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WorksheetsScientific Pointers Quiz
Total questions: 28
Worksheet time: 28mins
The combination of β-blocker with ACEI/ARB in systemic hypertension is especially beneficial in patients with:
Ischemic heart disease and ventricular dilatation
Atrial fibrillation
Ventricular dilatation and heart failure
All of the above
Treatment with ACE inhibitors or ARBs may lead to:
Decreased renin activity
Renin upregulation
Sympathetic suppression
Sodium overload
Concomitant use of a β-blocker with RAAS blockade prevents:
Hypokalemia
Renin upregulation
Hypoglycemia
Reflex bradycardia
By how much do β-blockers prevent the reactive increase of renin when combined with ACE inhibitors or diuretics?
1-fold
2-fold
3-fold
No effect
The combined use of β-blocker and ARB provides:
Pure vasodilation
Comprehensive neuroendocrine blockade
Only HR reduction
Reflex tachycardia
In patients with hypertension caused by sympathetic overdrive, optimal control requires:
ACE inhibitor only
Calcium channel blocker only
A β-blocker component
Diuretic monotherapy
A selective β1-blocker has which advantage over non-selective β-blockers?
More bronchospasm
Preserves β2-mediated vasodilation
Blocks β2 activity in skeletal muscles
Increases peripheral vascular resistance
β1-blockers inhibit sympathetic activity primarily in:
Brain and liver
Heart and kidney
Lung and muscle
Pancreas and thyroid
Overactivity of SNS is strongly associated with:
Dyslipidemia
Diabetes
Hypertension and obesity
All of the above
Sympathetic overactivity contributes to:
LVH
Coronary atherosclerosis
Insulin resistance
All of the above
Sympathetic vasoconstriction in skeletal muscle leads to:
Increased glucose uptake
Insulin resistance
Hypoglycemia
No effect
β1 blockade is effective in regressing and stabilizing:
Pulmonary fibrosis
Coronary atheromatous plaque
Osteoporosis
Neuropathy
Angiotensin II plays a pivotal role in:
Hypertension
Cardiovascular disease
Vascular stiffness
All of the above
Pharmacologic regulation of Ang II is central to controlling BP and preventing damage to:
Liver and pancreas
Kidney and brain
Thyroid and lungs
Skin and eyes
ARBs overcome detrimental effects of Ang II by:
Blocking AT1 receptors
Blocking AT2 receptors
Reducing renin synthesis
Increasing aldosterone
Local RAAS activation contributes to:
Arterial stiffness
Insulin sensitivity
Increased elastin
Low BP
Increased arterial stiffness results in:
Increased ventricular afterload
Decreased coronary perfusion
LVH and ischemia
All of the above
The therapeutic aim in young hypertensives is:
Only reduce BP
Reduce arterial stiffness and prevent CVD
Avoid β-blockers
Increase vascular tone
Which drugs have demonstrated reduction in arterial stiffness?
ARB
ACEI
Bisoprolol
All of the above
Which ARB is most preferred among Indian physicians?
Losartan
Telmisartan
Valsartan
Olmesartan
Telmisartan is the first ARB to demonstrate:
Renal protection only
CV prevention in high-risk patients
Only BP control
Pulmonary protection
The ONTARGET trial demonstrated Telmisartan reduced:
Only stroke
CV morbidity and mortality
Only renal failure
No significant effect
The TRANSCEND study reported reduction in risk of CV death by:
10%
20%
35%
5%
TRANSCEND trial also showed reduction in myocardial infarction risk by:
5%
14%
25%
50%
Stroke risk reduction with Telmisartan in TRANSCEND was:
9%
19%
25%
30%
Prevalence of sympathetic overactivity in newly diagnosed hypertensives in India is:
30%
45%
62.42%
80%
Sympathetic overactivity contributes to which metabolic abnormality?
Hypoglycemia
Insulin resistance & hyperinsulinemia
Low triglycerides
Increased HDL
Which class of drugs directly addresses hypertension caused by sympathetic overdrive?
ARB
β-blockers
ACE inhibitors
Calcium channel blockers
