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WorksheetsHuntington's Disease
Total questions: 7
Worksheet time: 4mins
What is the significance of the CAG repeat sequence in Huntington's disease?
It leads to a shortened protein tail.
It causes a toxic gain of function.
It is unrelated to the disease.
It prevents protein formation.
How is the onset of Huntington's Disease currently determined?
Genetic testing only
Clinical onset motor symptoms
Blood tests
MRI scans
Which of the following is a component of the basal ganglia?
Hippocampus
Caudate nucleus
Amygdala
Cerebellum
What are the two parts of the substantia nigra?
Pars reticulata and pars compacta
Medial and lateral
Anterior and posterior
Superior and inferior
What type of receptors are expressed in the indirect pathway of the neuron diagram?
D1 receptors
D2 receptors
GABA receptors
Glutamate receptors
What are some of the impaired voluntary movements observed in the late stage of Huntington's Disease?
Abnormal eye movements and general restlessness
Inappropriate hand and toe movements
Rigidity, bradykinesia, and dystonia
Onset of involuntary movements
Psychiatric symptoms in Huntington's Disease may precede motor symptoms by how long?
A few months
A year
A decade or more
They occur simultaneously
