Font size
WorksheetsAntibiotics P1
Total questions: 30
Worksheet time: 15mins
Which statement best defines a health care–associated infection (HAI)?
Infection present at admission
Infection occurring >48 hours after admission
Infection acquired in the community
Infection present with colonization only
Empiric antibiotic therapy refers to:
Using narrowest drug after cultures return
Immediate broad coverage based on likely pathogens
Withholding therapy until sensitivities result
Prophylaxis before clean procedures
Which pair shares the same mechanism of action?
Macrolides and tetracyclines
Penicillins and cephalosporins
Quinolones and aminoglycosides
Sulfonamides and monobactams
A patient reports throat swelling with penicillin. Which antibiotic is most concerning?
Azithromycin
Cefazolin
Doxycycline
Ciprofloxacin
Sulfonamides are commonly used for which infection due to high renal concentrations?
Otitis media
Urinary tract infection
Cellulitis
Pharyngitis
Which macrolide effect can be therapeutically useful in gastroparesis?
QT shortening
GI motility stimulation
Calcium channel blockade
Beta-lactamase inhibition
Which carbapenem-related precaution is priority?
Seizure risk
Red man syndrome
Ototoxicity
Photosensitivity
Aztreonam is most active against:
Anaerobes
Gram-positive cocci
Aerobic gram-negative rods
Fungi
Which organism is typically treated with vancomycin as drug of choice?
MRSA
ESBL E. coli
CRE Klebsiella
Pseudomonas
Which lab/monitoring is essential with daptomycin therapy?
Lipase weekly
CPK levels
TSH monthly
Amylase only
Gentamicin should be held and prescriber notified if trough is:
0.6 mcg/mL
1.0 mcg/mL
1.8 mcg/mL
2.4 mcg/mL
Which teaching for ciprofloxacin is correct?
Take with antacids for absorption
Avoid separating from iron
Space doses from calcium/magnesium
No effect with zinc supplements
Linezolid food interaction to avoid:
High-fiber foods
Tyramine-rich foods like aged cheese
High-fat meals only
Grapefruit juice
Which adverse effect is strongly associated with clindamycin?
Neutropenia
Pseudomembranous colitis
QT prolongation
Dose-dependent tinnitus
Nitrofurantoin key counseling includes:
Safe in severe hepatic disease
Crush tablets for better absorption
Take with food and fluids
Primarily for skin infections
Which statement about aminoglycosides is true?
Time-dependent killing
Bind 50S ribosome
Concentration-dependent killing with postantibiotic effect
Primarily gram-positive monotherapy
Quinolone IV infusions should generally be administered over:
<15 minutes rapidly
1 to 1.5 hours
3 hours
Only by IV push
Red Man Syndrome during vancomycin infusion is best managed by:
Stopping and never restarting
Immediate epinephrine
Slowing infusion rate
Giving IV push to finish faster
CRE infections are generally susceptible to:
Meropenem
Tigecycline
Amoxicillin
Ceftriaxone
Which pairing demonstrates synergy for serious gram-positive infections?
Gentamicin + penicillin
Macrolide + tetracycline
Ciprofloxacin + antacid
Vancomycin + zinc
Features of ESBL-producing organisms include: (Select all that apply.)
Resistance to many beta-lactams
Susceptibility to aztreonam
Often require carbapenems
Easily treated with amoxicillin alone
Can evolve further to carbapenemase production
Aminoglycoside toxicity surveillance should include monitoring for: (Select all that apply.)
Tinnitus and dizziness
Rising creatinine
Hyperglycemia
Ataxia and nystagmus
Photosensitivity
Macrolides are effective for intracellular pathogens such as: (Select all that apply.)
Chlamydia
Legionella
Listeria
Mycoplasma
Campylobacter
Nursing actions for vancomycin therapy: (Select all that apply.)
Draw trough before 4th dose
Administer via IV push for faster effect
Monitor for hypotension/flushing
Combine routinely with aminoglycosides to reduce nephrotoxicity
Check renal function regularly
Quinolone major precautions include: (Select all that apply.)
Separate from Ca/Mg/Fe/Zn
Risk of QT prolongation
Peripheral neuropathy risk
Contraindicated in all pediatric patients absolutely
Potential liver injury in older adults
First action when a patient develops wheezing and hives during piperacillin infusion:
Slow the infusion rate
Stop the infusion and notify the provider
Document and reassess in 30 min
Give acetaminophen
Which task can be delegated to NAP for a patient on IV gentamicin?
Assess for tinnitus
Measure intake and output
Interpret trough levels
Monitor for nystagmus
Before starting empiric antibiotics for sepsis, the priority is to:
Start maintenance IV fluids
Obtain blood and site cultures
Administer acetaminophen
Order an ECG
During vancomycin infusion the patient becomes flushed with mild hypotension. Best immediate action:
Stop permanently and label allergic
Slow the infusion and continue monitoring
Bolus NS and IV push vanco
Administer IM epinephrine immediately
Patient teaching points for tetracyclines include: (Select all that apply.)
Avoid dairy/antacids close to dose
Use sunscreen due to photosensitivity
Safe during pregnancy
Take with iron to improve effect
May cause tooth discoloration in children
