WorksheetsHEMA-8
Total questions: 117
Worksheet time: 59mins
Name
Class
Date
1.
Aplastic anemia
a)
Normal or decreased reticulocyte count
b)
Increased reticulocyte count
2.
Kidney disease
a)
Normal or decreased reticulocyte count
b)
Increased reticulocyte count
3.
Acute blood loss
a)
Normal or decreased reticulocyte count
b)
Increased reticulocyte count
4.
Paroxysmal nocturnal hemoglobinuria
a)
Normal or decreased reticulocyte count
b)
Increased reticulocyte count
5.
Paraxosymal cold hemoglobinuria
a)
Normal or decreased reticulocyte count
b)
Increased reticulocyte count
6.
Sickle cell disease
a)
Normal or decreased reticulocyte count
b)
Increased reticulocyte count
7.
Enzyme deficiencies (G6PD deficiency, Pk deficiency)
a)
Normal or decreased reticulocyte count
b)
Increased reticulocyte count
8.
Other hemolytic anemias
a)
Normal or decreased reticulocyte count
b)
Increased reticulocyte count
9.
Anemia is defined as the decrease or below normal of one or more of the following:
a)
Number of red blood cells
b)
Number of white blood cells
c)
Hemoglobin
d)
Hematocrit
e)
Platelet
10.
described as a rare but potentially deadly bone marrow failure syndrome
a)
Aplastic anemia
b)
Sideroblastic anemia
c)
Anemia of chronic inflammation
d)
Iron deficiency anemia
11.
characteristic features:
• pancytopenia (marked ↓ in the number of RBCs, WBCs, and platelets in the blood)
• reticulocytopenia
• bone marrow hypocellularity
• depletion of hematopoietic stem cells
a)
Aplastic anemia
b)
Sideroblastic anemia
c)
Anemia of chronic inflammation
d)
Iron deficiency anemia
12.
approximately 80 to 85% of aplastic anemia cases
a)
Acquired aplastic anemia
b)
Inherited aplastic anemia
c)
Fanconi anemia
13.
has 2 categories: idiopathic acquired aplastic anemia and secondary acquired aplastic anemia
a)
Acquired aplastic anemia
b)
Inherited aplastic anemia
c)
Fanconi anemia
14.
CHLORAMPHENICOL = drug most frequently implicated in
a)
Acquired aplastic anemia
b)
Inherited aplastic anemia
c)
Fanconi anemia
15.
approximately 15% to 20% of aplastic anemia cases
a)
Acquired aplastic anemia
b)
Inherited aplastic anemia
c)
Fanconi anemia
16.
associated diseases:
(1) Dyskeratosis congenita
(2) Shwachman-Bodian-Diamond syndrome
a)
Acquired aplastic anemia
b)
Inherited aplastic anemia
c)
Fanconi anemia
17.
most common of the inherited aplastic anemias
a)
Acquired aplastic anemia
b)
Inherited aplastic anemia
c)
Fanconi anemia
18.
which of the following is a chromosome instability disorder?
a)
Acquired aplastic anemia
b)
Inherited aplastic anemia
c)
Fanconi anemia
19.
which of the following is characterized by aplastic anemia, cancer susceptibility, and physical abnormalities?
a)
Acquired aplastic anemia
b)
Inherited aplastic anemia
c)
Fanconi anemia
20.
physical abnormalities may include:
*skeletal abnormalities (ex.: thumb malformations, microcephaly, scoliosis)
*skin pigmentation (ex.: hyperpigmentation, hypopigmentation, café-au-lait lesions)
*short stature
*abnormalities of the eyes, kidneys, and genitals
a)
Acquired aplastic anemia
b)
Inherited aplastic anemia
c)
Fanconi anemia
21.
Which of the following is also known as Marchiava-Micheli syndrome?
a)
Paroxysmal nocturnal hemoglobinuria
b)
Paroxysmal cold hemoglobinuria
22.
It is cased by a deficiency of DAF (decay-accelerating factor, or CD55), and MIRL (membrane inhibitor of reactive lysis, or CD59)
a)
Paroxysmal nocturnal hemoglobinuria
b)
Paroxysmal cold hemoglobinuria
23.
Tests for this disease include Ham's acidified serum test, sugar water test, and flow cytometry using FLAER or fluorescein-labeled proaerolysin variant
a)
Paroxysmal nocturnal hemoglobinuria
b)
Paroxysmal cold hemoglobinuria
24.
What is the confirmatory test for PNH?
a)
Ham's Acidified Serum Test
b)
Sugar water test
c)
Flow cytometry using FLAER
25.
Sugar water test is also known as _____ hemolysis test
a)
Glucose
b)
Lactose
c)
Maltose
d)
Sucrose
26.
no known cause
a)
idiopathic acquired aplastic anemia
b)
secondary acquired aplastic anemia
27.
associated with an identified cause
- some of the causes include: chemicals (ex.: insecticides, benzene), viruses (ex.: Epstein-Barr virus), drugs (ex.: chloramphenicol)
a)
idiopathic acquired aplastic anemia
b)
secondary acquired aplastic anemia
28.
Chronic blood loss
a)
Microcytic, Hypochromic anemia
b)
Macrocytic, Normochromic anemia
29.
Thalassemia
a)
Microcytic, Hypochromic anemia
b)
Macrocytic, Normochromic anemia
30.
Anemia of chronic inflammation
a)
Microcytic, Hypochromic anemia
b)
Macrocytic, Normochromic anemia
31.
Iron deficiency anemia
a)
Microcytic, Hypochromic anemia
b)
Macrocytic, Normochromic anemia
32.
Lead poisoning
a)
Microcytic, Hypochromic anemia
b)
Macrocytic, Normochromic anemia
33.
Sideroblastic anemia
a)
Microcytic, Hypochromic anemia
b)
Macrocytic, Normochromic anemia
34.
Megaloblastic anemia
a)
Microcytic, Hypochromic anemia
b)
Macrocytic, Normochromic anemia
35.
Pernicious anemia
a)
Microcytic, Hypochromic anemia
b)
Macrocytic, Normochromic anemia
36.
Nonmegaloblastic anemia
a)
Microcytic, Hypochromic anemia
b)
Macrocytic, Normochromic anemia
37.
was originally called ACD (anemia of chronic disease)
a)
Anemia of chronic inflammation
b)
Iron deficiency anemia
c)
Lead poisoning
d)
Sideroblastic anemia
38.
most common anemia among hospitalized patients
a)
Anemia of chronic inflammation
b)
Iron deficiency anemia
c)
Lead poisoning
d)
Sideroblastic anemia
39.
associated with chronic infections such as tuberculosis, chronic inflammatory conditions such as rheumatoid arthritis, and tumors
a)
Anemia of chronic inflammation
b)
Iron deficiency anemia
c)
Lead poisoning
d)
Sideroblastic anemia
40.
body stores have abundant iron; red cells are deficient in iron
a)
Anemia of chronic inflammation
b)
Iron deficiency anemia
c)
Lead poisoning
d)
Sideroblastic anemia
41.
develop when the production of protoporphyrin or the incorporation of iron into protoporphyrin is prevented
a)
Anemia of chronic inflammation
b)
Iron deficiency anemia
c)
Lead poisoning
d)
Sideroblastic anemia
42.
Iron is trapped in the mitochondria (cannot be fully utilized in Hb synthesis)
a)
Anemia of chronic inflammation
b)
Iron deficiency anemia
c)
Lead poisoning
d)
Sideroblastic anemia
43.
Dimorphic peripheral blood picture (normochromic and hypochromic RBCs)
a)
Anemia of chronic inflammation
b)
Iron deficiency anemia
c)
Lead poisoning
d)
Sideroblastic anemia
44.
the most common anemia
a)
Anemia of chronic inflammation
b)
Iron deficiency anemia
c)
Lead poisoning
d)
Sideroblastic anemia
45.
possible causes:
o Blood loss (especially menstruating women)
o Nutritional deficiency (infants)
o ↑ iron demand (pregnancy, lactation, adolescence)
o Malignancies of gastrointestinal tract
o Hookworm infections
a)
Anemia of chronic inflammation
b)
Iron deficiency anemia
c)
Lead poisoning
d)
Sideroblastic anemia
46.
Clinical features: Fatigue, weakness, irritability, headache, palpitations, loss of concentration, koilonchia, glossitis, pica or craving for nonfood items
a)
Anemia of chronic inflammation
b)
Iron deficiency anemia
c)
Lead poisoning
d)
Sideroblastic anemia
47.
The “rings” in ring sideroblasts represents ______ loaded with iron
a)
Cytoplasm
b)
Mitochondria
c)
Nucleus
d)
Nucleoli
48.
nucleated RBC precursor with cytoplasmic iron granules
a)
Sideroblast
b)
Siderocyte
49.
anucleate RBC w/ iron granules
a)
Sideroblast
b)
Siderocyte
50.
Storage Iron Depletion
a)
Stage 1
b)
Stage 2
c)
Stage 3
51.
Transport Iron Depletion
a)
Stage 1
b)
Stage 2
c)
Stage 3
52.
When does TIBC increases in IDA?
a)
Stage 1
b)
Stage 2
c)
Stage 3
53.
Functional Iron Depletion
a)
Stage 1
b)
Stage 2
c)
Stage 3
54.
indirectly measures the concentration of transferrin by measuring its ability to bind iron
a)
Hemoglobin
b)
Serum Iron
c)
TIBC
d)
Serum Ferritin
55.
reveals the body’s tissue iron stores
a)
Hemoglobin
b)
Serum Iron
c)
TIBC
d)
Serum Ferritin
56.
-good indicator of iron storage status
a)
Hemoglobin
b)
Serum Iron
c)
TIBC
d)
Serum Ferritin
57.
-useful in diagnosing iron deficiency (generally the first laboratory test to become abnormal when iron stores begin to decline)
a)
Hemoglobin
b)
Serum Iron
c)
TIBC
d)
Serum Ferritin
58.
-measured using radioimmunoassay
a)
Hemoglobin
b)
Serum Iron
c)
TIBC
d)
Serum Ferritin
59.
In stage 1 of IDA, what decreases first?
a)
Hemoglobin
b)
Serum Iron
c)
TIBC
d)
Serum Ferritin
60.
In stage 2 of IDA, what decreases second?
a)
Hemoglobin
b)
Serum Iron
c)
TIBC
d)
Serum Ferritin
61.
In stage 2 of IDA, what increases?
a)
Hemoglobin
b)
Serum Iron
c)
TIBC
d)
Serum Ferritin
62.
In stages 1 and 2 of IDA, hemoglobin is?
a)
Increased
b)
Normal
c)
Decreased
63.
In stage 3 of IDA, what decreases?
a)
Hemoglobin
b)
Serum Iron
c)
TIBC
d)
Serum Ferritin
64.
Serum Iron: High
TIBC: Normal
Serum Ferritin: High
Free Erythrocyte Protoporphyrin: Normal
a)
Thalassemia
b)
Anemia of Chronic Inflammation
c)
Iron Deficiency Anemia
d)
Lead poisoning
e)
Sideroblastic anemia
65.
Serum Iron: Low
TIBC: Low
Serum Ferritin: High
Free Erythrocyte Protoporphyrin: High
a)
Thalassemia
b)
Anemia of Chronic Inflammation
c)
Iron Deficiency Anemia
d)
Lead poisoning
e)
Sideroblastic anemia
66.
Serum Iron: Low
TIBC: High
Serum Ferritin: Low
Free Erythrocyte Protoporphyrin: High
a)
Thalassemia
b)
Anemia of Chronic Inflammation
c)
Iron Deficiency Anemia
d)
Lead poisoning
e)
Sideroblastic anemia
67.
Serum Iron: Normal to high in adults and normal to low in chidlren
TIBC: Normal
Serum Ferritin: Normal
Free Erythrocyte Protoporphyrin: High
a)
Thalassemia
b)
Anemia of Chronic Inflammation
c)
Iron Deficiency Anemia
d)
Lead poisoning
e)
Sideroblastic anemia
68.
Serum Iron: High
TIBC: Normal
Serum Ferritin: High
Free Erythrocyte Protoporphyrin: Mixed (high and low)
a)
Thalassemia
b)
Anemia of Chronic Inflammation
c)
Iron Deficiency Anemia
d)
Lead poisoning
e)
Sideroblastic anemia
69.
Serum iron in THALASSEMIA
a)
Low
b)
Normal
c)
High
70.
TIBC in THALASSEMIA
a)
Low
b)
Normal
c)
High
71.
Serum ferritin in THALASSEMIA
a)
Low
b)
Normal
c)
High
72.
Free erythrocyte protoporphyrin in THALASSEMIA
a)
Low
b)
Normal
c)
High
73.
Serum iron in ACI
a)
Low
b)
Normal
c)
High
74.
TIBC in ACI
a)
Low
b)
Normal
c)
High
75.
Serum ferritin in ACI
a)
Low
b)
Normal
c)
High
76.
FEP in ACI
a)
Low
b)
Normal
c)
High
77.
Serum iron in IDA
a)
Low
b)
Normal
c)
High
78.
TIBC in IDA
a)
Low
b)
Normal
c)
High
79.
Serum ferritin in IDA
a)
Low
b)
Normal
c)
High
80.
FEP in IDA
a)
Low
b)
Normal
c)
High
81.
TIBC in lead poisoning
a)
Low
b)
Normal
c)
High
82.
Serum ferritin in lead poisoning
a)
Low
b)
Normal
c)
High
83.
FEP in lead poisoning
a)
Low
b)
Normal
c)
High
84.
Serum iron in sideroblastic anemia
a)
Low
b)
Normal
c)
High
85.
TIBC in sideroblastic anemia
a)
Low
b)
Normal
c)
High
86.
Serum ferritin in sideroblastic anemia
a)
Low
b)
Normal
c)
High
87.
FEP in sideroblastic anemia
a)
Low
b)
Normal
c)
High
88.
Serum iron in lead poisoning on adults
a)
Normal to low
b)
Normal to high
89.
Serum iron in lead poisoning on children
a)
Normal to low
b)
Normal to high
90.
In thalassemia, what is HIGH?
a)
Serum iron
b)
TIBC
c)
Serum ferritin
d)
FEP
91.
In thalassemia, what is NORMAL?
a)
Serum iron
b)
TIBC
c)
Serum ferritin
d)
FEP
92.
In ACI what is LOW?
a)
Serum iron
b)
TIBC
c)
Serum ferritin
d)
FEP
93.
In ACI what is HIGH?
a)
Serum iron
b)
TIBC
c)
Serum ferritin
d)
FEP
94.
In IDA, what is LOW?
a)
Serum iron
b)
TIBC
c)
Serum ferritin
d)
FEP
95.
In IDA, what is HIGH?
a)
Serum iron
b)
TIBC
c)
Serum ferritin
d)
FEP
96.
In lead poisoning, what is NORMAL? (excluding the variation ng normal to high in adults and normal to low in children)
a)
Serum iron
b)
TIBC
c)
Serum ferritin
d)
FEP
97.
In lead poisoning, what is HIGH?
a)
Serum iron
b)
TIBC
c)
Serum ferritin
d)
FEP
98.
In sideroblastic anemia, what is normal?
a)
Serum iron
b)
TIBC
c)
Serum ferritin
d)
FEP
99.
In sideroblastic anemia, what is mixture of high and low?
a)
Serum iron
b)
TIBC
c)
Serum ferritin
d)
FEP
100.
In sideroblastic anemia, what is HIGH?
a)
Serum iron
b)
TIBC
c)
Serum ferritin
d)
FEP
101.
Which of the tests below will be helpful in distinguishing IDA from Thalassemias?
1.) TIBC
2.) FEP
3.) Serum ferritin
4.) Serum iron
a)
a. 1, 2, 3, and 4
b)
b. 1 and 3
c)
c. 2 and 4
d)
d. 1, 2 and 3
102.
Vitamin B12 deficiency – may be caused by
: ✓ inadequate intake
✓ increased need (occurs during pregnancy, lactation and growth)
✓ competition (ex.: D. latum infection)
✓ lack of intrinsic factor (IF) (ex.: gastrectomy, H. pylori infection, Pernicious Anemia)
a)
Megaloblastic anemia
b)
Nonmegaloblastic anemia
103.
Liver disease
• Alcoholism (chronic)
• Bone marrow failure
a)
Megaloblastic anemia
b)
Nonmegaloblastic anemia
104.
Presence of hypersegmented neutrophils (with > 6 lobes) MEGALOBLASTIC ANEMIA
a)
Present
b)
Absent
105.
Presence of megaloblasts in the bone marrow MEGALOBLASTIC ANEMIA
a)
Present
b)
Absent
106.
Presence of megaloblasts in the bone marrow NONMEGALOBLASTIC ANEMIA
a)
Present
b)
Absent
107.
Presence of hypersegmented neutrophils (with > 6 lobes) NONMEGALOBLASTIC ANEMIA
a)
Present
b)
Absent
108.
may be caused by:
✓ inadequate intake
✓ increased need
✓ renal dialysis
a)
Vitamin B12 deficiency
b)
Folate deficiency
109.
may be caused by
: ✓ inadequate intake
✓ increased need (occurs during pregnancy, lactation and growth)
✓ competition (ex.: D. latum infection)
✓ lack of intrinsic factor (IF) (ex.: gastrectomy, H. pylori infection, Pernicious Anemia)
a)
Vitamin B12 deficiency
b)
Folate deficiency
110.
Shape of macrocytes in megaloblastic anemia
a)
Oval
b)
Round
111.
Shape of macrocytes in nonmegaloblastic anemia
a)
Oval
b)
Round
112.
Vitamin B12 is also known as
a)
Cyanocobalamin
b)
Methylcobalamin
c)
Cobalamin
d)
Folate
113.
synthetic form of vitamin B12 (found only in supplements)
a)
Cyanocobalamin
b)
Methylcobalamin
c)
Cobalamin
d)
Folate
114.
naturally occurring form that may be obtained from either food sources or supplements
a)
Cyanocobalamin
b)
Methylcobalamin
c)
Cobalamin
d)
Folate
115.
not destroyed by cooking
a)
Cyanocobalamin
b)
Methylcobalamin
c)
Cobalamin
d)
Folate
116.
heat labile (overcooking of foods can ↓ their nutritional value)
a)
Cyanocobalamin
b)
Methylcobalamin
c)
Cobalamin
d)
Folate
117.
eurologic symptoms may be noticeable and neuropsychiatric symptoms may also be present. o Neurologic symptoms include:
▪ memory loss
▪ numbness
▪ tingling in toes and fingers
▪ loss of balance
▪ further impairment of walking by loss of vibratory sense, especially in the lower limbs
o Neuropsychiatric symptoms include:
▪ personality changes
▪ psychosis
a)
Vitamin B12 deficiency
b)
Vitamin B9 deficiency
100 %
