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Worksheetsfinal pharma 2nd exam
Total questions: 20
Worksheet time: 30mins
GABA receptors are an example of which of the following receptors type
DNA- linked intracellular receptors
Tyrosine kinase-linked receptors
G-protein-linked receptors
None of the above
Absorption of vitamin B12/intrinsic factor complex by the ileum has occurred under
Facilitated diffusion
Simple diffusion
Endocytosis
Active transport
Which of the following drug(s) is(are) considered a liver microsomal inducer(s):
Phenobarbitone
Testosterone
Na-valporate
Cimetidine
Urinary excretion of amphetamine can be increased by
Using activated charcoal
Use of vitamin C
Decrease urine pH
b and c
All of the following are physical mechanisms of drugs except:
Demulcent
Osmosis
Neutralization
Adsorption
If two drugs have the same efficacy and safety, it is called:
Bioequivalence
Therapeutically equivalence
Bioavailability
a and b
Hemodialysis is useful in treatment of acute toxicity by drugs have:
Low Vd
Low toxicity c
Low bioavailability
a andc
Which of the following is the example for conversion of drug to toxic metabolite:
Phenacetin to paracetamol
Enalapril to Enalaprilater
Methanol to formaldehyde
Non of the bove
The dose required to achieve therapeutic effect in an adult is called
Loading dose
Median effective dose
Therapeutic dose
10-Females usually require smaller doses than males of the same age because
Female sex hormones
Higher body fat
Menstrual cycle
A and B
G-coupled receptor type-i (Gi) like M2-recptors is mediated by:
Increase DAG
Decrcased cyclic AMP
Increase phospholipase-c
A and C
Drug first pass metabolism can be overcome by:
Change the route of drug administration
Use of long-acting formulation
Use of unionized form of the drug
None of the above
Transfer of the drug from the site of administration to the systemic circulation.
Absorption
Distribution
Metabolism
Excretion
Drugs that are extensively bound to plasma proteins and drugs that have a very
high molecular weight are distributed in:
Plasma only
Plasma and interstitial fluid
Interstitial fluid only
All compartments
Drugs that are of low molecular weight, non-ionized, and lipophilic are distributed
in:
Plasma only
Plasma and interstitial fluid
Interstitial fluid only
All compartments
Volume of distribution may be increased by:
Renal failure
Liver failure
Dehydration
A and B
Concerning pharmacokinetics, pick the INCORRECT statement of the following:
Passive diffusion occurs with concentration gradient.
Ionized drugs cannot cross cell membranes.
Active transport needs both energy and carrier.
Conjugation with glucuronic acid is a phase I biotransformation reaction
Prodrug is the drug that:
Converted from active to inactive
Converted from inactive to active
Converted from active-to-active
Converted from inactive to inactive
Lipophilic drugs have the ability to be used in all the following steps EXCEPT:
Difficulty excreted from kidney
Pass Blood brain barrier
Poorly absorbed from GIT
Pass placental barrier
Oral bioavailability of drug 70% means
70% of the drug can reach blood
30% of the drug is lost
70% of the drug is lost
A and B
