WorksheetsAdverse Drug Reactions Quiz
Total questions: 40
Worksheet time: 20mins
Which of the following best defines an Adverse Drug Reaction (ADR)?
Intentional drug misuse
Harmful reaction at normal dose
Drug overdose
Medication error
Which organization defines ADR as a "noxious and unintended response at normal doses"?
FDA
WHO
CDC
ICH
Which of the following is NOT considered an ADR?
Anaphylaxis due to penicillin
Headache from aspirin at normal dose
Liver damage due to paracetamol overdose
Rash after sulfa drug administration
ADR differs from a side effect because:
Side effects are not dose-dependent
ADRs are always mild
Side effects are known and predictable
ADRs occur only in children
Which is a Type B (bizarre) ADR?
Diarrhea with antibiotics
Hypoglycemia with insulin
Anaphylaxis with penicillin
Drowsiness with antihistamines
Type A ADRs are typically:
Unpredictable
Immunologic
Dose-dependent
Genetic
Which of the following is a delayed ADR?
Rash within minutes
Tardive dyskinesia with antipsychotics
Cough due to ACE inhibitors
Nausea with metformin
Which system is most commonly involved in ADRs?
Respiratory
Gastrointestinal
Nervous
Cardiovascular
Who is most at risk for ADRs?
Middle-aged athletes
Children
Young adults
Elderly on polypharmacy
Which is an example of a dose-independent ADR?
Nausea with metronidazole
Hepatotoxicity with isoniazid
Anaphylaxis to penicillin
Sedation with diazepam
Which is an example of excessive pharmacological effect?
Insulin-induced hypoglycemia
Penicillin allergy
Drug withdrawal seizure
Warfarin-induced bleeding
Secondary pharmacologic effect occurs when:
A drug is withdrawn
A drug acts on an unintended system
Genetic mutation occurs
Liver fails to detoxify
Which case suggests a secondary pharmacological effect?
Codeine causing constipation
Beta-blockers causing bradycardia
Paracetamol causing hepatotoxicity
Furosemide causing hypokalemia
A patient experiences severe extrapyramidal symptoms after antipsychotic use. This is likely:
Excessive pharmacologic effect
Secondary pharmacologic effect
Idiosyncratic reaction
Genetically determined toxicity
Which of the following is a hallmark of idiosyncratic reactions?
Predictable and dose-dependent
Due to immunological mechanisms
Unexpected and unusual reaction
Happens in everyone
Which is an idiosyncratic ADR?
Stevens-Johnson syndrome from carbamazepine
Drowsiness from diphenhydramine
Bleeding with aspirin
Headache from isosorbide
Allergic drug reactions typically involve:
Liver enzymes
T-cell suppression
Immune system
Dopamine receptor blockade
Which type of hypersensitivity is most involved in penicillin allergy?
Type I
Type II
Type III
Type IV
Genetically determined ADRs are seen in:
Aspirin-induced asthma
G6PD-deficiency with primaquine
Constipation from opioids
Nausea from antibiotics
What does pharmacogenomics help prevent?
Secondary effects
Drug abuse
Genetically linked ADRs
Drug interactions
Sudden withdrawal of which drug can cause seizures?
Atenolol
Morphine
Diazepam
Paracetamol
Withdrawal symptoms suggest:
New disease
Dependence
Genetic variation
Allergic reaction
Which class of drugs is notorious for withdrawal toxicity?
Antibiotics
Benzodiazepines
NSAIDs
Antacids
Abrupt withdrawal of corticosteroids may cause:
Hypertension
Addisonian crisis
Hyperglycemia
GI bleeding
Which classification includes Stevens-Johnson syndrome?
Secondary effect
Allergic reaction
Excessive effect
Withdrawal
A 24-year-old develops angioedema after first dose of penicillin. Type of ADR?
Excessive effect
Type A
Type B
Drug interaction
Patient on warfarin with high INR and bleeding. Likely classification?
Secondary effect
Excessive pharmacologic effect
Idiosyncrasy
Allergy
Patient starts ACE inhibitors and develops a chronic cough. Likely cause?
Idiosyncratic
Excessive effect
Secondary effect
Type I allergy
A 60-year-old alcoholic develops liver toxicity after isoniazid. Likely cause?
Idiosyncrasy
Drug-drug interaction
Excessive pharmacologic effect
Genetic toxicity
After stopping propranolol suddenly, patient gets chest pain. This is:
Rebound ADR
Allergy
Genetic toxicity
Type A ADR
Teenager on carbamazepine develops rash and fever. Which ADR?
Withdrawal
Idiosyncratic
Excessive pharmacologic
Type A
A patient with sulfa allergy experiences urticaria. What kind of hypersensitivity?
Type I
Type III
Type II
Type IV
A patient on phenytoin has gingival hyperplasia. This is an example of:
Secondary effect
Excessive effect
Withdrawal
Idiosyncratic
Patient with G6PD deficiency given sulfa drug develops hemolysis. This is due to:
Immune response
Genetic defect
Drug interaction
Excessive dose
Chronic corticosteroid use stopped abruptly leading to hypotension. Cause?
Allergy
Withdrawal toxicity
Side effect
Genetic variation
Which ADR type is most preventable?
Type A
Type B
Genetic
Idiosyncratic
Rechallenge with the same drug causes same reaction. This confirms:
New allergy
Predictable ADR
Causality
Tolerance
Which tool helps assess ADR causality?
APGAR Score
Naranjo Algorithm
ABC Score
CAGE Questionnaire
Patient develops fatigue, jaundice after rifampicin use. Likely ADR type?
Genetic
Type A
Idiosyncratic
Allergy
Which ADR type is common but usually mild and reversible?
Type B
Type C
Type A
Type D
