune system
True, it is a part of our adaptive immunity
False, it has no role in immunity
True, it is a part of our Innate Immunity
False, however saliva plays a major role in immunity
Which are the following is a characteristic of adaptive immunity?
Self/Non-self Recognition
Time-Released Defenses against invading molecules
Has specificity but lacks diversity
Has no ability to remember infection, develops new immune responses each time it encouters a dangerous molecule
Which of the following is a major difference between MHC 1 and MHC II receptors?
The antigen for MHC Class I is typically extracellular
The antigen for MHC Class II is typically extracellular
The antigen for MHC Class II is typically endogenous
There is no major difference between the two
