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Cancer I

Total questions: 71

Worksheet time: 42mins

Name
Class
Date
1.

Cancer is described as the disease of CELL ___

a)

growth

b)

diffirentation

c)

division

d)

accumulation

e)

immaturity

2.

% of death cause by cancer in Canada

(a)  

3.

ratio of those who will develop cancer in their lifetime

a)

1 in 2

b)

1 in 4

4.

ratio of those who will DIE in cancer

a)

1 in 2

b)

1 in 4

5.

ratio & percentage of cancer in MALE

a)

1 in 2.2

b)

1 in 2.3

c)

45%

d)

43%

6.

ratio & percentage of cancer in FEMALE

a)

1 in 2.2

b)

1 in 2.3

c)

45%

d)

43%

7.

#1 in Cancer incidence rates

a)

Non-melanoma Skin Cancer

b)

Lungs & Bronchus

c)

Breast

d)

Colorectal

e)

Prostate

8.

#2 in Cancer incidence rates

a)

Non-melanoma Skin Cancer

b)

Lungs & Bronchus

c)

Breast

d)

Colorectal

e)

Prostate

9.

#3 in Cancer incidence rates

a)

Non-melanoma Skin Cancer

b)

Lungs & Bronchus

c)

Breast

d)

Colorectal

e)

Prostate

10.

#4 in Cancer incidence rates

a)

Non-melanoma Skin Cancer

b)

Lungs & Bronchus

c)

Breast

d)

Colorectal

e)

Prostate

11.

#5 in Cancer incidence rates

a)

Non-melanoma Skin Cancer

b)

Lungs & Bronchus

c)

Breast

d)

Colorectal

e)

Prostate

12.

#1 in Cancer MORTALITY rates

a)

Pancreas

b)

Lungs & Bronchus

c)

Breast

d)

Colorectal

e)

Prostate

13.

#2 in Cancer MORTALITY rates

a)

Pancreas

b)

Lungs & Bronchus

c)

Breast

d)

Colorectal

e)

Prostate

14.

#3 in Cancer MORTALITY rates

a)

Pancreas

b)

Lungs & Bronchus

c)

Breast

d)

Colorectal

e)

Prostate

15.

#4 in Cancer MORTALITY rates

a)

Pancreas

b)

Lungs & Bronchus

c)

Breast

d)

Colorectal

e)

Prostate

16.

#5 in Cancer MORTALITY rates

a)

Pancreas

b)

Lungs & Bronchus

c)

Breast

d)

Colorectal

e)

Prostate

17.

Age Group & Cancer

highest % of cancer

a)

leukemia

b)

thyroid

c)

breast

d)

colorectal

e)

breast

18.

characteristic of dysplasia where cells are irregularly sized and shaped

(a)  

19.

which are the characteristics of NUCLEUS in dysplastic cells?

a)

irregularly shaped nucleus

b)

pre-cancerous cells

c)

increased size & density of nucleus

d)

reduced nucleic cells

20.

which are the characteristics of CYTOPLASM in dysplastic cells?

a)

reduced cytoplasm

b)

pre-cancerous cells

c)

immature cytoplasm & organelles

d)

lost cytoplasm integrity

21.

Dysplastic Cells are capable of normal mitosis

a)

True

b)

False

22.

which term denotes abnormal growth of tissue?

a)

tumor

b)

neoplasia

c)

neoplasm

d)

cancer

23.

which term denotes MALIGNANT growth

a)

tumor

b)

neoplasia

c)

neoplasm

d)

cancer

24.

process of abnormal and uncontrolled cell growth

a)

tumor

b)

neoplasia

c)

neoplasm

d)

cancer

25.

when naming cancer disease, CARCINOMA refers to which type of cancers:

a)

glands

b)

ducts

c)

covering of body surfaces

d)

connective tissue

e)

muscle

26.

when naming cancer disease, SARCOMA refers to which type of cancers:

a)

glands

b)

nerves

c)

fat

d)

connective tissue

e)

muscle

27.

malignant cancer in lymph nodes

a)

leukemia

b)

melanoma

c)

lymphoma

d)

hematoma

28.

cell's ability to divide and increase in number

(a)  

29.

which are true about BENIGN CANCERS?

a)

more differentiated tumors

b)

resemble tissue of origin

c)

lost ability to control proliferation

d)

high chances of recurrence

e)

common necrotic areas

30.

which are true about MALIGNANT CANCERS?

a)

more aggressive

b)

can metastasize

c)

undifferentiated

d)

high chances of recurrence

e)

common necrotic areas

31.

Benign tumor cells may still function normally

a)

True

b)

False

32.

Because benign tumors are not threatening, they can't cause atrophy

a)

False

b)

True

33.

used to describe cells that lack diffirentation

(a)  

34.

biggest predictor of cancer survival

indicator of course of treatment

a)

cancer stages

b)

carcinogenisis

c)

Tumor System

35.

factors to consider in identifying tumor

a)

size, depth, invasiveness, spread, and lymph nodes migration

b)

size, depth, invasiveness, spread, and stage of carcinogenesis

c)

size, organ type, migration of lymph nodes, depth, rate of spread

d)
Age, gender, family history, treatment history, lab results.
36.

In cancer stages system,

Stage 0 means

a)

not yet cancer but group of abnormal cells

b)

cancer is small

c)

tumor is larger than in stage I

d)

large & spread to tissues & lymphnodes

e)

spread distantly & metastasized

37.

In cancer stages system,

Stage 2 means

a)

not yet cancer but group of abnormal cells

b)

cancer is small

c)

tumor is larger than in stage I

d)

large & spread to tissues & lymphnodes

e)

spread distantly & metastasized

38.

In cancer stages system,

Stage 3 means

a)

not yet cancer but group of abnormal cells

b)

cancer is small

c)

tumor is larger than in stage I

d)

large & spread to tissues & lymphnodes

e)

spread distantly & metastasized

39.

process of normal cells transformation to cancer cells

(a)  

40.

In behavioral abnormalities of cancer,

what is described as loss of differentiation where they become embryonic stem cells and lose their function?

a)

Anaplasia

b)

Angiogenesis

c)

Autonomous

d)

Apoptosis Avoidance

41.

In behavioral abnormalities of cancer,

cancer cells are considered "bad neighbours" because of changes in CADHERINS or GAP junction proteins

a)

Anaplasia

b)

Angiogenesis

c)

Autonomous

d)

Apoptosis Avoidance

42.

measure used to identify level of differentiation & number of mitoses in tumours

a)

tumour grading

b)

TNM system

c)

Tumour Staging

43.

In behavioral abnormalities of cancer,

mutations can bypass programmed cell death pathway

prevent self-destruct signals from being created or sensed by cell

a)

Anaplasia

b)

Angiogenesis

c)

Autonomous

d)

Apoptosis Avoidance

44.

In behavioral abnormalities of cancer,

pertains to growth of new blood vessels

mutations can produce signals for new blood vessel growth

a)

Anaplasia

b)

Angiogenesis

c)

Autonomous

d)

Apoptosis Avoidance

45.

In behavioral abnormalities of cancer,

mutation deactivate "proof-reading" enzymes = accumulations of DNA mutation quickly

a)

Genetically Unstable

b)

Growth Factor Independence

c)

Loss of Contact Inhibition & Anchorage Independence

d)

Limitless Replication

46.

In behavioral abnormalities of cancer,

cancer cells do not need external growth signal

they produced their own

a)

Genetically Unstable

b)

Growth Factor Independence

c)

Loss of Contact Inhibition & Anchorage Independence

d)

Limitless Replication

47.

In behavioral abnormalities of cancer,

lost of density dependent inhibition of growth & division

a)

Genetically Unstable

b)

Growth Factor Independence

c)

Loss of Contact Inhibition & Anchorage Independence

d)

Limitless Replication

48.

In behavioral abnormalities of cancer,

telomeres shorten, leading to apoptosis (after 50 divisions)

a)

Genetically Unstable

b)

Growth Factor Independence

c)

Loss of Contact Inhibition & Anchorage Independence

d)

Limitless Replication

49.

required number of cells to activate angiogenesis

a)

100-300 cells

b)

400 cells

c)

50-250 cells

50.

which signals attract new blood vessels growth?

a)

FGF

b)

AMF

c)

VEGF

d)

p53

51.

Any virus that integrates into host genome has potential to ____

a)

carry oncogenes

b)
reduce viral replication
c)
promote cell growth
d)

cause cancer

52.

virus that cause

Kaposis Sarcoma

a)

HHV8 Infection

b)

Epstein Barr Virus

c)

Hepatitis B or C

d)

HPV

e)

Helicobacter Pylori

53.

virus that cause

Burkitt Lymphoma

a)

HHV8 Infection

b)

Epstein Barr Virus

c)

Hepatitis B or C

d)

HPV

e)

Helicobacter Pylori

54.

virus that cause

Liver Cancer

a)

HHV8 Infection

b)

Epstein Barr Virus

c)

Hepatitis B or C

d)

HPV

e)

Helicobacter Pylori

55.

virus that cause

Cervical Cancer

a)

HHV8 Infection

b)

Epstein Barr Virus

c)

Hepatitis B or C

d)

HPV

e)

Helicobacter Pylori

56.

virus that cause

infects 50% of world population

infects stomach leading to GRASTIC LYMPHOMA and Carcinomas

a)

HHV8 Infection

b)

Epstein Barr Virus

c)

Hepatitis B or C

d)

HPV

e)

Helicobacter Pylori

57.

how does bacteria cause cancer?

a)
Bacteria are beneficial and help in cancer treatment.
b)
Bacteria only affect the digestive system and do not cause cancer.
c)
Bacteria can cause cancer by inducing chronic inflammation and producing carcinogenic substances.
d)
Bacteria can enhance immune response and prevent cancer.
e)

Bacteria can generate free radicals, alter secretion of cytokines & growth factors

58.

benign tumours can become invasive tumours

a)

true

b)

false

59.

the first step towards metastasis

a)

local-spread

b)

cellular multiplication

c)

decreased adhesion

60.

cellular multiplication of cancer is dictated by the following:

a)

number of cells dividing

b)

duration of cell cycle

c)

rate at which tumour cells are dying

d)

size of local spread

61.

invasiveness of tumor depends on tumor growth

a)

increased motility

b)

cellular multiplication

c)

decreased adhesion

d)

mechanical pressure

e)

lytic enzymes

62.

pressure from expanding tumor forces sheets or fingers of tumor cells along paths of least resistance

a)

increased motility

b)

cellular multiplication

c)

decreased adhesion

d)

mechanical pressure

e)

lytic enzymes

63.

produce by malignant tumor cells to breakthrough membrane CONNECTIVE TISSUE to gain access to blood vessels

a)

increased motility

b)

cellular multiplication

c)

decreased adhesion

d)

mechanical pressure

e)

lytic enzymes

64.

cancer cells has defected or lack of cadherins

they slip between normal cells

a)

increased motility

b)

cellular multiplication

c)

decreased adhesion

d)

mechanical pressure

e)

lytic enzymes

65.

stimulated by variety of agents including

matrix components & autocrine (AMF)

to stimulate own movement

a)

increased motility

b)

cellular multiplication

c)

decreased adhesion

d)

mechanical pressure

e)

lytic enzymes

66.

self-secreted growth factors, causing cytoskeletal changes

(a)  

67.

Clinical Manifestation of Cancer:

severe weight loss due to loss of fat & muscle

common cause of death

may be due to increased energy expenditure

a)

cachexia

b)

paraneoplastic syndrome

c)

leukopenia

d)

anemia

e)

fatigue

68.

Clinical Manifestation of Cancer:

indirect effect of cancer

mutations cause productions of other products

a)

cachexia

b)

paraneoplastic syndrome

c)

leukopenia

d)

anemia

e)

fatigue

69.

Clinical Manifestation of Cancer:

decreased WBCs = increased infections

decreased platelet count = increased bleeding

direct tumor invasion

a)

cachexia

b)

paraneoplastic syndrome

c)

leukopenia

d)

anemia

e)

fatigue

70.

Clinical Manifestation of Cancer:

causes chronic bleeding

severe malnutrition

bone marrow impairment

due to LOW RBC and HEMOGLOBLIN

a)

cachexia

b)

paraneoplastic syndrome

c)

leukopenia

d)

anemia

e)

fatigue

71.

hospital related infections

(a)  

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