Worksheetsmetabolic life style diseases
Total questions: 20
Worksheet time: 7mins
1. Which of the following is NOT a criterion in the NCEP ATP III definition of metabolic syndrome?
Elevated triglycerides
Low HDL cholesterol
Insulin resistance measured by HOMA-IR
Increased waist circumference
. According to IDF criteria, central obesity is:
. Optional criterion
Mandatory criterion
Not considered
Only for men >102 cm waist
Which of the following best describes the pathophysiological driver of metabolic syndrome?
Hyperuricemia
. Insulin resistance
Vitamin D deficiency
Low physical activity alone
The presence of metabolic syndrome increases the risk of:
Stroke by ~2x
Type 2 Diabetes by ~5x
Cardiovascular disease by ~2x
All of the above
Which adipokine is most strongly associated with the pathogenesis of metabolic syndrome?
Leptin
Adiponectin
Ghrelin
. Resistin
. In 2023, the term NAFLD was replaced with:
ALD
MAFLD
. MASLD
NASH only
The gold standard for diagnosis of NASH remains:
Ultrasound
Fibroscan
Liver biopsy
MRI-PDFF
Which of the following is least sensitive for detecting hepatic steatosis?
Ultrasound
. MRI-PDFF
CAP (FibroScan)
Proton MR spectroscopy
9. Which non-invasive score is most validated for fibrosis risk stratification in MASLD?
FIB-4
MELD
APRI
Child-Pugh
Which drug currently has the strongest RCT evidence for biopsy-proven NASH improvement?
Pioglitazone
Metformin
Vitamin E
. Statins
11. Which of the following best defines prediabetes (ADA 2023)?
. FPG 100–125 mg/dL or HbA1c 5.7–6.4%
FPG 110–125 mg/dL or HbA1c 6.0–6.4%
FPG 126–139 mg/dL
OGTT 2h >200 mg/dL
12. According to UKPDS, every 1% reduction in HbA1c reduces microvascular complications by:
5%
15%
. 25%
37%
13. Which agent has the best evidence for cardiovascular risk reduction in T2DM?
Sulfonylureas
GLP-1 receptor agonists
DPP-4 inhibitors
Pioglitazone
14. Which class is most strongly recommended in T2DM with CKD (ADA 2025)?
. SGLT2 inhibitors
Insulin
GLP-1 RA
Sulfonylureas
15. In T2DM, the primary mechanism of metformin is:
. Increased insulin secretion
Reduced hepatic gluconeogenesis
release
C. Increased GLP-1
D. Blocking renal glucose reabsorption
16. The minimum recommended weekly physical activity for adults (WHO 2020):
A. 60 min moderate activity
B. 150–300 min moderate activity
C. 75 min vigorous activity only
D. 60 min daily
17. Which type of exercise has the strongest evidence for insulin sensitivity improvement?
A. Resistance training
B. Aerobic exercise
C. Combined aerobic + resistance
D. Yoga only
18. In patients with fatty liver, weight reduction target for histological improvement:
A. 2–3%
B. 5–7%
C. 10% or more
D. 15%
19. The Mediterranean diet is proven to reduce:
A. Insulin resistance
B. Cardiovascular events
C. Progression of MASLD
D. All of the above
20. The DPP (Diabetes Prevention Program) showed lifestyle modification reduced T2DM risk by:
A. 25%
B. 35%
C. 50%
D. 58%
