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WorksheetsQuiz Week 1-3 Block FMS I
Total questions: 50
Worksheet time: 25mins
An abnormal chromosome with two identical arms is called
Paracentric Inversion
Reciprocal Translocation
Isochromosome
Dicentric chromosome
Pericentric Inversion
Meiotic error in human oogenesis (the process of producing the female gametes) may cause following conditions except:
XYY
Trisomy 18
XXY
Trisomy 13
XXX
β-thalassemia case common in South East Asia is often due to a point mutation E26K in the β-globin gene. This mutation results in a β-globin protein that ______
Contains lysine at position 26 instead of glutamate (glutamic acid)
Contains aspartate (aspartic acid) at position 26 instead of lysine
Cannot be synthesized (no β-globin protein at all)
Is only 26 amino acids long with lysine as the last amino acid
Contains lysine at position 26 instead of aspartate (aspartic acid)
Individuals with CYP2D6*4 allele are considered poor metabolizer for the cancer drug Tamoxifen. These allelic variants lead to:
Inactive CYP2D6 enzymes
Reduced drug dose
Increased risk of side-effect
A and B
A, B and C
Daughter strands in a replication are always made of one strand of old DNA and one newly synthesized complementary strand. This nature of DNA replication is referred as
Discontinuous
Semiconservative
Antiparallel
Conservative
Dispersive
In Gene Therapy, viral vectors are generally preferred over non-viral vectors because viral vectors:
Can only carry RNA
Can be engineered to target specific types of cells
Are pathogenic
Are expensive
Can induce immune response
Coli cells grown on 15N medium are transferred to 14N medium and allowed to grow for two more generations (two rounds of DNA replication). DNA extracted from these cells is centrifuged. What density distribution of DNA would you expect in this experiment?
One low-density and one intermediate-density band
One high-density and one low-density band
One intermediate-density band
One low-density band
One high-density and one intermediate-density band
Consider this sequence A-B-C-D-E-O-F-G-H, to be a DNA sequence where O is the centromere. Which of the following will be a paracentric inversion?
A-B-C-F-G-O-D-E-H
A-B-C-F-G-O-E-D-H
A-B-D-E-O-F-G-H
A-B-C-B-C-D-E-O-F-G-H
A-D-C-B-E-O-F-G-H
Which of the following statement about Endoplasmic Reticulum is CORRECT?
Messenger RNA need to enter rough ER to be translated into proteins
The pH in the ER is lower than the Lysosomes
Smooth and rough ER are separated organelles
Proteins synthesized in the ER can be targeted to mitochondria
Proteins synthesized in the rough ER may have errors
UV radiation can cause DNA damage in form of thymine dimers formation. This DNA damage is usually repaired by the DNA repair mechanism of
MMR
NHEJ
BER
HDR
NER
Gene expression can be suppressed (“knocked out” or “switched off”) by introducing an antisense RNA or a double stranded RNA (dsRNA) of the corresponding gene into the cells. This method is called _______
Genome editing
RNAi (RNA interference)
Alternative splicing
DNA silencing
CRISPR/Cas9
Choose the answer that has these events of protein synthesis (translation) in the proper sequence.
An aminoacyl-tRNA binds to the A site
A peptide bond forms between the new amino acid and a polypeptide chain
tRNA leaves th P site, and the P site remains vacant
A small ribosomal subunit binds with mRNA
tRNA translocates to the P site
1, 3 , 2, 4, 5
2, 4, 5, 1, 3
4, 1, 2, 5, 3
5, 4, 3, 2, 1
4,1,3,2,5
Gram positive bacteria differs from Gram negative bacteria in which of the following
The presence of plasma membrane
The presence of large periplasmic space
The absence of cell wall
The absence of DNA
The presence of teichoic acid
Which of the following statements about Cell is FALSE?
Different cells use different genetic code
All cells need energy to operate
Proteins control the activities, functions, and structures in all cells
All cells synthesize proteins by using the ribosome
All cells store information in genes in the form of D
Cellular adaptation that occurs due to an increase in workload that results in an increase in the number of cells is
Metaplasia
Atrophy
Hypertrophy
Dysplasia
Hyperplasia
Chimerism is the result of
Double fertilization
Sex-linked Recombination
Chromosomal Deletion
Non-Disjunction in Mitosis
Non-Disjunction in Meiosis I
The regions of a gene located at -10 and -35, with respect to the start of transcription, are termed
Origin of replication (ori)
Promoters
Enhancer sequences
Start codons
Terminator
The process called _______________ is thought to be one of mechanisms allowing human cells to produce more proteins from only one single gene.
RNA silencing
Alternative splicing
RNAi (RNA interference)
Silence mutation
Genome editing
In eukaryotic cells, transcription cannot begin until
DNA nucleases have isolated the transcription unit
Several transcription factors have bound to the promoter
The DNA introns are removed from the template
The two DNA strands have completely separated and exposed the promoter
The 5' caps are removed from the mRNA
Autophagy includes all the following except
Secretory Vesicle formation
Degradation of unneeded Peroxisome
Degradation in Lysosome
Vesicle breakdown
Vesicle elongation
The body's natural process for removal of the body's dead and non-functioning cells is
Inflammation
Necrosis
Apoptosis
Chaperone mediated degradation
Fatty acid change
Which of the following best describes the flow of information in eukaryotic cells?
RNA → proteins → DNA
proteins → DNA → RNA
DNA → RNA → proteins
RNA → DNA → proteins
DNA → proteins → RNA
The anticodon of a particular tRNA molecule is
Complementary to the corresponding triplet in rRNA
Changeable, depending on the amino acid that attaches to the tRNA
Catalytic, making the tRNA a ribozyme
Complementary to the corresponding mRNA codon
The part of tRNA that bonds to a specific amino acid
When two or more genes are responsible for a single phenotype, this is called:
Polydactyly
Polyploidy
Polygenic inheritance
Pleiotropy
Epistasis
In Mendel’s experiment with the pea plants, which trait was observed in the F1 generation?
Incomplete dominance
Recessive
Dominant
Co-dominant
Incomplete recessive
Nuclear pore allows the movement of
Ion and protein
RNA
Ion, protein and RNA
Protein
Ion
Secretory cells that release relatively large quantities of glycoproteins contain relatively large amounts of which of the following?
Smooth endoplasmic reticulum
Smooth endoplasmic reticulum, Golgi apparatus
Smooth endoplasmic reticulum, Golgi apparatus, Mitochondria
Rough endoplasmic reticulum, Golgi apparatus, Mitochondria
Rough endoplasmic reticulum, Golgi apparatus
Which of the following statement about Lysosomes is FALSE?
Lysosomes degrade molecules coming from exocytosis
Proton pump on Lysosomal membrane require ATP
The internal acidic environment of lysosomes requires proton pump
Lysosomal enzymes degrade a wide variety of molecules
Lysosomes can fuse with plasma membrane
The cytoskeleton includes all the following except
Lamin
Myosin
Actin
Tubulin
Vimentin
The following pedigree is characteristic for a disease which is inherited in____________ manner
X-linked recessive
Y-linked dominant
X-linked dominant
Autosomal recessive
Autosomal dominant
In eukaryotic cell, the following structure consists of double membrane
Cytoplasm
Ribosome
Golgi Apparatus
Endoplasmic Reticulum
Nuclear Envelope
Lysosomal Storage Diseases are the result of
Defective Ion Transporter
Defective Lysosomal Enzyme
Defective Glycosylation in Golgi Apparatus
A, B
A, B and C
In a nucleosome, the DNA is wrapped around
A thymine dimer
Satellite DNA
Histones
Polymerase molecules
Ribosomes
Individuals with the following karyotype will most likely
Have cleft palate
Sterile
Not survive
Mentally retarded
Taller than average
A cross between two individuals results in a ratio of 9:3:3:1 for four possible phenotypes. This is an example of
Monohybrid cross
Dihybrid cross
Trihybrid cross
Test cross
None of the above
Interaction between enhancer sequence and an activator in a regulation of gene expression is an example of
DNA-DNA interaction
Protein-protein interaction
RNA-protein interaction
DNA-RNA interaction
DNA-protein interaction
You would expect an individual with a tetrasomy to have ___________ chromosomes
46
47
45
48
69
Enlargement of skeletal muscle with exercise is an example of
Atrophy
Hypertrophy
Hyperplasia
Dysplasia
Metaplasia
White blood cells engulf foreign material by using the process of
Receptor-mediated endocytosis.
Phagocytosis
Regulated secretion
Pinocytosis
Constitutive secretion
Which of the following help(s) to stabilize mRNA by inhibiting its degradation?
Spliceosomes
5' cap and poly (A) tail
Introns
RNA polymerase
TATA box
In the Ubiquitin Proteasome Pathway, Ubiquitin acts as
Protease Complex
Chaperone for Protein Folding
Conjugating Enzyme for cellular protein
Activating Enzyme for degradation
Marker for cellular protein targeted for degradation
In analyzing the number of different bases in a DNA sample, which result would be consistent with the base-pairing rules?
G = T
A = C
A + G = C + T
A = G
A + T = G + T
Which of the following statements is not correct about Apoptosis?
Activation through extracellular signals
Activation through intracellular signals
Activation of Caspase Cascade
Induces nucleus condensation
Induces inflammatory response
The following statements for SNP are correct, except:
Present in <1% of study population
Detected in non-coding region
Occur when a single base is altered
Detected in coding region
May have effect on drug transport
Marfan syndrome is a human genetic disorder affecting the connective tissues, caused by mutations of the fibrillin-1 (FBN1) gene. This disease commonly affects the eyes, heart, blood vessels, and skeleton. This is an example of:
Polyploidy
Polygenic inheritance
Pleiotropy
Polydactyly
Epistasis
Which of the following statements is TRUE about Necrosis?
It results in fragmentation of the cell
No loss of membrane integrity
No inflammatory response
Pre-lytic DNA fragmentation
It affects groups of cells
After fertilization, the resulting zygote begins to divide by
Synapsis
Meiosis
Mitosis
Binary fission
Autophagocytosis
The following pedigree is an example of
X-Linked Recessive
Autosomal Recessive
X-Linked Dominant
Mitochondrial Inheritance
Autosomal Dominant
Which of the following is not true of RNA processing?
snRNP and snRNA may function in RNA splicing
Nucleotides may be added at both ends of the RNA
Exons are cut out before mRNA leaves the nucleus
A primary transcript is often much longer than the final RNA molecule that leaves the nucleus
RNA splicing can be catalyzed by spliceosomes
Which of the following is not true of RNA processing?
snRNP and may function in RNA splicing
Nucleotides may be added at both ends of the RNA
Exons are cut out before mRNA leaves the nucleus
A primary transcript is often much longer than the final RNA molecule that leaves the nucleus
RNA spilicing can be catalyzed by spliceosomes
