WorksheetsCBT 2025
Total questions: 300
Worksheet time: 3hrs 30mins
In what ventricular structure is cerebrospinal fluid not produced by the choroid plexus?
Roof of the fourth ventricle
Floor of the third ventricle
Lateral recess of the foramen of Luschka
Temporal horn of the lateral ventricle
Roof of the third ventricle
What is another name for the medial striate artery?
Tentorial artery (of Bernasconi and Cassinari)
McConnel capsular artery
Frontopolar artery
Recurrent artery of Heubner
Medial lenticulostriate artery
What midbrain anatomic structure is responsible for pain modulation?
A patient has an intractable nosebleed following transsphenoidal pituitary surgery. What artery likely is injured?
Middle meningeal artery
Infraorbital artery
Sphenopalatine artery
Anterior ethmoidal artery
From superior to inferior (rostral to caudal), what are the correct layers, in order, of the roof of the third ventricle?
Fornix, tela choroidea, velum interpositum, tela choroidea, and choroid plexus
Choroid plexus, velum interpositum, tela choroidea, and fornix
Fornix, velum interpositum, tela choroidea, choroid plexus, and tela choroidea
Tela choroidea, fornix, tela choroidea, velum interpositum, and choroid plexus
Fornix, velum interpositum, and choroid plexus
The lateral cord of the brachial plexus is formed from what structure(s)?
Anterior divisions of the upper and middle trunks
Nerve roots C5, C6, and C7
Posterior divisions of the superior, middle, and inferior trunks
Anterior divisions of the inferior trunk
Posterior divisions of the superior trunk
The vertebral artery often is divided into numbered segments. What segment exits the axial and curves posteromedially in a groove on the atlas and enters the foramen magnum?
V2
V3
V4
V5
V6
In this spinal cord cross-sectional image, what letter corresponds to the location of the spinothalamic tract?
A
B
C
D
E
What blood vessel is at risk of injury during a Chiari decompression?
Lateral medullary segment of the posterior inferior cerebellar artery
Telovelotonsillar segment of the posterior inferior cerebellar artery
Tonsillomedullary segment of the posterior inferior cerebellar artery
Posterior spinal artery
V2 segment of the vertebral artery
Number 2 in this image represents what structure?
Pars orbitalis
Premotor gyrus
Pars triangularis
Angular gyrus
Supramarginal gyrus
In brain dead, what happens to the intracranial pressure (ICP) as the mean arterial pressure (MAP) rises ?
Cerebral autoregulation increases ICP
Cerebral autoregulation decreases ICP
The lack of cerebral autoregulation causes an increase in ICP
The lack of cerebral autoregulation causes a decrease in ICP
Cerebral autoregulation maintains a relatively constant ICP
A patient has a hormone-producing pituitary microadenoma that puts him at risk (if left untreated) for peripheral neuropathies, cardiac arrhytmias, and sleep apnea. What hormone is the adenoma producing ?
Adrenocorticotropic hormone (ACTH
Growth hormone
Prolactin
Thyroid-stimulating hormone
Follicle-stimulating hormone
What is the mechanism of action for temozolamide (Temodar) ?
Microtubule inhibitor
DNA cross-linking
Anti-VEGF antibody
DNA alkylation
Topoisomerase inhibitor
What component of the blood-brain barrier is most responsible for its integrity, creation, and maintenance ?
Astrocytic foot processes
Arachnoid “cap” cells
Pericytes
Endothelial cells
A 52-year-old woman with a history of decompressive left hemicraniectomy for a large middle cerebral artery territory infarction presents with new-onset headache, vomiting, and lethargy. Her CT scan is shown in this image. What is the next appropriate step for her management?
Cranioplasty
Surgical evacuation
Contralateral craniectomy
Lumbar spinal fluid drain
What is the brain’s response to rising PCO2 with regard to cerebral blood flow (CBF) and intracranial pressure (ICP) ?
Decrease CBF and increase ICP
Increase CBF and decrease ICP
Decrease CBF and decrease ICP
Increase CBF and keep ICP constant
Increase CBF and increase ICP
How do cytotoxic and vasogenic edema differ ?
Cytotoxic edema responds better to steroids than does vasogenic edema
The blood-brain barrier is closed in cytotoxic edema and disrupted in vasogenic edema
Cells shrink in vasogenic edema but expand in cytotoxic edema
Cytotoxic but not vasogenic edema occurs after ischemic injury
Protein expand the extracellular space in cytotoxic edema
What typically prevents axonal regeneration in the central nervous system ?
Reduced axonal growth factors following injury
Astrocytic scarring
Lack of progenitor cells
Lack of directional markers and/or architecture
Apert syndrome is distinguished from Crouzon syndrome as individuals with Apert, and not Crouzon, syndrome tend to have:
Absence of a cleft palate
Normal intelligence
Mental retardation
Complex syndactyly
Craniosynostosis
What involuntary movement disorder typically persists during sleep?
Hemifacial spasm
Blepharospasm
Athetosis
Facial myokymia
A 49-year-old man presents with left elbow pain. His symptoms have not improved with rest, ice, splinting and analgetics. He has noticed progressive weakness in extension of his thumb and fingers without weakness of his wrist or arm. There is no sensory loss. What is the suspected diagnosis ?
Radial nerve neuropathy in the upper arm
Tennis elbow
Posterior interosseous neuropathy
C8 radiculopathy
Radial tunnel syndrome
A man with lethargy, confusion, and one episode of seizures underwent an MRI of the brain, shown in these images. What is the likely diagnosis?
Infiltrative glioma
Acute infarct
Osmotic demyelination
Brainstem encephalitis
A woman is referred to you for treatment of a cerebellopontine angle tumor. She has obvious weakness of the right side of her face. She does have some motion but has no motor contraction over her forehead, she cannot close her eye completely, and she has noticeable asymmetry of her mouth when attempting to smile. What is her House-Brackmann classification grade?
2
3
4
5
6
An 81-year-old man with a history of hip replacement 3 weeks ago complicated by a mild myocardial infarction is brought to the hospital with an acute-onset middle cerebral artery stroke. The patient has been maintained on warfarin, and the INR is 2,3. The platelet count is 120,000. In this patient, what is an absolute contraindication to thrombolysis ?
Age over 80 years
Hip replacement within 3 weeks of presentation
Recent history of myocardial infarction
INR of 2,3
Platelet count of 120,000
A 30-year-old man with a history of homocystinuria develops a headache followed by hemiparesis and focal epilepsy. He is brought to the emergency room for evaluation. What is the most sensitive imaging modality to detect this patient disease ?
Noncontrast CT scan
T2-weighted MRI
Angiogram
Whole body PET CT
Perfusion-weighted imaging
What is classically described as the cause of an immediate coma in a patient after a head injury without evidence of an intracranial mass or ichemia ?
Severe concussion
Diffuse axonal injury
Dural sinus thrombosis
Atlantoaxial dislocation
A 7-year-old boy is reffered to your office by his endocrinologist after an MRI was obtained during a workup for precocious puberty. The MRI reveals a nonenhancing T1 isointense and T2 isointense lesion within the hypothalamus. Other than precocious puberty, there are no focal findings on exam. While you are interviewing his parents, you notice that the patient occasionally has brief episodes of laughter. What is the most likely diagnosis, and what is the natural history of the described seizures ?
Low-grade astrocytoma; good seizure control with dietary modifications
Germ cell tumor; excellent control of seizures with ethosuximide
Hypothalamic hamartoma; poor seuzire response to medications
Lipoma; good control of seizures with topiramate
Following trauma to his arm, a patient is unable to abduct and oppose his thumb. He has weakness in forearm pronation and wrist and finger flexion. What other physical exam finding is this patient expected to have ?
Benediction sign and claw hand deformities
Ape hand and benediction sign deformities
Claw hand and wrist drop deformities
Wrist drop and benediction sign deformities
A 69-year-old man incidentally was found to have 85% stenosis of his right internal carotid artery. According to the North American Symptomatic Carotid Endarterectomy Trial (NASCET), what management option is the most likely to prevent a future stroke in the patient ?
Warfarin therapy
Carotid angioplasty
Statin therapy
Carotid endarterectomy
Aspirin therapy
A 78-year-old woman presents to the emergency room after experiencing dizzinesss and syncope. A neurologic exam revealed decrease pain/temperature sensation on the right side of the body, a left facial palsy, decreased pain/temperature sensation on the left side of the face, left-sided hearing loss, ptosis, nausea, vomiting, and vertigo. An infarction in what vessel is suspected ?
Vertebral/posterior inferior cerebellar artery
Anterior inferior cerebellar artery
Superior cerebellar artery
Short circumferential pontine basilar perforators
Artery of Percheron
A patient with a history of intravenous drug use is seen in clinic with new-onset severe back pain. An MRI is obtained that demonstrates bony erosion and collapse of the L2/L3 disk. What is the next step in the management of this patient ?
Perform a lumbar puncture, and send spinal fluid cultures
Obtain a CT scan of the spine
Obtain blood cultures
Obtain a bone scan
Schedule follow up with a repeat MRI in 4 to 6 weeks
Multiple sclerosis is a contraindication to what procedural treatment for trigeminal neuralgia?
Microvascular decompression
Percutaneous radiofrequency rhizotomy
Percutaneous glycerol injection into the Meckel cave
Percutaneous balloon microcompression
Stereotactic radiosurgery
A woman with a known pituitary macroadenoma presents to the emergency room with a sudden, intense headache and a new-onset ophthalmoplegia with her chronic visual field cuts. She endorses photophobia. After imaging confirms the most likely diagnosis, what is the next step in her management?
Sumatriptan administration
Follow-up with repeat imaging in 6 weeks
Repeat pituitary lab work as an outpatient
Observation
Preparation for transsphenoidal decompression immediately
Over 95% of vestibular schwannomas present with progressive unilateral or asymmetric sensorineural, high-frequency hearing loss. In general, what is considered the definition of serviceable hearing ?
Pure tone audiogram of 40 dB or less; speech discrimination score of at least 40%
Pure tone audiogram of 60 dB or less; speech discrimination score of at least 60%
Pure tone audiogram of 60 dB or less; speech discrimination score of at least 40%
Pure tone audiogram of 40 dB or less; speech discrimination score of at least 60%
American Academy of Otolaryngology–Head and Neck Surgery (AAO-HNS) class C or D
A 50-year-old woman presents with an acute onset of severe headache, bitemporal hemianopsia, and cranial nerve III palsy. She is alert and conversant. What is the most appropriate next step in this patient’s management ?
Rapid administration of corticosteroids
Cerebral angiography
Administration of nimodipine
Obtaining an erythrocyte sedimentation rate, C-reactive protein concentration, and blood cultures
Intracranial pressure monitoring
A 19-year-old man presents following a motor vehicle collision complaining of lower extremity weakness. He is found to have a thoracic spine Chance fracture. He has full strength in his upper extremities. He has sensation in his lower extremities and perineum, and his motor strength in his lower extremities ranges from 4-/5 to 4/5. What is his American Spinal Injury Association (ASIA) impairment scale score ?
A
B
C
D
E
A patient presents in the emergency room with a cervical spine fracture and the following radiographic findings: a triangular bone fragment fractured off the anterior inferior vertebral body, retrolisthesis of the caudal vertebrae, and disruption of the facet joints and the disk space. What type of fracture is suspected ?
Avulsion fracture
Clay-shoveler fracture
Jefferson fracture
Teardrop fracture
Locked facets
A 37-year-old man presents with a sudden onset of the “worst headache of my life.” The CT shows intraventricular hemorrhage that you suspect resulted from hemorrhage entering through the lamina terminalis. You are suspicious of an aneurysm at what location ?
Middle cerebral artery bifurcation
Posterior communicating artery
Internal carotid artery terminus
Anterior communicating artery
Basilar artery tip
An 82-year-old woman presents to the neurosurgery clinic with typical trigeminal neuralgia. She has substantial medical comorbidities and would like to avoid surgery. The patient opts for stereotactic radiosurgery. What factor would predict a favorable outcome ?
Absence of atypical pain
Using a radiation dose less than 60 Gy
Prior successful surgical microvascular decompression
Decreased sensation in the affected nerve prior to treatment
Trigeminal neuralgia related to multiple sclerosis
A 35-year-old woman presents with spontaneous neck pain. A noncontrast head CT demonstrates subarachnoid hemorrhage, and an angiogram reveals a lesion suspicious for an intradural vertebral artery dissection. What is the appropriate treatment for this finding
Observation if asymptomatic
Immediate heparinization followed by oral anticoagulation
Immediate surgery or endovascular treatment
Delayed surgery to allow for swelling resolution
Nonoperative treatment followed by a delayed angiogram in 5 to 7 days to assess healing
What structure is indicated by the arrow in this image from an endoscopic third ventriculostomy ?
Optic chiasm
Pituitary stalk
Tip of basilar artery
Fornix
Mammillary bodies
A 3-year-old boy presents with a history of spinal cord de-tethering and excision of a thoracic dermal sinus tract during infancy. What is the most likely spinal cord lesion seen on the current T2 MRI shown in this image ?
Syrinx
Ependymoma
Astrocytoma
Dermoid tumor
Epidermoid tumor
An 8-year-old child with a history of myelomeningocele repair after birth presents with progressive leg weakness and a neurogenic bladder. An MRI of lumbar spine, shown in this image, suggests:
Syringomyelia secondary to a tethered
spinal cord
Idiopathic syringomyelia
Spinal lipoma
Dermoid tumor
Thickened filum terminale
A 3-month-old baby has an abnormal head shape. Based on the 3D reconstruction imaging of the skull, shown in this image, what syndrome is suspected ?
Pierre Robin syndrome
Treacher Collins syndrome
Pfeiffer syndrome
Goldenhar syndrome
Moebius syndrome
An 11-month-old boy presents with macrocrania and failure to thrive. An MRI of the brain, shown in this image, confirms what likely type of hydrocephalus ?
Communicating hydrocephalus
Obstructive hydrocephalus secondary
to a Dandy-Walker malformation
Obstructive hydrocephalus secondary
to aqueductal stenosis
Obstructive hydrocephalus secondary
to a posterior fossa tumor
Obstructive hydrocephalus secondary
to a vein of Galen aneurysm
Obstructive hydrocephalus secondary
to a vein of Galen aneurysm
Acute odontoid fracture
Os odontoideum
Clival chordoma
Condylar fracture
Ligamentous injury
The MRI shown in this image suggests that the cause of the cervicothoracic syringomyelia in this child is due to:
An idiopathic cause
Trauma
A Chiari malformation
Tethered cord due to a cervical dermal
sinus tract
A craniocervical ependymoma
A child presents with a second episode of middle cerebral artery stroke. The cerebral angiogram, shown in this image, suggests:
Anterior communicating artery aneurysm
Arteriovenous malformation
Cavernous malformations
Moyamoya disease
Vein of Galen malformation
A 6-year-old boy presents with new-onset seizures. MRI of the brain, shown in this image, demonstrates an enhancing temporal mass. What is the most likely diagnosis?
Anaplastic astrocytoma
Ependymoma
Ganglioglioma
Meningioma
Primitive neuroectodermal tumor
An endoscope-assisted strip craniectomy procedure for an infant with sagittal craniosynostosis, shown in this image, followed by helmet therapy will have the best cosmetic outcome if it is performed at what age ?
18 months
12 months
9 months
6 months
3 months
A 24-year-old man is brought to the emergency department following a single midline gunshot wound to the forehead. On arrival, he is GCS 7T with bilateral sluggishly reactive pupils and localizing in the left upper extremity to noxious stimulus. His non-contrast head CT is depicted (Figure 1). This patient is most at risk for what acute complication of penetrating brain injury ?
Cavernous-carotid fistula
Traumatic arterial dissection
Arteriovenous malformation
Venous sinus thrombosis
Traumatic intracranial aneurysm
A 23-year-old man presents to the emergency department after an intoxicated fall and head injury. He has a moderate occipital headache and nausea without vomiting. On exam, the patient has normal vital signs and no focal neurological deficits. His non-contrast head CT is shown (Figure 1). The volume of the hematoma is measured to be 35 cm³. What is the most appropriate treatment for this patient ?
Posterior fossa craniotomy for evacuation of hematoma
Close neurological monitoring with serial head CT imaging
Burr hole evacuation of hematoma
External ventricular drain for CSF diversion and intracranial pressure monitoring
Embolization of the transverse sinus
A 5-month-old infant was a passenger in a car seat in a high-speed crash resulting in ejection. On exam, she only demonstrates right parietal scalp swelling. A head CT scan shows separation of the lambdoid suture and faint hypodensity in the subjacent brain (Figure 1). CT scanning of the cervical spine and other routine trauma investigations were negative. She was discharged in stable condition after 1 day. Which of the following is the most active concern for outpatient follow-up?
Hypopituitarism
Traumatic meningoencephalocele
Atlanto-occipital instability
Chronic subdural hematoma
Hydrocephalus
A 23-year-old male involved in a motor vehicle accident exhibits neurological decline from an initial GCS of 15 to 8, with a neurological exam notable for left hemiparesis and right dilated pupil. What is the most appropriate initial step in management of this patient ?
Hypertonic (3%) saline 250 mL bolus
Right temporal burr hole placement
Intubation and Hyperventilation
Fosphenytoin 15–18 mg/kg IV rapid infusion
Mannitol 1 mg/kg IV bolus
A 25-year-old man presents after assault with bilateral contusions and subarachnoid hemorrhage. His admission GCS is 4T, and an ICP monitor is placed. ICP steadily increases despite sedation, CSF diversion, hyperosmolar therapy, and hypothermia. What additional non-surgical intervention is most appropriate ?
Acetazolamide
Maintain CPP > 60 mmHg
10 mg IV dexamethasone
Hyperventilate with goal PCO₂ < 30 mmHg
Increase PEEP > 10 mmHg
A patient initially presents after closed head injury with a GCS of 14. Head CT demonstrates a small amount of pneumocephalus. Two hours later, the patient becomes unresponsive (GCS 4). A repeat head CT is obtained (Fig. 1). What is the most appropriate next step in management ?
Lumbar puncture to rule out meningitis
Repeat head CT with fine cuts to identify a basal skull fracture
Administer 1 g/kg of mannitol
Surgical evacuation of pneumocephalus
Treatment with high flow oxygen
A 17-year-old sustains a gunshot wound to the head. On examination, he has decorticate posturing on the right and he localizes on the left. His left pupil is 2 mm larger than the right but is still reactive. His non-contrast head CT (see figures) demonstrates metal and bone fragments within the left frontal region with an associated subdural hematoma with midline shift. What is the most appropriate management of this patient ?
Right frontal ventriculostomy placement
Craniotomy, hematoma evacuation, superficial debridement
Superficial debridement of wound
Craniotomy, hematoma evacuation, removal of all bone and metal fragments
Expectant care
A 22-year-old man without a significant medical history presents with progressive midthoracic pain. An MRI examination of the spine is shown in these images. What is the most likely diagnosis ?
Astrocytoma
Ependymoma
Metastasis
Tumefactive demyelination
A patient presents after a motor vehicle accident (MVA) with the head CT shown in the figure. His GCS is 14. His blood alcohol level is 0.31%. What is the most appropriate initial management?
Bifrontal craniotomy and evacuation of SDH
Intubate, sedate, and monitor ICP
Placement of ventriculostomy
Bifrontal decompressive craniectomy
Admit to ICU for observation
A 54-year-old man underwent an MRI of the spine. Sagittal and axial postcontrast T1-weighted images are shown in these images. What is the patient’s likely diagnosis ?
Leptomeningeal metastasis
Neurofibroma
Schwannoma
Meningioma
A woman underwent a head CT, shown in these images. What is the likely diagnosis ?
Infiltrative tumor
Acute infarct
Intracranial hemorrhage
Meningitis
A 38-year-old man who sustained a gunshot wound to the head underwent an emergent CT scan, shown in this image. What finding portends the worst prognosis ?
Presence of both entry and exit wounds
Involvement of the inner and outer tables
of the calvaria
Bullet tract crossing the deep midline
structures
Presence of metallic fragments along
the bullet trajectory
Presence of an open comminuted fracture
A man is reported to have a “string of pearls” appearance on his angiogram. What is the likely diagnosis ?
Severe carotid artery stenosis
Dural arteriovenous fistula
Fibromuscular dysplasia
Arteriovenous malformation
Carotid artery dissection
A 29-year-old female presents after a motor vehicle accident with left hemiplegia, weak localization on right, and a dilated unreactive right pupil. Her head CT is shown. What is the most appropriate surgical management ?
Placement of brain tissue oxygenation and ICP probe
Decompressive right hemicraniectomy
Craniotomy and hematoma evacuation
Temporal burr hole and hematoma drainage
Placement of ventriculostomy
Sagittal CT and MRI STIR sequences of the cervical spine are shown in these images. What is the injury type demonstrated?
Hangman fracture
Clay-shoveler fracture
Jefferson fracture
Flexion-distraction injury
Locked facets
What is true regarding the lesion shown in this CT image? ?
Usually heals well with traction and
immobilization
Usually considered stable
Constitutes the most common type
of fracture at this site
Fracture occurs above the transverse
band of the cruciform ligament
Most likely fracture type to progress
to nonunion
What is a characteristic of the injury shown on this CT scan ?
Combined offset of the lateral C1
masses relative to C2 greater
than 6 mm, which suggests
disruption of the alar ligaments
Frequently associated with diving
head first into shallow water
High frequency of neurologic injury
Most commonly occurs in infants
and young children
Usually warrants emergent surgical
fixation
A 12-year-old boy presents complaining of left eye visual loss and occasional headache. Endocrine evaluation reveals the presence of mild diabetes inspidus and hypothyroidism. His MRI is shown in Figure 1&2. You recommend an attempt at complete tumor resection . Which of the following is the most likely surgical complication?
Hydrocephalus
Seizure disorder
Blindness
Mutism
Pan-hypopituitarism
The spinal cord lesion in the T2-weighted MRI shown in this image is consistent with what disease process ?
Poliomyelitis
Amyotrophic lateral sclerosis
Guillain-Barré syndrome
Subacute combined degeneration
The left vertebral artery usually arises from the:
Arch of the aorta
Brachiocephalic trunk
Left common carotid
Left subclavian artery
Costocervical trunk
A 12-year-old boy presented to the emergency department with progressive headaches, nausea, and vomiting. Axial T2 and contrast-enhanced T1-weighted imaging and apparent diffusion coefficient maps are shown in these images. What is the patient’s likely diagnosis ?
Medulloblastoma
Ependymoma
Pilocytic astrocytoma
Hemangioblastoma
Metastasis
A 4-week-old was transferred to the Trauma Service from an outlying emergency department after an evaluation for a seizure that included a CT scan of the head (Figure 1). What additional diagnostic investigation is most appropriate?
Echocardiography
Cerebral angiography
Urine amino acids
Skeletal survey
Lumbar puncture
A 34-year-old female presents with spontaneous proptosis and chemosis of the left eye. Cerebral angiography (left common carotid injection) is shown . What is the best management option?
Transvenous embolization
Transarterial carotid sacrifice
Craniotomy
Optic nerve sheath fenestration
Ventriculoperitoneal shunt
A 17-year-old boy is struck on the right side of the head during a sports match. He is dazed initially and is taken off the field despite saying he feels fine. He becomes more sleepy over the subsequent 15 min and an ambulance is called. In the emergency department his GCS is E2V3M5 with a sluggish right pupil and weakness on the left side of his body. CT head is shown. Which one of the following is LEAST likely to be an indication for surgery in this type of pathology?
Lesion volume greater than 30 cm³ with anisocoria
and 20 mm maximal thickness
Lesion volume greater than 30 cm³
GCS 8 or less with evidence of anisocoria
Lesion volume 15 cm³ with anisocoria but no
midline shift
Lesion volume 35 cm³ with atrophic brain without
midline shift
A 75-year-old woman presents with a 2-month history of progressive difficulty walking, headache, and memory difficulties. Magnetic resonance imaging is shown (figure). Histopathology shows nests of small blue cells amid a pink fibrillary matrix. What is the most likely diagnosis?
Medulloblastoma
Glioblastoma multiforme
Pilocytic astrocytoma
Subependymoma
Meningioma
A 27-year-old presents to the ED after an assault. His GCS is 15/15 but he has evidence of facial fractures involving the frontal sinus and evidence of some CSF rhinorrhea. He is admitted for observation and initial conservative management of CSF leak. On day 3 post-injury, he developed three episodes of vomiting and became drowsy. On examination he was obtunded and lethargic, but arousable. His BP was 140/90 mmHg, heart rate 59/min, respiratory rate 20/min, and oxygen saturation 92% on room air. Examination revealed a dilated right pupil, while the rest of the neurological and systemic examination was normal. Which one of the following is the most appropriate acute management?
High-flow oxygen
Burr hole decompression
Cranialization of the frontal sinus
Decompressive craniectomy
Minicraniotomy
A physician diagnoses a 67-year-old patient with the beginning stages of Alzheimer's disease. The patient's neurologic exam is otherwise intact. A treatment plan of deep brain stimulation to minimize the rate of brain deterioration is created. Where should the surgeon place the stimulator within the brain?
Near the fornix
Within the thalamus
Within frontal cortex
Within the midbrain
A view from above into the anterior third ventricle is shown. The ideal location for performing a third ventriculostomy is indicated by which number?
9
6
5
8
7
A 57-year-old patient presents with head injury after falling backwards and sudden onset of agitation. Two hours later her blood pressure is 220/110 mmHg, her heart rate is 39 beats per minute, and her consciousness is fluctuating. She is intubated and ventilated. CT is shown. Regarding this type of lesion and its location, which one of the following is LEAST likely to be an indication for surgical evacuation ?
Neurological dysfunction or deterioration referable to the lesion
Distortion, dislocation, or obliteration of the fourth ventricle
Compression or loss of visualization of the temporal horns
Presence of obstructive hydrocephalus
Underlying depressed skull fracture
What structure does the arrow point to in the figure?
Superior petrosal sinus
Inferior petrosal sinus
Cavernous sinus
Superior ophthalmic vein
Internal jugular vein
A 58 year-old right handed male presents with bifrontal headaches and a partial left ophthalmoplegia. MRI results are shown. Biopsy revealed this tumor to be a chordoma. An extensive subtotal skull-based resection was performed. Which is the best choice for adjuvant therapy regimen?
Procarbazine, CCNU and vincristine (PCV) chemotherapy
Stereotactic radiosurgery
Proton beam radiotherapy
Brachytherapy
Conventional fractionated radiotherapy
A 41 year-old woman undergoes gross total resection for the lesion shown (Figure). Pathology confirms a grade 2 oligodendroglioma. What is the recommended course of treatment?
Radiation
Chemotherapy
Chemotherapy and radiation
Serial MRI
Clinical observation
A 16-year-old boy presents with headaches, nausea, and blurred vision. His neurological examination is remarkable for impaired upgaze and convergence nystagmus. Contrast-enhanced MRI of the brain is shown (figure). Serum beta-HCG and alpha-fetoprotein levels are normal. What is the most likely diagnosis?
Germinoma
Embryonal carcinoma
Endodermal sinus tumor
Meningioma
Choriocarcinoma
Occlusion of which artery causes the stroke shown in the figure?
Recurrent artery of Heubner
Subcallosal artery
Medial lenticulostriate perforator
Orbitofrontal Artery
Artery of Percheron
A 35 year old female presents with headaches and progessive left sided hearing loss. What is the BEST treatment for the lesion depicted in the MR images?
Endoscopic fenestration.
Craniotomy for lesion removal.
Stereotactic aspiration.
Cystoperitoneal shunt.
Radiation therapy
What type of tumor harbors the histopathological structure seen in the figure?
Pleomorphic xanthoastrocytoma
Pilomyxoid astrocytoma
Ependymoma
Glioblastoma
Anaplastic oligodendroglioma
A view of the fundus (lateral end) of the internal acoustic meatus is shown in the figure. Which number represent the location of the cochlear nerve segment?
4
2
3
1
5
You are performing surgery on a patient with a suspected nerve entrapment, and discover that the nerve is severely narrowed (>50%) along the point of entrapment. What is the most appropriate treatment for this condition?
Neurorrhaphy
Nerve transfer
Neuroplasty
Internal neurolysis
Nerve transposition
What is the first clinically important branch given off by the upper trunk of the brachial plexus?
Musculocutaneous nerve
Phrenic nerve
Suprascapular nerve
Axillary nerve
Dorsal scapular nerve
Based on the cerebral angiogram, which vessel is the PRIMARY arterial blood supply for this tumor?
Superior cerebellar artery.
Persistent trigeminal artery.
Ascending pharyngeal artery.
Middle meningeal artery.
Meningohypophyseal trunk.
What extent of surgical resection of low grade gliomas contributes to a survival benefit?
50-75%
0-25%
75-100%
25-50%
The figure is a cadaveric dissection of the anterior portion of the left cavernous sinus. What deficit would be seen with damage to this structure?
Ptosis, meiosis and anhidrosis
Periocular numbness
Facial numbness
Diplopia that corrects with head tilt
Monocular blindness
A 24-year-old woman presents with a history of menstrual irregularity and headache. Magnetic resonance (MR) imaging reveals a nonenhancing 1.6-cm tumor of the sellar/suprasellar region with displacement of the optic chiasm. If the patient was noted to have a prolactin level of 265, which of the following is the most appropriate management strategy?
Dopamine agonist with serial visual fields
Observation
Craniotomy for decompression of the optic apparatus
Transsphenoidal resection
Stereotactic radiosurgery
On which chromosome is the gene mutation associated with the syndrome depicted by the MRI shown (figure)?
22
3
11
9
17
What imaging finding of a sphenoid wing meningioma significantly diminishes the possibility of safe gross-total resection?
Infratemporal fossa extension
Tumor size
Optic canal extension
Cavernous sinus invasion
Cerebral edema
What recess is indicated by the arrow in this image?
Opticocarotid cistern
Carotico-oculomotor cistern
Interpeduncular cistern
Lamina terminalis
Cerebellopontine angle
During a far lateral approach, exposure of what anatomic structure first indicates that more than the posterior one-third of the occipital condyle has been removed?
Jugular bulb
The dentate ligament
Transverse ligament of atlas
The vertebral artery
The anterior condylar vein
What is the most common location for the “pearly” tumor shown in this image
As part of the dural along the cerebral convexities
Cerebellopontine angle
Thalamus
Extra-calvarial
Pineal gland
Which one of the following PET tracers is LEAST appropriate for detection of de novo low-grade glioma?
18F-FET
18F-FDG
18F-DOPA
11C-MET
18F-DOPA
A sagittal T2-weighted image of a patient with a tethered cord is shown in this image. What is a characteristic of the pathology represented here?
Reduced risk following folic acid supplementation
Associated with Chiari 2 malformations
Secondary to premature disjunction of the neural ectoderm
Most cases are familial
A 55-year-old woman presents to the clinic with the complaint of increasingly blurry vision over the past several weeks. Besides, she notes a persistent headache that is worst in the morning and occasionally awakens her from sleep. On physical exam, extraocular movements are impaired. The patient is unable to intort and extort her eye. It is also noted that there is a diminished pupillary light reflex. MRI reveals an intracranial mass. Which of the following locations is most likely affected?
Trochlear nucleus
Trochlear nerve
Cavernous sinus
Below the inferior colliculus
What structure is indicated by the arrow in this image from an endoscopic third ventriculostomy?
Optic chiasm
Pituitary stalk
Tip of basilar artery
Fornix
Mammillary bodies
A 43-year-old female presents to the clinic with chronic headaches worsening over the past three months. Imaging identifies a colloid cyst in the third ventricle. Which of the following findings best indicates a transcortical open craniotomy for treatment of the colloid cyst compared to other possible treatment modalities?
4 mm colloid cyst with small lateral ventricles
4 mm colloid cyst with large lateral ventricles
24 mm colloid cyst with small lateral ventricles
24 mm colloid cyst with large lateral ventricles
A child presents with a second episode of middle cerebral artery stroke. The cerebral angiogram, shown in this image, suggests
Anterior communicating artery aneurysm
Arteriovenous malformation
Cavernous malformations
Moyamoya disease
Vein of Galen malformation
During lateral osteophyte removal in an anterior decompressive discectomy, you encounter brisk bleeding in the region of the nerve root. What is the best next step?
Call interventional radiology
Order blood for transfusion
Explore the vertebral artery
Abort the procedure
Apply gelfoam and pressure
A 54-year-old female was taken to an emergency room after collapsing at work. She was alert and communicative, with a severe headache, photophobia, nuchal rigidity, and blurry vision. Computed tomography (CT) of the brain revealed diffuse subarachnoid blood in the basal cisterns, mild hydrocephalus, and no intraparenchymal hematoma. Her angiogram is depicted below. What is the clinical Hunt and Hess grade of this patient?
Grade I
Grade II
Grade III
Grade IV
Grade V
You are seeing a patient with multiple stab wounds to the upper extremity. The patient has isolated deficits in finger extension and ulnar wrist extension. What is the most likely level of injury?
Radial nerve at the distal forearm
Posterior interosseous nerve
Radial nerve at the elbow
Median nerve at the elbow
Ulnar nerve at the mid forearm
Which one of the following is most likely given the image below?
Arachnoid cyst
Cavernous sinus meningioma
Craniopharyngioma
Giant MCA aneurysm
Pituitary macroadenoma
You have diagnosed your patient with a nerve entrapment and have decided to decompress the entrapped nerve. Which of the following procedures would be most appropriate for the majority of nerve entrapments?
Neuroplasty
Nerve transposition
Internal neurolysis
Neurorrhaphy
Nerve transfer
A 45-year-old man presents with sudden onsent headache, nausea, vomiting and visual disturbance. On examination he is apyrexial, hypotensive, and tachycardic but does not have neck stiffness or photophobia. Visual fields appear to be constricted on confrontation. CT head is abnormal therefore MRI is done. Which one of the following is appropriate acute management?
Dexamethasone
Formal visual field tests
Pituitary profile and start empirical intra- venous hydrocortisone
Lumbar puncture
Transsphenoidal surgery
A 40-year-old ex-IV drug abuser presents to the emergency room with a seizure. CT head with contrast shows 3 cm diameter ring enhancing lesion periventricular location. MRI is performed and the lesion is bright on DWI and dark on ADC map. Which one of the following would be the appropri- ate next step in management?
Blood cultures and external ventricular drain then start intravenous antibiotics
Craniotomy and excision of abscess then start intravenous antibiotics
Image-guided aspiration of abscess then start intravenous antibiotics
Endoscopic aspiration and irrigation
Real-time ultrasound-guided excision of abscess and start intravenous antibiotics
Which one of the following is most likely based on the MRI shown ?
Blake's pouch cyst
Chiari III malformation
Dandy-Walker Malformation
Joubert's syndrome
Mega cysterna magna
A 9-year-old is brought into the emergency room lethargic with a stiff neck and fever. Despite aggressive therapy in the ITU the child dies. Postmortem evaluation reveals that the child had primary amoebic meningoen- cephalitis. This condition is usually acquired through which one of the following means?
Animal bites
Drinking contaminated water
Eating contaminated meat
Freshwater swimming
IV drug abuse
A 55-year-old man presents to your office with difficulty ambulating and buttoning his shirt. It started 2 years ago but has worsened significantly over the last year. On physical exam he is unable to perform a tandem gait and has a positive Hoffman's sign bilaterally, however he has no ankle clonus and flexor plantars bilaterally. He has 4/5 strength in his hands, but 5/5 strength in all other muscle groups. Sagittal MRI is shown. Which one of the following is the most appropriate next step in management?
C3-C6 laminectomy with lateral mass screw fixation
C3-C6 ACDF without instrumentation
Cervical epidural steroid injection
C3-C6 laminectomy
C3-C6 bilateral foraminotomies
A 27-year-old man presents to his primary care doctor with a low-grade fever, headache, and neck stiffness, which have become more both- ersome over the past 1-2 weeks. Serum is pos- itive for Borrelia burgdorferi IgM. CSF polymerase chain reaction (PCR) is also positive for this organism. The cranial nerve most commonly affected in this disease is most likely?
Abducens nerve
Facial nerve
Glossopharyngeal nerve
Oculomotor nerve
Trigeminal nerve
A 30-year-old woman presents with progressive difficulty using her hands and gait dysfunction. She has pain in the back of her neck that radiates into her head. She notes pain and paraesthesias in both arms that are refractory to neuropathic pain medication. Her imaging is shown in the figures. What is the most appropriate initial surgical management ?
VP shunt
Cyst shunt
Suboccipital decompression
Cervical laminectomy and duraplasty
Cyst fenestration
A 19-year-old female is involved in a high-speed motor vehicle accident and sustained facial injuries from hitting the dashboard. She was GCS 4/15 at the scene and was intubated for transfer. Her pupils are reactive to light. CT head was performed as part of the trauma protocol but did not show any mass lesions or fractures. As this was an isolated head injury, a decision was made to wean sedation and assess neurology, but she remained unresponsive. CT is shown below. These are most likely indicative of which one of the following ?
Subarachnoid hemorrhage
Diffuse axonal injury
Cortical contusion
Global hypoxic brain damage
Cerebral venous sinus thrombosis
A 32-year-old recent immigrant from Southeast Asia presents with back pain and a new kyphotic deformity after tripping up in his flat. T1and T2 WMRI are shown. Which one of the following is most likely diagnosis?
Ankylosing spondylitis
Discitis
Multiple myeloma
Pyogenic vertebral osteomyelitis
Spinal tuberculosis
A 62-year-old with known metastatic renal cell cancer presents with unbearable back pain and lower extremity myelopathy after a fall. Her imaging is displayed in the accompanying figures. The best management strategy of this lesion would be:
Stereotactic radiosurgery
Kyphoplasty/Vertebroplasty followed by
radiotherapy
Conventional external beam radiotherapy
Laminectomy and resection of epidural disease followed by radiotherapy
Vertebrectomy with posterior stabilization followed by radiotherapy
The pathology sample shown here was taken from a 30 year-old woman with an incidental mass found on headache evaluation. Which of the following pathological hallmarks is demonstrated in the photomicrograph?
Pseudopalisading necrosis and microvascular proliferation
Meningothelial nests and whirls
Rosenthal fibers
Pseudorosettes
Homer Wright rosettes
An 8-year-old child with Down syndrome presents to the emergency department with decreased neck movements three days following an adenoidectomy and tonsillectomy. On examination, he is not in distress. He is afebrile and able to speak normally. His oral intake has been limited to small amounts of clear liquids. He is uncooperative, and so Kernig and Brudzinski signs cannot be assessed. What is the most likely diagnosis?
Eagle syndrome
Atlanto-axial subluxation
Velopharyngeal insufficiency
Meningitis
A 47-year-old diabetic woman presents with pain across her buttocks and bilateral lower extremities with ambulation, improved by leaning forward. She reports transient response to epidural injections and no response to NSAIDs and neuropathic pain medication. She has no neurologic deficit. Imaging is shown (figures). What intervention is most likely to best reduce her disability over 4 years ?
L4-5 laminectomy
L4-5 decompression and fusion
Bilateral L4-5 hemilaminotomies with preservation of midline structures
Long-term corticosteroids
L4-5 dynamic interspinous spacer placement
A 72-year-old male develops a worsening headache over the course of 3 weeks. There is no relevant past medical history, except for a minor head injury 6 weeks ago. On examination there is no focal deficit. CT head is shown. In the UK, which one of the following is the appropriate next management?
Twist drill craniotomy
Single burr hole with or without subdural drain
Human prothrombin complex concentrate
Dexamethasone 2 mg twice daily
Minicraniotomy and excision of membranes
A 55-year-old female with obesity presents for a right breast mass removal. She is considered for an erector spinae plane block that could potentially reduce her pain during and after surgery. The block is technically difficult to perform due to the patient's body habitus, but the proceduralist finally able to successfully place an ESP catheter. Which adverse effect is most likely to occur in this patient as a result of the ESP catheter placement?
Shortness of breath
Muscle rigidity
Severe hoarseness
Horner syndrome
Which of the following conditions is depicted in the magnetic resonance image (MRI) shown?
Holoprosencephaly
Schizencephaly
Polymicrogyria
Periventricular nodular heterotopia
Porencephaly
A 45-year-old man is involved in a high-speed road traffic accident and was GCS E2V3M4 at the scene. He was intubated and ventilated and transferred to a trauma center. En route, his left pupil became sluggish and mannitol was administered. CT head scan is shown. Given the scenario and type of injury shown, which one of the following is the LEAST appropriate indication for surgery according to current guidelines?
Midline shift greater than 5 mm
GCS score less than 9, with or without
ICP > 20 mmHg
Documented drop in GCS by 2 or more
points since injury
Asymmetric or fixed and dilated pupils
Thickness greater than 10 mm
A 36-year-old restrained driver presented after a motor vehicle collision. What is the classification of the spinal injury illustrated in the figure ?
Teardrop fracture
Fracture dislocation
Chance fracture
Compression fracture
Burst fracture
Which one of the following statements regarding the lesion shown is LEAST accurate ?
Pattern represents about 20% of cases
of moderate TBI cerebral contusions
Due to acceleration/deceleration injury
Associated with ascending transalar
herniation
Decompressive craniectomy would
require cutting the anterior falx
Cerebral edema usually peaks between
day 5 and 10
A sagittal, upright long-cassette radiograph is shown (figure) for a 54-year-old woman with a history of T12-L5 instrumented fusion 2 months ago who now presents with back and thigh pain. Which of the following diagnoses is most likely based on her history and imaging ?
Instrumentation failure
Flatback syndrome
Pseudarthrosis
Adjacent segment disease
Sagittal spinal imbalance
A 16-year-old male presented to his primary care provider with right earache and pus discharge for the past four days. He had flu one week ago after which his current symptoms developed. He was started on oral antibiotic therapy. After one week, he presents to the emergency department with neck rigidity and projectile vomiting for the past 2 hours. Computed tomography (CT) of the head reveals partial opacification of the mastoid air cells and leptomeningeal enhancement. What is the most likely diagnosis of this patient?
Sinusitis
Postauricular abscess
Mastoiditis
Acute otitis media
A 29-year-old is assaulted and is GCS E3V4M5 at the scene. On examination there is significant bruising to the right side of his head with a 5-cm laceration and does not appear to have any focal neurological deficit. He is awaiting a CT scan when you are told he is less responsive. On examination, he is GCS E2V3M4, his right pupil is dilated and on application of painful stimulus appears to only be moving his left side. Which one of the following is most likely to be responsible for these findings?
Transalar (transsphenoidal) herniation
Unilateral uncal herniation
Ascending transtentorial herniation
Tonsillar herniation through the foramen magnum
Subfalcine herniation
You are asked to see a 6-month-old infant who sustained a skull fracture after his older brother accidentally pulled down the flat screen TV that landed on the infant’s head. Follow-up CT scan is demonstrated below. What is the diagnosis?
Growing skull fracture
Arachnoid cyst
Intraparenchymal hemorrhage
Normal bone healing
According to randomized control trials of hemicraniectomy for malignant MCA infarction, what is the time frame for the performance of hemicraniectomy associated with reduced mortality?
48 hours
6 hours
12 hours
24 hours
3 hours
Which one of the following pathologies is most likely to give the appearances shown ?
Anterior communicating artery aneurysm
Basilar tip aneurysm
Posterior communicating artery aneurysm
Posterior inferior cerebellar artery aneurysm
Middle cerebral artery aneurysm
A 60-year-old male with type 2 diabetes presents with fever, back pain, and < 24 hours of acute onset 2/5 motor weakness in the lower extremities. Thoracic MRI (Figure 1) and CT (Figure 2) imaging is performed. What is the most appropriate management for this patient’s acute neurologic deficits ?
Thoracic laminectomy
Kyphoplasty
Corpectomy and instrumented fusion
Percutaneous aspiration
Antibiotic therapy and external orthosis
A 21-year-old female presented to the emergency department after a new-onset seizure. Before this, she was complaining of a severe headache with blurred vision for the last 2 days. Physical examination demonstrates a somnolent female with normal vitial signs and bilateral papilledema. She has mild weakness of her right face, arm, and leg. Computed tomographic (CT) imaging of the head without contrast and CT angiography of the brain with contrast are shown. Which of the following is the most appropriate treatment?
Intravenous (IV) antihypertensive
IV unfractionated heparin
Oral aspirin
Hematoma evacuation
IV corticosteroid
A 33-year-old man presents with spontaneous tinnitus and nausea. Which one of the following is most likely based on the imaging shown ?
Arteriovenous malformation
Cavernous angioma
Hemangioblastoma
Intracerebral hemorrhage
Medulloblastoma
What is the Fisher score in a patient with a 2 mm thick subarachnoid hemorrhage with no intraventricular or parenchymal extension?
V
I
IV
III
II
A 75-year-old man with a history of recent memory impairment is admitted with headache, confusion, and a left homonymous hemianopsia. There is no history of hypertension or malignancy. Non-contrast CT scan and GRE MRI are shown. Which one of the following is the most likely cause of this patient’s symptoms and signs
Multi-infarct dementia
Mycotic aneurysm
Amyloid angiopathy
Undiagnosed hypertension
Gliomatosis cerebri
Which one of the following is most likely given the image below ?
Arachnoid cyst
Cavernous sinus meningioma
Craniopharyngioma
Giant cavernous aneurysm
Pituitary macroadenoma
The North American Symptomatic Carotid Endarterectomy Trial (NASCET) reported the surgical results in patients who underwent carotid endarterectomy (CEA). According to the trial, what is the rate of perioperative permanent disabling stroke and death related to CEA?
<5%
10-15%
15-20%
20-25%
5-10%
A 37-year-old man presents with seizures. Which one of the following is NOT thought to increase risk of hemorrhage in this type of lesion ?
Deep venous drainage
Intranidal aneurysm
Prior hemorrhage
Single draining vein
Smoking
A 27-year-old presents with a generalized tonic-clonic seizure. On examination there is no residual neurological deficit or speech disturbance. Some spots of calcification are seen on CT therefore MRI is performed. Which one of the following statements regarding this type of tumor is LEAST accurate?
Functional mapping is a perquisite for resection
MRS findings may include increased 2-hydroxyglutarate
Prognosis is related to extent of resection
The majority of patients with dominant hemisphere lesions of this type presentwith seizures
Tumor margins are usually seen best on T1+gad MRI sequences
What factor is most predictive of postoperative intracerebral hemorhage after carotid endarterectomy?
Calcified plaque
Length of stenosis
Female sex
Cerebral hypoperfusion
Young age
Which one of the following pathologies is most likely demonstrated by the angiogram ?
Anterior choroidal artery aneurysm
Basilar tip aneurysm
MCA bifurcation
PCA aneurysm
Supraophthalmic aneurysm
Which one of the following clinical findings would you look for in this patient ?
Abducens palsy
Absent corneal reflex
Bitemporal hemianopia
Oculomotor palsy
Pituitary dysfunction
You are evaluating a 45-year-old man who experienced a first-time seizure; subsequent MRI was performed and is demonstrated below. What would be useful during surgical resection of this mass?
Motor mapping
Awake language mapping
Somatosensory evoked potentials
EMG
Which one of the following mechanisms is most likely responsible for the finding in the angiogram ?
Connective tissue disorder
Infection
Traumatic dissection
Neoplasia
Toxin
A 26-year-old male presents after a motor vehicle crash with absent right and partially preserved left lower extremity motor function (more than half of left leg muscles have less than antigravity strength). Sensation to pain and temperature is markedly diminished in the left leg. Proprioception is markedly diminished in the right leg. Neuroimaging studies are obtained and depicted in Figures 1 and 2. Which spinal cord syndrome BEST describes the injury?
Brown-Sequard
Central cord
Anterior spinal
Cauda equina
Posterior cord
A 44 year old man with a history of blunt head trauma 4 days earlier presents with a progressively pulsatile exophthalmus, headache, and double vision. A CT head performed after his initial trauma was normal. What is the most appropriate treatment for this condition?
Urgent endovascular repair
Craniotomy for open repair
Delayed endovascular repair
Radiation
A trial of manual direct compression of cervical carotid 3-4x daily
A 66-year-old woman presents to your clinic with a first-time seizure and an MRI was performed which is demonstrated below. What is the next best step?
Total spine MRI
CT chest, abdomen, and pelvis
Gamma knife
Whole brain radiation
The following appearances are seen during endovascular treatment of an anterior communicating artery aneurysm. What is the next appropriate management step ?
Ask the anesthetist to reduce systolic
blood pressure to 100 mmHg
Check pupillary reflexes and perform CT head
Continue with endovascular
treatment
ICP monitoringn
Insertion of external ventricular drai
What are the standard radiographic criteria for ventriculomegaly in order to diagnose hydrocephalus?
Frontal horns are >20% of the brain width
Frontal horns are >30% of the brain width
Temporal horns width > 1 mm
Frontal horns are >50% of brain width
Temporal horns width >0.5 mm
Placement of lumbar pedicle screws at L3 and L4 level should use which one of the following entry points ?
The site where the transverse process joins the superior articular process just lateral to the pars interarticularis
The site where the lamina joins the superior articular process just lateral to the pars interarticularis
The site where the transverse process joins the inferior articular process just lateral to the pars interarticularis
The site where the lamina joins the inferior articular process just lateral to the pars interarticularis
The pars interarticularis
You are evaluating a 33-year-old man who experienced a first-time seizure; subsequent MRI was performed and is demonstrated below. If you decided to operate on this patient, what operative adjunct would be useful in this case?
Motor mapping
Diffusion tensor imaging
Awake language mapping
Somatosensory evoked potentials
EMG
After invasive grid monitoring and mapping of eloquent cortex, surgical resection is recommended for a 19-year-old man with drug-resistant epilepsy. The patient’s seizures involve speech arrest with tonic posturing of the upper extremities in a “fencing posture.” Where is the likely seizure focus ?
Primary motor cortex
Supplementary motor area
Primary sensory cortex
Mesial temporal lobe
Lateral temporal lobe
The primary goal of dynamic stabilization techniques in the spine is best described as which one of the following ?
Produce less stress on adjacent vertebral segments
Reduce implant failure
Reduce motion between segments compared to currently available constructs
Increase the rate of spinal arthrodesis
Avoid the need for pedicle screw placement
A patient presented to your clinic for treatment of a low-flow indirect carotid cavernous fistula. You are performing the exposure for a direct cannulation of the superior ophthalmic vein. You have made your superior sulcus incision and opened the orbicularis oculi and orbital septum. You are unable to identify the superior ophthalmic vein, even after tracing back the supraorbital vein. What is the next best operative step?
Discontinue the operation. I will not be possible to cannulate the superior ophthalmic vein in this scenario
Perform a lateral orbitotomy to expose the superior ophthalmic vein in the lateral orbital wall
Continue aggressive dissection within the orbital fat pad to identify the superior ophthalmic vein
Make an additional eyebrow incision to facilitate an orbitofrontal bone flap. The superior ophthalmic vein will be identified running immediately under the superior rectus muscle
A 55-year-old man presents with a 3-month history of progressive right hemiparesis. A contrast-enhanced magnetic resonance image of the brain was obtained in the emergency room and is shown here. What is the most likely diagnosis for the lesion shown?
Meningioma
Glioblastoma
Central nervous system(CNS) lymphoma
Ependymoma
Metastasis
The spinal construct shown below would most likely have been used for which one of the following ?
Basilar invagination in
rheumatoid arthritis
C3 vertebral body metastasis
Hangman fracture
Jefferson fracture
Type II odontoid peg fracture
When counseling a patient regarding temporal lobectomy for temporal lobe epilepsy, what is the most consistent and important predictor of a very favorable outcome after surgery ?
Duration of epilepsy 20 years
Confirmation of laterality based on invasive monitoring
Male gender
Greater than 50 years old
Absence of generalized seizures preoperatively
Site of entry for thoracic pedicle screw is best described as which one of the following ?
Where the facet joint and transverse process intersect
Where the pars interarticularis and lamina intersect
Where the superior facet and lamina intersect
Where the inferior facet and lamina intersect
Where the transverse process and lamina intersect
A 14-year-old male presents with a 9 cm, highly vascular mass centered in the posterior nasal cavity and sphenopalatine foramen invading the infratemporal fossa (ITF), middle cranial fossa, and cavernous sinus. Staged surgical resection is being planned. Which of the following is the best imaging modality to evaluate this patient's vascular anatomy for preoperative planning?
CT angiography (CTA)
MR angiography (MRA)
Angiography
Doppler ultrasound
A 65-year-old presents with difficulty initiating movements, rigidity, and a mild resting tremor. Which of the following neurotransmitters is likely deficient in this patient ?
Norepinephrine
Acetylcholine
Serotonin
GABA
Dopamine
EMG abnormalities in which one of the following muscles is LEAST specific for C5 radiculopathy?
Infraspinatus
Levator scapulae
Pronator teres
Rhomboids
Supraspinatus
Which one of the following is most likely based on the MRI shown ?
Basilar invagination
Corpus callosum agenesis
Hydrocephalus
Lissencephaly
Type II Chiari malformation
A 6-year-old boy is brought to the emergency department by his parents for 3 weeks of headache, 2 weeks of increasing ataxia, and 2 days of headache and vomiting. A magnetic resonance image is obtained, and postcontrast T1 sagittal imaging is shown. Based on the most likely diagnosis, which of the following is the best first treatment?
Intravenous antibiotics
Surgical resection
Embolization
Intravenous chemotherapy
Craniospinal radiation
MRI shows the appearances below, and the lesion is bright on T2WI and dark on fat suppression sequences and does not show any contrast enhancement. Which one of the following is most likely ?
Colloid cyst
Craniopharyngioma
Intracranial lipoma
Intraventricular hemorrhage
Pericallosal aneurysm
Which one of the following is most likely based on the MRI shown ?
Blake’s pouch cyst
Chiari III malformation
Dandy–Walker malformation
Joubert’s syndrome
Mega cisterna magna
Which one of the following is most likely based on the MRI shown?
Arachnoid cyst
Dandy–Walker variant
Epidermoid cyst
Medulloblastoma
Type II Chiari malformation
A child undergoes MRI scan as part of epilepsy evaluation after two seizures unrelated to febrile episodes. There are no symptoms of hydrocephalus. MRI appearances are shown, and there is no diffusion restriction. Which one of the following is most likely ?
Arachnoid cyst
Dandy–Walker malformation
Epidermoid cyst
Mega cisterna magna
Type III Chiari malformation
Which one of the following is most likely based on the imaging shown below ?
Lissencephaly with band
heterotopia
Porencephalic cyst
Pachygyria
Schizencephaly
Semilobar
holoprosencephaly
A 24-year-old man has refractory complex partial seizures localized to the left temporal lobe with EEG. MRI is consistent with left mesial temporal sclerosis. What is the most appropriate next step in his management ?
Vagal nerve stimulation
Corpus callosotomy
Intracarotid amytal test (WADA test)
Temporal lobectomy
Invasive EEG monitoring
Which one of the following is most likely based on the imaging shown below ?
Atretic cephalocele
Encephalocele
(meningoencephalocele)
Gliocle
Meningocele
Meningoencephalocystocele
A newborn infant has an apneic event with cyanosis and he was brought to the hospital. His evaluation was remarkable for developmental delay, bilateral lower-extremity frog-leg flaccid paralysis, with a large open defect in his lower back. At birth, the defect was covered by a transparent membrane, which subsequently ruptured and drained clear fluid for several weeks. Based on the imaging below, what is the cause of the infant’s apneic events ?
Dermal sinus tract
Dorsal enteric fistula
Lipomyelomeningocele
Myelocele
Type II Chiari malformation
A 63-year-old woman with Parkinson disease undergoes unilateral deep brain stimulator (DBS) electrode implantation. Three months later, she returns to the office with redness, pain, swelling, and purulence from the cranial incision. Culture grows methicillin-sensitive Staphylococcus aureus. What is the most appropriate management ?
Removal of the implantable pulse generator (IPG) only
Removal of the intracranial lead only
Removal of the entire hardware system with antibiotics
Removal of the implantable pulse generator (IPG) and extension with antibiotics
Antibiotics only
A 4 year-old boy with a history of congenital hydrocephalus and VP shunt placement near birthpresented one week following proximal shunt revision with lethargy, fevers to 38.4 C and erythema along the shunt tract. He underwent complete removal of the VP shunt system and placement of an external ventricular drain. CSF cultures grow MSSA and the patient is started on intravenous oxacillin, when should the shunt be replaced?
After 21 days of negative CSF cultures
After 3 days of negative CSF cultures
After 1 day of negative CSF cultures
After 5 days of negative CSF cultures
After 10 days of negative CSF cultures
You plan to perform a foramen magnum decompression on the patient shown below. Which one of the following investigations may be helpful ?
CSF flow study
CT cisternography
CT cervical angiogram
Flexion/extension X-rays
Nerve conduction studies
A 36-year-old man presents with a 1-year history of gradual bilateral hearing loss, a sense of aural fullness, and progressively impaired balance. He has a history of juvenile cataracts, and his brother and father have similar difficulties with their hearing. A brain magnetic resonance image (MRI) with contrast is shown. Which of the following is the most likely cause of his symptoms?
Medulloblastoma
Leptomeningeal metastases from unknown primary tumor
Bilateral vestibular schwannomas
Glioblastoma
Meningioma
A 6-month-old girl with a lipomyelomeningocele is undergoing surgical detethering of their lumbar lipoma, filum sectioning, arachnoid adhesion lysis, and aggressive debulking of the intradural lipoma to the margins of the neural placode. What is the next surgical step?
Further lipoma resection until a gross total resection is achieved
Patch-graft duraplasty
Primary dural closure with an absorbable, braided suture
Primary dural closure with a nonabsorbable monofilament suture
Pial closure and tubularization of the placode/distal cord
What is the most common side effect of vagus nerve stimulation ?
Dyspnea
Dyspepsia
Wound infection
Voice hoarseness
Cardiac arrhythmia
A 54-year-old male had a good result from left-sided thalamotomy for essential tremor 10 years ago. He now wishes to have his other side treated. What is the MOST appropriate surgical procedure for his contralateral side ?
Subthalamic DBS
Thalamic DBS
Pallidotomy
Pallidal DBS
Thalamotomy
A 56-year-old female presents with neck pain worsened by activity over the last 6 months. On examination, she has full power bilaterally in the upper and lower extremities. She has a normal gait and no difficulties with manual dexterity. Which one of the following is the most appropriate next step in management?
Posterior laminectomy C5-C7
Physiotherapy
Cervical epidural injection
C5/C6 ACDF
C5/C6 foraminotomy
An 8-year-old boy with cerebral palsy and spastic quadriparesis presents to the emergency room with excessive somnolence. His baclofen pump was adjusted earlier today and his mother notes that he has remarkably little tone now. What is the best pharmacological treatment option ?
Naloxone
Physostigmine
Baclofen
Atropine
Flumazenil
During a pterional exposure of the sylvian fissure, you encounter significant brain swelling. In order to achieve rapid brain relaxation, identify the most appropriate point on the associated figure through which to place a ventriculosotomy and access the frontal horn of the lateral ventricle.
1
2
3
4
5
An ultrasound of a 29-year-old pregnant woman reveals a lumbar myelomeningocele in the fetus. What is the primary difference in outcome for fetal myelomeningocele repair as opposed to post-natal repair?
The chance of maternal pregnancy complications is not affected
The odds of walking without devices or braces decreases
The likelihood of premature birth is not affected
The risk of symptomatic hindbrain herniation increases
The rate of shunt placement for hydrocephalus decreases
A 33-year-old woman with no neurological history complains of subtle left upper extremity weakness without headache or other symptoms. She is noted to have a mild left hemiparesis and otherwise normal neurological examination. EEG is normal. The MR scan is shown (figure). A stereotactic biopsy yields no evidence of glioma. What is the most likely diagnosis ?
Progressive multifocal leukoencephalopathy
Lymphoma
Demyelinating plaque
Glioblastoma multiforme
Subacute sclerosing panencephalitis
A 37-year-old man presents with worsening low back pain and right L5 radicular pain and a normal examination. Lumbar spine MRI (Figure 1) and CT (Figure 2) are shown. Work-up revealed this solitary lesion. What is the most appropriate next step in management ?
External beam radiotherapy
Observation with serial imaging
Surgical excision and stabilization
Open surgical biopsy
CT-guided biopsy
Histopathology of a cerebellopontine angle tumor is shown in the figures below. The findings are most consistent with what type of pathology ?
Psammomatous meningioma
Endolymphatic sac tumor
Choroid plexus papilloma
Schwannoma
Cholesteatoma
A 45-year-old male presents with several months of progressive headaches and an intracranial lesion (figure). Following surgical resection, histopathological analysis demonstrates a well-circumscribed, uniformly cellular tumor with no atypia and numerous ectatic, thin-walled branching vessels in staghorn configurations. Which of the following is a possible associated clinical development ?
Pheochromocytoma
Metastases outside the CNS
Bilateral vestibular schwannomas
Unilateral optic nerve glioma
De novo glioblastoma
A 34-year-old male presents with a several month history of neck pain, with intermittent episodes of arm and leg numbness. MRI is shown. Which one of the following is most likely?
Ependymoma
Ganglioglioma
Meningioma
Neurofibroma
Schwannoma
A 54-year-old man presents with biopsy-proven esthesioneuroblastoma and has a normal neurological exam. MRI shows involvement of the right nasal cavity with minimal intracranial extension through the cribriform plate (Figure 1). There is no cervical adenopathy or evidence of metastatic disease. Which of the following is the best management strategy for this patient ?
Neo-adjuvant radiation therapy followed by
chemotherapy
Surgical resection followed by conformal
radiation therapy to the tumor bed
Surgical resection followed by conformal
radiation therapy to the tumor bed and
systemic chemotherapy
Chemotherapy alone
Surgical resection
A 75-year-old healthy woman suffered a fall 3 months ago and immediately noticed neck pain. She has been treating her pain with over-the-counter medications, but the pain continues to worsen over time. On exam, she has no focal deficits. X-ray (Figure 1) and CT (Figure 2) are depicted. What is the optimal management for this patient ?
Odontoid screw placement
Cervical collar
C1–2 posterior fusion
Occipital–cervical fusion
Halo-vest placement
Which of the following answers most appropriately pairs a sign or symptom of hydrocephalus (or shunt malfunction in the setting of a patient with a shunt) and an appropriate age or patient population?
Adult – suture splaying
Child – tense fontanel
Infant – visual loss
Adult – progressive macrocephaly
Child – decline in IQ or school performance
A 47-year-old woman presented with a first seizure and underwent magnetic resonance imaging of the brain with multi-voxel spectroscopy. The spectroscopy shown in Figure 1 is most consistent with what diagnosis ?
Bacterial abscess
Meningioma
Toxoplasmosis
Glial neoplasm
Demyelinating plaque
What is the most likely craniosynostosis adepicted in this image?
Bilateral Coronal synostosis
Cloverleaf (Kleeblattschadel)
Lambdoid synostosis
Metopic synostosis
Sagittal synostosis
A 16-year-old boy presents with headaches, nausea, and blurred vision. His neurological examination is remarkable for impaired upgaze and convergence nystagmus. Contrast-enhanced MRI of the brain is shown (figure). Serum beta-HCG and alpha-fetoprotein levels are normal. What is the most likely diagnosis ?
Endodermal sinus tumor
Embryonal carcinoma
Germinoma
Choriocarcinoma
Meningioma
A 12-year-old male presents to the emergency department with a new-onset headache and blurry vision for 6 hours. The patient denies a history of prior seizures. Past medical history includes a right-hand corrective surgery for polydactyly at eight months of age. The neurological examination reveals no abnormalities. CT head without contrast shows a mass in the suprasellar region. MRI of the brain further confirms the presence of a hypothalamic hamartoma. A rare genetic disorder is suspected. Which of the following best describes the patient's clinical syndrome?
Pallister-Hall syndrome
Greig cephalopolysyndactyly syndrome
Oral-facial-digital syndrome
Acrocallosal syndrome
A 58-year-old right-handed male presents with bifrontal headaches and a partial left ophthalmoplegia. MRI results are shown. Biopsy revealed this tumor to be a chordoma. An extensive subtotal skull-based resection was performed. Which is the best choice for adjuvant therapy regimen ?
Stereotactic radiosurgery
Procarbazine, CCNU and vincristine (PCV)
chemotherapy
Conventional fractionated radiotherapy
Proton beam radiotherapy
Brachytherapy
A 12-year-old boy presents complaining of left eye visual loss and occasional headache. Endocrine evaluation reveals the presence of mild diabetes insipidus and hypothyroidism. His MRI is shown in Figure 1 & 2. You recommend an attempt at complete tumor resection. Which of the following is the most likely surgical complication ?
Seizure disorder
Mutism
Hydrocephalus
Pan-hypopituitarism
Blindness
Which one of the following is most likely based on the imaging shown?
Alobar holoprosencephaly
Anencephaly
Dandy-Walker malformation
Porencephalic cyst
Schizencephaly
A 10-year-old boy presents with headache and imbalance. Examination discloses mild papilledema, right-sided dysmetria, and ataxia. MRI with contrast is shown in the figure. What is the most important prognostic factor for this patient ?
The presence of endothelial proliferation
on histology
The extent of resection of the cyst walls
The presence of hydrocephalus at
presentation
The extent of resection of the enhancing
mass
The presence of mitoses on histology
A 9-year-old girl presents with headache and vomiting. On examination there is bilateral papilledema but she is otherwise neurologically stable. MRI is performed. Which one of the following is the next appropriate step?
ICP monitoring
Lumbar puncture
Serum AFP and HCG
External ventricular drain
Endoscopic third ventriculostomy and biopsy of lesion
A 76 year-old undergoes a craniotomy for evacuation of a subdural hematoma. Three days later, the patient is noted to have increased confusion and a heart rate of 102 bpm. His blood pressure is 83/52, and his respiratory rate is 31 breaths per minute. The nurse measures a temperature of 38.5 degrees C. He has coarse breath sounds and his urine output was 15cc/hr over the prior 6 hours. His symptoms do not respond to a saline bolus. What is the most appropriate next step?
Send blood cultures and start broad spectrum antibiotics
Obtain EKG and send cardiac enzymes
Obtain a CT chest to rule out pulmonary embolus
Administer a diuretic
Send the patient for a STAT repeat head CT
An 8-month-old female child who previously fell from a changing table. She presented on referral from her pediatrician for evaluation of a left frontoparietal mass. Which one of the following management strategies is most appropriate?
Cranioplasty
Conservative management
Dural repair
Duraplasty and autologous cranioplasty
Head bandage
A 30-year-old male is brought to the emergency department after a motor vehicle crash. His Glasgow Coma Scale score is 13. He begins to have seizure activity in the emergency department and the seizure is continuing after several minutes. What is the pharmacologic treatment of choice for the seizure?
Pancuronium
Paraldehyde
Phenobarbital
Phenytoin
Lorazepam
A 58-year-old male who sustained traumatic fractures to the upper cervical spine following a motor vehicle accident. After a detailed evaluation of the fracture characteristics and imaging studies, you recommend posterior instrumentation and fusion from the occiput to C2. The patient asks you how would this affect his range of motion. You should inform him that he would probably experience which one of the following?
A decrease in cervical spine rotation of 50%.
A decrease in cervical spine flexion-extension of 50%.
Decrease of cervical spine rotation of 50% and a decrease of cervical spine flexion-extension of 50%.
Decrease of cervical spine rotation of 50% and a decrease of cervical spine flexion-extension of 10%.
A 47 year old man presents with confusion, agitation, fatigue, fever (104F), hyponatremia, hypoglycemia, and hypotension after resection of a right frontal metastasis lesion 3 weeks ago. Phenytoin and steroids were discontinued at 2.5 weeks post-operatively. Head CT reveals no acute abnormality. What is the most appropriate management of this patient?
Heparin
Fosphenytoin
Fludricortisone
Haloperidol
Hydrocortisone
The lesion marked by the arrows in the following MRI will most likely cause
Subarachnoid hemorrhage
Gelastic seizures
Absence seizures
Panhypopituitarism
Metastasis
A 78-year-old man with a 10-year history of intermittent chronic neck pain has cervical spine X-rays (Figure 1) and MRI (Figure 2). The patient denies any current neck pain, radiculopathy, or subjective symptoms of myelopathy. His exam is normal. What is the recommended management for this patient?
Clinical observation
Immobilization with cervical collar
High-dose steroids and cervical traction
Surgery
Serial MRI
A sagittal, upright long-cassette radiograph is shown (figure) for a 54-year-old woman with a history of T12-L5 instrumented fusion 2 months ago who now presents with back and thigh pain. Which of the following diagnoses is most likely based on her history and imaging?
Adjacent segment disease
Instrumentation failure
Flatback syndrome
Pseudarthrosis
Sagittal spinal imbalance
What finding is more frequently associated with nasal and occipital dermoid cysts compared to other locations ?
Intracranial extension
Hydrocephalus
Superinfection
Cyst rupture
Malignant transformation
A frontal view digital subtraction angiogram following a right carotid artery injection is shown in this image. What is the likely etiology of the lesion demonstrated?
Atherosclerosis
Immune vasculitis
Congenital
Endocarditis
Which one of the following statements regarding moderate traumatic brain injury is LEAST accurate?
Include head injuries with GCS 9-13
30% chance of having a brain lesion (intra- or extra-axial)
Mortality is around 30%
Account for 5-7% of head injury attendances in the emergency department
Includes patients who “talk and die”
A 12-year-old African-American male with a history of asthma presents with fever, lethargy, seizure activity, and left hemiparesis. Inflammatory markers are elevated. After stabilization, a CT head with contrast is obtained (figure). What is the most appropriate next step in management ?
Bedside subdural drain
Craniotomy / craniectomy
Sinus surgery
Lumbar puncture
Burrholes
What anatomic structure is indicated by the arrow in this image?
Oculomotor nerve
Trochlear nerve
Trigeminal nerve
Abducens nerve
Glossopharyngeal nerve
A 4-year-old boy presents with progressive gait dysfunction, headache, and vomiting. A CT shows hyperdense areas suggestive of calcification. The MRI is shown (figures). What is the most likely diagnosis ?
Atypical teratoid / rhabdoid tumor (AT/RT)
Medulloblastoma
Choroid plexus papilloma
Ependymoma
Pilocytic astrocytoma
A 29-year-old is assaulted and is GCS E3V4M5 at the scene. On examination there is significant bruising to the right side of his head with a 5-cm laceration and does not appear to have any focal neurological deficit. He is awaiting a CT scan when you are told he is less responsive. On examination, he is GCS E2V3M4, his right pupil is dilated and on application of painful stimulus appears to only to be moving his left side. Which one of the following is most likely to be responsible for these findings?
Transalar (transsphenoidal) herniation
Unilateral uncal herniation
Ascending transtentorial herniation
Tonsillar herniation through the foramen magnum
Subfalcine herniation
A patient is in coma with the respiratory pattern shown in this image. Where is the patient’s lesion?
Diencephalon or bilateral cerebral hemispheres
Nonorganic (psychogenic origin)
Superior medulla or inferior pons
Superior pons
Medulla
An 8-year old child is brought to the emergency department after being struck by a car while crossing the street. He is not alert. He required immediate intubation at the scene by emergency management services. His Glasgow coma scale is 8. He appears to have a significant laceration of his scalp on the left side, but there are no skeletal fractures. The initial chest x-ray reveals a right-side pneumothorax. A chest tube was inserted. His hematocrit is 30%, and his hemoglobin is 10.6 g/dL. Heart rate is 100 bpm, blood pressure 100/60 mmHg, and respirations 20/minute. What is the next step in management?
CT of the head, thorax, and abdomen
Repeat chest x-ray
Repeat blood work
MRI of the head and neck
A 6-month-old infant presents with enlarging head circumference, full anterior fontanelle, splitting of the cranial sutures and developmental delay. The results of a neurological examination are otherwise normal. Computed tomographic scans are obtained (Figures 1 and 2). What is the most likely diagnosis ?
Aqueductal stenosis
Chiari III malformation
Dandy-Walker malformation
Retrocerebellar arachnoid cyst
An 8-year-old female presented with symptoms of persistent headaches, nausea, and emesis for 1 week. The patient was somewhat lethargic and was noted to have a mild left hemiparesis on examination. Axial contrasted Tl-weighted MRI illustrates what abnormality?
Pilocytic astrocytoma
Subependymoma
Choroid plexus papilloma
Hemangioblastoma
Medulloblastoma
What is the most appropriate initial management of newly-diagnosed primary CNS lymphoma in an immunocompetent patient?
IV methotrexate
Intrathecal cytarabine
Gross total resection
Stereotactic radiosurgery
Oral temozolomide
A 7-year-old female presents with worsening gait disturbance and upper back pain. A spinal MRI is shown. After surgical exposure, frozen specimen analysis suggests juvenile pilocytic astrocytoma. What is the next best step in intraoperative management ?
Internal debulking and resection until the normal-abnormal boundary is indistinct
Multiple sample biopsies for diagnostic confirmation
Divide dentate ligaments to permit spinal cord rotation
Gross total resection along the tumor capsule
Duraplasty and laminoplasty with no further tumor resection
What abnormality is depicted on the following unenhanced sagittal Tl-weighted MRI
Pituitary adenoma
Rathke's cleft cyst
Meningioma
Chordoma
Fibrous dysplasia
On histopathology, central neurocytoma has strong positivity with which stain?
S100
Vimentin
EMA
Synapthophysin
GFAP
A 19-year-old male presents with tussive headaches located at the posterior base of the skull. Neurologic examination reveals weakness of the hands bilaterally with hypesthesia. MR of the brain and cervical spine are shown in the figures. What is the best initial management strategy for this presentation?
Posterior fossa decompression
Anterior transoral odontoid resection
Ventriculoperitoneal shunt
Syringo-subarachnoid shunt
Posterior cervical decompression
34-year-old male presents with increasing neck and back pain, quadriparesis, and bowel and bladder incontinence. His MRl is depicted below. These lesions most likely represent
Spinal ependymomas
Spinal schwannomas
Spinal neurofibromas
Spinal meningiomas
Metastatic disease
A 52 y/o restrained driver presented after a motor vehicle accident with an L2 sensory level, 4/5 strength in his proximal and 4-/5 strength in his distal lower extremities and a severe L2 fracture. What is this patient's ASIA Impairment Scale score (modified Frankel score)?
D
B
E
C
A
An 8-month-old infant was sent for imaging (figures) by his pediatrician because of irritability, poor feeding, and macrocephaly with a bulging fontanel. The preceding pregnancy and delivery had been unremarkable. The infant had been well up until this presentation, and review of systems was noncontributory. What additional diagnostic investigation is indicated ?
Pyloric ultrasound
Measurement of parents' head circumferences
Blood lead level
Dilated funduscopic examination
Urine amino acids
An 8-year-old child with a history of myelomeningocele repair after birth presents with progressive leg weakness and a neurogenic bladder.
An MRI of lumbar spine, shown in this image, suggests:
Syringomyelia secondary to a tethered spinal cord
Idiopathic syringomyelia
Spinal lipoma
Dermoid tumor
Thickened filum terminale
An asymptmatic 2-year-old child with macrocephaly has the finding seen on CT (Figure 1). He has no signs or symptoms of increased intracranial pressure. Six months later, a routine follow-up MRI is obtained (Figure 2) and repeat testing reveals mild developmental delay and early papilledema. There is no diffusion restriction. What is the most likely diagnosis?
Astrocytoma
Epidermoid
Abscess
Encephalomalacia
Arachnoid cyst
A patient who was shunted for hydrocephalus after intracerebral hemorrhage presents with severe headaches. Head CT is shown. What is the most likely diagnosis ?
New intracranial hemorrhage
Shunt malfunction
Overdrainage
Shunt infection
Post-hemorrhagic headache syndrome
A 4-week-old, 26-week premature infant presents with a Grade IV intraventricular hemorrhage and posthemorrhagic hydrocephalus (Figure 1). Examination reveals stable vital signs, normal head circumference growth curve, and soft anterior fontanelle. Weight is 1.2 kg. What is the best initial management of the hydrocephalus ?
Placement of a ventricular reservoir
Serial lumbar punctures
Placement of external ventricular drain
Creation of a permanent ventriculoperitoneal shunt
Serial cranial ultrasounds with daily head circumference measurements
An 8-year-old boy was evaluated due to short stature and headaches. Sagittal MRI with contrast (figure) is most consistent with what diagnosis ?
Arachnoid cyst
Medulloblastoma
Germinoma
Craniopharyngioma
Pituitary macroadenoma
A 50-year-old patient has a history of right-sided hemiparesis and recurrent seizures. On examination, he has a port-wine stain in the left V1 and V2 distribution. What is the most likely diagnosis ?
Encephalotrigeminal angiomatosis
Tuberculosis with leptomeningeal involvement
Meningioangiomatosis
Neurocutaneous melanosis
Hemorrhagic hereditary telangiectasia (Rendu–Osler–Weber syndrome)
Of the following, which symptom, associated with advanced Parkinson disease and/or its long-term medical treatment, is most reliably controlled by the therapeutic lesion depicted in the magnetic resonance image shown in Figure 1 ?
Akinesia
Levodopa-induced dyskinesia
Tremor
Rigidity
Ataxia
A 50-year-old male patient with a history of atrial fibrillation presents with acute onset left hemiparesis and drowsiness for 24 hours. MRI of the brain is shown. The National Institute of Health Stroke Scale (NIHSS) score is 16. What treatment option has been shown to decrease mortality rates for such a patient ?
Decompressive hemicraniectomy
External ventricular drainage
Medical management only
Intra-arterial tPA
Mechanical thrombectomy
A 24-year-old pregnant woman in her third trimester presents with severe headache and a non-focal neurological examination. A head CT angiogram is shown. What is the most likely diagnosis ?
Aneurysmal subarachnoid hemorrhage
Eclampsia
Posterior reversible encephalopathy syndrome
Meningioma
Dural venous sinus thrombosis
A 61-year-old man presents with confusion. Susceptibility-weighted MR imaging demonstrates multiple abnormalities (figure). What is the most likely diagnosis ?
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy)
Hypertensive hemorrhages
Creutzfeldt–Jakob disease
Leptomeningeal carcinomatosis
Cerebral amyloid angiopathy
What neurological deficit may result from embolization of the artery with liquid embolics indicated on this angiogram ?
Loss of smell
Unilateral facial palsy
Contralateral hemiparesis
Blindness
Unilateral tongue atrophy
A 30-year-old female, 2 weeks post-partum, presents to the ED after 4 hours with acute onset right hemiplegia, lethargy, and left gaze deviation. Her NIHSS score is 24. Her angiogram is shown. What is the best management option ?
EC/IC bypass
Thrombectomy with stent-retrieval
I
V abciximab
Aspirin
IV tPA
A 44-year-old man presents with seizure, headache, and left visual field cut. MRI is shown. What is the most likely benefit of embolization for this lesion ?
Complete obliteration of the AVM
Decreased risk of rupture before further therapy
Improvement of vision
Reducing AVM volume for subsequent treatment
Decreased risk of seizures
Which vein is indicated by the arrow in the figure ?
Basal vein of Rosenthal
Vein of Galen
Internal cerebral vein
Vein of Trolard
Thalamostriate vein
A 54-year-old man presents with acute onset of right neck pain radiating to his jaw. He denies any other symptoms. His clinical findings are demonstrated on the photograph below. Which of the following would be the most appropriate imaging study to order ?
MRI of the brain and orbits
MRI of the cervical spine
CT angiogram of the neck
CT scan of the chest
CT angiogram of the head
A 38-year-old presents with a one-month history of difficulty swallowing, mild hoarseness, and right facial numbness and tingling. The imaging studies are shown below. What is the most likely diagnosis ?
Medulloblastoma
Capillary hemangioma
Arteriovenous malformation
PICA aneurysm
Cavernous angioma
An 80-year-old male presents with headache, confusion, and the accompanying MR imaging (figure). If the perfusion MRI demonstrates low relative cerebral blood flow, what is the most likely diagnosis?
Primary CNS lymphoma
Metastatic adenocarcinoma
Glioblastoma multiforme
Low grade glioma
ependymoma
A 62 year old with known metastatic renal cell cancer presents with unbearable back pain and lower extremity myelopathy after a fall. Her imaging is displayed in the accompanying figures. The best management strategy of this lesion would be:
Laminectomy and resection of epidural disease followed by radiotherapy
Conventional external beam radiotherapy
Stereotactic Radiosurgery
Vertebrectomy with posterior stabilization followed by radiotherapy
Kyphoplasty/Vertebroplasty followed by radiotherapy
A 47 year-old diabetic woman presents with pain across her buttocks and bilateral lower extremities with ambulation, improved by leaning forward. She reports transient response to epidural injections and no response to NSAIDs and neuropathic pain medication. She has no neurologic deficit. Imaging is shown (figures). What intervention is most likely to best reduce her disability over 4 years?
L4-5 decompression and fusion
L4-5 laminectomy
Bilateral L4-5 hemilaminotomies with preservation of midline structures
L4-5 dynamic interspinous spacer placement
Long term corticosteroids
A 37-year-old HIV positive male presents with headache, confusion, new right-sided weakness progressing over the previous week. He has been on highly active retroviral therapy for the last 10 years and not had any problems. On examination, his responses are slow and he has some difficulty sustaining attention. He has a right hemiparesis with increased reflexes on the right. FBC, U+E and CRP are normal. T1 contrast MRI is shown. Which one of the following organisms is the most likely cause?
Cryptococcus neoformans
Herpes zoster
Pneumocystic jerovecii
Toxoplasma gondii
Tuberculosis
A 29-year-old ex-IVDU who previously underwent aspiration of a brain abscess and prolonged inpatient antibiotic course re-presents after several generalized tonic- clonic seizures progressing into status epilepticus. Contrast CT head is shown. What is the next appropriate action?
Cerebral angiogram
Decompressive craniectomy
External ventricular drain
Lumbar drain
Palliative care
A 27-year-old immigrant from South America presents with a generalized seizure. After awakening, he relates that he has had two or three episodes of unexplained loss of consciousness in the past 2 years. He has otherwise been healthy and worked as a farmer. His examination is normal. MRI head was performed and T2 and T1+GAD images are shown. What is the most likely organism?
Histoplasma
Mucor
Schistosoma mansonii
Taenia solium
Toxoplasma gondii
An 8-year-old boy was evaluated due to short stature and headaches. Sagittal MRI with contrast (figure) is most consistent with what diagnosis?
Craniopharyngioma
Arachnoid cyst
Germinoma
Medulloblastoma
Pituitary macroadenoma
In a patient with the MRI shown in the figure, a tumor in what other location would increase the probability of germinoma?
Frontal lobe
Supersellar region
Orbit
Fourth ventricle
Brainstem
A 25 year old patient is involved in a motor vehicle accident and is intubated and sedated in the field before a complete neurological examination can be obtained. His non-contrast head CT is shown. (figure 1) What is the appropriate next step in management?
Obtain an urgent MRI with diffusion weighted imaging
Place an intracranial pressure monitor and admit to ICU
Take to the OR for an emergent craniotomy for evacuation of hematoma
Awaken the patient for neurological examination
MRI shows the appearances below, and the lesion is bright on T2WI and dark on fat sup- pression sequences and does not show any contrast enhancement. Which one of the following is most likely?
Colloid cyst
Craniopharyngioma
Intracranial lipoma
Intraventricular haemorrhage
Pericallosal aneurysm
A 9-year-old girl visits her optometrist because of a 1-month progressive history of blurry vision and headaches. The optometrist notes papilledema. Imaging is obtained. What course of action is indicated?
Endoscpic third ventriculostomy
LP shunt insertion
Stereotactic biopsy
Conformal radiation therapy
Lumbar puncture for cytology and markers
The current model of basal ganglia physiology suggests that the 'negative symptoms' of Parkinson disease (i.e., rigidity and bradykinesia) are attributable to which of the following physiological events:
Excessive glutamatergic input from the disinhibited subthalamic nucleus results in GPi hyperactivity.
The hyperactive GPi hyperinhibits the ventrolateral (VL) nucleus of the thalamus.
Inhibitory input to the globus pallidus pars internus (GPi) via the direct pathway from the striatum is decreased.
Glutamatergic input from the VL thalamus to the supplementary motor area is decrease
All of the above
A 38 year old male experiences severe acute right arm pain and then develops severe deltoid weakness and mild biceps and triceps weakness. After 6 weeks, he seeks consultation. Axial MRI imaging at C4-5 and C5-6 are shown. What is the next most appropriate step in management?
CT myelogram
EMG/NCS
ACDF C4-5 and C5-6
Cervical traction
Epidural steroid injection
You are seeing a patient with new onset foot drop and dorsal foot numbness and pain. You obtain the following MRI. What is the most likely diagnosis?
Intraneural ganglion cyst
Tibial nerve hematoma
Peroneal nerve schwannoma
Baker cyst
Tibulofibular joint dislocation
A 23 year-old man presents to the emergency department after an intoxicated fall and head injury. He has a moderate occipital headache and nausea without vomiting. On exam, the patient has normal vital signs and no focal neurological deficits. His non-contrast head CT is shown (Figure 1). The volume of the hematoma is measured to be 35 cm3. What is the most appropriate treatment for this patient?
Burr hole evacuation of hematoma
Posterior fossa craniotomy for evacuation of hematoma
Emobilization of the transverse sinus
External ventricular drain for CSF diversion and intracranial pressure monitoring
Close neurological monitoring with serial head CT imaging
The patient whose magnetic resonance image is shown in Figure 1 most likely underwent surgery to control which of the following symptoms associated with which disease:
Torticollis associated with cervical dystonia.
Tremor associated with Essential Tremor.
Levodopa-induced dyskinesia associated with Parkinson disease
Akinesia associated with Parkinson disease.
Rigidity associated with Parkinson disease.
A 21-year-old male presents to the emergency department after being involved in a gunfight. His GCS is 15 with a non-focal examination but several bullet holes are noted in his scalp with protruding cerebral tissue. His CT scan of the head is shown in the figure. What is the BEST definitive management strategy for this injury?
14 day course of antibiotics
Cranioplasty and removal of accessible fragments
Surgical removal of all bullet fragments
Bedside laceration repair
Surgical durotomy repair
A 17-year-old boy patient presents with left arm clumsiness. MRI is shown. Which one of the following is most likely?
Hemangioblastoma
Medulloblastoma
Neuroblastoma metastasis
Pilocytic astrocytoma
Vestibular schwannoma
A 15 year-old male presents with severe low back pain. The pain responds poorly to acetaminophen but responds well to aspirin. CT demonstrates a 1.5 cm dense lytic lesion with a calcified nidus and circumferential sclerosis (figure). What is the diagnosis?
Hemangioma
Osteoblastoma
Osteoid osteoma
Osteochondroma
Fibrous dysplasia
The axial noncontrast head CT (obtained for unrelated reasons) shown from an affected neonate results from which of the following deformities?
Sagittal synostosis
Bicoronal synostosis
Metopic synostosis
Unicoronal synostosis
Lambdoid synostosis
A 8-month-old infant was sent for imaging (figures) by his pediatrician because of irritability, poor feeding, and macrocephaly with a bulging fontanel. The preceding pregnancy and delivery had been unremarkable. The infant had been well up until this presentation, and review of systems was noncontributory. What additional diagnostic investigation is indicated?
Measurement of parents head circumferences
Urine amino acids
Blood lead level
Pyloric ultrasound
Dilated funduscopic examination
A patient initially presents after closed head injury with a GCS of 14. Head CT demonstrates a small amount of pneumocephalus. Two hours later, the patient becomes unresponsive (GCS 4). A repeat head CT is obtained (Fig. 1). What is the most appropriate next step in management?
Administer 1g/kg of mannitol
Repeat head CT with fine cuts to identify a basal skull fracture
Surgical evacuation of pneumocephalus
Lumbar puncture to rule out meningitis
Treatment with high flow oxygen
A 30-year-old male with no prior medical history presents with four days of rapidly progressive bilateral lower extremity weakness, reduced sensation below the level of the umbilicus, and urinary retention. See figure for MRI of the thoracic spine T2 and T1 with contrast. Spinal fluid evaluation including NMO IgG are unremarkable. Which of the following is the most effective first line management of this patient’s condition?
Supportive care including maintenance of MAP >80 mmHg
T10-T12 Laminectomy for spinal cord decompression
High dose intravenous glucocorticoid therapy
Interferon
Exicisional biopsy with subsequent radiation and chemotherapy
A 7-year-old child with a two week history of difficulty walking, dysarthric speech and facial weakness has the MRI shown in the figure. What is the most appropriate initial treatment?
Chemotherapy
Surgical debulking
Conformal radiotherapy
Whole-brain radiation
Gamma-knife
A 9-year-old male presented to his pediatrician with headaches and growth delay. He was found to have tumor in the region of the sella. Histology is shown. What is the most likely diagnosis:
Craniopharyngioma
Pilocytic astrocytoma
Colloid cyst
Pituitary adenoma
Hypothalamic hamartoma
Which one of the following pathologies is most likely demonstrated by the angiogram?
Anterior communicating artery aneurysm
Basilar artery aneurysm
Basilar invagination
Left PCA artery aneurysm
Superior hypophyseal artery aneurysm
Which one of the following pathologies is most likely to give the appearances shown?
Anterior communicating artery aneurysm
Basilar tip aneurysm
Posterior communicating artery aneurysm
Posterior inferior cerebellar artery aneurysm
Middle cerebral artery aneurysm
A 39-year-old female presents with subarachnoid hemorrhage. Her angiogram is shown. What is the most likely diagnosis?
Saccular Aneurysm
Blister aneurysm
Fusiform aneurysm
Sipraclinoid ICA dissection
Infundibulum
What neurological deficit may result from embolization of the artery with liquid embolics indicated on this angiogram?
Unilateral tongue atrophy
Loss of smell
Unilateral facial palsy
Blindness
Contralateral hemiparesis
A 19 year-old man presents after a helmeted ATV accident. On examination the patient is neurologically intact. He denies any midline tenderness. Trauma survey and labs are normal. What imaging test should be ordered before clearing his collar.
Cervical CT Scan
No Imaging
Cervical X-ray
Cervical CTA
Cervical MRI
A 33 year old woman with no neurological history complains of subtle left upper extremity weakness without headache or other symptoms. She is noted to have a mild left hemiparesis and otherwise normal neurological examination. EEG is normal. The MR scan is shown (figure). A stereotactic biopsy yields no evidence of glioma. What is the most likely diagnosis?
Subacute sclerosing panencephalitis
Demyelinating plaque
Progressive multifocal leukoencephalopathy
Lymphoma
Glioblastoma multiforme
An 11-month-old boy presents with macrocrania and failure to thrive. An MRI of the brain, shown in this image, confirms what likely type of hydrocephalus?
Communicating hydrocephalus
Obstructive hydrocephalus secondary to a Dandy-Walker malformation
Obstructive hydrocephalus secondary to aqueductal stenosis
Obstructive hydrocephalus secondary to a posterior fossa tumor
Obstructive hydrocephalus secondary to a vein of Galen aneurysm
A 68 year-old man undergoes resection of a GBM. Post-operative imaging is shown. He awakes from surgery with left arm numbness and mild weakness. What is the most likely cause of his new deficit?
Ischemia
Direct injury to neural structures
Edema
Seizure
Abscess
What is the best method to screen for cervical spine injury in the unconscious, intubated multitrauma patient?
A/P, Lateral, Oblique, and Open Mouth Odontoid radiographs
C-Spine MRI
Dynamic traction fluoroscopy
Fluoroscopic Flexion/Extension Imaging
C-spine CT
A 58 year-old man with history of lung adenocarcinoma presents with headaches. MRI of the brain shows 3 supratentorial lesions, the largest of which is shown (Figure). The patient undergoes stereotactic radiosurgery to each of the three lesions. Based on randomized controlled trials, how is the addition of whole brain radiation therapy likely to affect overall survival?
It is likely to shorten overall survival.
It is likely to lengthen overall survival.
There is conflicting evidence regarding overall survival.
There is insufficient evidence regarding overall survival.
It is likely not to affect overall survival
To what structure does the arrow point?
Vidian artery
McConnel's Capsular artery
Persistent stapedial artery
Persistent otic artery
Caroticotympanic artery
A 42 year-old man undergoes resection of this tumor (Figure 1). The immunohistochemistry for BRAF V600E mutation is shown (Figure 2). What is the most likely diagnosis?
Pleomorphic xanthoastrocytoma
Ganglioglioma
Pilocytic astrocytoma
Glioblastoma
Ependymoma
A patient develops Wallenberg syndrome 4 days after C5-C6 fracture dislocation: Which one of the following statements regarding further management is most accurate?
CT head, CT angiogram and start anticoagulation
Diffusion weighted MRI
Clinical observation
CT head and anticoagulation
CT head and commence antiplatelet
A 25-year-old man presents with a new onset of right facial droop associated with horizontal diplopia. MRI of the brain shows a brainstem hyperintensity on T2 and FLAIR images (see figure). What anatomical structure is affected by this lesion causing the diplopia?
Abducens nucleus
Trochlear nucleus
Abducens fibers
Medial longitudinal fasciculus
Trapezoid body
You are called to the NICU to see a 1 day old child who appears as demonstrated in figures 1 and 3. His CT scan is shown in figure 2. He has been stable, although with occasional apnea when agitated. On exam, he has a bulging fontanelle. His parents wish to pursue aggressive care. When should he undergo a cranial vault procedure?
At 6 months of age.
In the next several days.
At 12 months of age.
At 24 months of age.
At 18 months of age.
What neurological deficit is most at risk with surgery for the lesion shown (figures 1 and 2)?
Diplopia
Anterograde amnesia
Upgaze palsy
Expressive aphasia
Gerstmann syndrome
When treating status epilepticus in adults, which intravenous medication should be co-administered with benzodiazepines?
Nitroprusside.
Phenobarbital
Phenytoin.
Propofol.
Succinylcholine.
A 24-year-old woman presents with right arm weakness and the accompanying T1-weighted, contrast-enhanced MRI. Stereotactic needle biopsy demonstrates Rosenthal fibers on histopathological analysis. Which of the following treatment paradigms is associated with long-term disease control?
Radiotherapy combined with IV methotrexate
Complete microsurgical resection alone
Radiotherapy alone
Complete microsurgical resection followed by adjuvant radiotherapy
Radiotherapy combined with high-dose corticosteroids
Seven days ago a 3 year old boy developed a low-grade fever which resolved and was followed by a vesicular rash (see Figures). Two days ago, he had sudden onset of truncal ataxia and horizontal nystagmus. He has moderate dysmetria of both arms when reaching for toys, cannot stand or walk, and his speech is slurred. His mental status is fully intact. Fundi show sharp disc margins. His strength is full and deep tendon reflexes are present. What is the MOST likely diagnosis?
Guillain-Barre Syndrome
Posterior fossa mass
Opsoclonus myoclonus syndrome
Acute disseminated encephaloymyelitis
Post-infectious cerebellar ataxia
A 47-year-old woman presented with a first seizure and underwent magnetic resonance imaging of the brain with multi-voxel spectroscopy. The spectroscopy shown in Figure 1 is most consistent with what diagnosis?
Glial neoplasm
Demyelinating plaque
Bacterial abscessmeningioma
Toxoplasmosis
You are operating on a patient with a nerve sheath tumor that you suspect is a benign schwannoma of the ulnar nerve. After initial exposure and dissection of the lesion, you discover that the tumor is securely attached to the nerve by a pair of fascicles as marked with asterisks in Figure 1. What is the most appropriate maneuver at this point?
Excise the lesion and nerve and perform a graft repair of the nerve
Perform an internal debulking of the lesion
Divide the fascicles and remove the lesion
Leave the tumor and fascicles alone and close
Biopsy the lesion for frozen and permanent sections and close
An 84-year-old male has an MRI that reveals an enhancing lesion involving the left internal acoustic canal (see figure). On exam, he has diminished hearing in his left ear. What is the most appropriate next step in the management of this patient?
Stereotactic radiosurgery in a single session
Stereotactic radiosurgery in 3-5 fractions
Surgical removal via a restrosigmoid approach
Surgical removal via a translabyrinthine approach
Reassurance and follow-up MRI in 6 months
A 10 year old child is referred to your interdisciplinary spasticity clinic. It is determined that he has spasticity as well as significant disabling dystonia in all four extremities, the face, and the neck. His symptoms have been medically refractory. What is the most appropriate treatment
Botox injections
Deep brain stimulation
Selective dorsal rhizotomy
Intrathecal baclofen therapy
Stereotactic pallidotomy
A 10-year-old boy presents with headache and imbalance. Examination discloses mild papilledema, right-sided dysmetria, and ataxia. MRI with contrast is shown in the figure. What is the most important prognostic factor for this patient?
The presence of endothelial proliferation on histology
The extent of resection of the cyst walls
The presence of hydrocephalus at presentation
The extent of resection of the enhancing mass
The presence of mitoses on histology
A 28-year-old with NF-1 has progressive headaches. Axial and coronal T1-weighted MR images with gadolinium are shown (Figures 1 and 2). The next morning she becomes suddenly unresponsive with a dilated right pupil. What is the most likely diagnosis?
Metastatic tumor
High-grade astrocytoma
Pilocytic astrocytoma
Ganglioglioma
Meningioma
A 17-year-old sustains a gunshot wound to the head. On examination, he has decorticate posturing on the right and he localizes on the left. His left pupil is 2 mm larger than the right but is still reactive. His non-contrast head CT (see figures) demonstrates metal and bone fragments within the left frontal region with an associated subdural hematoma with midline shift. What is the most appropriate management of this patient ?
Right frontal ventriculostomy placement
Craniotomy, hematoma evacuation, superficial debridement
Superficial debridement of wound
Craniotomy, hematoma evacuation, removal of all bone and metal fragments
Expectant care
A 26-year-old male presents after a motor vehicle crash with absent right and partially preserved left lower extremity motor function (more than half of left leg muscles have less than antigravity strength). Sensation to pain and temperature is markedly diminished in the left leg. Proprioception is markedly diminished in the right leg. Neuroimaging studies are obtained and depicted in Figures 1 and 2. Which spinal cord syndrome BEST describes the injury?
Brown-Sequard
Central cord
Anterior spinal
Cauda equina
Posterior cord
A 37-year-old man presents with worsening low back pain and right L5 radicular pain and a normal examination. Lumbar spine MRI (Figure 1) and CT (Figure 2) are shown. Work-up revealed this solitary lesion. What is the most appropriate next step in management ?
External beam radiotherapy
Observation with serial imaging
Surgical excision and stabilization
Open surgical biopsy
CT-guided biopsy
A 58-year-old right-handed male presents with bifrontal headaches and a partial left ophthalmoplegia. MRI results are shown. Biopsy revealed this tumor to be a chordoma. An extensive subtotal skull-based resection was performed. Which is the best choice for adjuvant therapy regimen ?
Stereotactic radiosurgery
Procarbazine, CCNU and vincristine (PCV) chemotherapy
Conventional fractionated radiotherapy
Proton beam radiotherapy
Brachytherapy
