WorksheetsPRC-HEMA_3MT3
Total questions: 90
Worksheet time: 45mins
Name
Class
Date
1.
a group of malignant neoplasms of hematopoietic tissues characterized by diffuse replacement of bone marrow or lymph nodes with abnormally proliferating blood cells and the presence of leukemic cells in the peripheral blood. May be chronic or acute, myeloid, lymphoid, or mixed lineage.
a)
Leukemia
b)
Lymphoma
2.
Represents a group of malignant tumors of lymphoid tissue (lymph nodes, spleen).
a)
Leukemia
b)
Lymphoma
3.
Primary site of involvement: Lymph nodes, spleen, or other extra nodal sites.
a)
Leukemia
b)
Lymphoma
4.
Progenitors, immature cells.
a)
Acute leukemia
b)
Chronic leukemia
5.
Abrupt onset, patients may only last within months post diagnosis.
a)
Acute leukemia
b)
Chronic leukemia
6.
Abrupt onset, patients may only last within months post diagnosis.
a)
Acute leukemia
b)
Chronic leukemia
7.
Primary site of involvement: Blood or bone marrow
a)
Leukemia
b)
Lymphoma
8.
Other generalizations of leukemia include:
a)
Increased WBC count with shift to the right
b)
Increased WBC count with shift to the left
c)
Decrease WBC count with shift to the right
d)
Decrease WBC count with shift to the left
9.
What is the M:E ratio in leukemia?
a)
1:5
b)
10:1
c)
1:10
d)
20:1
10.
The type of anemia usually present in leukemia
a)
normocytic, normochromic
b)
microcytic, hypochromic
c)
macrocytic, hypochromic
11.
Rapidly progressive disease that lasts several days to 6 months.
a)
Acute leukemia
b)
Subacute leukemia
c)
Chronic leukemia
12.
Lasts 2 to 6 months.
a)
Acute leukemia
b)
Subacute leukemia
c)
Chronic leukemia
13.
Variable, depending on the age of the patient and the type of cell involved; most of the patients lived a minimum of 1-2 years or greater.
a)
Acute leukemia
b)
Subacute leukemia
c)
Chronic leukemia
14.
WBCs present in the peripheral blood: WBC ct. >15,000/μL
a)
Leukemic leukemia
b)
Subleukemic leukemia
c)
Aleukemic leukemia
15.
WBCs present in the peripheral blood: WBC ct. <15,000/μL with immature or abnormal forms of WBCs present in the peripheral blood.
a)
Leukemic leukemia
b)
Subleukemic leukemia
c)
Aleukemic leukemia
16.
WBCs present in the peripheral blood: WBC ct. <15,000/μL with NO immature or abnormal WBCs in the peripheral blood.
a)
Leukemic leukemia
b)
Subleukemic leukemia
c)
Aleukemic leukemia
17.
Predominance of immature types (blasts and progenitors).
a)
Acute leukemia
b)
Chronic leukemia
18.
Cell types are predominantly mature.
a)
Acute leukemia
b)
Chronic leukemia
19.
Morphology, cytochemistry and phenotyping
a)
French American British (FAB) class
b)
World Health Organization (WHO) class
20.
Morphology, cytochemistry, immunophenotyping, cytogenetics, and clinical features.
a)
French American British (FAB) class
b)
World Health Organization (WHO) class
21.
≥20% blasts
a)
French American British (FAB) class
b)
World Health Organization (WHO) class
22.
Widely used.
a)
French American British (FAB) class
b)
World Health Organization (WHO) class
23.
First system that is still used by some but is being replaced
a)
French American British (FAB) class
b)
World Health Organization (WHO) class
24.
≥30% blasts
a)
French American British (FAB) class
b)
World Health Organization (WHO) class
25.
The most common form of childhood leukemia
a)
Acute lymphocytic leukemia
b)
Acute myeloid leukemia
c)
Chronic lymphocytic leukemia
d)
Chronic myelogenous leukemia
26.
The Philadelphia chromosome (t9;22) is found in 90% of the cases of this disease
a)
Acute lymphocytic leukemia
b)
Acute myeloid leukemia
c)
Chronic lymphocytic leukemia
d)
Chronic myelogenous leukemia
27.
The absence of the Philadelphia chromosome is associated with a poorer prognosis.
a)
Acute lymphocytic leukemia
b)
Acute myeloid leukemia
c)
Chronic lymphocytic leukemia
d)
Chronic myelogenous leukemia
28.
In chronic myelogenous leukemia ___ of Philadelphia chromosome is associated with a poor prognosis.
a)
presence
b)
absence
29.
The most common type of leukemia in the elderly.
a)
Acute lymphocytic leukemia
b)
Acute myeloid leukemia
c)
Chronic lymphocytic leukemia
d)
Chronic myelogenous leukemia
30.
Characterized by persistent lymphocytosis, and an increased number of smudge cells and Rieder cells in the PBS.
a)
Acute lymphocytic leukemia
b)
Acute myeloid leukemia
c)
Chronic lymphocytic leukemia
d)
Chronic myelogenous leukemia
31.
Most common lymphocyte involved: B cells
a)
Acute lymphocytic leukemia
b)
Acute myeloid leukemia
c)
Chronic lymphocytic leukemia
d)
Chronic myelogenous leukemia
32.
Most common type of leukemia in adults.
a)
Acute lymphocytic leukemia
b)
Acute myeloid leukemia
c)
Chronic lymphocytic leukemia
d)
Chronic myelogenous leukemia
33.
Lymphoblasts are small and homogenous.
a)
L1 ALL
b)
L2 ALL
c)
L3 ALL
34.
It is the most common type of childhood ALL.
a)
L1 ALL
b)
L2 ALL
c)
L3 ALL
35.
Has the best prognosis
a)
L1 ALL
b)
L2 ALL
c)
L3 ALL
36.
Lymphoblasts are larger and variable in size.
a)
L1 ALL
b)
L2 ALL
c)
L3 ALL
37.
Adult type of ALL.
a)
L1 ALL
b)
L2 ALL
c)
L3 ALL
38.
Lymphoblasts are large but varies little in size (homogenous).
a)
L1 ALL
b)
L2 ALL
c)
L3 ALL
39.
Also known as the Burkitt-type of ALL.
a)
L1 ALL
b)
L2 ALL
c)
L3 ALL
40.
Rarest subclass with a poor prognosis.
a)
L1 ALL
b)
L2 ALL
c)
L3 ALL
41.
AML, minimally differentiated
a)
M0
b)
M1
c)
M2
d)
M3
42.
AML, without maturation
a)
M0
b)
M1
c)
M2
d)
M3
43.
AML, with maturation
a)
M0
b)
M1
c)
M2
d)
M3
44.
(+) DIC (+) Faggot cells
a)
M0
b)
M1
c)
M2
d)
M3
45.
Most common subtype of AML. (+) Auer rods
a)
M0
b)
M1
c)
M2
d)
M3
46.
Acute Promyelocytic Leukemia
a)
M0
b)
M1
c)
M2
d)
M3
47.
Acute Myelomonocytic Leukemia (AMML
a)
M4
b)
M5
c)
M6
d)
M7
48.
Also known as Naegeli leukemia
a)
M4
b)
M5
c)
M6
d)
M7
49.
Acute Monocytic Leukemia
a)
M4
b)
M5
c)
M6
d)
M7
50.
Also known as Schilling leukemia
a)
M4
b)
M5
c)
M6
d)
M7
51.
Also known as Di Guglielmo leukemia
a)
M4
b)
M5
c)
M6
d)
M7
52.
Acute Erythroleukemia
a)
M4
b)
M5
c)
M6
d)
M7
53.
Acute Megakaryocytic Leukemia
a)
M4
b)
M5
c)
M6
d)
M7
54.
Requires immunocytochemical staining for accurate diagnosis (Factor VIII stain)
a)
M4
b)
M5
c)
M6
d)
M7
55.
2nd most common AML subtype
a)
M4
b)
M5
c)
M6
d)
M7
56.
Which subtype of M4 demonstrates increased marrow eosinophils?
a)
M4A
b)
M4B
c)
M4C
d)
M4D
e)
M4E
57.
(+) Auer rods Macro-Normo anemia PAS (+)
a)
M4
b)
M5
c)
M6
d)
M7
58.
Which subtype of M5 is poorly differentiated?
a)
M5a
b)
M5b
59.
Which subtype of M5 is well differentiated?
a)
M5a
b)
M5b
60.
Solid tumor counterpart: Lymphoma, poorly differentiated
a)
Acute lymphoblastic leukemia (ALL)
b)
Chronic lymphocytic leukemia (CLL)
c)
Monocytic leukemia
d)
Acute myelogenous granulocytic leukemia
61.
Solid tumor counterpart: Lymphoma, well differentiated
a)
Acute lymphoblastic leukemia (ALL)
b)
Chronic lymphocytic leukemia (CLL)
c)
Monocytic leukemia
d)
Acute myelogenous granulocytic leukemia
62.
Solid tumor counterpart: Reticulum cell sarcoma
a)
Acute lymphoblastic leukemia (ALL)
b)
Chronic lymphocytic leukemia (CLL)
c)
Monocytic leukemia
d)
Acute myelogenous granulocytic leukemia
63.
Solid tumor counterpart: Chloroma
a)
Acute lymphoblastic leukemia (ALL)
b)
Chronic lymphocytic leukemia (CLL)
c)
Monocytic leukemia
d)
Acute myelogenous granulocytic leukemia
64.
Solid tumor counterpart: Multiple myeloma
a)
Plasma cell leukemia
b)
Stem cell leukemia
65.
Solid tumor counterpart: Lymphoma, undifferentiated
a)
Plasma cell leukemia
b)
Stem cell leukemia
66.
BCR:ABL1 Positive (+)
a)
Chronic myeloid leukemia
b)
Essential thrombocythemia
c)
Polycythemia vera
d)
Primary Myelofibrosis
67.
JAK2 mutation Positive (+)
a)
Chronic myeloid leukemia
b)
Essential thrombocythemia
c)
Polycythemia vera
d)
Primary Myelofibrosis
68.
WBC count: HIGH
a)
CML
b)
LR
c)
Both
69.
PBS: Shift to the left WITH blasts
a)
CML
b)
LR
c)
Both
70.
Philadelphia chromosome: Positive
a)
CML
b)
LR
c)
Both
71.
LAP: Low
a)
CML
b)
LR
c)
Both
72.
PBS: Shift to the left RARE blasts
a)
CML
b)
LR
c)
Both
73.
Philadelphia chromosome: Negative
a)
CML
b)
LR
c)
Both
74.
LAP: HIGH
a)
CML
b)
LR
c)
Both
75.
Characterized by fibrosis and granulocytic hyperplasia of the bone marrow, with granulocytic and megakaryocytic proliferation in the liver and spleen.
a)
Myelofibrosis with Myeloid
b)
Essential Thrombocythemia
c)
Polycythemia Vera
76.
Chronic MPD characterized by thrombocytosis in excess of 1,000 x 109/L with spontaneous aggregation of functionally abnormal platelets.
a)
Myelofibrosis with Myeloid
b)
Essential Thrombocythemia
c)
Polycythemia Vera
77.
Associated with bleeding and thrombotic tendencies.
a)
Myelofibrosis with Myeloid
b)
Essential Thrombocythemia
c)
Polycythemia Vera
78.
Presence of dacryocytes (“teardrop cells”).
a)
Myelofibrosis with Myeloid
b)
Essential Thrombocythemia
c)
Polycythemia Vera
79.
JAK2 molecular abnormality.
a)
Myelofibrosis with Myeloid
b)
Essential Thrombocythemia
c)
Polycythemia Vera
80.
Characterized by an absolute increase in red blood cells, white blood cells, and platelets (panhyperplasia).
a)
Myelofibrosis with Myeloid
b)
Essential Thrombocythemia
c)
Polycythemia Vera
81.
Molecular abnormalities: JAK2 V617F
a)
Myelofibrosis with Myeloid
b)
Essential Thrombocythemia
c)
Polycythemia Vera
82.
Decrease in Erythropoietin.
a)
Myelofibrosis with Myeloid
b)
Essential Thrombocythemia
c)
Polycythemia Vera
83.
Distinguished from other lymphomas by the presence of Reed-Sternberg cells.
a)
Hodgkin's disease
b)
Burkitt's lymphoma
84.
Classification schemes include Rye classification and Ann-Arbor classification
a)
Hodgkin's disease
b)
Burkitt's lymphoma
85.
Most often found in children in Africa and New Guinea.
a)
Hodgkin's disease
b)
Burkitt's lymphoma
86.
Commonly affecting the jaw and the facial bones.
a)
Hodgkin's disease
b)
Burkitt's lymphoma
87.
Epstein-Barr Virus: plays a role in transforming the B-cells by binding to their surface receptors.
a)
Hodgkin's disease
b)
Burkitt's lymphoma
88.
cells has a dark blue cytoplasm with multiple vacuoles, creating a “Starry sky”.
a)
Hodgkin's disease
b)
Burkitt's lymphoma
89.
based on the histologic appearance of the tissue involved, from lymph node biopsy.
a)
Rye's classification
b)
Ann-Arbor classification
90.
the most widely used; depends on both the histologic type and extent of the tissue involvement.
a)
Rye's classification
b)
Ann-Arbor classification
100 %
