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WorksheetsPEDIGREE 2025 PG QUIZ
Total questions: 25
Worksheet time: 25mins
Hereditary orotic aciduria type II is due to deficiency of the following enzyme:
Dihydroorotate dehydrogenase
Orotate phosphoribosyl transferase
Aspartate transcarbamoylase
Orotidylate decarboxylase
A 5 month old infant presents with a seizure. His mother gave history of lethargy and irritability past several days. The infant is hypoglycemic and urine ketones are negative. Short chain dicarboxylic acids are elevated. The most likely enzyme deficiency is
Carnitine Acyltransferase I
Medium chain Acyl CoA Dehydrogenase
Very Long Chain Acyl CoA Dehydrogenase
Fatty Acyl CoA Synthase
Assertion: The Fatty Acid Synthase Complex & Acetyl-CoA Carboxylase Are Adaptive Enzymes
Reason: These enzymes adapt to the physiologic needs of the body by Covalent modification
Both Assertion and Reason are true, and Reason is the correct explanation for Assertion
Both Assertion and Reason are true, and Reason is not the correct explanation for assertion
Assertion is true, but Reason is false
Assertion is false, but Reason is true
A 50-year-old male patient has high cholesterol levels and is placed on lovastatin. He is counselled to stop drinking his usual glass of grapefruit juice every morning. Which of the following may be the correct reason for stopping grapefruit juice?
Grapefruit juice inhibits the cytochrome p450 enzyme which modifies lovastatin for excretion.
Grapefruit juice stimulates the cytochrome p450 enzyme which modifies lovastatin for excretion.
Grapefruit juice is a competitive inhibitor of lovastatin binding to cholesterol.
Grapefruit juice is a competitive inhibitor of HMG-CoA reductase.
Assertion: Low carbohydrate and high fat diets are commonly prescribed in weight reduction programs.
Reason: This type of diet is ketogenic indicating active fatty acid synthesis and gluconeogenesis for energy production
Both Assertion and Reason are true, and Reason is the correct explanation for Assertion
Both Assertion and Reason are true, and Reason is not the correct explanation for assertion
Assertion is true, but Reason is false
Assertion is false, but Reason is true
One of the following bonds is/are responsible for the semi rigidity of the Peptide bond
α-Carbon (Cα) to the Carbonyl carbon (Co)
Carbonyl carbon (Co) to the α-Nitrogen
α-Carbon (Cα) to α-Nitrogen
None of the above
All of the following is true about Methemoglobin except:
Less than 1% of Hb is present as methemoglobin normally.
It is Ferrihemoglobin
does not transport O2 but stores O2
congenital methemoglobinemia can be treated by large doses of ascorbate
All of the following are true about blood group antigens except:
ABO blood group is determined by glycoproteins with O-linked oligosaccharides on the surface of RBCs.
H substance formed by the action of a fucosyl transferase is Fucose—Gal—GluNAc—Protein
Blood group A substance encodes a N-acetyl-galactosaminyl transferase that adds the terminal GalNAc to H substance
Blood group B substance encodes a galactosyl transferase that adds the Gal residue to H substance.
All of the following are true about the action of Hexokinase except:
has a Km of 0.01mmol/L for glucose
It provides glucose-6-phosphate at a constant rate to the liver
Acts as a Glucose sensor in pancreatic β-islet cells
Not induced by Insulin
True about Sugar alcohols being used as sweetening agents except
less calorie content than ordinary sugar
less likely to contribute to tooth decay
only partially absorbed in the small intestine
Prepared by oxidation of sugars
One of the following statement is true about isomerism except
Optical isomers rotate the plane polarized light either to right or left
Constitutional isomers have the same functional groups
Epimers are non-superimposable mirror images of each other
D and L isomers rotate the plane polarized light either to clockwise or anticlockwise direction.
In an experiment, where liver mitochondria is isolated and incubated in limited amount of malate. After 3 minutes, Cyanide is added and the reaction is allowed for 7 minutes, which component of ETC will be in oxidized state?
Complex I
Complex II
Complex III
Complex IV
A 43 yrs old man presented to vascular surgery OPD for peripheral vascular disease. He was a non-smoker but had underwent CABG one year ago. O/E: He had palmar striae and tuberous Xanthoma. Some of his lab results are as follows
Fasting Serum Cholesterol: 386.6 mg/dL
HDL Cholesterol: 33.2mg/dL
TGL: 8115 mg/dL
His Apolipoprotein E genotype was E2/E2
Type 1 hyperlipidemia
Type 2a hyperlipidemia
Type 2b hyperlipidemia
Type 3 hyperlipidemia
Which enzyme deficiency results in elevated urine levels of maltotriose?
Debranching enzyme
Branching enzyme
Glycogen synthase
Phosphorylase kinase
A defect in UGT1A1 causes
Gilbert syndrome
Rotor syndrome
Dubin-Johnson syndrome
Crigler-Najjar syndrome type II
The defect in Segawa syndrome involves
Dopamine β-hydroxylase
GTP cyclohydrolase I
COMT
Monoamine oxidase
The most common mode of inheritance in Ehlers-Danlos syndrome is
Autosomal recessive
Autosomal dominant
X-linked dominant
Mitochondrial
What is the pH of a solution with 5 mmol/L of hydrogen ions?
3.0
1.3
2.3
5.0
Imiglucerase is used in the treatment of
Tay-Sachs disease
Gaucher’s disease
Niemann-Pick disease
Fabry disease
Lipoprotein(a) shows structural similarity to the kringle domain of
Albumin
Fibrinogen
Plasminogen
Apolipoprotein A-I
The reducing property of homogentisic acid is due to its
Carboxyl group
Methylene bridge
Benzene group
Phenolic hydroxyl group
Which of the following porphyrins fluoresce under Wood’s lamp?
Protoporphyrin IX
Uroporphyrinogen I
Coproporphyrin III
Hematoporphyrin
Canagliflozin, a hypoglycemic drug acts by inhibiting
SGLT-1
SGLT-2
GLUT 4
GLUT 3
The rationale for the usage of benzoic acids in urea cycle disorder defect is
It provides an alternative route for N2 excretion through N- Acetyl glucouronic acid conjugate Kynurenine
It provides an alternative route for N2 excretion through glycine conjugate,Hippuric acid
It inhibits glutamate dehydrogenase
It inhibits adenylate deaminase
Net ATP generation on complete oxidation of stearic acid is
106
108
120
122
