What type of repair pathway would repair oxidative damage?

What type of repair pathway would repair UV-induced damage?

Who am I? I recognize a damaged nucleotide(s) that was damaged by oxidative damaged or alkylation & will flip the base out to cleave it out

Who am I? I recognize abasic sites and cleave the abasic site to remove the sugar phosphate group & create a nucleotide gap

Who am I? I bind the bulky lesion after it has been recognized by other proteins (I am sorry I know this one is hard but if you can draw out this pathway you will be so set)

Choose all that are a source of DSBs (double-strand breaks)

If a cancer patient takes cisplatin (anti-tumor drug), what pathways will begin repair in the presence of interstrand crosslinks that are induced? (Multiple answers)

Who am I? I cap the ends of DSB for protection

Who am I? I sense double-stranded DNA damage such as a DSB

Who am I? I cause end resection with BRCA1 in HR

What pathway would be triggered by cisplatin (anti-tumor drug)

What DSB repair would likely occur during the same cycle of DNA replication (S phase)?

What DSB repair would likely occur during G1?

Who am I? I recognize single mismatched base pairs

If you have a BRCA1/2 mutation, what repair pathway would you be deficient in?

If you have a XPC mutation, what repair pathway would you be deficient in?

If you had hereditary nonpolyposis colon cancer and you know it was due to a germline mutation, what do you likely have a deficiency in?

What type of DNA damage is typically repaired by mismatch repair (MMR)?

Ku70/Ku80 heterodimer is primarily involved in which pathway?

A patient has a mutation in XPA. Which repair pathway is defective?

24. Oxidative damage like 8-oxoG forms during replication. Which repair fixes it?

6. UV light causes pyrimidine dimers, repaired by:

9. NHEJ is generally considered

19. Holliday junction resolution occurs in: