WorksheetsCC-P8
Total questions: 133
Worksheet time: 1hrs 7mins
Name
Class
Date
1.
What is the Gel electrophoresis pattern of Chylomicrons ?
a)
Origin
b)
Increased in Beta region
c)
Increased in Beta, alpha-2 / pre-beta region
d)
Increased in between alpha-2 / pre-beta region
2.
What is the Gel electrophoresis pattern of LDL (type 2A)?
a)
Origin
b)
Increased in Beta region
c)
Increased in Beta, alpha-2 / pre-beta region
d)
Increased in between alpha-2 / pre-beta region
3.
What is the Gel electrophoresis pattern of Low density lipoprotein (LDL) and Very low density lipoprotein (VLDL) (type 2B)?
a)
Origin
b)
Increased in Beta region
c)
Increased in Beta, alpha-2 / pre-beta region
d)
Increased in between alpha-2 / pre-beta region
4.
What is the Gel electrophoresis pattern of Intermediate density lipoprotein (IDL)(type 3)?
a)
Origin
b)
Increased in Beta region
c)
Increased in Beta, alpha-2 / pre-beta region
d)
Increased in between alpha-2 / pre-beta region
5.
What is the Gel electrophoresis pattern of Very Low Density Lipoprotein (VLDL) (type 4)?
a)
Origin
b)
Increased in Beta region
c)
Increased in Beta, alpha-2 / pre-beta region
d)
Increased in between alpha-2 / pre-beta region
6.
What is the Gel electrophoresis pattern of Very Low Density Lipoprotein (VLDL) AND chylomicrons (type 5)?
a)
Origin
b)
Increased in Beta region
c)
Increased in Beta, alpha-2 / pre-beta region
d)
Increased in between alpha-2 / pre-beta region
7.
Refrigerator test: POSITIVE, Clear plasma
a)
Type 1 - Elevated chylomicrons
b)
Type 2a- Elevated LDL
c)
Type 2b - Elevated LDL and VLDL
d)
Type 3 - Elevated IDL
e)
Type 4 - Elevated VLDL
8.
Refrigerator test: POSITIVE, Cloudy plasma
a)
Type 1 - Elevated chylomicrons
b)
Type 2a- Elevated LDL
c)
Type 3 - Elevated IDL
d)
Type 4 - Elevated VLDL
e)
Type 5 - Elevated VLDL and Chylomicron
9.
Elevated: Chylomicrons (Type 1)
Refrigerator test result:
a)
Positive, Clear plasma
b)
Negative, Clear plasma
c)
Negative, Cloudy plasma
d)
Negative, Occasional cloudy plasma
e)
Positive, Cloudy plasma
10.
What is the Refrigerator test result: of Low density lipoprotein (LDL) (type 2A)?
a)
Positive, Clear plasma
b)
Negative, Clear plasma
c)
Negative, Cloudy plasma
d)
Negative, Occasional cloudy plasma
e)
Positive, Cloudy plasma
11.
What is the Refrigerator test result: of Low density lipoprotein (LDL)?
a)
Positive, Clear plasma
b)
Negative, Clear plasma
c)
Negative, Cloudy plasma
d)
Negative, Occasional cloudy plasma
e)
Positive, Cloudy plasma
12.
What is the Refrigerator test result: of Low density lipoprotein (LDL) and Very Low Density Lipoprotein (VLDL) (type 2B)?
a)
Positive, Clear plasma
b)
Negative, Clear plasma
c)
Negative, Cloudy plasma
d)
Negative, Occasional cloudy plasma
e)
Positive, Cloudy plasma
13.
What is the Refrigerator test result: of Low density lipoprotein (LDL) and Very Low Density Lipoprotein (VLDL)?
a)
Positive, Clear plasma
b)
Negative, Clear plasma
c)
Negative, Cloudy plasma
d)
Negative, Occasional cloudy plasma
e)
Positive, Cloudy plasma
14.
What is the Refrigerator test result: of Intermediate Density Lipoprotein (IDL) (type 3)?
a)
Positive, Clear plasma
b)
Negative, Clear plasma
c)
Negative, Cloudy plasma
d)
Negative, Occasional cloudy plasma
e)
Positive, Cloudy plasma
15.
What is the Refrigerator test result: of Intermediate Density Lipoprotein (IDL)?
a)
Positive, Clear plasma
b)
Negative, Clear plasma
c)
Negative, Cloudy plasma
d)
Negative, Occasional cloudy plasma
e)
Positive, Cloudy plasma
16.
What is the Refrigerator test result: of Very Low density Lipoprotein (VLDL) (type 4)?
a)
Positive, Clear plasma
b)
Negative, Clear plasma
c)
Negative, Cloudy plasma
d)
Negative, Occasional cloudy plasma
e)
Positive, Cloudy plasma
17.
What is the Refrigerator test result: of Very Low Density Lipoprotein (VLDL) AND chylomicrons (type 5)?
a)
Positive, Clear plasma
b)
Negative, Clear plasma
c)
Negative, Cloudy plasma
d)
Negative, Occasional cloudy plasma
e)
Positive, Cloudy plasma
18.
What is the Refrigerator test result: of Very Low Density Lipoprotein (VLDL) AND chylomicrons?
a)
Positive, Clear plasma
b)
Negative, Clear plasma
c)
Negative, Cloudy plasma
d)
Negative, Occasional cloudy plasma
e)
Positive, Cloudy plasma
19.
All of the following are associated with coronary disease EXCEPT;
a)
Type 1 - Elevated chylomicrons
b)
Type 2a- Elevated Low Density Lipoprotein (LDL)
c)
Type 3 - Elevated Intermediate Density Lipoprotein (IDL)
d)
Type 4 - Elevated Very Low Density Lipoprotein (VLDL)
e)
Type 5 - Elevated VLDL and Chylomicron
20.
Familial chylomicronemia falls under...
a)
Type 1 - Elevated chylomicrons
b)
Type 2a- Elevated Low Density Lipoprotein (LDL)
c)
Type 3 - Elevated Intermediate Density Lipoprotein (IDL)
d)
Type 4 - Elevated Very Low Density Lipoprotein (VLDL)
e)
Type 5 - Elevated VLDL and Chylomicron
21.
Primary hypertriglyceridemia falls under...
a)
Type 1 - Elevated chylomicrons
b)
Type 2a- Elevated Low Density Lipoprotein (LDL)
c)
Type 3 - Elevated Intermediate Density Lipoprotein (IDL)
d)
Type 4 - Elevated Very Low Density Lipoprotein (VLDL)
e)
Type 5 - Elevated VLDL and Chylomicron
22.
Mixed hyperlipidemia falls under...
a)
Type 1 - Elevated chylomicrons
b)
Type 2a- Elevated Low Density Lipoprotein (LDL)
c)
Type 3 - Elevated Intermediate Density Lipoprotein (IDL)
d)
Type 4 - Elevated Very Low Density Lipoprotein (VLDL)
e)
Type 5 - Elevated VLDL and Chylomicron
23.
Familial combined hyperlipoproteinemia falls under..
a)
Type 1 - Elevated chylomicrons
b)
Type 2a - Elevated Low Density Lipoprotein (LDL)
c)
Type 2b - Elevated Low Density Lipoprotein (LDL) and Very Low Density Lipoprotein (VLDL)
d)
Type 3 - Elevated Intermediate Density Lipoprotein (IDL)
e)
Type 4 - Elevated Very Low Density Lipoprotein (VLDL)
24.
Familial hypercholesterolemia falls under..
a)
Type 1 - Elevated chylomicrons
b)
Type 2a- Elevated Low Density Lipoprotein (LDL)
c)
Type 3 - Elevated Intermediate Density Lipoprotein (IDL)
d)
Type 4 - Elevated Very Low Density Lipoprotein (VLDL)
e)
Type 5 - Elevated VLDL and Chylomicron
25.
All of the following are associated with coronary disease EXCEPT;
a)
Type 1 - Elevated chylomicrons
b)
Type 2a- Elevated LDL
c)
Type 2b - Elevated LDL and VLDL
d)
Type 3 - Elevated IDL
e)
Type 4 - Elevated VLDL
26.
Associated with Xanthelasma and hypercholesterolemia (select 2)
a)
Type 1 - Elevated chylomicrons
b)
Type 2a- Elevated LDL
c)
Type 2b - Elevated LDL and VLDL
d)
Type 3 - Elevated IDL
e)
Type 4 - Elevated VLDL
27.
Associated with pancreatitis (select 2)
a)
Type 1 - Elevated chylomicrons
b)
Type 2a- Elevated LDL
c)
Type 3 - Elevated IDL
d)
Type 4 - Elevated VLDL
e)
Type 5 - Elevated VLDL and Chylomicron
28.
Associated with eruptive xanthoma (select 3)
a)
Type 1 - Elevated chylomicrons
b)
Type 2a- Elevated LDL
c)
Type 3 - Elevated IDL
d)
Type 4 - Elevated VLDL
e)
Type 5 - Elevated VLDL and Chylomicron
29.
In Familial hypercholesterolemia, there is a DEFECTIVE.. receptor.
a)
Chylomicrons
b)
Very low density lipoprotein (VLDL)
c)
High density lipoprotein (HDL)
d)
Low density lipoprotein (LDL)
30.
If this is increased, total cholesterol is increased as well leading to xanthelasma, tendinous xanthoma and increased risk for coronary heart disease.
a)
Chylomicrons
b)
Very low density lipoprotein (VLDL)
c)
High density lipoprotein (HDL)
d)
Low density lipoprotein (LDL)
31.
If these are increased, triglycerides increase as well leading to eruptive xanthoma and an increased risk for acute pancreatitis.
a)
Chylomicrons
b)
Very low density lipoprotein (VLDL)
c)
High density lipoprotein (HDL)
d)
Low density lipoprotein (LDL)
32.
Pathogenomonic feature: a broad abnormal band between (SELECT 2)
a)
Chylomicrons
b)
Very low density lipoprotein
c)
High density lipoprotein
d)
Low density lipoprotein
33.
Absent in Abetalipoproteinemia (SELECT 3)
a)
Chylomicrons
b)
Very low density lipoprotein
c)
High density lipoprotein
d)
Low density lipoprotein
34.
All of the following are absent in Abetalipoproteinemia EXCEPT;
a)
Chylomicrons
b)
Very low density lipoprotein
c)
High density lipoprotein
d)
Low density lipoprotein
35.
In Tangier's disease, this is absent due to mutation in the ABCA1
a)
Chylomicrons
b)
Very low density lipoprotein
c)
High density lipoprotein
d)
Low density lipoprotein
36.
Lipoprotein Lipase (LPL) deficiency is associated with the inability to clear.. particles
a)
Chylomicrons
b)
Very low density lipoprotein
c)
High density lipoprotein
d)
Low density lipoprotein
37.
LOW in Abetalipoproteinemia (SELECT 2)
a)
Cholesterol
b)
Very low density lipoprotein
c)
High density lipoprotein
d)
Low density lipoprotein
e)
Triglycerides
38.
TC and LDL-C are 2 to 3x above the normal
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
39.
defective LDL receptor
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
40.
defective LDL receptor
TC and LDL C are 2 to 3x above normal.
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
41.
Pathogenomonic feature: a broad abnormal band between VLDL and LDL
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
42.
Pathogenomonic feature: a broad abnormal band between VLDL and LDL
b. it is involved in the accumulation of plasma VLDL rich in cholesterol and chylomicrons remnants.
c. reference value VLDL-c/TAG ratio: 0.2
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
43.
Involved in accumulation of plasma VLDL rich in cholesterol and chylomicrons remnants
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
44.
Defective Apo-B synthesis
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
45.
Defective Apo-B synthesis / Bassen-Kornzweig syndrome
Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL), and Chylomicrons are ABSENT
While Cholesterol and Triglycerides (TAG) are LOW
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
46.
; autosomal recessive disorder involving mutations in the MTTP gene with absolute nonexistent levels of apoB48 and apoB100, absence of ApoB-containing lipoproteins; total cholesterol very low, triglyceride level nearly undetectable
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
47.
Bassen-Kornzweig syndrome
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
48.
Cholesterol and Triglycerides (TAG) are LOW in which of the following conditions?
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
49.
VLDL, LDL, and chylomicrons are ABSENT
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
50.
Characterized by Apo-B DEFICIENT
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
51.
autosomal dominant disorder caused by nonsense or missense mutations in the apoB gene; low total cholesterol and triglyceride levels
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
52.
Characterized by Apo-B DEFICIENT
a. Low Density Lipoprotein (LDL-CHOLE) and Total cholesterol are LOW
b. Very Low Density Lipoprotein-Chole (VLDL-CHOLE) and Total Triglycerides are NORMAL or LOW
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
53.
LDL-chole and total cholesterol are LOW levels
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
54.
VLDL-chole and total TAG are low or normal
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
55.
It is associated with SEVERELY ELEVATED TAG levels and LOW HIGH DENSITY LIPOPROTEIN (HDL) level
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
56.
common autosomal dominant disorder characterized by low HDL-C levels (<30 mg/dL in men or <40 mg/dL in women)
a)
Familial hypercholesterolemia
b)
Familial dysbetalipoproteinemia
c)
Abeta lipoproteinemia
d)
Hypobetalipoproteinemia
e)
Hypoalphalipoproteinemia
57.
abetalipoproteinemia
a)
autosomal recessive
b)
autosomal dominant
c)
x-linked
58.
tangier disease
a)
autosomal recessive
b)
autosomal dominant
c)
x-linked
59.
hypobetalipoproteinemia
a)
autosomal recessive
b)
autosomal dominant
c)
x-linked
60.
hypoalphalipoproteinemia
a)
autosomal recessive
b)
autosomal dominant
c)
x-linked
61.
2 to 19 years old moderate risk
a)
>= 170 mg/dL
b)
>= 200 mg/dL
c)
>= 220 mg/dL
d)
>= 240 mg/dL
62.
2 to 19 years old high risk for CHD
a)
>= 185 mg/dL
b)
>= 200 mg/dL
c)
>= 220 mg/dL
d)
>= 240 mg/dL
63.
Absent HDL due to mutation in the ABCA1
a)
Tangier's disease
b)
Lecithin cholesterol Acyl transferase (LCAT) deficiency
c)
Tay-Sach's disease
d)
Lipoprotein Lipase (LPL) deficiency
64.
rare autosomal recessive disorder characterized by undetectable HDL due to a mutation in the ABCA1 gene
a)
Tangier's disease
b)
Lecithin cholesterol Acyl transferase (LCAT) deficiency
c)
Tay-Sach's disease
d)
Lipoprotein Lipase (LPL) deficiency
65.
Associated with fish eye disease
a)
Tangier's disease
b)
Lecithin cholesterol Acyl transferase (LCAT) deficiency
c)
Tay-Sach's disease
d)
Lipoprotein Lipase (LPL) deficiency
66.
Deficiency of the enzyme hexosaminidase A >> Spingolipid accumulation
a)
Tangier's disease
b)
Lecithin cholesterol Acyl transferase (LCAT) deficiency
c)
Tay-Sach's disease
d)
Lipoprotein Lipase (LPL) deficiency
67.
inability to clear chylomicron particles
a)
Tangier's disease
b)
Lecithin cholesterol Acyl transferase (LCAT) deficiency
c)
Tay-Sach's disease
d)
Lipoprotein Lipase (LPL) deficiency
68.
VLDL-chole and total TAG are .. in Hypobetalipoproteinemia
a)
Absent
b)
Low or normal
c)
Low only
69.
LDL-chole and total cholesterol are .. in Hypobetalipoproteinemia
a)
Absent
b)
Low or normal
c)
Low only
70.
Chole and TAG are .. in Abetalipoproteinemia
a)
Absent
b)
Low or normal
c)
Low only
71.
VLDL, LDL, and chylomicrons are .. in Abetalipoproteinemia
a)
Absent
b)
Low or normal
c)
Low only
d)
Elevated
72.
Levels of TAG in hypoalphalipoproteinemia
a)
Absent
b)
Low or normal
c)
Low only
d)
Elevated
73.
Levels of HDL in hypoalphalipoproteinemia
a)
Absent
b)
Low or normal
c)
Low only
d)
Elevated
74.
Familial dysbetalipoproteinemia reference value VLDL-C/TAG ratio
a)
0.1
b)
0.2
c)
0.3
d)
0.4
75.
It is the element that distinguishes proteins from carbohydrates and lipid compounds
a)
Hydrogen
b)
Oxygen
c)
Nitrogen
d)
Carbon dioxide
76.
Proteins EXCEPT immunoglobulins are synthesized in...
a)
Kidneys
b)
Pancreas
c)
Liver
d)
Gallbladder
77.
Linear sequence of the amino acid. It determines the identity of protein
a)
Primary protein structure
b)
Secondary protein structure
c)
Tertiary protein structure
d)
Quaternary protein structure
78.
It represents the number and types of amino acid
a)
Primary protein structure
b)
Secondary protein structure
c)
Tertiary protein structure
d)
Quaternary protein structure
79.
Involved in winding of the polypeptide chain
a)
Primary protein structure
b)
Secondary protein structure
c)
Tertiary protein structure
d)
Quaternary protein structure
80.
Structures include alpha helix, Beta pleasted sheetm and turns; most serum proteins in this structures are helical as well.
a)
Primary protein structure
b)
Secondary protein structure
c)
Tertiary protein structure
d)
Quaternary protein structure
81.
3-dimensional configuration/overall shape/overall conformation. Physical and chemical properties; conformation is known as FOLD
a)
Primary protein structure
b)
Secondary protein structure
c)
Tertiary protein structure
d)
Quaternary protein structure
82.
2 or more polypeptide chains; examples include Hb, LDH, and CPK
a)
Primary protein structure
b)
Secondary protein structure
c)
Tertiary protein structure
d)
Quaternary protein structure
83.
Albumin doesn't have this structure
a)
Primary protein structure
b)
Secondary protein structure
c)
Tertiary protein structure
d)
Quaternary protein structure
84.
Also known as Transthyretin
a)
Pre-albumin
b)
Albumin
c)
Analbuminemia
d)
Bisalbuminemia
85.
Migrates before albumin in the serum protein electrophoresis
a)
Pre-albumin
b)
Albumin
c)
Transferrin
d)
Hemopexin
86.
Transport protein for thyroid hormones; transports vitamin A by forming a complex with retinol-binding protein
a)
Pre-albumin
b)
Albumin
c)
Transferrin
d)
Hemopexin
87.
Decreased in hepatic damage, acute-phase inflammatory response, and tissue necrosis
a)
Pre-albumin
b)
Albumin
c)
Transferrin
d)
Hemopexin
88.
sensitive marker of poor nutritional status
a)
Pre-albumin
b)
Albumin
c)
Transferrin
d)
Hemopexin
89.
Increased in patients receiving steroids, in alcoholism, and in chronic renal failure
a)
Pre-albumin
b)
Albumin
c)
Transferrin
d)
Hemopexin
90.
Provide nearly 80% of colloid osmotic pressure (COP) of intravascular fluids, buffers pH, and binds to various substances in blood like hormones, drugs, electrolytes, and unconjugated bilirubin.
a)
Pre-albumin
b)
Albumin
c)
Transferrin
d)
Hemopexin
91.
decreased in liver disease, malnutrition, malabsorption, kidney loss, and hemodilution
a)
Pre-albumin
b)
Albumin
c)
Transferrin
d)
Hemopexin
92.
Vitamin A and thyroxine
a)
Pre-albumin
b)
Albumin
c)
Analbuminemia
d)
Bisalbuminemia
93.
Malnutrition - indicator of nutritional status
a)
Pre-albumin
b)
Albumin
c)
Analbuminemia
d)
Bisalbuminemia
94.
CSF landmark
a)
Pre-albumin
b)
Albumin
c)
Analbuminemia
d)
Bisalbuminemia
95.
Highest concentration; makes up 1/2 of plasma proteins.
a)
Pre-albumin
b)
Albumin
c)
Analbuminemia
d)
Bisalbuminemia
96.
Greatest concentration in serum
a)
Pre-albumin
b)
Albumin
c)
Analbuminemia
d)
Bisalbuminemia
97.
It serves as a circulating reservoir of amino acids
a)
Pre-albumin
b)
Albumin
c)
Analbuminemia
d)
Bisalbuminemia
98.
Considered as a general transport protein
a)
Pre-albumin
b)
Albumin
c)
Analbuminemia
d)
Bisalbuminemia
99.
Responsible for maintaining osmotic or oncotic pressure
a)
Pre-albumin
b)
Albumin
c)
Analbuminemia
d)
Bisalbuminemia
100.
Considered as a pH buffer
a)
Pre-albumin
b)
Albumin
c)
Analbuminemia
d)
Bisalbuminemia
101.
Second indicator of nutritional status as well
a)
Pre-albumin
b)
Albumin
c)
Analbuminemia
d)
Bisalbuminemia
102.
marker of cystic fibrosis
a)
Pre-albumin
b)
Albumin
c)
Analbuminemia
d)
Bisalbuminemia
103.
Hereditary absence of albumin
a)
Pre-albumin
b)
Albumin
c)
Analbuminemia
d)
Bisalbuminemia
104.
Characterized by two albumin bands
a)
Pre-albumin
b)
Albumin
c)
Analbuminemia
d)
Bisalbuminemia
105.
Negative APR - decreased value in acute inflammation..
i. ___
ii. ___
iii. transferrin
a)
Pre-albumin
b)
Albumin
c)
Analbuminemia
d)
Bisalbuminemia
106.
Most widely used methods for determining albumin
a)
Dye binding
b)
Bromcresol green
c)
Bromcresol purple
d)
Methyl orange
107.
Most commonly used dye for albumin
a)
Dye binding
b)
Bromcresol green
c)
Bromcresol purple
d)
Methyl orange
108.
Dye associated with falsely low result when exposed to penicillin
a)
Dye binding
b)
Bromcresol green
c)
Bromcresol purple
d)
Methyl orange
109.
Most specific dye for albumin; PREFERRED
a)
Dye binding
b)
Bromcresol green
c)
Bromcresol purple
d)
Methyl orange
110.
Nonspecific dye for albumin
a)
Dye binding
b)
Bromcresol green
c)
Bromcresol purple
d)
Methyl orange
111.
Dye binding: ___ solution + (-) albumin -> (+) albumin + ____ dye = dye absorbance
a)
Acid
b)
Alkaline
c)
Ionic
d)
Anionic
112.
Purpose: Hydrolysis of cholesterol esters
a)
Saponification
b)
Extraction
c)
Purification
d)
Colorimetry
113.
Purpose: Removal of protein interference
a)
Saponification
b)
Extraction
c)
Purification
d)
Colorimetry
114.
Purpose: Formation of colored compound
a)
Saponification
b)
Extraction
c)
Purification
d)
Colorimetry
115.
What is the reagent in saponification?
a)
alcoholic KOH
b)
Bloor's reagent (ethanol ether)
c)
Digitonin
d)
H2SO4, Acetic anhydride (Lieberman Burchard), or Fe3+ (Salkowski)
116.
What is the reagent in extraction?
a)
alcoholic KOH
b)
Bloor's reagent (ethanol ether)
c)
Digitonin
d)
H2SO4, Acetic anhydride (Lieberman Burchard), or Fe3+ (Salkowski)
117.
What is the reagent in purification?
a)
alcoholic KOH
b)
Bloor's reagent (ethanol ether)
c)
Digitonin
d)
H2SO4, Acetic anhydride (Lieberman Burchard), or Fe3+ (Salkowski)
118.
What is the reagent in colorimetry?
a)
alcoholic KOH
b)
Bloor's reagent (ethanol ether)
c)
Digitonin
d)
H2SO4, Acetic anhydride (Lieberman Burchard), or Fe3+ (Salkowski)
119.
CDC reference method which involves saponification with alcoholic KOH, extraction with n-hexane or petroleum ether, and colorimetry using the Lieberman Burchard reaction
a)
Liebermann-Burchatdt
b)
Salkowski
c)
Modified Abell-Kendall
120.
Purpose: Precipitation of free cholesterol
a)
Saponification
b)
Extraction
c)
Purification
d)
Colorimetry
121.
Hyperlipoproteinemia types 2a, 2b, 3, nephrotic syndrome, poorly controlled diabetes mellitus, hypothyroidism
a)
Hypercholestrolemia
b)
Hypocholesterolemia
122.
Severe liver disease, malnutrition, malabsorption, hyperthyroidism
a)
Hypercholestrolemia
b)
Hypocholesterolemia
123.
Hyperlipoproteinemia types 1, 2b, 3, 4, 5, pancreatitis, alcoholism, obesity, hypothyroidism, nephrotic syndrome, and lipid storage diseases
a)
Hypertrilgyceridemia
b)
Hypotriglyceridemia
124.
Malnutrition, malabsorption syndrome, hyperthyroidism
a)
Hypertrilgyceridemia
b)
Hypotriglyceridemia
125.
involves adjusting the sample to a density of 1.063 (potassium bromide) followed by centrifugation at high speed for 24 h
a)
Ultracentrifugation
b)
Homogenous (direct assay)
c)
Precipitation
d)
ultracentrifugation, heparin-Mn2+ precipitation, and Abell-Kendall assay 4
126.
done on apoB-containing lipoproteins by polyanion-divalent cations (e.g. heparin sulfateMn2+, dextran sulfate-Mg2+, sodium phosphotungstate-Mg2+, heparin-Ca2+) followed by cholesterol determination on the supernatant using the POD-coupled method
a)
Ultracentrifugation
b)
Homogenous (direct assay)
c)
Precipitation
d)
ultracentrifugation, heparin-Mn2+ precipitation, and Abell-Kendall assay 4
127.
CDC reference method
a)
Ultracentrifugation
b)
Homogenous (direct assay)
c)
Precipitation
d)
ultracentrifugation, heparin-Mn2+ precipitation, and Abell-Kendall assay 4
128.
involves ultracentrifugation (to separate VLDL and chylomicrons) and precipitation (to remove HDL)
a)
B quantification
b)
Homogenous (direct assay)
129.
uses detergents or other chemicals to block or solubilize non-LDL lipoprotein classes to allow for quantitation of LDL
a)
B quantification
b)
Homogenous (direct assay)
130.
VLDL = TG/adjustable facto
a)
Friedewald
b)
De Long
c)
Martin-Hopkins
131.
unreliable when TG level is high (noticeable error at TG >200 mg/dL; error unacceptably high at TG >400 mg/dL)
a)
Friedewald
b)
De Long
c)
Martin-Hopkins
132.
In standing plasma test, __ mL plasma in 10 x 75 mm test tube is allowed to stand at 4 degree Celsius undisturbed overnight
a)
1 mL
b)
2 mL
c)
3 mL
d)
4 mL
133.
immunologic assay involving blockage of non-HDL lipoproteins using an antibody to apo B-100
a)
Ultracentrifugation
b)
Homogenous (direct assay)
c)
Precipitation
d)
ultracentrifugation, heparin-Mn2+ precipitation, and Abell-Kendall assay 4
100 %
