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WorksheetsHIGH FLUX AND HIGH EFFICIEANCY DIALYSIS
Total questions: 20
Worksheet time: 10mins
What is the main characteristic of a high-flux dialyzer?
Small surface area
Low ultrafiltration coefficient
High membrane permeability
Low blood flow rate
High-efficiency dialyzers are primarily defined by:
Inability to clear middle molecules
Low urea clearance
Use of cellulose membranes
High surface area and high urea clearance
Which molecule is most effectively cleared by high-flux dialyzers compared to low-flux dialyzers?
Urea
β2-microglobulin
Creatinine
Sodium
What is the typical ultrafiltration coefficient (Kuf) for high-flux dialyzers?
10–20 mL/mmHg/h
< 10 mL/mmHg/h
> 20 mL/mmHg/h
. Kuf is not used to measure dialyzer function
One major requirement for safely using high-flux dialyzers is:
Addition of calcium to dialysate
Use of saline dialysate
Reversal of dialysate flow
Use of ultrapure dialysate to reduce endotoxin exposure
Which of the following best describes the function of high-flux membranes?
Cannot be reused under any circumstances
Filter only water and glucose
Remove both small and "middle" molecules
Remove only small solutes like sodium
One potential risk when using high-flux dialyzers without proper water treatment is:
Hypernatremia
Endotoxin exposure
Electrolyte retention
Glucose overload
What is the most common indication for using a high-flux dialyzer?
Anemia
Edema
Removal of middle molecules like β2-microglobulin
Control of blood pressure
Which of the following patients would benefit MOST from high-flux dialysis?
A newly diagnosed hypertensive patient
A long-term dialysis patient with signs of amyloidosis
A patient with acute kidney injury (AKI)
A child with minimal uremic symptoms
19. What is the primary type of solute removal in high-efficiency dialysis?
A. Diffusion
B. Convection
C. Adsorption
D. Osmosis
One of the main advantages of high-flux dialysis over low-flux dialysis is:
Reduced ultrafiltration rate
Better phosphate retention
Improved removal of larger uremic toxins
Use of higher dialysate temperature
What is a common clinical benefit observed with high-flux dialysis?
Higher erythropoietin requirements
Reduced inflammation markers
Lower serum albumin levels
Increased cardiovascular risk
What does the mass transfer-area coefficient (KoA) of a dialyzer represent?
The efficiency of solute transfer across the membrane
The maximum ultrafiltration rate of a dialyzer
The dialyzer’s ability to remove water only
The total blood flow rate required during dialysis
In hemodialysis, KoA is commonly expressed in units of:
mL/min
mg/dL
m²
mL/min/mmHg
If the dialyzer’s KoA is low, which of the following is most likely true?
The dialyzer has high solute clearance efficiency
The dialyzer membrane has poor permeability or small surface area
The dialyzer removes large molecules very efficiently
Blood flow rate is excessively high
In the context of dialyzers, the term "flux" typically refers to:
The electrical conductivity of the dialyzer
The rate of blood flow through the dialyzer
The rate of solute or fluid transfer per unit membrane area
The resistance offered by the dialysate
The driving force for diffusive flux in a dialyzer is:
Pressure gradient
Temperature gradient
Concentration gradient
Membrane thickness
Ultrafiltration flux in a dialyzer depends on:
Concentration gradient only
Diffusivity of the solute
Transmembrane pressure
Dialysate temperature
The ultrafiltration coefficient (Kuf) is defined as:
. Surface area of the dialyzer
Pressure required to stop filtration
Volume of plasma filtered per unit pressure per time
The amount of urea removed per minute
Which type of solute is least efficiently removed by diffusive flux in a dialyzer?
Large proteins like albumin
Small electrolytes like Na⁺
Creatinine
Urea
