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WorksheetsRenal Cell Carcinoma (1)
Total questions: 30
Worksheet time: 15mins
What is the most common histologic subtype of RCC?
Papillary
Chromophobe
Clear cell
Collecting duct
Clear cell RCC originates from:
Proximal tubule
Loop of Henle
Distal tubule
Collecting duct
Most common site of metastasis in RCC:
Bone
Liver
Lung
Brain
Classic triad of RCC includes all except:
Hematuria
Flank pain
Fever
Palpable mass
Which cytogenetic abnormality is seen in clear cell RCC?
Trisomy 7
Chromosome 3p deletion
Monosomy X
Trisomy 17
Which RCC subtype is most likely to respond to immunotherapy?
Papillary
Chromophobe
Collecting duct
Clear cell
The T2b stage in TNM classification refers to tumor size:
<4 cm
4-7 cm
7-10 cm
>10 cm confined to kidney
Which of the following is not a standard imaging modality for staging RCC?
CT abdomen
MRI brain
Chest X-ray
CT chest
Paraneoplastic syndrome in RCC includes all except:
Hypercalcemia
Polycythemia
Cushing syndrome
Diabetes mellitus
Which gene is mutated in Von Hippel-Lindau syndrome associated with RCC?
BRCA1
FLCN
VHL
MET
Type II papillary RCC is associated with:
Better prognosis than type I
Basophilic cytoplasm
Chromosome 3p loss
Aggressive behavior
Characteristic color of clear cell RCC on gross pathology:
White
Tan
Yellow
Gray
Which subtype of RCC is associated with Birt-Hogg-Dubé syndrome?
Clear cell
Papillary
Chromophobe
Collecting duct
Which of the following therapies is first-line in metastatic clear cell RCC?
IL-2 monotherapy
Sorafenib
Nivolumab + Ipilimumab
Radiotherapy
The most important prognostic factor in RCC is:
Tumor size
Histologic subtype
Pathologic stage
Nuclear grade
Sarcomatoid differentiation is most often seen in:
Papillary RCC
Clear cell RCC
Chromophobe RCC
Oncocytoma
Renal vein thrombus in RCC is classified as:
T1
T2
T3a
T3b
Which of the following renal tumors is most sensitive to chemotherapy?
Clear cell RCC
Chromophobe RCC
Collecting duct carcinoma
Oncocytoma
Bosniak IV cyst is considered:
Benign
Inflammatory
Malignant
Infective
Preferred treatment for localized T1a RCC in young patient:
Radical nephrectomy
Observation
Radiofrequency ablation
Partial nephrectomy
Which of the following is a typical feature of chromophobe RCC?
Small basophilic cells
Perinuclear halos
Papillary structures
Clear cytoplasm
What is the Bosniak classification used for?
RCC histologic grading
Predicting RCC metastasis
Classifying renal cysts
Identifying renal vein thrombus
Which of the following RCC subtypes has the best prognosis?
Clear cell
Type II papillary
Chromophobe
Collecting duct
The most common symptom at presentation of RCC is:
Flank pain
Hematuria
Weight loss
Incidental finding on imaging
Which of the following is not a risk factor for RCC?
Smoking
Obesity
Hypertension
Diabetes insipidus
Which type of nephrectomy is preferred in patients with bilateral RCC?
Radical nephrectomy
Laparoscopic nephrectomy
Partial nephrectomy
Nephron-sparing cryotherapy
Which statement about RCC in children is correct?
Clear cell RCC is most common
Wilms tumor is a subtype of RCC
Papillary RCC is rare in children
RCC in children is often hereditary
Which of the following imaging findings is most suggestive of RCC?
Simple cyst with thin wall
Enhancing solid renal mass
Non-enhancing hypodense lesion
Calcified renal stone
The Furhman grading system is based on:
Tumor size
Cell morphology
Lymph node involvement
Vascular invasion
What is the role of renal biopsy in RCC diagnosis?
Always required
Never used
Optional, useful in small indeterminate masses
Only for metastatic RCC
