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WorksheetsPharmacology Quiz
Total questions: 30
Worksheet time: 15mins
The principles and applications of bioassay are important in pharmacology because:
They help determine drug potency and efficacy using biological systems.
They are only used for cosmetic products.
They are not relevant to drug development.
They are used to measure the color change in chemical reactions.
Who established the endocrine function of testosterone and in which year?
Berthold, 1849
Darwin, 1859
Watson, 1953
Mendel, 1865
What is the starting material for testosterone synthesis?
Glucose
Cholesterol
Amino acids
Fatty acids
Which effect is testosterone responsible for during puberty in boys?
Decrease in bone thickness
Pubertal spurt of growth
Reduction in muscle mass
Loss of appetite
How does testosterone promote muscle building?
By decreasing nitrogen accretion
By increasing water-body weight and accretion of minerals
By inhibiting protein synthesis
By reducing protoplasm formation
Testosterone accelerates erythropoiesis by which mechanism?
Decreasing erythropoietin production
Increasing erythropoietin production and direct action on haeme synthesis
Inhibiting red blood cell formation
Reducing iron absorption
Which of the following is a method of administering testosterone?
Subcutaneous implantation
Oral inhalation
Topical eye drops
Intrathecal injection
What is the main reason testosterone is usually injected rather than given orally?
It is rapidly metabolised in the liver when given orally
It causes severe stomach ulcers if taken orally
It is tasteless and odorless
It is more expensive to inject
Which of the following conditions is a contraindication for the use of androgens?
Carcinoma of prostate
Osteoporosis
Hypogonadism
Muscle wasting in AIDS
Testosterone therapy has been shown to improve which of the following in AIDS patients with low testosterone levels?
Weakness and muscle wasting
Liver function
Renal insufficiency
Cholestatic jaundice
Why has the clinical use of anabolic steroids like nandrolone in debilitating disease been disappointing?
The expected increase in protein synthesis and muscle development has not been achieved
They cause severe allergic reactions
They are too expensive
They are only effective in women
Why is raloxifene considered useful in postmenopausal women?
It prevents and treats osteoporosis and reduces the incidence of estrogen receptor-positive breast cancer
It increases the risk of breast cancer
It causes severe menopausal symptoms
It is only used for treating infertility
During which phase of the menstrual cycle is progesterone secreted by the corpus luteum?
Later half of the menstrual cycle
First half of the menstrual cycle
During ovulation only
During menstruation
Which of the following is a newer compound among 19-nortestosterone derivatives?
Norethindrone
Lynestrenol
Desogestrel
Allylestrenol
Which progesterone derivative is considered a newer compound?
Medroxyprogesterone acetate
Megestrol acetate
Nomegestrol acetate
Dydrogesterone
Which of the following is NOT an older compound of 19-nortestosterone derivatives?
Norethindrone
Lynestrenol
Desogestrel
Allylestrenol
What is the effect of progesterone on the vaginal mucosa?
Decreases leukocyte infiltration
Induces pregnancy-like changes and increases leukocyte infiltration of cornified epithelium
Causes epithelial proliferation
Reduces mucosal thickness
What is the consequence of lack of progestational support in the uterus?
Increased epithelial proliferation
Mucosal shedding during menstruation
Enhanced uterine motility
Suppressed menstruation
Which hormone in relatively higher doses stimulates respiration, as occurs during pregnancy?
Estrogen
Testosterone
Progestins
Cortisol
Prolonged use of oral contraceptives can impair glucose tolerance in some women due to which component?
Estrogenic component
Progestational component
Androgenic component
Thyroid component
What happens when the hormone progesterone receptor (PR) binds to its hormone?
It undergoes dimerization and regulates transcription through coactivators
It is destroyed by lysosomes
It leaves the nucleus
It inhibits gene expression
How are the metabolites of progesterone excreted from the body?
In the urine after conjugation with glucuronic acid
Directly through sweat glands
Exhaled through the lungs
Stored in bone tissue
What is the effect of mifepristone when given during the follicular phase?
It attenuates the midcycle Gn surge and slows follicular development
It increases estrogen production
It stimulates ovulation
It enhances androgen secretion
Which of the following is a clinical use of oxytocin?
To induce or augment labour when the uterine muscle is not functioning adequately.
To treat hypertension.
To increase appetite.
To reduce fever.
How is oxytocin most often administered for pharmacological purposes?
By intravenous infusion.
By oral tablets.
By subcutaneous injection.
By inhalation.
How can ergometrine be administered?
Orally, intramuscularly, or intravenously
Only intravenously
Only orally
Only subcutaneously
Which unwanted effect is commonly associated with ergometrine?
Vomiting
Diarrhea
Skin rash
Insomnia
During which phase of the menstrual cycle is the prostaglandin-synthesising capacity of the endometrium and myometrium particularly substantial?
Second, proliferative phase
First, follicular phase
Third, luteal phase
Menstrual phase
Bio-standardization involves which of the following processes?
Measuring the color of a substance
Comparing and adjusting the strength of an unknown sample with a standard under controlled conditions
Testing the taste of a drug
Calculating the price of a drug
If a new drug's dose response curve (DRC) is not identical to the standard, what is the likely consequence?
The comparison of potency may not be accurate.
The drug will automatically be approved.
The drug will have no side effects.
The drug will be more expensive.
