WorksheetsVolume of Distribution and Drug Binding
Total questions: 13
Worksheet time: 15mins
A drug with a strong protein binding is likely to?
Be widely distributed
Remain in the plasma compartment
Cross cell membranes easily
Low Vd
Volume of Distribution is used for calculating the (a) dose of a drug.
What is the major drug-binding protein
Albumin
RBC
Alpha acid Glycoprotein
Albuterol
Which of the following is true about protein-bound drugs?
They are easily excreted
They are pharmacologically active
They cannot cross cell membranes
They have high clearance rates
Volume of distribution is calculated using the
formula:
Vd = (a) / Plasma Concentration
As VD increases, the dose (Q) of drug required to achieve a particular plasma concentration (Cp) ?
Decreases
Increases
Does not change
NOTA
What type of drug is pharmacologically active and able to cross the cell membrane?
Bound drug
Free drug
Protein-bound drug
The (a) dose administered after the loading dose that is used to maintain the steady state
A patient receives 800 mg of Drug X, and the plasma concentration after equilibrium is 40 mg/L. What is the volume of distribution (Vd)?
(a)
If the Vd of Drug Y is 25 L and the desired plasma concentration is 10 mg/L, what dose should be administered?
(a)
A drug has a Vd of 60 L and a dose of 1200 mg. What is the resulting plasma concentration?
(a)
Calculate the loading dose for a drug with:
Vd = 45 L
Target concentration = 6 mg/L
Bioavailability = 0.75
(a)
Determine the maintenance dose for a drug with:
Clearance = 5 L/hr
• Target concentration = 8 mg/L
• Dosing interval = 12 hours
• Bioavailability = 0.8
(a)
