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Ivsa quiz competition(vet)

Total questions: 10

Worksheet time: 5mins

Name
Class
Date
1.

Which glycoprotein of the rabies virus is responsible for receptor binding and induction of neutralizing antibodies?

a)

Nucleoprotein (N)

b)

Phosphoprotein (P)

c)

Glycoprotein (G)

d)

Matrix protein

2.

Rabies virus enters the central nervous system primarily via:

a)

Hematogenous spread

b)

Retrograde axonal transport

c)

Lymphatic drainage

d)

Direct passage across the blood-brain barrier

3.

Which receptor is most implicated in rabies virus binding at the neuromuscular junction?

a)

Acetylcholine receptor

b)

Dopamine receptor

c)

Nicotinamide receptor

d)

Toll-like receptor 4

4.

Rabies pathogenesis, viral replication first occurs in:

a)

Brain neurons

b)

Dorsal root ganglia

c)

Muscle cells at the inoculation site

d)

Salivary gland cells

5.

Which immunological response is most critical for survival after rabies exposure?

a)

Cell-mediated cytotoxicity

b)

Neutralizing antibody production

c)

Complement activation

d)

Innate immune interferon response

6.

The "dumb" (paralytic) form of rabies is primarily due to viral infection of:

a)

Hippocampus

b)

Brainstem and spinal cord

c)

Cerebellum

d)

Basal ganglia

7.

Which diagnostic technique is considered the “gold standard” for rabies confirmation worldwide?

a)

Mouse inoculation test

b)

Direct Fluorescent Antibody Test (dFAT)

c)

RT-PCR

d)

Rapid Immunodiagnostic Test (RIT)

8.

In the 12D concept of rabies vaccine production, the “D” represents:

a)

Dose equivalence

b)

Decimal reduction time

c)

Dilution factor

d)

Duration of immunity

9.

Why is rabies virus almost always fatal once clinical signs appear?

a)

Rapid viral replication destroys neurons

b)

Strong immune evasion and late antibody response

c)

Virus remains in peripheral tissues only

d)

Excessive cytokine storm

10.

Which WHO-recommended post-exposure prophylaxis regimen involves intradermal administration of the vaccine?

a)

Essen regimen (IM, 5 doses)

b)

Zagreb regimen (IM, 4 doses)

c)

Thai Red Cross regimen (ID, 2-2-2-0-2 schedule)

d)

Modified Habel regimen