WorksheetsHEMA-14
Total questions: 94
Worksheet time: 47mins
Name
Class
Date
1.
M0
a)
Myelocytic
b)
Myelocytic, monocytic
c)
Monocytic only
d)
Erythrocytic, myelocytic
e)
Megakaryocytic
2.
M1
a)
Myelocytic
b)
Myelocytic, monocytic
c)
Monocytic only
d)
Erythrocytic, myelocytic
e)
Megakaryocytic
3.
M2
a)
Myelocytic
b)
Myelocytic, monocytic
c)
Monocytic only
d)
Erythrocytic, myelocytic
e)
Megakaryocytic
4.
M3
a)
Myelocytic
b)
Myelocytic, monocytic
c)
Monocytic only
d)
Erythrocytic, myelocytic
e)
Megakaryocytic
5.
M4
a)
Myelocytic
b)
Myelocytic, monocytic
c)
Monocytic only
d)
Erythrocytic, myelocytic
e)
Megakaryocytic
6.
M5
a)
Myelocytic
b)
Myelocytic, monocytic
c)
Monocytic only
d)
Erythrocytic, myelocytic
e)
Megakaryocytic
7.
M6
a)
Myelocytic
b)
Myelocytic, monocytic
c)
Monocytic only
d)
Erythrocytic, myelocytic
e)
Megakaryocytic
8.
M7
a)
Myelocytic
b)
Myelocytic, monocytic
c)
Monocytic only
d)
Erythrocytic, myelocytic
e)
Megakaryocytic
9.
AML, minimally differentiated
a)
M0
b)
M1
c)
M2
d)
M3
10.
AML, without maturation
a)
M0
b)
M1
c)
M2
d)
M3
11.
Most common subtype of AML
a)
M0
b)
M1
c)
M2
d)
M3
12.
Acute promyelocytic leukemia (APL)
a)
M0
b)
M1
c)
M2
d)
M3
13.
Associated with Disseminated Intravascular Coagulopathy (DIC) and faggot cells
a)
M0
b)
M1
c)
M2
d)
M3
14.
microgranular variant : cells have the characteristic “butterfly", “bowtie”, “coin-on-coin” or “apple core” nuclei; often mistaken to be belonging to other types of leukemia
a)
M1V
b)
M3V
c)
M5V
d)
M2V
15.
May demonstrate Auer rods
a)
M0
b)
M1
c)
M2
d)
M3
16.
AML, with maturation
a)
M0
b)
M1
c)
M2
d)
M3
17.
MPO negative, SBB negative
a)
M0
b)
M1
c)
M2
d)
M3
18.
Non-lymphocytic leukemias or aka myelogenous leukemias are generally myeloperoxidase and sudan black B...
a)
Positive
b)
Negative
19.
Erythroid cells in AML M6 is PAS =
a)
Positive
b)
Negative
20.
M0 is MPO and SBB..
a)
Positive
b)
Negative
21.
Normal erythroid cells is PAS..
a)
Positive
b)
Negative
22.
Acute Myelomonocytic Leukemia (AMML)
a)
M4
b)
M5
c)
M6
d)
M7
23.
Naegeli Monocytic leukemia
a)
M4
b)
M5
c)
M6
d)
M7
24.
Second most common subtype of AML
a)
M4
b)
M5
c)
M6
d)
M7
25.
Acute monocytic leukemia (AMoL)
a)
M4
b)
M5
c)
M6
d)
M7
26.
aka Schilling leukemia
a)
M4
b)
M5
c)
M6
d)
M7
27.
Acute erythroleukemia
a)
M4
b)
M5
c)
M6
d)
M7
28.
aka Diguglielmo's syndrome
a)
M4
b)
M5
c)
M6
d)
M7
29.
Macrocytic, normochromic
a)
M4
b)
M5
c)
M6
d)
M7
30.
Acute megakaryocytic leukemia
a)
M4
b)
M5
c)
M6
d)
M7
31.
- requires immunocytochemical staining for accurate diagnosis
a)
M4
b)
M5
c)
M6
d)
M7
32.
Factor VIII stain positive
a)
M4
b)
M5
c)
M6
d)
M7
33.
“AMML, w/ increased marrow eosinophils"
a)
M4E
b)
M5a
c)
M5b
34.
“AMoL, poorly differentiated” :seen in children
a)
M4E
b)
M5a
c)
M5b
35.
>80% Monoblasts in bone marrow
a)
M4E
b)
M5a
c)
M5b
36.
<80% Monoblasts in bone marrow
a)
M4E
b)
M5a
c)
M5b
37.
“AMoL, well differentiated” : seen in middle-aged adults
a)
M4E
b)
M5a
c)
M5b
38.
Which of the following is seen in middle-aged adults?
a)
M4E
b)
M5a
c)
M5b
39.
Which of the following is well differentiated?
a)
M4E
b)
M5a
c)
M5b
40.
Which of the following is poorly differentiated?
a)
M4E
b)
M5a
c)
M5b
41.
Which of the following is seen in children?
a)
M4E
b)
M5a
c)
M5b
42.
May demonstrate auer rods
a)
M4
b)
M5
c)
M6
d)
M7
43.
MPO, SBB, and SE is positive in which of the following conditions?
a)
Myelocytic origin
b)
Monocytic origin
c)
Myelocytic and monocytic origin
44.
NSE (Butyrate) and NSE (Acetate) is positive in which of the following conditions?
a)
Myelocytic origin
b)
Monocytic origin
c)
Myelocytic and monocytic origin
45.
M1, M2, and M3 is positive on..
a)
MPO
b)
SBB
c)
Naphthol AS-D Chloroacetate (SE)
d)
a-Naphthyl Butyrate Esterase (NSE)
e)
a-Naphthyl Acetate Esterase (NSE)
46.
M1, M2, and M3 is negative on..
a)
MPO
b)
SBB
c)
Naphthol AS-D Chloroacetate (SE)
d)
a-Naphthyl Butyrate Esterase (NSE)
e)
a-Naphthyl Acetate Esterase (NSE)
47.
M4 (AMML) is positive on....
a)
MPO
b)
SBB
c)
Naphthol AS-D Chloroacetate (SE)
d)
a-Naphthyl Butyrate Esterase (NSE)
e)
a-Naphthyl Acetate Esterase (NSE)
48.
M5 (AMoL) is positive on....
a)
MPO
b)
SBB
c)
Naphthol AS-D Chloroacetate (SE)
d)
a-Naphthyl Butyrate Esterase (NSE)
e)
a-Naphthyl Acetate Esterase (NSE)
49.
M5 (AMoL) is variable on....
a)
MPO
b)
SBB
c)
Naphthol AS-D Chloroacetate (SE)
d)
a-Naphthyl Butyrate Esterase (NSE)
e)
a-Naphthyl Acetate Esterase (NSE)
50.
M5 (AMoL) is negative on....
a)
MPO
b)
SBB
c)
Naphthol AS-D Chloroacetate (SE)
d)
a-Naphthyl Butyrate Esterase (NSE)
e)
a-Naphthyl Acetate Esterase (NSE)
51.
M6 (Erythroleukemia) is variable on....
a)
MPO
b)
SBB
c)
Naphthol AS-D Chloroacetate (SE)
d)
a-Naphthyl Butyrate Esterase (NSE)
e)
a-Naphthyl Acetate Esterase (NSE)
52.
M7 (Megakaryocytic leukemia) exhibits localized positivity in..
a)
MPO
b)
SBB
c)
Naphthol AS-D Chloroacetate (SE)
d)
a-Naphthyl Butyrate Esterase (NSE)
e)
a-Naphthyl Acetate Esterase (NSE)
53.
M7 (Megakaryocytic leukemia) is negative on...
a)
MPO
b)
SBB
c)
Naphthol AS-D Chloroacetate (SE)
d)
a-Naphthyl Butyrate Esterase (NSE)
e)
a-Naphthyl Acetate Esterase (NSE)
54.
M7 (Megakaryocytic leukemia) is positive on..
a)
MPO
b)
Factor VIII stain
c)
Naphthol AS-D Chloroacetate (SE)
d)
a-Naphthyl Butyrate Esterase (NSE)
e)
a-Naphthyl Acetate Esterase (NSE)
55.
Chronic Myelogenous Leukemia (CML) is also known as:
a)
A. Chronic monocytic leukemia
b)
B. Chronic lymphocytic leukemia
c)
C. Chronic granulocytic leukemia
d)
D. Chronic erythroid leukemia
56.
The Philadelphia chromosome results from a reciprocal translocation between which chromosomes?
a)
A. 8 and 14
b)
B. 9 and 22
c)
C. 15 and 17
d)
D. 11 and 22
57.
The BCR-ABL1 fusion gene formed in CML is the result of:
a)
A. Gene duplication
b)
B. Deletion mutation
c)
C. Reciprocal translocation of chromosomes 9 and 22
d)
D. Nondisjunction
58.
Who first described the Philadelphia chromosome in 1960?
a)
A. James Watson
b)
B. Peter C. Nowell
c)
C. Paul Ehrlich
d)
D. Karl Landsteiner
59.
Peter C. Nowell discovered the Philadelphia chromosome while studying WBCs of patients with:
a)
A. Acute Myeloid Leukemia (AML)
b)
B. Chronic Myelogenous Leukemia (CML)
c)
C. Acute Lymphocytic Leukemia (ALL)
d)
D. Chronic Lymphocytic Leukemia (CLL)
60.
CML typically progresses through three clinical phases, which include:
a)
A. Acute, subacute, chronic
b)
B. Initial, intermediate, terminal
c)
C. Chronic phase, accelerated phase, blast crisis
d)
D. Induction, consolidation, maintenance
61.
Which of the following features helps differentiate CML from a leukemoid reaction?
a)
A. Presence of left shift
b)
B. Elevated WBC count
c)
C. Presence of Philadelphia chromosome
d)
D. Neutrophilia
62.
A leukemoid reaction is best described as:
a)
A. Malignant proliferation of myeloid cells
b)
B. Excessive leukocytic response in peripheral blood mimicking leukemia
c)
C. Viral-induced suppression of white cell production
d)
D. Chronic infection involving monocytes
63.
The WBC count in a leukemoid reaction is usually:
a)
A. Below 10 × 10⁹/L
b)
B. Between 10–20 × 10⁹/L
c)
C. Greater than 50 × 10⁹/L
d)
D. Greater than 100 × 10⁹/L
64.
In a leukemoid reaction, which white cell type is typically increased?
a)
A. Lymphocytes
b)
B. Monocytes
c)
C. Neutrophils
d)
D. Eosinophils
65.
A marked left shift in a leukemoid reaction refers to:
a)
A. Presence of immature neutrophilic forms in circulation
b)
B. Decrease in mature neutrophils
c)
C. Predominance of lymphocytes
d)
D. Increase in basophils
66.
Which of the following statements about leukemoid reaction is TRUE?
a)
A. It is a malignant condition.
b)
B. It is most commonly associated with viral infections.
c)
C. It can occur as a benign response to severe infection or stress.
d)
D. It is always accompanied by anemia.
67.
What is the principle of Kaplow’s Method?
a)
A. Oxidation of glucose by peroxidase producing a colored compound
b)
B. Hydrolysis of sodium alpha-naphthyl phosphate by alkaline phosphatase producing a colored precipitate with a diazotized amine
c)
C. Reduction of nitroblue tetrazolium by NADPH
d)
D. Hydrolysis of hydrogen peroxide by catalase
68.
Kaplow’s Method is used to determine the activity of which enzyme?
a)
A. Myeloperoxidase
b)
B. Acid phosphatase
c)
C. Alkaline phosphatase
d)
D. Glucose-6-phosphate dehydrogenase
69.
In Kaplow’s Method, the substrate hydrolyzed by alkaline phosphatase is:
a)
A. Sodium beta-naphthyl phosphate
b)
B. Sodium alpha-naphthyl phosphate
c)
C. Phenolphthalein phosphate
d)
D. p-Nitrophenyl phosphate
70.
The colored precipitate in Kaplow’s Method is formed when the product of hydrolysis reacts with:
a)
A. Schiff reagent
b)
B. Diazotized amine
c)
C. Sulfanilic acid
d)
D. Methylene blue
71.
Kaplow's method fixative
a)
Methanol and formalin
b)
Propanediole
c)
Sodium alpha naphthyl phosphate
d)
Brentamine-fast garnet salt
e)
Aqueous Mayer's hematoxylin
72.
Kaplow's method buffer
a)
Methanol and formalin
b)
Propanediole
c)
Sodium alpha naphthyl phosphate
d)
Brentamine-fast garnet salt
e)
Aqueous Mayer's hematoxylin
73.
Kaplow's method substrate
a)
Methanol and formalin
b)
Propanediole
c)
Sodium alpha naphthyl phosphate
d)
Brentamine-fast garnet salt
e)
Aqueous Mayer's hematoxylin
74.
Kaplow's method initial stain
a)
Methanol and formalin
b)
Propanediole
c)
Sodium alpha naphthyl phosphate
d)
Brentamine-fast garnet salt
e)
Aqueous Mayer's hematoxylin
75.
Kaplow's method counterstain
a)
Methanol and formalin
b)
Propanediole
c)
Sodium alpha naphthyl phosphate
d)
Brentamine-fast garnet salt
e)
Aqueous Mayer's hematoxylin
76.
The Leukocyte Alkaline Phosphatase (LAP) test is primarily used to differentiate:
a)
AML from ALL
b)
CML from LR
c)
MDS from AML
d)
CLL from ALL
77.
he principle of the LAP test is based on:
a)
A. Decreased LAP activity in normally matured neutrophils
b)
B. Increased LAP activity in neutrophils that have undergone normal growth
c)
C. Hydrolysis of NADPH by neutrophil oxidase
d)
D. Reduction of peroxidase in immature granulocytes
78.
LAP activity reflects the function of which cell type?
a)
Lymphocytes
b)
Monocytes
c)
Neutrophils
d)
Eosinophils
79.
no reddish brown to black precipitate
a)
0
b)
1+
c)
2+
d)
3+
e)
4+
80.
slightly diffused reddish brown to black precipitate
a)
0
b)
1+
c)
2+
d)
3+
e)
4+
81.
moderately diffused reddish brown to black precipitate
a)
0
b)
1+
c)
2+
d)
3+
e)
4+
82.
heavily diffused reddish brown to black precipitate
a)
0
b)
1+
c)
2+
d)
3+
e)
4+
83.
very heavily diffused reddish brown to black precipitate
a)
0
b)
1+
c)
2+
d)
3+
e)
4+
84.
Within normal or increased LAP score
a)
Leukemoid reaction
b)
CML
85.
Decreased LAP score
a)
Leukemoid reaction
b)
CML
86.
Normal Kaplow's LAP score
a)
15 to 50
b)
25 to 100
c)
15 to 100
d)
60 to 90
87.
Third trimester of pregnancy
a)
Increased Kaplow's LAP score
b)
Decreased Kaplow's LAP score
88.
Polycythemia vera
a)
Increased Kaplow's LAP score
b)
Decreased Kaplow's LAP score
89.
Intoxication
a)
Increased Kaplow's LAP score
b)
Decreased Kaplow's LAP score
90.
Infections
a)
Increased Kaplow's LAP score
b)
Decreased Kaplow's LAP score
91.
CML
a)
Increased Kaplow's LAP score
b)
Decreased Kaplow's LAP score
92.
Paroxysmal nocturnal hemoglobinuria
a)
Increased Kaplow's LAP score
b)
Decreased Kaplow's LAP score
93.
Sideroblastic anemia
a)
Increased Kaplow's LAP score
b)
Decreased Kaplow's LAP score
94.
Myelodysplastic syndrome
a)
Increased Kaplow's LAP score
b)
Decreased Kaplow's LAP score
100 %
