WorksheetsANTI-PSYCHOTICS
Total questions: 10
Worksheet time: 20mins
Which of the following antipsychotics has high D2 antagonistic potency but minimal α-blocking and minimal sedative actions, making it suitable when postural hypotension must be avoided?
Chlorpromazine
Thioridazine
Haloperidol
Clozapine
Which of the following receptors profile BEST explains why clozapine causes minimal extrapyramidal symptoms despite being antipsychotic?
Potent D2 blockade + weak 5-HT2 blockade
Weak D2 blockade + potent D4 and 5-HT2 blockade
Potent D1 blockade + weak α blockade
Potent NMDA antagonism
A sudden severe drop in neutrophil count requiring weekly WBC monitoring is MOST strongly associated with which of the following antipsychotics?
Amisulpride
Risperidone
Clozapine
Olanzapine
A patient with schizophrenia on haloperidol develops worsening rigidity and tremors after a new medication is added. Which of the following drugs is MOST likely responsible?
Diazepam
Levodopa
Clonidine
Metoclopramide
Tardive dyskinesia results from which of the following mechanisms?
Acute D1 receptor blockade causing cholinergic excess
Chronic D2 blockade resulting in supersensitivity of striatal dopamine receptors
Serotonin receptor down-regulation
Excess glutamate release
Which of the following antipsychotics MOST strongly produces postural hypotension due to potent α-adrenergic blockade?
Aripiprazole
Clozapine
Haloperidol
Fluphenazine
Which of the following properties of chlorpromazine BEST explains why its effect persists longer than expected from its plasma half-life?
Poor bioavailability
High protein & tissue binding with high brain levels
Rapid renal excretion
Extensive enterohepatic recycling
A bipolar patient on lithium develops toxic tremors and confusion after starting treatment for hypertension. Which antihypertensives is MOST responsible?
Thiazide diuretics
ACE inhibitors
Calcium channel blockers
Beta blockers
Which of the following drugs increases lithium toxicity due to increased Na+ reabsorption?
Losartan
Amlodipine
Hydrochlorothiazide
Propranolol
A 68-year-old psychotic patient has Parkinson’s disease, making EPS highly undesirable. Which of the following drugs is MOST appropriate?
Fluphenazine
Haloperidol
Clozapine
Risperidone
