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Inflammation

Total questions: 34

Worksheet time: 39mins

Name
Class
Date
1.

The following describe inflammation

a)

Response of vascularized tissue to injury

b)

A specific response of tissue

c)

Lead to the accumulation of transudate

d)

A non-linear response

2.

The followings are functional response following leukocyte activation after chemotaxis events EXCEPT

a)

Eicosanoids production

b)

Degranulation

c)

Cytockines secretion

d)

Accumulation of leucocytes at the periphery of

blood flow

3.

Which of the followings is not general feature of chronic

inflammation?

a)

Tissue destruction

b)

Fibrosis

c)

Angiogenesis

d)

Neutrophils infiltration.

4.

Which of the following histologic features is expected in chronic inflammation tissues?

a)

Destruction of parenchyma

b)

Collection of neutrophils

c)

Congested blood vessels

d)

Normal parenchyma

5.

The followings are cell derived mediators except

a)

Histamine

b)

Bradykinin

c)

Prostaglandin

d)

Interleukin-1

6.

During the early stages of the inflammatory response, histamine induced

increased vascular permeability is most likely to occur in

a)

Arteries

b)

Pre-capillary arterioles

c)

Capillaries

d)

Post-capillary venules

7.

Which one of the listed statements best describes the process called

Chemotaxis?

a)

Abnormal fusion of phagosomes to primary lysosomes

b)

Movement of cells toward a certain site or source

c)

Attachment of chemicals to extracellular material to increase phagocytosis

d)

Dilation of blood vessels by

chemotherapeutic drugs

8.

During acute inflammation, histamine-induced increased vascular permeability causes the formation of exudates (inflammatory edema). Which one of the listed cell types is the most likely source of the histamine that causes the increased vascular permeability?

a)

Mast cells

b)

Endothelial cells

c)

Neutrophils

d)

Fibroblasts

9.

What type of leukocyte actively participates in acute inflammatory processes and contains myeloperoxidase within its primary (azurophilic) granules and alkaline phosphatase in its secondary (specific) granules?

a)

Eosinophils

b)

Neutrophils

c)

Monocytes

d)

Lymphocytes

10.

By definition, granulomas are composed of

a)

Cholesterol clefts

b)

Collagen

c)

Epithelioid cells

d)

Hemosiderin-laden macrophages

11.

Which of the followings is the possible outcomes for chronic inflammation?

a)

Slow resolution

b)

Abscess formation

c)

Exudate formation

d)

Pus formation

12.

A woman who is allergic to cats visits a neighbour who has several cats. During the visit, she inhales cat dander, and within minutes, she develops nasal congestion with abundant nasal secretions. Which of the following substances is most likely to produce these findings?

a)

Bradykinin

b)

Complement C5a

c)

Histamine

d)

Interleukin-1

13.

A 10-year-old child developed a sore throat and fever over 24 hours. Physical examination shows pharyngeal erythema and swelling. Laboratory findings include leukocytosis. The child is given acetylsalicylic acid (aspirin). Which of the following features of the inflammatory response is most affected by this drug?

a)

Vasodilation

b)

Chemotaxis

c)

Phagocytosis

d)

Release of leukocytes from bone marrow

14.

A 53-year-old woman has had a high fever and cough productive of yellowish sputum for the past 2 days. She was diagnosed to have acute bacterial pneumonia. Which of the following inflammatory cell types is most likely to be seen in greatly increased numbers in a sputum specimen?

a)

Macrophages

b)

Neutrophils

c)

Mast cells

d)

Langhans giant cells

15.

An experiment introduces bacteria into a perfused tissue preparation. Leukocytes leave the vasculature and migrate to the site of bacterial inoculation. The movement of these leukocytes is most likely to be mediated by which of the following substances?

a)

Bradykinin

b)

Chemokines

c)

Histamine

d)

Prostaglandins

16.

A 63-year-old man develops worsening congestive heart failure 2 weeks after an acute myocardial infarction. He dies 1 day later. At autopsy, a section of the infarct shows that the necrotic myocardium has largely been replaced by capillaries, fibroblasts, and collagen. Various inflammatory cells are present. Which of the following inflammatory cell types in this lesion plays the most important role in the healing process?

a)

Macrophages

b)

Plasma cells

c)

Lymphocytes

d)

Neutrophils

17.

A 32-year-old woman has had cough with fever for the past month. On physical examination, she has a temperature of 37.5°C, and on auscultation of the chest, crackles are heard in all lung fields. A chest radiograph shows many small, ill-defined nodular opacities in all lung fields. A transbronchial biopsy specimen shows interstitial infiltrates with lymphocytes, plasma cells, and epithelioid macrophages. Which of the following infectious agents is the most likely cause of this appearance?

a)

Staphylococcus aureus

b)

Plasmodium falciparum

c)

Candida albicans

d)

Mycobacterium tuberculosis

18.

A 36-year-old man has had midepigastric abdominal pain for the past 3 months. An upper gastrointestinal endoscopy shows a 2-cm ulceration of the gastric antrum. A biopsy specimen of the ulcer base shows angiogenesis, fibrosis, and mononuclear cell infiltrates with lymphocytes, macrophages, and plasma cells. Which of the following terms best describes this pathologic process?

a)

Acute inflammation

b)

Serous inflammation

c)

Granulomatous

inflammation

d)

Chronic inflammation

19.

A 9-year-old boy has had cough and fever for the past month. A chest radiograph shows enlargement of hilar lymph nodes and bilateral pulmonary nodular interstitial infiltrates. A transbronchial biopsy specimen shows granulomatous inflammation within the lung, marked by the presence of Langhans giant cells. Which of the following mediators is most likely to contribute to giant cell formation?

a)

Interferon-γ

b)

Leukotriene B4

c)

Complement

C3b

d)

Tumor

necrosis factor

20.

This picture shows an open gallbladder with gallstones inside. What was the pathologic process occured in this organ?

a)

Inflammation

b)

Acute inflammation

c)

Chronic Inflammation

d)

Abscess formation

21.

Select the type of this inflammation.

a)

Serous

b)

Catarrhal

c)

Fibrinous

d)

Allergic

22.

This tissue showed TWO multinucleated giant cells. What is the most possible aetiology of this reaction?

a)

Mycobacterium tuberculosis

b)

Sutures

c)

Aspergillus fumigatus

d)

Talc

23.

Which of the followings is a disease of chronic inflammation?

a)

allergic rhinitis

b)

common cold

c)

syphilis

d)

pharingitis

24.

Function of inflammation

a)

develop fibrous tissue

b)

induce fever

c)

destroy or wall off the aetiology

d)

destroy the affected tissue

25.

A patient came to the Emergency Department with blunt trauma in her head. What type of pathology occurred to her?

a)

Necrosis

b)

Degenerative

c)

Acute inflammation

d)

Chronic inflammation

26.

A 30-year-old male has a small cut on his forearm from two days ago. The area around the cut is red, swollen, and warm. He feels some pain. The redness is spreading slightly around the wound. What causes the redness?

a)

Leakage of plasma proteins from the blood vessels

b)

Vasoconstriction of blood vessels at the injury site

c)

Increased vascular permeability allowing fluid buildup in tissues

d)

Vasodilation of blood vessels increasing blood flow to the area

27.

A 25-year-old female twisted her ankle while jogging two days ago. The ankle is swollen, slightly painful, and warm to the touch. She also noticed that the skin around the ankle felt tight due to the swelling. What is the main cause of the swelling?

a)

Blood vessels narrowing

b)

Increased leakage of fluid from blood vessels

c)

Overproduction of white blood cells

d)

Breakdown of tissue proteins

28.

A 40-year-old male presents to the emergency department with sharp chest pain and difficulty breathing. A chest X-ray reveals fluid buildup in the pleural cavity. The physician performs a thoracentesis. The fluid sample appears cloudy. Which are the most likely lab findings in the fluid sample?

a)

Low protein content

b)

High leukocyte count and high protein content

c)

Low leukocyte count and low glucose levels

d)

Absence of bacteria in the fluid

29.

A 5-year-old child presents to the clinic with a sore throat, difficulty swallowing, and a low-grade fever. Upon examination, the doctor observes a thick, grayish-white membrane covering the tonsils and parts of the throat. The throat swab result showed positive for Corynebacterium diphtheria. The child is having

a)

suppurative inflammation

b)

membranous inflammation

c)

fibrinous inflammation

d)

catarrhal inflammation

30.

A 45-year-old female presents to the emergency department with chest pain, fever, and shortness of breath. She has a history of pneumonia and is currently experiencing a cough-producing rusty sputum. Upon examination, the doctor suspects inflammation based on the patient's clinical presentation and history. A thoracentesis is performed to analyze pleural fluid, which reveals a thick, fibrous exudate. What type of inflammation is she having?

a)

classic

b)

serous

c)

allergic

d)

fibrinous

31.

A 50-year-old male presents to the clinic with severe abdominal pain, fever, and malaise. The doctor suspects an acute inflammatory response due to possible appendicitis. Blood tests are ordered to assess the inflammatory response. What is the most likely finding?

a)

elevated CRP & ESR

b)

decreased in CRP & ESR

c)

decreased in IL-6 & IL-1

d)

elevated IL-6 & IL-1

32.

A 30-year-old female sustained a cut on her arm from a kitchen accident. Initially, the wound was red, swollen, and painful. After 2 weeks receiving treatment, including cleaning the wound and applying an antibiotic ointment, the wound healed, and there was no redness or swelling. Select the outcome of her inflammation

a)

resolution

b)

abscess formation

c)

healing by fibrosis

d)

chronic inflammation

33.

A 55-year-old male presents to the clinic with a non-healing skin lesion on his forearm that has been present for several months. The lesion is firm and raised, and there is some surrounding redness. A biopsy of the lesion reveals the presence of Touton giant cells. The biopsy indicate

a)

The inflammation is acute and resolving

b)

There is a chronic inflammation

c)

The lesion is likely cancerous

d)

The inflammation is due to a bacterial infection

34.

A 30-year-old male presents to the clinic with multiple skin nodules on his arms and legs. He reports a history of intravenous drug use. Upon examination, the nodules are firm and painful, with surrounding redness. A biopsy will reveal the presence of

a)

Immune granuloma

b)

Caseating granuloma

c)

Gumma

d)

Foreign body granuloma