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DFT-PSM D5-26/09/2025

Total questions: 10

Worksheet time: 8mins

Name
Class
Date
1.

In an oncological study, the performance status of patients is evaluated using the Eastern Cooperative Oncology Group (ECOG) scale, which ranges from 0 (fully active) to 5 (dead). A biostatistician is advising the research team on the appropriate statistical tests to use for analyzing this data. From a purely statistical standpoint, how should the ECOG performance status score be classified?

a)

Ordinal variable

b)

Ratio variable

c)

Interval variable

d)

Nominal variable

2.

In a neonatal intensive care unit (NICU) quality improvement project, researchers analyze the Apgar scores of neonates at 1 and 5 minutes. The score, a composite value from 0 to 10, is used to assess newborn well-being. What type of variable is the Apgar score?

a)

Quantitative, Discrete

b)

Qualitative, Ordinal

c)

Quantitative, Continuous

d)

Qualitative, Nominal

3.

A public health researcher is analyzing survey data on the perceived quality of hospital care, rated by patients on a 5-point Likert scale (1=Poor, 2=Fair, 3=Good, 4=Very Good, 5=Excellent). This data is classified as ordinal. What is the most statistically appropriate measure of central tendency to report the typical patient rating?

a)

Median

b)

Mean

c)

Mode

d)

Grubbs' test

4.

A clinical researcher is evaluating two new diagnostic assays for a novel biomarker. Assay 1 measures the biomarker in nmol/L with a mean of 500 and a standard deviation of 100. Assay 2 measures the same biomarker using a different method, yielding results in µg/dL with a mean of 80 and a standard deviation of 20. To compare the relative variability and consistency of the two assays, which of the following is the most appropriate statistical measure to use?

a)

Coefficient of Variation (COV)

b)

Standard Deviation (SD)

c)

Variance

d)

Range

5.

A clinical trial investigates the efficacy of a new non-steroidal anti-inflammatory drug (NSAID) on renal function. Glomerular Filtration Rate (GFR) is measured in 75 participants with osteoarthritis at baseline and again 12 weeks after initiating daily therapy. The primary objective is to determine if a statistically significant change in mean GFR occurred. Which statistical test is most appropriate for this analysis?

a)

Paired Student’s t-test

b)

Independent samples t-test

c)

Analysis of Variance (ANOVA)

d)

Chi-square test

6.

In the original study evaluating dietary modification on serum cholesterol, researchers found a significant improvement. However, a senior epidemiologist noted that without a control group, the observed effect might be partially attributable to the participants' knowledge of being monitored, leading them to adopt healthier behaviors beyond the prescribed diet. This phenomenon is known as:

a)

Hawthorne effect

b)

Pygmalion effect

c)

Confounding bias

d)

Recall bias

7.

A 58-year-old male, a lifelong non-smoker, presents with a three-year history of progressive dyspnea on exertion and a persistent dry cough. His occupational history reveals he spent 30 years working in a factory manufacturing abrasive cleaning powders and engineered quartz countertops. A high-resolution computed tomography (HRCT) of the chest reveals numerous small, well-defined centrilobular and subpleural nodules, predominantly in the upper lobes, along with evidence of hilar lymph node calcification in an 'egg-shell' pattern. Which of the following is the most likely diagnosis?

a)

Silicosis

b)

Asbestosis

c)

Byssinosis

d)

Stannosis

8.

A 52-year-old male employed in a battery recycling plant presents with a 3-month history of colicky abdominal pain, constipation, and bilateral hand weakness, most prominent in the extensors of his wrists and fingers. His hematological workup is significant for a normochromic, normocytic anemia with prominent punctate basophilic stippling on the peripheral blood smear. The characteristic basophilic stippling observed is a direct consequence of the toxin's interference with what process?

a)

Degradation of ribosomal ribonucleic acid

b)

Heme synthesis at the ferrochelatase step

c)

Globin chain precipitation due to oxidative stress

d)

Erythrocyte membrane sodium-potassium transport

9.

The National Family Welfare Programme of India provides several contraceptive options to address the diverse needs of the population. One of these options, a non-hormonal pill developed indigenously, has a unique mechanism of action compared to traditional steroid-based contraceptives. Which statement accurately describes this agent?

a)

Centchroman, developed at CDRI, Lucknow, acts as a SERM, primarily causing asynchrony in the endometrial lining to prevent implantation.

b)

Mala-N is a non-steroidal agent distributed free of cost that primarily works by inhibiting sperm capacitation in the fallopian tubes.

c)

Saheli contains a low-dose progestin that primarily thickens cervical mucus and requires a daily dosing schedule for efficacy.

d)

Chhaya is a high-potency steroidal combination that completely and irreversibly inhibits ovulation after the first three months of use.

10.

A 28-year-old nulliparous woman with a history of a single deep vein thrombosis (DVT) five years ago following leg immobilization and a history of migraines with aura presents for contraceptive counseling. She also reports menorrhagia. She desires a highly effective, long-term contraceptive method. Which of the following is the most appropriate contraceptive recommendation for this patient?

a)

Levonorgestrel-releasing intrauterine system (LNG-IUS)

b)

Copper intrauterine device (Cu-IUD)

c)

Depot medroxyprogesterone acetate (DMPA) injection

d)

Low-dose combined oral contraceptive pill