WorksheetsHEMA-11
Total questions: 93
Worksheet time: 47mins
Name
Class
Date
1.
Neutrophilc and monocytes are direct descendants of a common progenitor known as:
a)
CLP
b)
GMP
c)
MEP
d)
HSC
2.
Type II myeloblasts are characterized by:
a)
The presence of fewer than 20 primary granules per cell
b)
Basophilic cytoplasm with many secondary granules
c)
The absence of granules
d)
The presence of a folded nucleus
3.
What is the common progenitor that neutrophils share with monocytes?
a)
Granulocyte Monocyte Progenitor
b)
Granulocyte Colony Stimulating Factor
c)
Granulocyte Macrophage Progenitor
4.
half-life of neutrophils
a)
60 hours
b)
7 hours
c)
18 hours
d)
2 to 5 days
e)
3 days
5.
Monocytes remain in the circulation roughly:
a)
60 hours
b)
7 hours
c)
18 hours
d)
2 to 5 days
e)
3 days
6.
lifespan of basophils
a)
60 hours
b)
7 hours
c)
18 hours
d)
2 to 5 days
e)
3 days
7.
a dye that can bind with acid mucopolysaccharides in blood cells to form metachromatic complexes
a)
Oil Red O
b)
Toluidine Blue
c)
Sudan Black B
d)
Prussian Blue
8.
valuable in identifying basophils and mast cells, especially neoplastic forms in which the number of granules may be considerably reduced.
a)
Oil Red O
b)
Toluidine Blue
c)
Sudan Black B
d)
Prussian Blue
9.
half-life of eosinophils
a)
60 hours
b)
7 hours
c)
18 hours
d)
2 to 5 days
e)
3 days
10.
Survival time of eosinophils in human tissues
a)
7 days
b)
7 hours
c)
18 hours
d)
2 to 5 days
11.
unique form of neutrophil cell death
a)
Apoptosis
b)
Netosis
c)
Ketoacidosis
d)
Pyknosis
12.
What is the order of formation of neutrophil granules?
a)
Primary > Secondary > Tertiary > Secretory
b)
Secretory > Tertiary > Secondary > Primary
c)
Primary > Secretory > Tertiary > Secondary
d)
Secondary > Tertiary > Primary > Secretory
13.
What is the order of size (largest to smallest) of neutrophil granules?
a)
Primary > Secondary > Tertiary > Secretory
b)
Secretory > Tertiary > Secondary > Primary
c)
Primary > Secretory > Tertiary > Secondary
d)
Secondary > Tertiary > Primary > Secretory
14.
What is the order of degranulation of neutrophil granules?
a)
Primary > Secondary > Tertiary > Secretory
b)
Secretory > Tertiary > Secondary > Primary
c)
Primary > Secretory > Tertiary > Secondary
d)
Secondary > Tertiary > Primary > Secretory
15.
What is the only WBC that has alkaline phosphatase?
a)
Neutrophil
b)
Eosinophil
c)
Basophil
d)
Lymphocyte
e)
Monocyte
16.
●NUCLEUS: - Generally, deep purple, round, oval, or indented - Nucleoli may be visible
●CYTOPLASM: Generally: Sky-blue or “Robin egg” blue
a)
Neutrophil
b)
Eosinophil
c)
Basophil
d)
Lymphocyte
e)
Monocyte
17.
Least common WBC in normal peripheral blood
a)
Neutrophil
b)
Eosinophil
c)
Basophil
d)
Lymphocyte
e)
Monocyte
18.
●NUCLEUS: - Round, horse-shoe shaped or lobulated, usually with some degree of folding or convolutions -Chromatin: “lace-like” or “stringy” -Nuclear vacuoles may be present
●CYTOPLASM: -Abundant, blue-gray, containing fine, indistinct granules called azure dust (ground-glass appearance) - Small pseudopods or blebs may be observed -Cytoplasmic vacuoles may be present
a)
Neutrophil
b)
Eosinophil
c)
Basophil
d)
Lymphocyte
e)
Monocyte
19.
aid to be rich in muramidase.
a)
Neutrophil
b)
Eosinophil
c)
Basophil
d)
Lymphocyte
e)
Monocyte
20.
The nonspecific esterase enzymes alpha-naphthyl acetate and butyrate esterase are used clinically to recognize cells of monocytic origin. If the enzyme is of monocytic origin, it is inhibited by sodium fluoride; however, no sodium fluoride inhibition of enzyme occurs if the enzyme is of granulocytic or lymphocytic origin.”
a)
True
b)
False
21.
an enzyme that exhibits bactericidal, fungicidal, and viricidal properties
a)
CD11b/CD18
b)
Lysozyme
c)
Alkaline phosphatase
d)
Lactoferrin
e)
Myeloperoxidase
22.
flow cytometry and cytochemical staining = used to detect __ in myeloid precursors in acute leukemia
a)
CD11b/CD18
b)
Lysozyme
c)
Alkaline phosphatase
d)
Lactoferrin
e)
Myeloperoxidase
23.
aka muramidase; an antimicrobial enzyme
a)
CD11b/CD18
b)
Lysozyme
c)
Alkaline phosphatase
d)
Lactoferrin
e)
Myeloperoxidase
24.
contribute to tight stationary binding between neutrophil and endothelial cells
a)
CD11b/CD18
b)
Lysozyme
c)
Alkaline phosphatase
d)
Lactoferrin
e)
Myeloperoxidase
25.
Myeloperoxidase
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
26.
Acid β-glycerophosphatase
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
27.
Cathepsins
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
28.
Proteinase-3
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
29.
β2-microglobulin
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
30.
Elastase
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
31.
Neutrophil gelatinase-associated lipocalin
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
32.
Transcobalamin I
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
33.
Lactoferrin
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
34.
Acetyltransferase
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
35.
Collagenase
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
36.
Gelatinase
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
37.
Defensins
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
38.
Formed during the band and segmented neutrophil stages
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
39.
First to be released and fuse to plasma membrane
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
40.
CD11b/CD18
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
41.
Vesicle-associated membrane-2
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
42.
Complement receptor-1
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
43.
Alkaline phosphatase
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
44.
Complement 1q receptor
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
45.
Cytochrome b558
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
46.
CD10, CD13, CD14, CD16
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
47.
Lysozyme
a)
Primary (Azurophilic Granules)
b)
Secondary (Specific) Granules
c)
Tertiary (Gelatinase Granules
d)
Secretory Granules (Secretory Vesicles)
48.
Hematopoietic stem cells
a)
Stem Cell Pool
b)
Mitotic (Proliferation) Pool
c)
Storage (Maturation) Pool
49.
-includes: CMP (aka: CFU-GEMMs) [colony-forming units-granulocyte, erythrocyte, monocyte, and megakaryocyte]
a)
Stem Cell Pool
b)
Mitotic (Proliferation) Pool
c)
Storage (Maturation) Pool
50.
-includes:
GMP
✓ Myeloblast
✓ Promyelocyte
✓ Myelocyte
a)
Stem Cell Pool
b)
Mitotic (Proliferation) Pool
c)
Storage (Maturation) Pool
51.
-includes:
✓ Metamyelocyte
✓ Band
✓ Segmented neutrophils
a)
Stem Cell Pool
b)
Mitotic (Proliferation) Pool
c)
Storage (Maturation) Pool
52.
Found in the plasma
a)
Circulating Neutrophil Pool (CNP)
b)
Marginal Neutrophil Pool (MNP)
53.
Found adhering on the blood vessel wall
a)
Circulating Neutrophil Pool (CNP)
b)
Marginal Neutrophil Pool (MNP)
54.
●NUCLEUS: Dark purple, usually has two lobes ●CYTOPLASM: Filled with large, spherical granules of uniform size that stain bright orange
a)
Neutrophils
b)
Eosinophil
c)
Basophils
d)
Lymphocytes
e)
Monocytes
55.
●NUCLEUS: -Difficult to observe because of overlying granules -Generally unsegmented or bilobed ●CYTOPLASM: -Densely stained, dark violet to purple-black granules (variable in size and unevenly distributed)
a)
Neutrophils
b)
Eosinophil
c)
Basophils
d)
Lymphocytes
e)
Monocytes
56.
l production is increased in helminthic infections, and in vitro studies have shown that this leukocyte is capable of destroying tissue-invading helminths by secretion of MBP and eosinophil cationic protein as well as the production of reactive oxygen species.
a)
Neutrophils
b)
Eosinophil
c)
Basophils
d)
Lymphocytes
e)
Monocytes
57.
regulate mast cell function through the release of MBP [major basic protein] (causes mast cell degranulation and cytokine production), and they also produce nerve growth factor that promotes mast cell survival and activation
a)
Neutrophils
b)
Eosinophil
c)
Basophils
d)
Lymphocytes
e)
Monocytes
58.
Most specific cytokine for eosinophil lineage
a)
IL-1
b)
IL-2
c)
IL-3
d)
IL-4
e)
IL-5
59.
Which eosinophil granules is formed during the promyelocyte stage?
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
60.
Which eosinophil granules is contain CHARCOT LEYDEN crystals?
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
61.
Which eosinophil granules is formed throughout remaining maturation?
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
62.
Major basic protein (core)
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
63.
Eosinophil cationic protein (matrix)
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
64.
Lysozyme (eo)
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
65.
Catalase
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
66.
β-Glucuronidase (core and matrix)
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
67.
Cathepsin D (core and matrix)
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
68.
nterleukins 2, 4, and 5 (core)
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
69.
Interleukin-6 (matrix)
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
70.
Granulocyte-macrophage colony-stimulating factor (core)
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
71.
Acid phosphatase
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
72.
Catalase
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
73.
Elastase
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
74.
Cytochrome b558
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
75.
Arylsulfatase B
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
76.
Eosinophil cationic protein
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
77.
Cyclooxygenase
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
78.
5-Lipoxygenase
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
79.
15-Lipoxygenase
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
80.
Leukotriene C4 synthase
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
81.
Eosinophil peroxidase
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
82.
Esterase
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
83.
Carry proteins from secondary granules to be released into the extracellular medium
a)
Primary granules
b)
Secondary Granules
c)
Small lysosomal granules
d)
Lipid bodies
e)
Storage or secretory vesicles
84.
granules move to the plasma membrane, fuse with the plasma membrane, and empty their contents into the extracellular space
a)
Classical exocytosis
b)
Compound exocytosis
c)
Piecemeal degranulation
d)
Cytolysis
85.
secretory vesicles remove specific proteins from the secondary granules. These vesicles then travel to the plasma membrane and fuse to empty the specific proteins into the extracellular space.
a)
Classical exocytosis
b)
Compound exocytosis
c)
Piecemeal degranulation
d)
Cytolysis
86.
happens when extracellular intact granules are deposited during cell lysis
a)
Classical exocytosis
b)
Compound exocytosis
c)
Piecemeal degranulation
d)
Cytolysis
87.
granules fuse together within the eosinophil prior to fusing with the plasma membrane
a)
Classical exocytosis
b)
Compound exocytosis
c)
Piecemeal degranulation
d)
Cytolysis
88.
aka Turk's Irritation Cell or Plasmacytoid lymphocyte
a)
Type I
b)
Type II
c)
Type III
89.
aka Infectious Mononucleosis Cell
a)
Type I
b)
Type II
c)
Type III
90.
Seen in German measles
a)
Type I
b)
Type II
c)
Type III
91.
Seen in infectious mononucleosis
a)
Type I
b)
Type II
c)
Type III
92.
characterized by flared skirt or fried egg appearance
a)
Type I
b)
Type II
c)
Type III
93.
Nucleus has finely reticulated nuclear chromatin pattern
a)
Type I
b)
Type II
c)
Type III
100 %
