WorksheetsiRAT 2.2 Week 3
Total questions: 5
Worksheet time: 9mins
Name
Class
Date
1.
A 27-year-old man is brought to the psychiatry clinic because of hearing voices and believing that strangers are following him. He has withdrawn from friends and appears emotionally flat. The psychiatrist suspects dopaminergic dysregulation involving two distinct pathways. Which dopaminergic imbalance best explains the combination of positive and negative symptoms in this patient?
a)
Hyperactivity in the mesolimbic pathway and hypoactivity in the mesocortical pathway
b)
Hypoactivity in the nigrostriatal pathway and hyperactivity in the mesolimbic pathway
c)
Hyperactivity in the mesocortical pathway and hypoactivity in the tuberoinfundibular pathway
d)
Decreased dopamine turnover in the hypothalamic–pituitary axis
e)
Overactivation of the nigrostriatal and mesolimbic pathways
2.
A 32-year-old woman treated for schizophrenia develops galactorrhea and amenorrhea after 2 months of risperidone therapy. She denies pregnancy. Laboratory evaluation shows elevated prolactin levels. Which dopaminergic pathway is most likely affected by her medication?
a)
Tuberoinfundibular pathway
b)
Mesolimbic pathway
c)
Mesocortical pathway
d)
Nigrostriatal pathway
e)
Hypothalamic–spinal pathway
3.
A 24-year-old university student seeks help for compulsive cocaine use. He reports craving and inability to stop despite academic failure. Neuroimaging shows increased dopamine release in the nucleus accumbens upon exposure to cocaine-related cues. Which statement best explains the neurobiological mechanism underlying his addiction?
a)
Cocaine blocks dopamine reuptake in the mesolimbic pathway, reinforcing drug-seeking behavior
b)
Cocaine inhibits dopamine synthesis in the mesocortical pathway
c)
Cocaine enhances serotonin turnover in the prefrontal cortex
d)
Cocaine antagonizes dopamine receptors in the basal ganglia
e)
Cocaine increases dopamine degradation through monoamine oxidase activation
4.
A 38-year-old woman with a 6-month history of anhedonia, low motivation, and psychomotor retardation is diagnosed with major depressive disorder. The psychiatrist explains that her symptoms may reflect deficient dopaminergic signaling in specific brain regions. Which dopaminergic pathway is most likely hypoactive in this condition?
a)
Mesocortical pathway
b)
Mesolimbic pathway
c)
Nigrostriatal pathway
d)
Tuberoinfundibular pathway
e)
Locus coeruleus projection pathway
5.
A 22-year-old man presents with agitation, hallucinations, and delusions of persecution after repeated methamphetamine use. He appears paranoid but oriented. His symptoms mimic schizophrenia. Which mechanism best explains his current psychotic state?
a)
Excessive dopamine release and receptor stimulation in the mesolimbic system
b)
Serotonin depletion in the raphe nuclei
c)
GABAergic inhibition in the basal ganglia
d)
Norepinephrine hyperactivity in the locus coeruleus
e)
Dopaminergic blockade in the prefrontal cortex
100 %
