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Worksheets

Unit 3

Total questions: 183

Worksheet time: 3hrs 25mins

Name
Class
Date
1.

Match the following definitions with the correct term.

a)

A biomacromolecule made of amino acid chains folded into a 3D shape.

1.

Protein

b)

A long chain of amino acids.

2.

Polypeptide

c)

The entire set of proteins expressed by an organism at a given time.

3.

Proteome

d)

The smallest building block of a polymer.

4.

Monomer

e)

A large molecule that is made up of small, repeated monomer subunits.

5.

Polymer

2.

Match each of the following explanations to the correct protein function.

a)

Speed up chemical reactions.

1.

Enzymes

b)

Control the entry and exit of substances from a cell.

2.

Transport

c)

Support cell and tissue shape.

3.

Structural

d)

Chemical messengers used to communicate and induce changes in cells.

4.

Hormones

3.

Match each of the following explanations to the correct protein function.

a)

Receive signals from the environment.

1.

Receptors

b)

Recognise and destroy pathogens.

2.

Defence

c)

Involved in the contraction and movement of muscles, internal cell contents and cilia/flagella.

3.

Motor/contractile

d)

Acts as reserves for metal ions and other molcules in organisms.

4.

Storage

4.

How many different amino acids are there?

a)

10

b)

20

c)

200

d)

2 billion

5.

Label the following diagram of an amino acid.

6.

Which of the following parts of an amino acid is variable (i.e. different in different types of amino acid)?

a)

Amino group

b)

Central carbon

c)

R-group

d)

Carboxyl group

7.

An amino acid with a hydrophobic R-group is most likely to form bonds with other amino acids that have:

a)

Hydrophobic R-groups

b)

Hydrophilic R-groups

c)

No R-groups

d)

Either hydrophobic or hydrophilic R-groups

8.

Match each of the following descriptions to the correct level of protein structure.

a)

The sequence (or order) of amino acids in a polypeptide chain.

1.

Primary structure

b)

The formation of alpha helices and beta pleated sheets due to hydrogen bonds between amino acids.

2.

Secondary structure

c)

The overall functional 3D shape of a protein.

3.

Tertiary structure

d)

The formation of a protein with two or more polypeptide chains joined together and/or with a prosthetic group.

4.

Quaternary structure

9.

Match each of the following pictures to the correct level of protein structure.

a)

1.

Tertiary structure

b)

2.

Secondary structure

c)

3.

Primary structure

d)

4.

Quaternary structure

10.

Nucleic acids are large polymers made up of small units called monomers. The specific monomers for nucleic acids are:

a)

Amino acids

b)

Nucleotides

c)

Monosaccharides

d)

Fatty acids

11.

Label the follow diagram of a nucleotide.

12.

The bonds between the sugar of one nucleotide and the phosphate of another are called:

a)

Phosphodiester bonds

b)

Peptide bonds

c)

Ionic bonds

d)

Hydrogen bonds

13.

DNA is composed of two polynucleotide strands, one running in a 3' to 5' direction and the other running in a 5' to 3' direction. The term used to describe this is:

a)
parallel
b)

complementary

c)

universal

d)
antiparallel
14.

Which of these nitrogenous bases is not found in DNA?

a)
Uracil
b)
Adenine
c)
Cytosine
d)
Thymine
e)
Guanine
15.

Which of the following correctly summarises the rules of complementary base pairing?

a)

A pairs with T
C pairs with G

b)

A pairs with C

G pairs with T

c)

A pairs with G

C pairs with T

16.

Which of these nitrogenous bases is not found in RNA?

a)
Uracil
b)
Adenine
c)
Cytosine
d)
Thymine
e)
Guanine
17.

Match each type of RNA with its function.

a)

Carries genetic information from the nucleus to the ribosomes for protein synthesis.

1.

mRNA

b)

Delivers specific amino acids to the ribosome after recognising specific nucleotide sequences on mRNA.

2.

tRNA

c)

Serves as the main structural component of ribosomes within cells.

3.

rRNA

18.

Sort the following based on whether they are characteristics of DNA, RNA or both.

Categorize the following

Double-stranded

Deoxyribose sugar

Adenine, thymine, cytosine, guanine

Inherited, long-term storage

Single-stranded

Ribose sugar

Adenine, uracil, cytosine, guanine

Temporary and short-lived

Made of nucleotides

Phosphate-sugar backbone

DNA
RNA
Both
19.

Place the following steps in the order in which they need to occur for a protein to be produced.

a)

Transcription

b)

RNA processing

c)

Translation

1)
2)
3)
20.

The genetic codes is read in groups of how many nucleotides?

a)

2

b)

3

c)

5

d)

10

21.

In DNA, a group of three nucleotides is called a:

a)

Triplet

b)

Codon

c)

Anticodon

d)

Trio

22.

In mRNA, a group of three nucleotides is called a:

a)

Triplet

b)

Codon

c)

Anticodon

d)

Trio

23.

Each triplet or codon codes for a specific:

a)

amino acid

b)

nitrogenous base

c)

sugar

d)

protein

24.

The start codon (AUG) also codes for the amino acid:

a)

methionine

b)

glycine

c)

leucine

d)

valine

25.

Match each of the following properties of the genetic code to its description.

a)

Nearly all organisms use the same codons to code for specific amino acids.

1.

Universal

b)

Each codon is capable of coding for one specific amino acid.

2.

Unambiguous

c)

Each amino acid may be coded for by multiple different codons.

3.

Degenerate or redundant

d)

Each triplet or codon is read independently.

4.

Non-overlapping

26.

Match each of the following regions of a gene with their description.

a)

Binding site for RNA polymerase

1.

Promoter

b)

Regions of non-coding DNA

2.

Introns

c)

Regions of coding DNA

3.

Exons

d)

Binding site for repressor proteins

4.

Operator

e)

Signals for the end of transcription

5.

Termination sequence

27.

Place the following steps involved in gene expression in the correct order.

a)

Transcription

b)

RNA processing

c)

Translation

1)
2)
3)
28.

In eukaryotes, transcription occurs in the:

a)

Nucleus

b)

Cytosol

c)

Mitochondria

d)

Ribosomes

29.

In prokaryotes, transcription occurs in the:

a)

Nucleus

b)

Cytosol

c)

Mitochondria

d)

Ribosomes

30.

Place the following steps (used to describe both transcription and translation) in the correct order.

a)

Initiation

b)

Elongation

c)

Termination

1)
2)
3)
31.

Match the following steps involved in transcription with their description.

a)

RNA polymerase binds to the promoter region ready to start transcription, and the DNA unwinds and unzips.

1.

Initiation

b)

RNA polymerase moves along the template strand, building a complementary pre-mRNA molecule.

2.

Elongation

c)

RNA polymerase reachs the termination sequence of a gene and detaches.

3.

Termination

32.

Match the following steps involved in translation with their description.

a)

mRNA binds to the ribosome and is read until the start codon (AUG) is recognised, then a tRNA molecule delivers the amino acid methionine.

1.

Initiation

b)

The mRNA molecule is fed through the ribosome, the mRNA codons are read, and tRNA molecules with complementary anticodons deliver specific amino acids and add them to the growing polypeptide through a condensation reaction.

2.

Elongation

c)

The process continues until the ribosome reachs a stop codon on the mRNA, causing the ribosome to stop translating and release the polypeptide.

3.

Termination

33.

Label the following diagram of transcription.

34.

Label the diagram showing the changes that occur during RNA processing.

35.

A single gene can code for many different proteins. This is due to a process known as alternative splicing where the final mRNA strand can contain varying combinations of:

a)

exons

b)

introns

c)

genes

d)

amino acids

36.

Translation occurs at the:

a)

Nucleus

b)

Cytosol

c)

Mitochondria

d)

Ribosomes

37.

Label the following diagram of translation.

38.

After translation, polypetides are folded and modified into a fully functional protein. This occurs at the:

a)

Ribosome

b)

Endoplasmic reticulum and Golgi apparatus

c)

Mitochondria

d)

Plasma membrane

39.

Label the following diagram showing the input and output of each stage of gene expression.

40.

True or false? Every cell somatic cell in the human body has the same DNA.

a)

True

b)

False

41.

Match the following defintions to the correct term.

a)

Responsible for producing proteins that are involved in the structure or function of a cell.

1.

Structural gene

b)

Responsible for the production of regulatory proteins (e.g. repressor proteins).

2.

Regulatory genes

c)

Multiple structural genes which share a common purpose and are arranged in groups.

3.

Operon

42.

The trp operon codes for proteins involved in the production of:

a)

Carbohydrates

b)

The amino acid tryptophan

c)

ATP

d)

Repressor molecules

43.

REPRESSION: When there are high levels of tryptophan in a cell, tryptophan will bind to this molecule, causing it to change into its active form.

a)

Repressor protein

b)

Promoter

c)

Operator

d)

Leader

44.

REPRESSION: When the repressor protein is in its active form it will bind to this part of the gene, thus preventing the transcription of the structural genes by blocking the path of RNA polymerase.

a)

Operator

b)

Promoter

c)

Leader

d)

RNA

45.

True or false? Transcription and translation take place at different times in prokaryotes.

a)

True

b)

False

46.

ATTENUATION: Put the following steps of attenuation in the correct order, reflecting a situation when there are high levels of tryptophan in a cell.

a)

The process of transcription and translation of the trp operon being and occur simultaneously.

b)

The ribosome involved in translation arrives at the attenuator sequence that codes for two tryptophan amino acids. The tRNA-bound tryptophan that is present in the cell travels to the ribosome and is added to the protein that is being made.

c)

This causes the mRNA molecule being read by the ribosome to fold in a specific way via hydrogen bonds and form a terminator hairpin loop.

d)

The folding of the terminator hairpin loops causes the mRNA molecule to separate from the template DNA at the attenuator sequence.

e)

RNA polymerase detaches from the DNA, causing transcription to stop before any structural genes are transcribed – therefore, no new tryptophan is synthesised.

1)
2)
3)
4)
5)
47.

ATTENUATION: Put the following steps of attenuation in the correct order, reflecting a situation when there are low levels of tryptophan in a cell.

a)

The process of transcription and translation of the trp operon being and occur simultaneously.

b)

The ribosome involved in translation arrives at the attenuator sequence that codes for two tryptophan amino acids. Due to their being no tRNA-bound tryptophan, it pauses. Meanwhile, the RNA polymerase involved in transcription continues along the DNA.

c)

This causes the mRNA molecule to fold in a specific way via hydrogen bonds and form an antiterminator hairpin loop.

d)

The antiterminator hairpin loop does not cause the mRNA to separate form the template strand at the attenuator sequence.

e)

RNA polymerase continues to read the DNA template strand, transcribing the structural genes for proteins involved in the synthesis of tryptophan, and translation can continue – therefore leading to more tryptophan being synthesised.

1)
2)
3)
4)
5)
48.

The attenuator sequence, crucial to the process of attenuation, is found in which part of the trp operon?

a)

Promoter

b)

Operator

c)

Leader

d)

Structural genes

49.

The attenuator sequence consists of:

a)

Two trp codons

b)

Multiple structural genes

c)

A hairpin loop

d)

A regulatory gene

50.

Exocytosis is:

a)

The process by which the contents of a vesicle are released from a cell.

b)

The process by which the contents of a vesicle are transported into a cell.

c)

A passive process

d)

Only peformed in prokaryotes.

51.

Place the stages of exocytosis in the correct order.

a)

A vesicle containing secretory products is transported to the plasma membrane.

b)

The membrane of the vesicle fuses with the plasma membrane.

c)

The secretory products are released from the cell into the extracellular environment.

1)
2)
3)
52.

Label the following diagram of exocytosis.

53.

Match the following functions to the correct organelle involved in the protein secretory pathway.

a)

Synthesises proteins

1.

Ribosome

b)

Folds and transports proteins

2.

Rough endoplasmic reticulum

c)

Transport vesicle

3.

Transports proteins

d)

Modifies and packages proteins

4.

Golgi apparatus

e)

Secretory vesicle

5.

Releases proteins outside of the cell

54.

Put the following organelles in the correct order in which they are involved in exocytosis.

a)

Ribosome

b)

Rough endoplasmic reticulum

c)

Transport vesicle

d)

Golgi apparatus

e)

Secretory vesicle

1)
2)
3)
4)
5)
55.

Match the following functions to the correct organelles (that are involved in exocytosis, but to a lesser extent).

a)

Provide the energy required

1.

Mitochondria

b)

Fuses with vesicles to faciliate the release of proteins from a cell.

2.

Plasma membrane

c)

Stores DNA which contains the instructions for mRNA and therefore protein synthesis.

3.

Nucleus

56.

Label the following diagram outlining the function of enzymes.

57.

Match the following features of enzymes with their description.

a)

An enzyme is not used up during a reaction, so it is free to catalyse future reactions.

1.

Reusable

b)

Most enzymes only bind to one specific substrate.

2.

Specific

c)

Most enzymes reactions can occur in either direction (building up molecules or breaking them down).

3.

Reversible

d)

Enzymes don't make reactions occur that wouldn't happen otherwise, they just make them faster.

4.

Speed up, not create

e)

Most enzymes are are made of one or more polypeptide chains.

5.

Are proteins

58.

Match the following features of enzymes with their description.

a)

Each enzyme has a region that is complementary in shape to its substrate, allowing it to bind.

1.

Have an active site

b)

All enyzmes are catalysts, but not all catalysts are enzymes.

2.

Are a subset of catalysts

c)

Enzymes catalyse each step in pathways of reactions.

3.

Act on entire biochemical pathways

d)

Many enzymes have the same suffix (e.g. catalase, ligase, lactase).

4.

End in '-ase'

e)

When writing a chemical equation, enzymes aren't included in the reactants or the products.

5.

Are drawn above the arrow

59.

The ​ (a)   of enzyme activity involves the substrate fitting perfectly into the active site, whereas the ​ (b)   involves the active site conforming to its substrate's shape.

Choose from the below words
lock-and-key model
induced-fit model
60.

A different enzyme is generally needed for each step of a biochemical pathway, as each step will have a different:

a)

substrate

b)

product

c)

activation energy

d)

active site

61.

As temperature increases, chemical reactions generally:

a)

Speed up

b)

Slow down

c)

Are not affected

62.

Enzymes found in the human body are likely to have an optimal temperature of about:

a)

37°

b)

70°

c)

d)

20°

63.

Classify the following as things that happen when enzymes are too hot or too cold.

Categorize the following

Enzyme denatures

Active site changes shape

Irreversible change

Molcules move slower

Less collisons occur

Reversible change

Too hot
Too cold
64.

Enzymes function best at their optimal conditions (e.g. optimal temperature), but also still function in a wider range of conditions known as their:

(a)  

65.

The main difference between how pH affects enzyme activity and how temperature affects enzyme activity is:

a)

Only high temperature denatures enzymes whereas only low pH denatures enzymes

b)

Only high temperature denatures enzymes whereas both high and low pH denatures enzymes

c)

Only low temperature denatures enzymes whereas only high pH denatures enzymes

d)

Only low temperature denatures enzymes whereas both high and low pH denatures enzymes

66.

Assuming enzyme concentration remains consant, increasing substrate concentration will generally:

a)

Increase the rate of reaction

b)

Decrease the rate of reaction

c)

Have no effect on the rate of reaction

67.

The point at which increasing substrate concentration will no longer increase the rate of reaction (as all active sites of enzymes are occupied) is known as the:

(a)  

68.

Increasing enzyme concentration will generally:

a)

Increase the rate of reaction

b)

Decrease the rate of reaction

c)

Have no effect on the rate of reaction

69.

Which variable on these graphs is most likely to represent temperature?

a)

Variable 1

b)

Variable 2

c)

Variable 3

d)

Variable 4

70.

Competitive inhibitors bind to an enzyme's ​ (a)   , blocking the substrate from attaching, whereas non-competitive inhibitors bind to an ​ (b)   , causing a change in the active site.

Choose from the below words
active site
allosteric site
71.

Reversible inhibitors bind to the enzyme with ​ (a)   bonds, meaing they can often be overcome by adding more ​ (b)   . Irreversible inhibtors bind to the enzyme with ​ (c)   bonds, meaning they can't be dislodged.

Choose from the below words
weak
substrate
strong
enzyme
72.

Coenzymes can be loaded or unloaded. Which of the following is an example of an unloaded coenzyme?

a)

ADP

b)

ATP

c)

NADH

d)

NADPH

73.

Match each of the following enzymes that manipulate DNA with their function.

a)

Cut DNA

1.

Endonucleases

b)

Join fragments of DNA or RNA

2.

Ligases

c)

Synthesise new molecules of DNA or RNA

3.

Polymerases

74.

The region of DNA targeted by a restriction endonuclease is known as the:

a)

Recognition site

b)

Active site

c)

Allosteric site

d)

Binding site

75.

Label the following diagram showing the possible outcomes when endonucleases cut a DNA molecule.

76.

If a circular DNA molecule is cut with a particular endocnuclease for which it has three recogntion sites, how many fragments of DNA will be produced?

a)

1

b)

2

c)

3

d)

4

77.

If a linear DNA molecule is cut with a particular endocnuclease for which it has three recogntion sites, how many fragments of DNA will be produced?

a)

1

b)

2

c)

3

d)

4

78.

When ligases join fragments of nucleic acids together, they do this by catalysing the formation of:

a)

Hydrogen bonds

b)

Phosphodiester bonds

c)

Peptide bonds

79.

A difference between ligases and endonucleases is:

a)

Ligases are specific, endonucleases are not

b)

Endonucleases are specific, ligases are not

c)

The action of endonucleases is reversible, the action of ligases is not.

d)

The action of ligases is reversible, the action of endonucleases is not.

80.

Which of the following enzymes is used in the process of transcription?

a)

RNA polymerase

b)

DNA polymerase

c)

DNA ligase

d)

Restriction endonucleases

81.

In which direction do polymerases synthesise a complementary strand of nucleic acid?

a)

5' to 3'

b)

3' to 5'

c)

They can synthesise in either direction

82.

The CRISPR-Cas9 system is naturally found in:

a)

Bacteria

b)

Humans

c)

Plants

d)

Viruses

83.

What type of molecule is Cas9?

a)

Endonuclease

b)

Ligase

c)

Polymerase

d)

Amino acid

84.

When a bacterium encounters a virus, it takes a 'mugshot' of its DNA and stores it within its own genome in a section called a:

a)

Spacer

b)

Repeat

c)

Palindrome

d)

Endonuclease

85.

The two enzymes involved in cutting out the viral DNA so that it can be stored as a spacer are:

a)

Cas1 and Cas2

b)

Cas1 and Cas9

c)

Cas2 and Cas9

d)

CRISPR and Cas9

86.

The short sequence that is easily recognisable by Cas9, therefore increasing its efficency, is called a:

a)

PAM sequence

b)

NGG sequence

c)

CRISPR sequence

d)

Palindromic sequence

87.

Spacers stored in the bacterial genome are transcribed and converted into a molecule known as:

a)

guide RNA (gRNA)

b)

messenger RNA (mRNA)

c)

ribosomal RNA (rRNA)

d)

transfer RNA (tRNA)

88.

Label the following diagram of a CRISPR-Cas9 complex.

89.

Enzymes within the bacterium will naturally act to repair any cuts to viral DNA, so it will continue to be repaired and re-cut until what occurs?

a)

Mutations in the viral gene occur making it non-functional

b)

Cas9 enzme and gRNA separate

c)

The cell runs out of energy

d)

The viral DNA has disappeared

90.

CRISPR-Cas9 can be harnessed by humans and used for gene editing. Put the following steps in order to outline how this process works.

a)

Synthetic sgRNA is created in a lab that has a complementary spacer to the target DNA that scientists wish to cut, and a Cas9 enzyme is obtained with an approproate PAM sequence.

b)

Cas9 and sgRNA are added together in a mixture and bind together to create the CRISPR-Cas9 complex, which is then injected into a specific cell.

c)

The Cas9 finds the target PAM sequence and checks whether the sgRNA aligns with the DNA. If it does, it cuts the DNA.

d)

The DNA has a blunt end cut that the cell will attempt to repair.

e)

When repairing the DNA, the cell may introduce new nucleotides into the DNA at this site. Scientists may inject particular nucleotide sequences into the cell with the hope they will ligate into the gap.

1)
2)
3)
4)
5)
91.

Which of the following is easier to do when using CRISPR-Cas9 for gene editing?

a)

Knock out (disrupt) a gene

b)

Add in a new segment of DNA

92.

The purpose of the polymerase chain reaction (PCR) is to:

a)

Amplify DNA

b)

Cut DNA

c)

Compare sample of DNA

d)

Edit DNA

93.

Match the following descriptions with the correct materials required for PCR.

a)

Contains the section of DNA that needs to be amplified

1.

DNA sample

b)

Type of DNA polymerase found in bacteria that will build new strands of DNA

2.

Taq polymerase

c)

Short DNA fragments used to initiate the synthesis of new DNA strands and allow Taq polymerase to attach

3.

Primers

d)

To be used by Taq polymerase to create a new strand of DNA

4.

Nucleotides

94.

Put the following steps outlining the process of PCR in the correct order.

a)

Denaturation: DNA is heated to approximately 90-95°C to break the hydrogen bonds between the bases and separate the strands, forming single-stranded DNA.

b)

Annealing: The single-stranded DNA is cooled to approximately 50-55°C to allow the primers to bind to complementary sequences on the single-stranded DNA.

c)

Elongation: The DNA is heated again to 72°C, which allows Taq polymerase to work optimally. Taq polymerase binds to the primer (as a starting point) and begins synthesising a new complementary strand of DNA.

d)

The previous steps are repeated multiple times.

1)
2)
3)
4)
95.

Match the following pictures to the correct stage of PCR.

a)

1.

Denaturation

b)

2.

Annealing

c)

3.

Elongation

d)

4.

Repeat

96.

Match the followings steps of PCR to the temperature at which they must occur.

a)

Denaturation

1.

95°C

b)

Annealing

2.

50-55°C

c)

Elongation

3.

72°C

97.

Which end of a DNA strand will a primer attach to?

a)

3' end

b)

5' end

c)

They can attach to either end

98.

In which direction will Taq polymerase synthesis a new strand of DNA?

a)

5' to 3' direction

b)

3' to 5' direction

c)

It can synthesis DNA in either direction

99.

Gel electrophoresis is a process that is used to:

a)

measure the size of DNA fragments

b)

create many copies of a DNA fragment

c)

insert a DNA fragment into a bacterial plasmid

d)

edit human DNA

100.

Place these steps involved in gel electrophoresis into the correct order.

a)

DNA samples are loaded into wells at one end of the gel.

b)

The gel is immersed in a buffer solution.

c)

An electric current is passed through the gel using two electrodes.

d)

DNA fragments move through the gel towards the positive electrode.

e)

The gel is stained with a dye to allow visualisation of the DNA bands.

1)
2)
3)
4)
5)
101.

Label the following diagram outlining the process of gel electrophoresis.

102.

What is the charge of a DNA molecule?

a)

Positive

b)

Negative

c)

Neutral

103.

Using the standard ladder shown, what is the approximate size of the DNA fragment circled in red?

a)

120 bp

b)

220 bp

c)

80 bp

d)

300 bp

104.

Gel electrophoresis can be used in the process of genetic testing due to different alleles often having a different:

a)

size

b)

base sequence

c)

chromosome locus

105.

If a person was homozygous for a particular gene, and you ran their DNA fragments through a gel, how many bands would you expect to see?

a)

0

b)

1

c)

2

106.

If a person was heterozygous for a particular gene, and you ran their DNA fragments through a gel, how many bands would you expect to see?

a)

0

b)

1

c)

2

107.

When using gel electrophoresis for DNA profiling, we analyse regions of DNA known as:

(a)  

108.

Match the following definitions to the correct term.

a)

A plasmid that has had an extra gene added to it.

1.

Recombinant plasmid

b)

When bacteria take up a recombinant plasmid.

2.

Bacterial transformation

c)

A small, circular DNA molecule that can replicate independently of chromosomal DNA in bacteria.

3.

Plasmid

d)

An enzyme used to cut the plasmid and the gene of interest.

4.

Endonuclease

e)

An enzyme used to join the plasmid and the gene of interest.

5.

DNA ligase

109.

Place the following steps involved in transforming bacteria in the correct order.

a)

A plasmid vector is selected into which the gene of interest will be inserted.

b)

The gene of interest and the plasmid vector are both cut with the same endonuclease.

c)

DNA ligase is used to join the gene of interest to the plasmid, creating a recombinant plasmid.

d)

Recombinant plasmids are inserted into bacteria using either heat shock or electroporation.

e)

Transformed bacteria are selected using antibiotics and/or a reporter gene, and then induced to produce the target protein.

1)
2)
3)
4)
5)
110.

What is the higest level of protein structure present in an inuslin molecule?

a)

Primary

b)

Secondary

c)

Tertiary

d)

Quaternary

111.

Place the following steps involved in producing human insulin in the correct order.

a)

Plasmid vectors which contain genes for resistance to ampicillin and tetracycline are prepared.

b)

Two plasmid vectors (one for insulin A and one for insulin B) are cut with EcoR1 and BamH1 (disrupting the tetR gene), and insulin genes are joined using DNA ligase.

c)

The plasmids are added to a solution of E. coli bacteria and some of the bacteria take up plasmids (recombinant and non-recombinant).

d)

Bacteria are then cultured on an agar plate containing ampicillin, killing the bacteria that did not take up any plasmid.

e)

Samples from suriving colonies are then cultured on an agar plate containing tetracycline, and the ones that die must have contained the recombinant plasmid.

1)
2)
3)
4)
5)
112.

Place the remaining steps involved in producing human insulin in the correct order.

a)

Plasmids are then cut open again to add a lacZ gene next to the insulin gene, which produces a large protein and stops the insulin protein from being digested.

b)

The recombinant plasmids containing lacZ are added to a new solution of bacteria and some of these plasmids are taken up.

c)

Bacteria are then grown on an agar plate with ampicillin and X-gal. Those with the recombinant plasmid will survive and turn blue.

d)

Transformed bacteria are placed in conditions where they will reproduce, insulin proteins are extracted, and the large protein attached to them is removed.

e)

The two different insulin chains (A and B) are mixed together and will bond to form human insulin.

1)
2)
3)
4)
5)
113.

What is the name of the large protein that is produced attached to an insulin chain to stop it being digested?

a)

β-galactosidase

b)

X-gal

c)

Cyanogen bromide

d)

Methionine

114.

Which of these processes would be it generally be necessary to perform before starting the process of bacterial transformation?

a)

Polymerase chain reaction (PCR)

b)

CRISPR-Cas9 gene editing

c)

Protein synthesis

d)

Transcription

115.

What term describes the feature of the genetic code that means genes from one species (e.g. humans) can function in another (e.g. bacteria)?

a)

Universal

b)

Redundant

c)

Degenerate

116.

Match the following terms with their correct definition.

a)

Any organism that has ben altered using genetic engineering technologies.

1.

Genetically modified organism (GMO)

b)

An organism with genes inserted from another species

2.

Transgenic organism

c)

An organism with genes inserted from the same species

3.

Cisgenic organism

117.

Label the following diagram.

118.

A particular species of bacteria has had a gene from a species of jellyfish inserted, making it glow when placed under a UV light. This bacteria could be classified as:

a)

A transgenic organism only

b)

A cisgenic organism only

c)

A transgenic organism and a genetically modified organism (GMO)

d)

A cisgenic organism and a genetically modified organism (GMO)

119.

Which of the following would not be a desirable characteristic in genetically modified crops?

a)

Increased resistance to pesticides

b)

Increased crop productivity

c)

Decreased resistance to disease

d)

Increased tolerance to drought

120.

Categorise each of the following as a biological, social or ethical implication of genetically modified organisms.

Categorize the following

Loss of genetic diversity

Reduced habitat loss due to crops

Better food security

Higher cost to farmers

Unnatural act, 'playing God'

Inhumane treatment of animals

Biological implication
Social implication
Ethical implication
121.

Complete the following word equation showing the reactants and products of photosynthesis.

122.

Which of these is not one of the possible uses of the glucose produced in photosynthesis?

a)

Used as an amino acid when synthesising polypeptides

b)

Used as a source of energy

c)

Stored as starch

d)

Used to form complex molecules such as cellulose

123.

The main site of photosynthesis in a plant are the​ (a)   , which are suited to this due to their ​ (b)   and the large numbers of ​

(c)   (an organelle that contains ​ (d)   ) in their ​ (e)   cells.

Choose from the below words
leaves
large surface area
chloroplasts
chlorophyll
mesophyll
124.

Water enters a plant through ​ (a)   , and is transported through the ​ (b)   , while carbon dioxide enters through small pores in the leaf known as ​ (c)   .

Choose from the below words
root hair cells
xylem
stomata
125.

Label the following diagram of a chloroplast.

126.

The light-dependent stage of photosynthesis occurs in the (a)   of the chloroplast.

127.

Sort the following molecules into inputs and outputs of the light-dependent stage of photosynthesis.

Categorize the following

12 water (H2O) molecules

12 NADP+

18 ADP + Pi

6 oxygen (O
2) molecules

12 NADPH

18 ATP

Inputs
Outputs
128.

Label the following diagram with the missing inputs and outputs of the light-dependent reaction.

129.

The light-independent stage occurs in the (a)   of the chloroplast.

130.

Sort the following molecules into inputs and outputs of the light-independent stage of photosynthesis.

Categorize the following

6 water (H2O) molecules

12 NADP+

18 ADP + Pi

12 NADPH

18 ATP

6 carbon dioxide (CO2) molecules

1 glucose (C6H12O6) molecule

Inputs
Outputs
131.

Label the following diagram with the missing inputs and outputs of the light-independent reaction.

132.

Classify the following as loaded or unloaded coenzymes.

Categorize the following

ATP

NADPH

ADP

NADP+

Loaded coenzymes
Unloaded coenzymes
133.

Fill in the missing labels on this diagram summarising the overall process of photosynthesis.

134.

Which stage of photosynthesis is the enzyme Rubisco involved in?

a)

Light-dependent stage

b)

Light-independent stage

135.

What molecule does Rubisco bind to, fixing the carbon into organic 3-PGA and initiating the calvin cycle?

a)

CO2

b)

Glucose

c)

Water

d)

Oxygen

136.

When Rubisco binds to oxygen instead of carbon dioxide, this is known as:

a)

Photorespiration

b)

Photosynthesis

c)

The Calvin cycle

d)

Glycolysis

137.

The combination of factors that make photorespiration most like to occur are:

a)

Low CO2 concentration, high O2 concentration, high temperatures

b)

Low CO2 concentration, high O2 concentration, low temperatures

c)

High CO2 concentration, low O2 concentration, high temperatures

d)

High CO2 concentration, low O2 concentration, low temperatures

138.

The majority of plants on Earth, which have no adapatations to reduce photorespiration, are what type of plants?

a)

C3

b)

C4

c)

CAM

139.

To avoid photorespiration, C4 plants separate their initial CO2 fixation and remainder of the Calvin cycle over:

a)

Space

b)

Time

c)

They don't separate these processes

140.

To avoid photorespiration, CAM plants separate their initial CO2 fixation and remainder of the Calvin cycle over:

a)

Space

b)

Time

c)

They don't separate these processes

141.

Match the type of plant to its most suited environment.

a)

C3

1.

Moderate, or cool and wet environments

b)

C4

2.

Hot, sunny habitats

c)

CAM

3.

Very hot, dry habitats

142.

Match the following definitions to the correct terms.

a)

Specialised cell where Rubisco acts in C4 plants

1.

Bundle-sheath cell

b)

Specialised cell where initial carbon fixation (not involving Rubisco) takes place in C4 plants

2.

Mesophyll cell

c)

Intermediate, 4-carbon molecule used as a source of CO2 in C4 and CAM plants

3.

Malate

143.

Sort the types of plants in categories based on when they open their stomata.

Categorize the following

CAM plants

C4 plants

C3 plants

Night
Day
144.

Which of the following best describes the relationship between light intensity and the rate of photosynthesis?

a)

As light intensity increases, rate of photosynthesis increases

b)

As light intensity increases, rate of photosynthesis increases to a point, then plateaus

c)

As light intensity increases, rate of photosynthesis decreases

d)

There is no relationship between light intensity and the rate of photosynthesis

145.

Which wavelengths of light result in the highest rate of photosynthesis?

a)

Blue and red

b)

Green and red

c)

Green and blue

d)

Red and yellow

146.

Temperature and pH both affect the rate of photosynthesis due to the _______ involved.

a)

enzymes

b)

carbon dioxide

c)

light energy

d)

water

147.

Which of the following best describes the relationship between carbon dioxide levels and the rate of photosynthesis?

a)

As carbon dioixde levels increase, rate of photosynthesis increases

b)

As carbon dioxide levels increase, rate of photosynthesis increases to a point, then plateaus

c)

As carbon dioxide levels increase, rate of photosynthesis decreases

d)

There is no relationship between carbon dioxide levels and the rate of photosynthesis

148.

Match the following graphs to the factor(s) that affects the rate of photosynthesis.

a)

1.

Light intensity or carbon dioxide

b)

2.

Temperature

c)

3.

pH

149.

Use CRISPR to modify plants in order to allow them to be grown in hot, dry areas would involve trying to minimise:

a)

photorespiration

b)

photosynthesis

c)

the Calvin cycle

d)

cellular respiration

150.

CRISPR-Cas9 technology is useful for improving crops as it is:

a)

precise and affordable

b)

imprecise and affordable

c)

imprecise and expensive

d)

precise and expensive

151.

Place the steps involved in using CRISPR-Cas9 to improve crops in the correct order.

a)

Understanding the entire photosynthetic process of the crop (including the photorespiration pathway).

b)

Utilising high-level computers to model the photosynthetic pathway and identify inefficiencies.

c)

Using CRISPR-Cas9 technologies to target and edit the genes responsible for the identified inefficiencies.

1)
2)
3)
152.

Match the examples of improvements to crops with their broader category.

a)

Modify Rubisco's activity

1.

Calvin cycle

b)

Longer shelf life

2.

Production enhancement

c)

Increase chloroplast efficiency

3.

Plant organelles

d)

Herbicide resistance

4.

Chemical resistance

e)

Immunity against viruses

5.

Disease resistance

153.

Which of these would not be a desired outcome of genetically modifying a crop?

a)

Reduced insect resistance

b)

Reduced disease susceptibility

c)

Increased photosynthetic efficiency

d)

Increased agricultural yield

154.

Cellular respiration primarily involves the breakdown of:

a)

glucose

b)

ATP

c)

carbon dioxide

d)

oxygen

155.

Label the following diagram to summarise the overall chemical equation for aerobic cellular respiration.

156.

Place the following stages of aerobic cellular respiration in the correct order.

a)

Glycolysis

b)

The Krebs cycle

c)

The electron transport chain

1)
2)
3)
157.

Label the following diagram of a mitochondrion.

158.

Match each stage of aerobic respiration to the location in which it occurs.

a)

Cytosol

1.

Glycolysis

b)

Mitochondrial matrix

2.

The Krebs cycle

c)

Cristae of the mitochondria

3.

The electron transport chain

159.

Classify the following molecules as inputs or outputs of glycolysis.

Categorize the following

1 glucose (C6H12O6)

2 ADP + 2Pi

2 NAD+ + 2 H+

2 pyruvate

2 ATP

2 NADH

Inputs
Outputs
160.

Between glycolysis and the Krebs cycle, a reaction called​ ​ (a)   converts ​​ (b)   to ​ (c)   . ​ (d)   is also produced.

Choose from the below words
the link reaction
pyruvate
acetyl-CoA
Carbon dioxide
the Calvin cycle
glucose
water
161.

Classify the following molecules as inputs or outputs of the Krebs cycle.

Categorize the following

2 ADP + 2Pi

6 NAD+ + 6 H+

2 ATP

6 NADH

2 acetyl-CoA

2 FAD + 4 H+

4 carbon dioxide

2 FADH2

Inputs
Outputs
162.

The main purpose of glycolysis and the Krebs cycle is to produce what for use in the electron transport chain?

a)

Loaded high-energy electron and proton carriers

b)

ATP

c)

Carbon dioxide

d)

Pyruvate

163.

Classify the following molecules as inputs or outputs of the electron transport chain.

Categorize the following

26 or 28 ADP + 26 or 28 Pi

10 NAD+ + 10 H+

26 or 28 ATP

10 NADH

2 FAD + 4 H+

2 FADH2

6 oxygen (O2) + 12 H+

6 H2O

Inputs
Outputs
164.

The overall output of ATP from one glucose molcule undergoing cellular respiration is:

a)

30 or 32

b)

26 or 28

c)

30 - 32

d)

30

165.

Classify each of the following as loaded or unloaded coenzymes.

Categorize the following

ATP

NADH

FADH2

ADP

NAD+

FAD

Loaded
Unloaded
166.

The term 'anaerobic' refers to a lack of (a)   .

167.

Which of these stages that make up the aerobic respiration pathway can still occur without the presence of oxygen?

a)

Glycolysis

b)

Kreb's cycle

c)

Electron transport chain

d)

None of them can occur

168.

The anaerobic fermentation pathway allows cells to produce some ​ (a)   in the absence of oxygen by recycling ​ (b)   to produce a steady supply of ​ (c)   . This allows glycolysis to continue.

Choose from the below words
ATP
NADH
NAD+
169.

Label this diagram showing the anaerobic fermentation pathway in animals.

170.

Add the missing labels to the diagram showing the aerboic fermentation pathway in yeast.

171.

Temperature and pH both affect the rate of cellular respiration due to the ______ involved.

a)

enzymes

b)

oxygen

c)

carbon dioxide

d)

water

172.

Which of the following best describes the relationship between glucose concentration and the rate of respiration?

a)

As glucose concentration increases, rate of respiration increases

b)

As glucose concentration increases, rate of respiration increases to a point, then plateaus

c)

As glucose concentration increases, rate of respiraiton decreases

d)

There is no relationship between glucose concentration and rate of respiration

173.

Which of the following best describes the relationship between oxygen concentration and the rate of respiration?

a)

As oxygen concentration increases, rate of respiration increases

b)

As oxygen concentration increases, rate of respiration increases to a point, then plateaus

c)

As oxygen concentration increases, rate of respiraiton decreases

d)

There is no relationship between oxygen concentration and rate of respiration

174.

Match the following graph shapes to the factor(s) that affect the rate of respiration.

a)

1.

Glucose or oxygen concentration

b)

2.

Temperature

c)

3.

pH

175.

Biofuels are fuels that can be made from organic material such as plant and animal waste called (a)   .

176.

Classify the following as characteristics of fossil fuels or biofuels.

Categorize the following

Non-renewable

Sourced from fosslised organic matter

High carbon emissions

Renewable

Sourced from crops, waste and animal by-products

Carbon neutral

Fossil fuels
Biofuels
177.

Biofuels are generally made by the process of ​ (a)   , which breaks down the starches and sugars in plants and converts that ​ (b)   into ​ (c)   and carbon dioxide.

Choose from the below words
fermentation
glucose
ethanol
178.

Place the following steps involved in producing bioethanol into the correct order.

a)

Deconstruction

b)

Digestion by enzymes

c)

Ethanol fermentation

d)

Purification and dehydration

1)
2)
3)
4)
179.

Match the following steps involved in producing bioethanol to the correct description.

a)

Biomass is broken down to increase its surface area

1.

Deconstruction

b)

Biomass is further broken down to convert large sugars to glucose

2.

Digestion by enzymes

c)

Yeast is use to facilitate fermentation of the glucose, producing ethanol

3.

Ethanol fermentaiotn

d)

Ethanol is distilled via the removal of water

4.

Purification and dehydration

180.

Biodiesel is produced by the formation of ​ (a)   combined with short-chain alcohols (e.g. ​ (b)   ).

Choose from the below words
fatty acids
ethanol
glucose
181.

Classify the following as strengths or weakness of biofuels.

Categorize the following

Reduce carbon emissions

Provide ongoing energy security

Allow energy to be produced locally

Could decrease amount of crops available for food

More expensive to produce than traditional fuels

Second-order environmental impacts

Strengths
Weaknesses
182.

Using edible food crops creates ​ (a)   biofuels, whereas using non-food crops such as wood waste and other by-products creates ​ (b)   biofuels.

Choose from the below words
first-generation
second-generation
183.

Classify the following as characteristics of first-generation or second-generation biofuels.

Categorize the following

Competition with food crops

No competition with food crops

Easy to convert biomass to biofuel

Harder to convert biomass to bioefuel

First-generation biofuels
Second-generation biofuels