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KROK 1 Pharmacology Test

Total questions: 23

Worksheet time: 12mins

Name
Class
Date
1.

Which of the following adverse effects is a common reason for discontinuing Metformin therapy in patients with Type 2 Diabetes Mellitus?

a)

Thyroid dysfunction.

b)

Severe hypoglycemia.

c)

Gastrointestinal disturbances (diarrhea, nausea).

d)

Peripheral edema and weight gain.

e)

Persistent dry cough.

2.

A patient on Warfarin therapy develops a significantly elevated International Normalized Ratio (INR) and presents with bleeding. Which agent is the most appropriate initial antidote to rapidly reverse the anticoagulant effect?

a)

Fresh Frozen Plasma (FFP) or Prothrombin Complex Concentrate (PCC).

b)

Protamine sulfate.

c)

Aspirin.

d)

Desmopressin.

e)

Vitamin K (Phytonadione).

3.

A patient who began taking the selective serotonin reuptake inhibitor (SSRI) Fluoxetine is also prescribed a Monoamine Oxidase Inhibitor (MAOI) for a different condition. This combination is absolutely contraindicated due to the high risk of which life-threatening syndrome?

a)

Neuroleptic Malignant Syndrome (NMS).

b)

Hepatic encephalopathy.

c)

Serotonin Syndrome.

d)

Hypertensive crisis.

e)

Agranulocytosis.

4.

Which antipsychotic drug carries a significant risk of agranulocytosis and requires mandatory weekly to biweekly Complete Blood Count (CBC) monitoring?

a)

Quetiapine.

b)

Risperidone.

c)

Olanzapine.

d)

Clozapine.

e)

Haloperidol.

5.

A patient with urolithiasis has unbearable spasmodic pain. To prevent pain shock,

he has been given an injection of atropine along with a narcotic analgesic having

antispasmodic effect. What drug was it?

a)

Morphine hydrochloride

b)

Tramadol

c)

Nalorphine

d)

Ethylmorphine hydrochloride

e)

Promedol

6.

Despite the administration of cardiotonics and a thiazide diuretic a patient with

chronic heart failure has persistent edemata, there is a risk of ascites. What

medication should be administered in order to enhance the diuretic effect of the drugs

used?

a)

Clopamide

b)

Furosemide

c)

Amiloride

d)

Spironolactone

e)

Manithol

7.

A 60-year-old male patient has a 9-year history of diabetes and takes insulin Semi-

lente for the correction of hyperglycemia. 10 days ago he began taking anaprilin for

hypertension. One hour after administration of the antihypertensive drug the patient

developed hypoglycemic coma. What is the mechanism of hypoglycemia in case of

anaprilin use?

a)

Reduction of glucagon half-life

b)

Inhibition of glycogenolysis

c)

Increase of insulin Semilente half-life

d)

Increase of bioavailability of insulin Semilente

e)

Decrease in glucose absorption

8.

A patient has been administered an anti-inflammatory drug that blocks the action

of cyclooxygenase. Specify this anti-inflammatory agent:

a)

Creatine

b)

Analgene

c)

Allopurinol

d)

Thiamin

e)

Aspirin

9.

A pneumonia patient has been administered acetylcysteine as a part of complex

therapy. What principle of therapy was taken into consideration when applying this

drug?

a)

Etiotropic

b)

Symptomatic

c)

Pathogenetic

d)

Antimicrobial

e)

Immunomodulatory

10.

A 26-year-old female patient with bronchitis has been administered a broad

spectrum antibiotic as a causal treatment drug. Specify this drug:

a)

Ambroxol

b)

Interferon

c)

BCG vaccine

d)

Doxycycline

e)

Dexamethasone

11.

A 12-year-old child has a viral infection complicated by obstructive bronchitis.

Bronchospasm can be eliminated by inhalations of a drug from the following

pharmacological group:

a)

M-anticholinergics

b)

B2-agonists

c)

N-cholinomimetics

d)

B2-adrenergic blockers

e)

Analeptics

12.

A patient has recurrent attacks of epileptic seizures and stays unconscious between

them. In order to stop convulsions the drugs of the following group should be used in

the first place:

a)

Tranquilizers

b)

Neuroleptics

c)

Muscle relaxants

d)

Sedatives

e)

Analeptics

13.

A patient with arthritis and varicose veins has been taking a non-steroidal anti-

inflammatory drug for a long time, which caused thrombosis of skin veins. Which of

the following drugs might have caused this complication?

a)

Phenylbutazone

b)

Indomethacin

c)

Aspirin

d)

Celecoxib

e)

Ibuprofen

14.

A patient with bacterial periodontitis has been administered iontophoresis with

the use ofiodine solution. Specify the mechanism of therapeutic action of this agent:

a)

Inhibition of the cell wall formation

b)

Reduction of the nitro group under the effect of nitroreductase

c)

Albumin formation

d)

Changing the surface tension of the bacterial cell membrane

e)

Substitution of hydrogen atoms when the protein amino group contains a nitrogen

atom

15.

A patient has arterial hypertension. What long-acting drug from the group of

calcium channelblockers should be prescribed?

a)

Octadine

b)

Amlodipine

c)

Pyrroxanum

d)

Atenolol

e)

Reserpine

16.

As a result of a home injury, a patient suffered a significant blood loss, which led

to a fall inblood pressure. Rapid blood pressure recovery after the blood loss is

provided by the following hormones:

a)

Adrenaline, vasopressin

b)

Cortisol

c)

Sex hormones

d)

Oxytocin

e)

Aldosterone

17.

A 65-year-old female patient has chronic constipations due to the colon

hypotonia. What drug should be chosen in this case?

a)

Castor oil

b)

Bisacodyl

c)

Magnesium sulfate

d)

Neostigmine methylsulfate

e)

Metoclopramide

18.

Administration of doxycycline hydrochloride caused an imbalance of the

symbiotic intestinalmicroflora. Specify the kind of imbalance caused by the antibiotic

therapy:

a)

Dysbacteriosis

b)

Sensibilization

c)

Idiosyncrasy

d)

Superimposed infection

e)

Bacteriosis

19.

An unconscious patient was delivered to the admission ward. Objectively: the

patient’s skin is cold, pupils are myotic, he has laboured Cheyne-Stokes respiration,

arterial pressure is low, urinary bladder is full. What substance has caused

intoxication?

a)

Tranquilizers

b)

Non-narcotican algetics

c)

Muscarinic receptor blockers

d)

Adrenaline

e)

Narcotic analgetics

20.

A woman works as railway traffic controller. She suffers from seasonal

vasomotor rhinitis and gets treatment in the outpatient setting. She was prescribed an

antihistamine that has no effect upon central nervous system. What drug is it?

a)

Promethazine

b)

Dimedrol

c)

Loratadine

d)

Suprastin

e)

Tavegil

21.

A patient who suffers from insomnia caused by emotional disorder was

prescribed a hypnotic drug with tranquillizing effect. What hypnotic was prescribed?

a)

Nitrazepam

b)

Phenobarbital

c)

Chloralhydrate

d)

Sodiumethaminal

e)

Bromisoval

22.

A 4 year old child was admitted to the orthopaedic department with shin fracture

together with displacement. Bone fragments reposition requires preliminary

analgesia. What medication should be chosen?

a)

Analgin

b)

Promedol

c)

Morphinehydrochloride

d)

Panadol

e)

-

23.

A 65 year old female patient suffers from chronic renal insufficiency

accompanied by evident edemata caused by chronic glomerulonephritis. What

diuretic should be administered for forced diuresis?

a)

Hydrochlorothiazide

b)

Chlorthalidone

c)

Cyclometazide

d)

Acetazolamide

e)

Furosemide