WorksheetsAntimicrobial Resistance BMS DMS
Total questions: 11
Worksheet time: 11mins
Which of the following is the main requirement for an antibiotic to be clinically useful?
A. Broad spectrum activity
B. Selective toxicity
C. Ability to kill viruses
D. Resistance to degradation
Human cells are not affected by antibacterial drugs because:
They lack a cell wall
They have identical ribosomes to bacteria
They produce β-lactamases
They use plasmids for replication
Bacteriostatic drugs differ from bactericidal drugs in that they:
Kill bacteria directly
Cause irreversible inhibition of growth
Cause reversible inhibition of growth
Target only gram-negative bacteria
Which of the following is a broad-spectrum antimicrobial?
Penicillin G
Vancomycin
Tetracycline
Isoniazid
Plasmid-mediated resistance is clinically significant because:
It occurs only in gram-positive bacteria
It usually affects a single drug
It transfers resistance rapidly across other organisms
It is always due to mutations
Which mechanism of resistance involves bacteria actively exporting drugs?
β-lactamase production
Efflux pump
Porin modification
Target modification
A methylated 23S rRNA can result in resistance to:
Penicillin
Streptomycin
Erythromycin
Vancomycin
One major implication of antimicrobial resistance is:
Reduced hospital stays
Increased treatment options
Higher healthcare costs and mortality
Elimination of nosocomial infections
What is the primary mechanism by which penicillin exerts its antibacterial effect?
Inhibition of metabolic pathways
Inhibition of nucleic acid synthesis
Disruption of cell wall synthesis
Inhibition of protein synthesis
Which of the following is a common side effect of broad-spectrum antibiotics?
Improved sleep quality
Increased appetite
Diarrhea
Weight gain
What is the role of β-lactamase enzymes in antibiotic resistance?
They degrade β-lactam antibiotics
They inhibit bacterial DNA replication
They enhance drug absorption
They promote bacterial growth
