WorksheetsNB3453 Tutorial 12/11/25
Total questions: 15
Worksheet time: 5mins
The Baltimore classification differentiates viruses primarily by
Virion size and symmetry.
Genome type and replication strategy.
Host species and transmission route.
Pathogenicity and clinical symptoms.
Presence of lipid envelope.
The envelope glycoproteins of animal viruses mainly function to
package viral genomes.
prevent host immune recognition.
mediate attachment and membrane fusion.
stabilize the nucleocapsid.
act as polymerases.
Non-structural proteins are typically involved in
host attachment.
virion stability.
regulatory roles during replication.
capsid formation.
glycosylation of surface proteins.
The following virus is classified in the Baltimore Class I:
Parvovirus B19
Herpes simplex virus
Rotavirus
Poliovirus
HIV
A virus achieves persistence in nature primarily by
rapid replication followed by lysis.
mutation to evade immunity.
continuous transmission between permissive hosts.
killing the host quickly.
avoiding genome packaging.
A permissive host cell is best defined as
the cell lacks antiviral defense.
the cell provides suitable receptors and factors for replication.
the cell is dead or non-dividing.
any eukaryotic cells.
a cell infected by multiple viruses.
During attachment, a virus initially binds
to nuclear membrane.
weakly to co-receptors.
directly to ribosomes.
to endosomes.
to DNA polymerase.
Viral genome packaging is guided by
host chaperone proteins.
packaging signal sequences in the viral genome.
random encapsidation.
spike glycoproteins.
host DNA ligase.
Herpesviruses replicate in the nucleus and remain latent because
they integrate into host RNA.
they only form latency-associated transcripts.
viral proteins maintain persistent viremia.
the viral genome circularizes irreversibly.
the viral genome is degraded.
Human papillomavirus (HPV) E6 and E7 proteins are oncogenic because they
activate viral capsid synthesis.
induce apoptosis of epithelial cells.
interfere with cellular tumor suppressors.
promote immune clearance.
integrate viral DNA into mitochondria.
Simian virus (SV) 40 shows binding affinity to
CD4 receptor.
MHC class I molecules.
integrins.
P antigen.
nectins.
Variola virus is
causing chickenpox.
causing smallpox.
causing benign zoonotic poxvirus.
a component of the polio vaccine.
still endemic worldwide.
Monkeypox (Mpox) differs from smallpox because it
is caused by varicella-zoster.
involves clade I and II, with clade IIb causing recent outbreaks.
is non-zoonotic.
lacks an envelope.
cannot infect humans.
Molluscum contagiosum is transmitted through
mosquito vectors.
skin and sexual contact.
aerosols.
blood transfusion.
saliva.
Fifth disease is caused by
parvovirus B19.
human papillomavirus (HPV)-11.
Molluscum contagiosum.
polyomavirus SV40.
Epstein-Barr virus (EBV).
