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Worksheets3. (Mo) Antiviral Practice Q's:
Total questions: 96
Worksheet time: 55mins
Which of the following is effective in the treatment of Shingles because it inhibits viral DNA repair by inhibiting the enzyme APEX nuclease-1?
Emtricitabine (Emtriva)
Fiactabine
Cytarabine (Cytosar-U)
Zidovudine (Retrovir)
Brivudine (Zostrex)
Which of the following is LEAST LIKELY to be classified as a Pyrimidine Nucleoside?
ara-A
Idoxuridine
Trifluridine
Bromovinyldeoxyuridine
Fluroiodoaracytidine
Which of the following is the recommended dosage of Acyclovir when it is used to treat Herpes Simplex Encephalitis?
200 mg PO Q4H x 10 days
20 mg/kg PO QID x 5 days
10 mg/kg IV Q8H x 21 days
800 mg IV QID x 21 days
40 mg/kg IV Q8H x 10 days
Which of the following is a Dihydroxypropxymethyl guanine preparation that is employed in the management of CMV Infections? SATA
Cymeval
Cymevene
Cytovene
Contravene
Vitrasert
Which of the following is LEAST LIKELY to be used to treat CMV-induced retinitis?
Lobucavir
Letermovir (Prevymis)
Boceprevir (Victrelis)
Ganciclovir (Cymevene/Vitrasert)
Cidofovir (Vistide)
Genvoya is used to treat AIDS; Which of the following is NOT a content of that product?
A pharmacokinetic booster
Emtricitabine
Tenofovir Disoproxil Fumarate
Elvitegravir
Cobicistat
The mechanisms of action of Interferons involve which of the following? SATA
Stimulation of Natural Killer Cells
Increased Antibody Production
Decreased Antibody Production
Decreased Production of Biological Response Markers
Stimulation of 2'-5'-Oligoisoadenylate sythetase
All of the following are NNRTIs EXCEPT:
Delavirdine
Doravirine
Nevirapine
Atevirdine
Taribavirin
Which of the following produces its pharmacological effect by binding to Gp120 and thus preventing HIV connection to CD4 on host cells?
Pleconaril
Fostemsavir (Rukobia)
Fosamprenavir (Lexiva)
Peramivir (Rapivab)
Atevirdine
Which of the following is NOT transmitted by Aedes Egypt mosquito? ____ Virus.
St. Louis Encephalitis
Chikungunya
Yellow Fever
Dengue
Zika
Aedes Aegypti is the vector for all of the following EXCEPT:
West Nile Encephalitis Virus
Yellow Fever Virus
Zika Virus
Chikungumya Virus
Dengue Virus
Which of the following is an immunization product that provides protection against a Respiratory Syncytial Virus (RSV) infection in a 60-year-old individual? SATA
Arexvy
Comirnaty
Abrysvo
Beyfortus
Novavax
All of the following drugs have been shown to possess an antiviral activity against RSV EXCEPT:
Palivizumab (Synagis)
Doravirine (Pifeltro)
Ribavirin (Copegus, Rebetol, Virazole)
Remdesvir (Veklury)
Interferon-alpha
A Medical Team wants to use a combination of Lamivudine, Tenofovir, and Efavirenz to treat Mr. Zog's HIV infections. Which of the following is the MOST APPROPRIATE product for a Pharmacist to recommend?
Sustiva
Delstrigo
Epzicom
Trizivir
Symfi
Which of the following is the causative agent of German Measles?
Rotavirus
Rabies Virus
Rubella Virus
Rhinovirus
Enterovirus
The causative agent of Kaposi Sarcoma belongs to which of the following virus groups?
Adenovirus
Arenavirus
Picornavirus
Herpes Virus
Reovirus
Which of the following is a causative agent of Kaposi Sarcoma?
Human Herpes Virus 8
Human Herpes Virus 6
Varicella Zoster Virus
Herpes Zoster Virus
Human Papilloma Virus
Which of the following is a nucleotide preparation that is used to treat Hepatitis B infections?
Adefovir
Lamivudine
Telbivudine
Entecavir
Famciclovir
Which of the following statements about Rilpivirine (Edurant) is FALSE?
It is administered orally and biotransformed by CYP3A4
It is about 99.7% Albumin-bound
It has a half-life of 5 hours
It is primarily excreted through the feces
It does not exhibit auto-induction
Which of the following statements about Rilpivirine is FALSE?
It is highly bound to Albumin
Its half-life is about 50 hr
It is mostly excreted through the feces
It should not be taken concurrently with Omeprazole
It exhibits auto induction
Which of the following is LEAST LIKELY to be observed as an adverse effect of Tenofovir Viread?
Exacerbation of Hepatitis B Virus Infection
Increased Bone Mineral Density
Flatulence and Bloating
Fanconi Syndrome
Osteomalacia
Which of the following, if administered concomitantly with Rilpivirine (Edurant), will decrease the GI absorption of Edurant? SATA
Omeprazole (Prilosec)
Famotidine (Pepcid)
Maalox (Aluminum Hydroxide + Magnesium Hydroxide)
Phenobarbital
Phenytoin
Which of the following is LEAST LIKELY to be observed as an adverse effect of Foscavir (Foscarnet)?
Paresthesias
Bradycardia
Hallucination
Seizures
Renal Impairment
Which of the following is an adverse effect of Foscarnet? SATA
Genital Ucleration
Tetanus
First Degree AV Block
Circumoral Paresthesias
Asthenia
Scleral Icterus may result from therapy with Atazanavir (Reyataz) because the drug produces which of the following?
Hyperbilirubinemia
Nephrolithiasis
Cholethiasis
Abdominal Pain
Insomnia
Which of the following is classified as a Hepatitis C Virus Polymerase Inhibitor?
Voxilaprevir
Ombitasvir
Dasabuvir (Exviera)
Daclatasvir
Simeprevir (Olysio)
All of the following are HIV Protease Inhibitors EXCEPT:
Saquinavir (Invirase)
Foscavir (Foscarnet)
Nelfnavir
Ritonavir (Novir)
Lopinavir
Which of the following produces its antiviral effect by binding to the first heptad repeat in the gp41 subunit of the envelope glycoprotein and thus impairing the fusion of a virus to the host cell?
Maraviroc
Zanamivir
Penciclovir
Mogamulizumab
Enfuvirtide (Fuzeon)
The mechanism of action of Ibalizumab involves the inhibition of the binding of HIV to which of the following Chemokine receptors? SATA
CCR4
CCR5
CX3CR
CXCR4
XCR5
Which of the following is the appropriate prophylactic dose of Tamiflu in an individual who weighs 44 lbs (20 kg)?
30 mg PO BID
45 mg PO BID
60 mg QD
45 mg PO QD
75 mg PO QD
The primary mechanism of action of Remdesivir (Veklury) is the inhibition of which of the following?
RNA-dependent DNA polymerase
DNA-dependent DNA polymerase
RNA-dependent RNA-polymerase
DNA-dependent RNA polymerase
DNA ligase
Which of the following is involved in the mechanism of action of Paxlovid? Inhibition of ______ SATA
Cytochrome P450 3A4
RNA-dependent DNA polymerase
Reverse Transcriptase
PLpro
Mpro
Which of the following statements about Paxlovid is FALSE?
Recurrence of COVID-19 symptoms may be observed after therapy with the drug
It shouldn't be administered to individuals who are at least 12 years old
It should be avoided in patients who have a GFR of 70 mL/min
It should be adminstered at a dosage of 3 tablets PO BID x 5 days in patients who do not have renal dysfunction
The patient who is on Paxlovid should be advised to complete the full 5-day treatment even if hospitalization is required
Which of the following is an adverse effect of AZT (Zidovudine)? SATA
Lactic Acidosis
Hepatomegaly with Steatosis
Myopathy
Hyperlipidemia
Lipodystrophy
Which of the following is LEAST LIKELY to be observed as an adverse effect of AZT?
Granulocytopenia
Microcytic Anemia
Wenicke's Encephalopathy
Skin and Nail Hyperpigmentation
Seizures
SELECT THE CORRECT STATEMENT: A concurrent administration of Raltegravir and ___ may result in the exacerbation of the skin-related adverse effect of Raltegravir/
Methotrexate
Atorvastati
Isoniazid
Tylenol
Darunavir/Ritonavir
Which of the following combination products that are employed in the treatment of Hepatitis C Virus Infection contains Paritaprevir, Ritonavir, Dasabuvir, and Ombitasvir?
Epclusa
Vosevi
Mavyret
Technivie
Viekira
Paxlovid can interfere with the biotransformation of which of the following? SATA
Flecainide
Propafenone
Simvastatin
Amlodipine
Midazolam
Which of the following products that are used in managing AIDS is NOT matched with its correct contents?
ODEFSEY: Rilpivirine + Emtricitabine + Tenofovir Disoproxil Fumarate
DOVATO: Dolutegravir + Lamivudine
JULUCA: Doletegravir + Rilpivirine
CABENUVA: Rilpivirine + Cabotegravir
SYMTUZA: Emtricitabine + Tenofovir Alafenamide + Cobicistat + Darunavir
A patient who is receiving Acyclovir (Zovirax) 400 mg PO BID most likely has which of the following conditions?
Genital Herpes
Infectious Mononucleosis
Shingles
Chicken Pox
Herpes Simplex Encephalitis
Which of the following is BEST classified as a Neuraminidase Inhibitor? SATA
Pleconaril
Xofluza (Baloxacir Marboxil)
Tamiflu (Oseltamivir)
Peramivir (Rapivab)
Rukobia (Fostemsavir)
Which of the following is used to manage cold sores?
Abreva (Docosanol)
Valtrex (Valcyclovir)
Baraclude (Entecavir)
Zovirax (Acyclovir)
Interferon a2A (Roferon-A)
Which of the following is a sign or symptom of Hepatitis?
Jaundice
Dark Colored Urine
Elevation of Bilirubin Levels
Elevation of AST
Elevation of ALT
Which of the following statements about Sofosbuvir (Sovaldi) is correct? SATA
It has a terminal half-life of 27 hours
About 2.5% of the administered dose will be excreted through expiration
It is a pro-drug
It is given orally
It has a PPB of about 61-65%
Which of the following is an adverse effect of Tenofovir (Viread)? SATA
Flatulence
Nausea and Vomiting
Fanconi Syndrome
Osteomalacia
Decreased Bone Density
Which of the following is LEAST LIKELY to be observed as an adverse effect of Atazanavir (Reyataz)?
Hypotriglyceridemia
Hyperbilirubinemia
Nausea and Diarrhea
Kidney Stones
Bile Stones
If a patient is severely allergic to Sofosbuvir which of the following agents would be avoided in that patient? SATA
Hepcinat Plus
Mavyrent
Vosevi
Harvoni
Epclusa
An individual who is severely allergic to Dolutegravir should NOT be treated with all of the following EXCEPT:
Juluca
Symtuza
Triumeq
Dovato
Tivicay
Which of the following is best classified as an Antisense Oligonucleotide that is used in the treatment of Genital Warts (Condyloma Acuminatum)?
Afovirsen
Fomivirsen
Nusinersen
Bepirovirsen
Mipomersen
Which of the following is BEST classified as an Antisense oligonucleotide that is used to treat Hepatitis B virus Infection?
Afovirsen
Fomivirsen
Bepirovirsen
Mipomersen
Nusinersen
Which of the following is an adverse effect of Foscavir (Foscarnet Sodium)? SATA
Tetanus
Asthenia
Roseola Infantum
1st Degree AV Block
Perioral Paresthesia
Which of the following is an RNA-containing Virus? SATA
Coxsackie Virus
Influenza Virus Type A
Hepatitis C Virus
RSV
Rubella Virus
Given with Zidovudine, ____ will increase the hematologic toxicity of Zidovudine (Retrovir) SATA
Aspirin
Probenecid
Rubavirin
Thymidine
Tylenol
Which of the following statements about Ganciclovir is INCORRECT? SATA
When given orally it is mostly excreted Renally
Administered intravenously as Cymevne or Cytovene
When it is implanted opthalmically, the formulation is Vitrasert
Its rate of absorption is higher in blacks than in caucasians
It is available as Zircon for ophthalmic administration
The mechanism of action of Letermovir involves which of the following?
Protease
Helciase
APEX nuclease
DNA Terminase Complex
Reverse Transcriptase
Amantadine is effective in the management of which of the following? SATA
Restless Leg Syndrome
Mild cases of Parkinson's Disease
Dyskinesia
Influenza Type A
Roseola Infantum
Which of the following is the vector of Eastern Equine Encephalitis?
Ixodes Ticks
Anopheles Mosquito
Culex Univittatus
Aedes Egypti
Culiseta Melanura
The Protease Inhibitor, Atazanavir, is a component of which of the following products?
Genvoya
Symfi
Evotaz
Prexcobix
Triumeq
Which of the following is LEAST LIKELY to be observed as a sign or symptom of Hepatitis A virus-induced hepatitis?
Light yellowish coloration of the urine
Yellowish coloration of the eyes
Jaundice
Hyperbilirubinemia
Elevation of AST and ALT
All of the following are RNA-containing viruses EXCEPT:
Respiratory Syncytial Virus
Rubella Virus
Influenza Virus Type A
Hepatitis B Virus
Coxsackie Virus
Which of the following statements about Xofluza is INCORRECT?
It is a prodrug
Its dosing is weight-based
It has low plasma protein-binding capability
Its half-life is about 79.1 hours
It is metabolized by UDP-Glucuronyl transferase
Which of the following is an Antisense oligonucleotide that is MOST LIEKLY used to treat Duchenne Muscular Dystrophy?
Eteplirsen
Bepirovirsen
Nusinersen
Mipomersen
Afovirsen
Which of the following is an indication of Zovirax? SATA
Herpes Labialis
Condylomata Acuminiata
Herpes Simplex Genitalis
Chicken Pox
Herpes Simplex Encephalitis
Progressive multifocal leukoencephalopathy is caused by which of the following?
Simian Vacuolating 40 Virus
John Cunningham Virus
Vaccinia Virus
Rotavirus
Epstein-Barr Virus
A Medical Team wants to use a combination of Sofosbuvir, Velpatasvir and Voxilaprevir only to treat Mr. Sul’s Hepatitis C virus infection. Which of the following is the MOST APPROPRIATE product for the Pharmacist to suggest?
Technivie
Viekira
Epclusa
Vosevi
Mavyret
Which of the following products that are used to treat Hepatitis C contains two Protease inhibitors, a Polymerase inhibitor and an NS 5A inhibitor?
Viekiera
Vosevi
Harboni
Technivie
Epclusa
Which of the following can be used to treat Hepatitis C virus infection in a patient who is severely allergic to Sofosbuvir?
Hepcinat Plus
Harvoni
Mavyret
Epclusa
Vosevi
Which of the following primarily inhibits the initiation of the packaging of a new virion?
Maribavir
Letermovir
Fanciclovir
Cidovir
Bictegravir
Which of the following is an Antisense oligonucleotide? SATA
Aforvirsen
Fomivirsen
Mipomersen
Eteplirsen
Nusinersen
Which of the following statements is FALSE? SATA: Both Intelence and Edurant:
Have a long half-life
Are primarily excreted through the feces
Are auto-inducers
Are highly bound to albumin
Can be administered enterally
Which of the following statements is FALSE? SATA: Both Intelence and Edurant:
Have a long half-life
Are primarily excreted through the feces
Are auto-inducers
Are highly bound to albumin
Can be administered enterally
As a part of his AIDS treatment, Mr. Zit is receiving Sustiva. Which of the following is Mr. Zit LEAST LIKELY to experience during therapy with that drug?
Elevation of liver enzymes
Hypercholesterolemia
Bradycardia
Insomnia and Somnolence
Depression and Suicidal Ideation
Since Ms. Kur is severely allergic to Sulfonamides, which of the following should be avoided when treating her HIV infection?
Saquinavir
Indinavir
Nelfinavir
Darunavir
Ritonavir
Which of the following should be avoided in a patient whose Creatine Clearance is 40 mL/min? SATA
Genvoya
Stribild
Symtuza
Prezcobix
Evotaz
A concomitant administration of Raltegravir and ____ will result in an elevation of AST:
Atorvastatin
Fenofibrate
Tylenol
Darunavir/Ritonavir
Aspirin
Mr. Jam is receiving Acyclovir 10 mg/kg IV every 8 hours for 21 days. Considering that treatment regimen, which of the following does Mr. Jam MOST LIKELY have?
EBV-induced infectious mononucleosis
Genital Herpes
Shingles
Chicken Pox
Herpes Simplex Encephalitis
Which of the following is a post-attachment inhibitor that blocks HIV from binding to CCR5 and CXCR4?
Mogamulizumab
Cetuximab
Bevacizumab
Ibalizumab
Adalimumab
Mr. Zam is a 77-lb young man who presents with signs and symptoms that are consistent with a diagnosis of an Influenza Type-A Infection. Mr. Zam's physician wants to use Tamiflu to treat the patient's infection. Which of the following is the MOST APPROPRIATE dosage for treating Mr. Zam?
30 mg PO QD
45 mg PO QD
50 mg PO BID
60 mg PO BID
75 mg PO BID
Mr. Zam is a 77-lb young man who presents with signs and symptoms that are consistent with a diagnosis of an Influenza Type-A infection. Mr. Zam's physician wants to use Tamiflu to treat the patient's infection. The causative agent of Mr. Zam's infection is BEST classified as a/an _____.
Papovavirus
Piconavirus
Paramyxovirus
Orthomyxovirus
Oncornavirus
Ms. Tear, who recently returned from a trip to West Africa, presents with facial edema, proteinuria, and diarrhea. She was placed on Ribavirin and the infection resolved in 7 days. Which of the following is MOST LIKELY the correct diagnosis of Ms. Tear's Infection?
Lassa fever
Dengue Fever
Ebola Fever
Yellow Fever
Zika Disease
Ms. Tear, who recently returned from a trip to West Africa, presents with facial edema, proteinuria, and diarrhea. She was placed on Ribavirin and the infection resolved in 7 days. The causative agent of Ms. Tear's infection is BEST CLASSIFIED as a/an:
Adenavirus
Arenavirus
Poxvirus
Reovirus
Coronavirus
Which of the following is an indication of Amantadine? SATA
Parkinson's Disease
Influenza Type A Prophylaxis
Influenza Type A Treatment
Influenza Type B Treatment
Duchenne Muscular Dystrophy
Which of the following is LEAST LIKELY to result from therapy with Foscavir?
Hyperphosphatemia
Hypermagnesemia
Hypokalemia
Hypocalcemia
Hypophopsphatemia
Which of the following statements about Ganciclovir is FALSE?
When given IV, it is mostly excreted through renal filtration and secretion
Its usual maintenance dose is 1 gm PO TID AC
Its plasma concentration is lower in African-Americans than in Caucasians
When given per os, it is mostly excreted in the feces
It can be infused intravenously for the treatment of CMV-retinitis in immunocompromised patients
Ms. Jen's Epstein-Barr Virus Infection is being treated with Phosphonoformic acid; Which of the following will she experience as a result of an adverse effect of the drug? SATA
Tetany
Numbness
Anemia
Perioral Paresthesias
Seizures
Dihydroxypropxymethy guanine is the active ingredient in which of the following antiviral products? SATA
Cymevene
Cymeval
Cytovene
Zirgan
Vitrasert
All of the following are adverse effects of Zidovudine EXCEPT:
Nystagmus, Ataxia, and Confusion
Hyperlipidemia, Lipodystrophy, and Hypoglycemia
Lactic Acidosis and Hepatomegaly with Steatosis
Inflammation and Degradation of Muscle
Macrocytic Anemia and Granulocytopenia
Which of the following combination products that are used to treat AIDS is NOT matched with its correct contents?
Genvoya: Emtricitabine, Tenofovir Disoproxil, Cobicistat, Elvitegravir
Prezcobix: Darunavir, Tybost
Triumeq: Dolutegravir, Abacavir, Lamivudine
Biktarvy: Bictegravir, Tenofovir Alafenamide, Emtricitabine
Dovato: Dolutegravir, Lamivudine
ONE BEST ANSWER: Which of the following statements about Maraviroc is correct?
Maraviroc is a protease inhibitor
Maraviroc is a CCR5 antagonist
Maraviroc is a HIV integrate inhibitor
Maraviroc is a nucleoside analogue
Maraviroc is a neuramidase inhibitor
ONE BEST ANSWER: Which of the following statements about Didanosine is CORRECT?
Didanosine is a protease inhibitor
Didanosine is a CCR5 antagonists
Didanosine is a HIV integrase inhibitor
Didanosine has low oral bioavailability (25%)
Didansonine has high oral bioavailability (92%)
ONE BEST ANSWER: Enfuvirtide binds to the ___ rich region of the gp41 protein.
Alanine
Proline
Glutamic Acid
Aspartic Acid
Tryptophan
ONE BEST ANSWER: Stavudine is a ______.
Purine analog
Sulfonamide analog
Peptide analog
Thymidine analog
Non-nucleoside analog
ONE BEST ANSWER: Which of the following statements about Oseltamivir is correct?
Oseltamivir has seven chiral centers
Oseltamivir is a deoxyguanosine analog
Oseltamivir is a M2 Proton Channel Inhibitor
Oseltamivir is a neuraminidase inhibitor
Oseltamivir is a deoxyadenine analog
ONE BEST ANSWER: Which of the following statements about Valacyclovir is CORRECT?
Valacyclovir is a prodrug of acyclovir. Acyclovir has the high oral bioavailability than Valacyclovir
Valacyclovir is a prodrug of acyclovir. Valcyclovir has the high oral bioavailability than Acyclovir
Acyclovir is a prodrug of Valacyclovir. Acyclovir has the high oral bioavailability than Valacyclovir
Valacyclovir is NOT a prodrug
Valacyclovir is a M2 Proton Channel Inhibitor
ONE BEST ANSWER: Which of the following statements about Famciclovir is correct?
Penciclovir is a pro-drug of Famciclovir
Famciclovir is a viral cell wall biosynthesis inhibitor
Famciclovir is a M2 Proton Channel Inhibitor
Famciclovir is a neuraminidase inhibitor
Famciclovir is a pro-drug of Penciclovir
ONE BEST ANSWER: Rimantadine is a
Nucleoside Analog
Sulfonamide Analog
M2 Proton Channel Inhibitor
Neuraminidase Inhibitor
Carbohydrate Analog
