WorksheetsDrug Bio-transformation Quiz
Total questions: 10
Worksheet time: 5mins
Which tissue has the greatest capacity to bio-transform drugs?
Brain
Kidney
Liver
Lung
Skin
Biotransformation of drugs is primarily directed to:
Activate the drug
Inactivate the drug
Convert lipid soluble drugs into nonlipid soluble metabolites
Convert nonlipid soluble drugs into lipid soluble metabolites
Which of the following is a prodrug?
Hydralazine
Clonidine
Captopril
Enalapril
What is a prodrug?
The prototype member of a class of drugs
The oldest member of a class of drugs
An inactive drug that is transformed in the body to an active metabolite
A drug that is stored in body tissues and is then gradually released in the circulation
Which of the following cytochrome P450 isoenzymes is involved in the metabolism of the largest number of drugs in human beings and has been implicated in some dangerous drug interactions?
CYP 3A4
CYP 2C9
CYP 2E1
CYP 1A2
The most common nonsynthetic reaction for drugs and their metabolites is:
Glucuronidation
Acetylation
Methylation
Oxidation
Which of the following is a phase II drug metabolizing reaction?
Acetylation
Hydrolysis
Oxidation
Reduction
Microsomal enzyme induction can be a cause of:
Tolerance
Physical dependence
Psychological dependence
Idiosyncrasy
The following drug metabolizing reaction is entirely nonmicrosomal:
Glucuronide conjugation
Acetylation
Oxidation
Reduction
What does the induction of drug metabolizing enzymes involve?
A conformational change in the enzyme protein to favour binding of substrate molecules
Expression of enzyme molecules on the surface of hepatocytes
Enhanced transport of substrate molecules into hepatocytes
Increased synthesis of enzyme protein
