WorksheetsGrand Rounds Review Summer 2025
Total questions: 114
Worksheet time: 3600secs
A 7-year-old patient presents with blurry vision in the left eye. Cycloplegic refraction reveals OD: +1.00 sph OS: +4.50 sph. BCVA is OD 20/20 and OS 20/40. Worth 4-dot testing shows 2 dots. What explains the patient’s binocular status?
Central suppression of the right eye at near
Central suppression of the right eye at near
Foveal suppression of the left eye
Normal binocular fusion with reduced stereoacuity
Which of the following would increase retinal image size?
Decreasing axial length
Increasing axial length
Placing a high-minus lens at the spectacle plane
Using a contact lens rather than a spectacle lens
Knapp’s Law predicts that retinal image sizes will be equalized in axial anisometropia when corrective lenses are placed:
Contact lenses are place directly on the cornea
Spectacle lenses with a 10 mm vertex distance
Spectacle lenses with the smallest possible vertex distance
Spectacle lenses with a 15-17 mm vertex distance
Your 60-year-old patient is diagnosed with an acute PVD without any associated retinal breaks. What is the most appropriate next step in management?
Vitrectomy
Prescribe topical corticosteroids
Follow up in 4-6 weeks for a dilated fundus exam
Urgent referral to retinal specialist
Which of the following is a likely complication of a PVD?
Macular edema
Retinal tear or detachment
Uveitis
Branch retinal vein occlusion
Which of the following sites is the strongest attachment of the vitreous and is most likely to remain attached even after a complete PVD?
Optic nerve head
Posterior lens capsule
Vitreous base
Which of the following is NOT a likely risk factor for early onset PVD?
Hyperopia
Myopia
Trauma
Inflammation
Hallmark sign of Dry AMD?
Drusen
Choroidal Nevi
Microaneurysm
Tortuous vessels
Which of the following is found in AMD?
Intraretinal fluid
Iris Neovascularization
Optic nerve hypoplasia
Subretinal fluid
Which of the following is NOT a complication of AMD? Select 2 that apply:
Posterior Subcapsular Cataract
Macular edema
Myopic Shift
Loss of central vision
Which of the following is typically NOT a diagnostic method for AMD?
OCT
Retinoscopy
Dilated Fundus examination
Fundus Autofluorescence
Wet stage macular degeneration will eventually progress to dry stage which is the more severe form of macular degeneration. True or false?
True
False
Wet stage macular degeneration will eventually progress to dry stage which is the more severe form of macular degeneration. True or false?
540-570 nm
460-480 nm
680-700 nm
740-700 nm
The uveal tunic is comprised of
Choroid, retina, iris
Sclera, Choroid, Ciliary body
Choroid, retina, sclera
Choroid, iris, ciliary body
Upon using the red free filter imaging choroidal pigment, what will happen to the pigment?
Will remain as it was
Will disappear
Will appear darker
Will appear lighter
The main concern for a choroidal nevus is
Choroidal nevi are never a concern and do not need to be monitored
Choroidal nevi always will cause a retinal detachment
Choroidal Nevi often cause a uveitis
The development of a choroidal melanoma
What is the first and most common structure choroidal melanoma will metastasize to when they become malignant?
Liver
Kidneys
Pancreas
Colon
Which of the following is a hallmark presentation of acanthamoeba keratitis?
Dendrite
Corneal ectasia
Ring-like stromal infiltrate
Fingerprint pattern
What treatment should NOT be used on a patient with Acanthameoba Keratitis?
Steroids
Biguanide (pool cleaner)
Diamidine
NSAIDs
What of the following should be done to prevent acanthamoeba infection?
Ensure contact lenses are stored in saline overnight
Wear contact lenses for a minimum of 10 hours a day
Use a hydrogen peroxide cleaning solution like ClearCare
Rub the contact lenses on the palm of your hand with a drop of water to clean them
What are the 2 most common causes of INO?
Lupus and Sjogren’s
Demyelinating disease and brain infarction
Conjunctivitis and corneal abrasion
Retinal detachment and diabetic retinopathy
What is a key feature of INO?
Esotropia
Inability to intort
Contralateral abducting nystagmus
Lid retraction
Which of the following is NOT a differential diagnosis of INO?
Myasthenia gravis
Thyroid eye disease
Cranial nerve 3 palsy
Blepharospasm
Why would you want to test the convergence of a patient with INO?
To better localize the lesion
To determine what prescription to give them
To determine their prognosis
To see which EOMs were affected
What percentage of the crystalline lens is composed of water?
35%
50%
65%
90%
What embryological cell type gives rise to every part of the crystalline lens?
Mesoderm
Endoderm
Neural ectoderm
Surface ectoderm
Which of the following is a classic sign of aphakia due to the lack of posterior support from the lens?
Miosis
Iridodonesis
Proptosis
Nystagmus
What is a disadvantage of correcting aphakia with spectacles?
Jack in the box effect
Reduced risk of infection
Less aniseikonia
Wider field of view
A patient with a right CN IV palsy would typically exhibit which of the following in primary gaze?
Left hypertropia
Right hypertropia
Esotropia
Exotropia
Increased vertical vergences (greater than 6 prism diopters base-up/base-down difference) often suggest which etiology of a vertical deviation?
Acute traumatic injury
Recent onset cranial nerve palsy
Congenital defect or long-standing condition
Ischemic event affecting the brainstem
Consider a patient presenting with a Left Hypertropia (LHT) in primary gaze that is greater in right gaze and greater with a left head tilt. According to Parks' 3-Step test, which muscle is most likely paretic?
Left superior oblique
Left inferior oblique
Right inferior rectus
Left superior rectus
Which of the following is a common cause of acquired CN IV palsy in adults?
Congenital absence of the trochlear nerve
Arnold-Chiari malformation
Trauma, often closed head injury
Duane syndrome
A patient with a suspected CN IV palsy also presents with a complete ptosis and a dilated pupil in the same eye. This finding is most suggestive of a palsy of which cranial nerve?
Cranial nerve III (Oculomotor)
Cranial nerve II (Optic)
Cranial nerve VI (Abducens)
Cranial nerve V (Trigeminal)
Which of the following is most helpful for confirming the diagnosis of retinal collateral vessels?
Fundus autofluorescence
Fluorescein angiography
Visual field testing
Electroretinography
Which of the following is most true about retinal collateral vessels?
They are unilateral and often leak fluid
They are found in both eyes and cross the fovea
They are unilateral and do not leak on FA
They are commonly associated with diabetic retinopathy
Retinal collaterals are best described as:
New vessels that form due to VEGF and hypoxia
Arterial loops around the optic nerve
Venous shunts that bypass blocked veins
Persistent fetal vasculature
Which population is most commonly affected by Vernal Keratoconjunctivitis?
Elderly women
Prepubescent boys
Infants
No age predilection
Which of the following corneal findings are typical of Vernal Keratoconjunctivitis?
Pannus
Shield Ulcers
Photokeratitis
Dystrophy
What is the most appropriate initial treatment to promote corneal healing and reduce inflammation in Vernal Keratoconjunctivitis?
Topical Corticosteroid
Preservative Free Artificial Tears
Mast Cell Stabilizer
Antihistamine
Which of the following is the primary cause of Fetal Alcohol Syndrome (FAS)?
Deficiency in the enzyme phenylalanine hydroxylase
Alcohol exposure during pregnancy
Genetic mutation on chromosome 22
Bacterial infection during gestation
A key ocular manifestation commonly observed in patients with Fetal Alcohol Syndrome, often characterized by shortened horizontal eyelid openings, is known as:
A) Epicanthal folds
Ptosis
Blepharophimosis
Telecanthus
The hypothetical mechanism by which ethanol causes birth defects in Fetal Alcohol Syndrome primarily involves its competition with which essential nutrient for an enzyme necessary in embryonic development?
Vitamin D
Vitamin C
Retinoic acid
Vitamin A
A 3-year-old child presents with global developmental delay and a "blonde fundus." Which of the following conditions would be a primary metabolic differential diagnosis for these ocular findings?
DiGeorge Syndrome
Fetal Alcohol Syndrome
Phenylketonuria (PKU)
Down Syndrome
When performing a comprehensive eye examination on a 3-year-old child, visual acuity (VA) is typically measured using which method?
Snellen letters
Tumbling E chart
LEA Symbols
Which of the following findings is most strongly associated with normal tension glaucoma (NTG) compared to high-tension POAG?
Elevated intraocular pressure above 21 mmHg
Corneal guttata and pigment dispersion
Drance hemorrhages at the optic disc margin
Bilateral optic disc edema
Which of the following is a key clinical feature that helps differentiate compressive optic neuropathy at the chiasm from NTG?
Normal interocular pressure
Visual field defects that respect the vertical meridian
Large optic disc cupping with bilateral presentation
Absence of color vision changes
3. Before diagnosing a patient with NTG, which of the following must be ruled out?
Retinal detachment and vitreous hemorrhage
Cataract
Compressive and ischemic optic neuropathies
Diabetic Retinopathy
Which systemic condition has the strongest documented association with normal tension glaucoma (NTG)?
Hyperthyroidism
Obstructive sleep apnea (OSA)
Chronic kidney disease
Rheumatoid arthritis
What is the recommended treatment for an internal hordeolum involving the Meibomian glands?
Erythromycin ointment only
Warm compresses and Tobradex
Cephalexin, Augmentin or Doxycycline orally
Hypochlorous acid spray twice daily
A patient presents with dryness, itching, and debris on her lashes. She admits to sleeping in strip lashes and using mascara daily. What is the most likely diagnosis?
Corneal abrasion
Anterior blepharitis
Allergic contact dermatitis
Internal hordeolum
Magnetic eyelashes are considered safer because they:
Are professionally applied and semi-permanent
Use less adhesive, reducing risk of gland blockage
Can be worn continuously for 6 weeks
Have no reported complications
A 38-year-old patient wears false lashes continuously and has not removed them in over 2 weeks. She reports photophobia and stabbing eye pain. What is the most appropriate diagnostic step?
Check IOP with Goldmann tonometry
Use fluorescein staining and slit-lamp exam
Perform a Schirmer test
Order an MRI of the orbit
Which of the following is true regarding allergic contact dermatitis from false eyelash adhesives?
It is a Type I hypersensitivity reaction
It may present with eyelid crusting, chemosis, and itching
It is caused only by formaldehyde
It requires no medical treatment unless infection is present
When is treatment for pterygium typically indicated?
In all cases, regardless of symptoms
Only if the patient requests cosmetic removal
When symptoms are present or the visual axis is affected
As soon as the lesion is identified, to prevent progression
Where does pterygium most commonly present on the eye?
Temporally
Nasally
Equally likely nasal or temporal
Superiorly
Why is obtaining a strong patient history important in managing pterygium?
It helps determine the underlying genetic causes
It aids in patient education on prevention and risk factor modification
It is necessary to rule out malignant transformation
It allows for immediate surgical planning
Why is it important to check angles above and below a pterygium during an eye exam?
To assess for glaucoma or angle closure
To determine the depth of corneal invasion
To evaluate the risk of retinal detachment
To ensure the pterygium is not affecting the optic nerve
Which of the following is a major risk factor for the development and progression of pterygium?
Chronic UV light exposure
Contact lens use
High intraocular pressure
History of allergic conjunctivitis
What is the most effective preventive measure against pterygium progression?
Use of artificial tears
Wearing UV-blocking sunglasses
Regular corneal transplantation
Long-term use of topical steroids
Which of the following is not a common ocular finding associated with Floppy Eyelid Syndrome (FES)?
Marked horizontal eyelid laxity
Chronic papillary conjunctivitis
Pigmented conjunctival nevus
Dry eye symptoms
What is the most likely underlying cause of elastin fiber degradation in FES?
Elevated collagen synthesis
Increased tear film osmolarity
Hypoxia-induced oxidative stress and elevated elastase activity
Vitamin A deficiency
Which of the following treatments is considered the definitive management for Floppy Eyelid Syndrome?
Antihistamine drops
Blepharoplasty
Warm compresses
Antibiotic ointment
Which condition is commonly associated with Floppy Eyelid Syndrome?
Cataracts
Obstructive sleep apnea
Age-related macular degeneration
Retinitis pigmentosa
What is the purpose of taping eyelids or wearing an eye shield during sleep in FES management?
A) To reduce intraocular pressure
B) To prevent eyelid trauma and exposure
C) To minimize pupillary dilation
D) To control blepharospasm
What ocular effects would patients experience if they have lattice degeneration?:
a. Flashes
b. Floaters
c. Sudden loss of vision
d. No effects
What is lattice degeneration?
a. Holes in the retina
b. Thinning of the retina
c. Thickening of the retina
d. Scarring of the retina
What is a potential risk factor for lattice degeneration?:
a. High hyperopia
b. High astigmatism
c. High myopia
d. Presbyopia
What complications are associated with lattice degeneration?:
a. Retinal detachment
b. Edema
c. Cataracts
d. Macular degeneration
What is a typical symptom that your patient has bacterial keratitis:
Itching
Watery discharge
Bilateral severe conjunctival injection
Mucopurulent discharge
All of the following are ways of confirming the patient has bacterial keratitis EXCEPT:
Swab culturing bacteria
Corneal scrapping
PCR
Ulceration viewed in SLE
All of the following are indications to perform a bacterial culture EXCEPT:
Poor response to antibiotics
Mild peripheral ulcer smaller than 1mm
Larger central ulcer
Progressive symptoms
What bacteria is typically associated with bacterial keratitis
S. aureus
P. aeruginosa
S. pneumoniae
H. influenzae
Which antibiotic is preferred for the treatment of bacterial keratitis:
Tetracyclines
Penicillins
Macrolides
Fluoroquinolones
Do you expect CI patients to have any distance complaints?
Yes
No
Maybe
Both distance and near
What questions can you ask during history to help you conclude a CI diagnosis? Select 2.
Is your blurry vision at near worse when you're tired/at EOD/after doing prolonged near work?
Do you have any double vision at near?
Did you have any weight loss?
Do you problems chewing?
You see a 16XP at near in an 8yo patient; what method and prism should be used to measure the compensating fusional vergence?
BO step vergences
BI step vergences
MAF (+)
PRA
A long standing, hyperopic patient of yours comes in for a CEE 3 weeks after getting in a MVA where they suffered a concussion. You observe a 14 XP at near, and measure -/10/4 BO Vergences and an AC/A of 5/1. Subjective refraction is +3.00D OU. What additional measure can you prescribe in the glasses to ensure the plus prescription does not worsen the CI?
6BI prism (3BI OD, 3BI OS)
6BO prism (3BO OD, 3BO OS)
6BI prism (3BI OD, 3BO OS)
6BO prism (6BO OD, 0 OS)
What is the life threatening concern associated with seeing a Hollenhorst plaque in the eye?
Stroke risk
Acute myocardial infarction
Peripheral vascular disease
Coronary artery disease risk
What is the name of the condition that a Hollenhorst plaque causes in the retina?
Hypertensive retinopathy
Branch retinal artery occlusion (BRAO)
Non-proliferative diabetic retinopathy
Proliferative diabetic retinopathy
What is the sight threatening concern associated with BRAO?
Macular edema
Retinal detachment
Vitreous hemorrhage
Neovascularization of the retina
True or false: If a plaque is thrown to a retinal artery, there is little to no chance that plaques are being thrown to other blood vessels in the body.
True
False
What is considered the hallmark sign of Demodex Blepharitis?
a) Blood-tinged scabs along lid margin
b) Collarettes
c) Dennie-Morgan Lines
d) Rhinophyma
Which of the pathophysiologic mechanisms that causes Demodex Blepharitis?
a) Direct mechanical damage
b) Bacterial involvement
c) Delayed hypersensitivity reaction
d) All of the above
3) What is the 1st and only FDA-approved treatment for Demodex Blepharitis?
a) Tea tree oil formulated lid wipes, foam and gel
b) Soolantra (Ivermectin) 1.0% cream
c) Xdemvy (Lotilaner ophthalmic solution) 0.25%
d) There is no FDA-approved treatment for Demodex Blepharitis
1. What is the definitive host for Toxoplasma gondii?
a. Dogs
b. Cats
c. Mosquitos
d. All of the above
2. Which of the following is NOT a route of infection for Toxoplasma gondii in humans?
a. Foodborne
b. Respiratory
c. Mother-to-Child
d. Infected blood transfusion
3. Signs of an active ocular toxoplasmosis infection include which of the following:
a. Congenital pigmented growth of the RPE
b. Vitritis
c. Choroidal tubercles
d. Flat and intact macula
What branch of CN VII is responsible for lacrimation?
a. Chorda tympani
b. Lacrimal nerve
c. GSPN
d. Stapedius
What is the name of the cells in the PNS that myelinate axons?
a. Oligodendocytes
b. Schwann cells
c. Astrocytes
d. Dendrites
An acoustic neuroma can potentially impact all of the following CNs except?
a. CN I
b. CN V
c. CN VIII
d. CN VI
Why is the base-out to blur finding at near often reduced in patients with accommodative insufficiency?
They cannot generate enough fusional divergence to maintain clear vision
They have difficulty increasing accommodation in response to increased convergence demand
They have an excessive AC/A ratio
Their NPC is reduced
Which of the following is NOT typically associated with accommodative insufficiency?
Reduced PRA
Reduced amplitude of accommodation (at least 2D below expected)
High lead of accommodation on MEM retinoscopy
Difficulty clearing -2.00D lenses on accommodative facility testing
A 23 year old has an amplitude of accommodation of 7D, based on Hofstetter’s minimum expected AA formula, does this patient meet the criteria for accommodative insufficiency?
No, because the patient’s amplitude is normal for their age
No, because their amplitude is only slightly below average
Yes, because their amplitude is significantly below the minimum expected value
Yes, because their PRA is also likely to be low
Which of the following is most likely to be reduced in a patient with accommodative insufficiency?
Base-in to blur at near
Base-out to blur at near
Base-in to break at distance
Negative fusional vergence
Which of the following is not a standard treatment for accommodative insufficiency?
Vision Therapy 24 sessions
Lifestyle modification (reduced near work, proper lighting)
Bifocal/PAL for myopic patient
BO prism in habitual Rx
Transplantation of all 5 layers of the cornea is done in:
Deep Anterior Lamellar Keratoplasty (DALK)
Descemet Stripping Endothelial Keratoplasty (DSEK)
Penetrating Keratoplasty
All of the above
Viscoelastic fills what structure during corneal transplant surgeries?
Tear film
Anterior chamber
Vitreous
All of the above
Which of the following are a sign of corneal transplant rejection?
Corneal edema
Khodadoust line
Corneal neovascularization
All of the above
Which of the medication used for Hordeolum treatment is contraindicated in children and pregnancy women as it can cause tooth discoloration?
Keflex (Cephalexin)
Augmentin (Amoxicillin + Clavulanic Acid)
Doxycycline
Erythromycin
Why is Bowan’s disease is dangerous?
It is a multi-system disorder that can lead to uveitis
It is a pre-cancerous lesion that can lead to sebaceous cell carcinoma
It is always pigmented and resembles melanoma
It is an inherited disorder associated with keratin gene mutations
What condition is most often misdiagnosed as recurrant chalazion?
Hyperkeratosis
Sebaceous cell carcinoma
Preseptal cellulitis
Madarosis
1. Why would one choose Polytrim (Polymyxin B/Trimethoprim) over a fourth-gen fluoroquinolone?
A. Contraindication in children’s growing cartilage
B. Contraindication of tendonitis and tendon rupture
C. Less expensive
D. All of the above
2. What is the most common bacteria seen in acute bacterial conjunctivitis?
A. Staphylococcus aureus
B. Streptococcus pyogenes
C. Neisseria gonorrhea
D. Chlamydia trachomatis
3. What are some buzzwords indicative of bacteria conjunctivitis?
A. Ropey and itchy
B. Follicles and teary
C. Papillae and mucopurulent
D. Red and pain
Which of the following is the most likely causative factor in Contact Lens Acute Red Eye (CLARE)?
Allergic reaction to lens cleaning solutio
Mechanical irritation from a poorly fitting lens
Immune response to endotoxins from gram-negative bacteria
Excessive tear production during contact lens wear
A typical presentation of CLARE includes all of the following EXCEPT:
Acute onset of redness upon waking
Pain and photophobia
Mucopurulent discharge
History of overnight contact lens wear
Which of the following is the most appropriate initial management for CLARE?
Continue lens wear with lubricating drops
Prescribe oral antibiotics and resume lens use after 24 hours
Discontinue contact lens wear and use topical corticosteroids if inflammation persists
Perform immediate corneal scraping and culture
A 32-year-old woman with -10.00 D myopia presents for routine eye care. Fundus examination reveals peripapillary atrophy and a posterior staphyloma. Which of the following best describes the primary structural cause of these findings?
Vitreous liquefaction and posterior hyaloid traction
Axial elongation with progressive scleral thinning
Retinal ischemia from capillary non-perfusion
Elevated episcleral venous pressure
2. Which of the following is most strongly associated with the development of degenerative myopia?
Poor nutrition and vitamin A deficiency
Early onset of myopia in childhood
Long-term use of topical steroids
Presence of drusen on fundus exam
3. Which of the following symptoms is most suggestive of macular involvement in a patient with degenerative myopia?
Peripheral field constriction
Night blindness
Metamorphopsia
Monocular diplopia
A 45-year-old male presents with a history of penetrating eye trauma one year ago. On exam, the eye appears shrunken with a flat anterior chamber and no light perception. Which of the following best describes this condition?
A. Microphthalmos
B. Endophthalmitis
C. Phthisis bulbi
D. Acute angle-closure glaucoma
Which of the following is the most common cause of phthisis bulbi worldwide?
A. Primary open-angle glaucoma
B. Retinitis pigmentosa
C. Penetrating ocular trauma
D. Congenital cataract
Which structure's dysfunction leads to ocular hypotony, a key step in the pathogenesis of phthisis bulbi?
A. Retina
B. Optic nerve
C. Ciliary body
D. Corneal endothelium
What is the primary visual prognosis for a patient diagnosed with phthisis bulbi?
Vision may recover with appropriate steroids
Partial vision may return with surgery
No light perception with no possibility of visual recovery
Visual acuity typically improves over months
