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WorksheetsWeek 6 MCP
Total questions: 20
Worksheet time: 40mins
A 6-year-old boy presents with recurrent Neisseria infections. Flow cytometry shows absent CD55 and CD59 expression on red blood cells. Which complement regulatory defect best explains his disease?
Failure of factor H binding
Mutation in PIGA gene
Absence of C3 convertase
Deficiency of C1 esterase inhibitor
Mutation in mannose-binding lectin
A 2-year-old with chronic diarrhea and recurrent viral infections is found to have a defect in MyD88. Which of the following is most impaired?
NF-κB–mediated cytokine production
IRF-mediated type I interferon production
Fas–FasL apoptosis signaling
NOD2 inflammasome activation
Granzyme B release
A researcher is studying phagocyte respiratory burst. Which enzyme is directly responsible for generating superoxide radicals in neutrophils?
iNOS
NADPH oxidase
Myeloperoxidase
Catalase
Vacuolar ATPase
A patient with pneumonia shows activated NK cells releasing IFN-γ. Which of the following best describes the reciprocal effect of IFN-γ?
Activates eosinophils to release granules
Increases macrophage phagocytic killing
Stimulates mast cells to release histamine
Induces Treg differentiation
Induces epithelial defensin production
A 24-year-old woman develops fever and facial edema after taking lisinopril. Which cytokine released by mast cells is most responsible for the acute vascular changes?
IL-1
IL-4
IL-5
IL-6
Histamine
A newborn has absent B cells on flow cytometry. Which immunoglobulin isotype is primarily responsible for protection in the first months of life?
IgM
IgA
IgE
IgD
IgG
A patient with chronic parasitic infection shows elevated IL-4 and IL-5 production. Which antibody isotype is most likely increased?
IgA
IgE
IgG
IgM
IgD
A mutation in RAG1 causes failure of V(D)J recombination. Which of the following immune cell receptors is directly impaired?
MHC Class I
B cell receptor
CD80
LFA-1
ICAM-1
A 34 year old man with HIV has low CD4+ T cells. Which type of antigen presentation is most impaired?
Intracellular peptides on MHC I
Extracellular peptides on MHC II
Lipids presented by CD1 molecules
Self-DNA sensed by cGAS-STING pathway
Viral RNA sensed by RIG-I
A 50-year-old renal transplant patient experiences acute rejection. Which property of HLA molecules most directly explains this outcome?
Co-dominant expression
Allelic polymorphism
Positive selection
Somatic hypermutation
Junctional diversity
A researcher isolates an MHC I molecule with a closed peptide binding cleft. Which type of antigen is this molecule most likely presenting?
Bacterial polysaccharide
Viral peptide, 9 amino acids
Fungal glycoprotein
Lipid antigen
Bacterial exotoxin
A child with recurrent viral infections is found to have Bare Lymphocyte Syndrome type I. Which molecule is deficient?
MHC1
MHC2
CD40
TCR
CD28
A patient receives a melanoma vaccine designed to enhance CD8+ T cell activity. Which co-stimulatory interaction is most critical for productive T cell activation?
TCR-MHC binding
CD28-CD80/86 binding
Fas-FasL binding
ICOS-CD275 binding
PD-1-PD-L1 binding
A patient develops disseminated tuberculosis. Which CD4+ T cell subset is primarily responsible for protective immunity?
Th1
Th2
Th17
Tfh
Treg
A patient with asthma has increased IL-4 and IL-5. Which transcription factor is the master regulator of this CD4+ T cell subset?
T-bet
GATA3
RORγT
FoxP3
NFAT
A biopsy of a colon lesion shows Th17 cells producing IL-17 and IL-22. Which is the primary effector function of these cytokines?
Recruitment of eosinophils
Activation of macrophages
Activation of B cell isotype switching
Recruitment of neutrophils
Induction of CTL cytotoxicity
A 45-year-old man with hepatocellular carcinoma is treated with checkpoint inhibitor therapy blocking PD-1. Which is the expected mechanism?
Prevents T cell exhaustion
Enhances Treg function
Inhibits NK cell cytotoxicity
Blocks IL-2 receptor signaling
Inhibits clonal expansion
A patient with lymphoma receives CAR-T therapy. Which modification best describes the engineered receptor?
Antibody Fc fused to cytokine
TCR variable domain fused to CD3
Antibody variable domain fused to TCR zeta chain and CD28
IgM pentamer fused to CD40
MHC molecule fused to Fas ligand
A patient with recurrent fungal infections has impaired IL-17 signaling. Which immune defect best explains this?
Defective Th1 differentiation
Defective Th2 differentiation
Defective Th17 differentiation
Impaired CTL cytotoxicity
Defective NK cell function
A researcher blocks CTLA-4 in a mouse model. Which immune outcome is most likely observed?
Decreased T cell activation
Increased T cell activation
Increased Treg suppression
Impaired B cell isotype switching
Decreased NK cytotoxicity
