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PODA Chem pt 1- CWSI

Total questions: 19

Worksheet time: 10mins

Name
Class
Date
1.

What crucial feature of a penicillin is involved in its mechanism of action?

a)

Thiazolidine ring

b)

Carboxylic acid

c)

Aromatic ring

d)

Acyl side chain

e)

Beta lactam ring

2.

WOTF is true for the methoxy substituent at ortho position in aromatic ring?

a)

The ortho-methoxy groups produced steric hindrance, decreasing its affinity to β-lactamases

b)

It is good for oral activity

c)

It is good for acid resistant

d)

The ortho-methoxy groups produced steric hindrance, increasing its affinity to transpeptidase

e)

The ortho-methoxy groups produced steric hindrance, increasing its affinity to β-lactamases

3.

Which of the following statements about nafcillin is/are correct? (Select all correct answers that apply)

a)

Nafcillin is acid resistant penicillin

b)

Ethoxy group produced steric hindrance, decreasing its affinity to β-lactamases

c)

Nafcillin is acid sensitive penicillin

d)

Ethoxy group produced steric hindrance, increasing its affinity to β-lactamases

e)

Nafcillin is a weak acid

4.

Penicillin antibiotics contains:

a)

5-membered lactam ring and 4 membered thiazolidine ring

b)

4-membered lactam ring and 5 membered imidazole ring

c)

4-membered lactam ring and 5 membered pyrazole ring

d)

4-membered lactam ring and 6 membered thiazolidine ring

e)

4-membered lactam ring and 5 membered thiazolidine ring

5.

Which of the following antibiotics inhibit bacterial cell wall synthesis? (Select all that apply)- delete

a)

Carbapenems

b)

Cephalosporins

c)

Tetracyclines

d)

Penicillins

e)

Vancomycin

6.

Which of the following pairs of amino acids are involved in the condensation reaction for penicillin biosynthesis?

a)

Condensation of cysteine and valine

b)

Condensation of cysteine and leucine

c)

Condensation of valine and leucine

d)

Condensation of valine and isoleucine

e)

Condensation of cysteine and isoleucine

7.

Which of the following statements about procaine benzyl penicillin is/are correct?

a)

Procaine benzyl penicillin is water soluble and used for parenteral administration

b)

Procaine benzyl penicillin is more acid stable and is an acid resistant penicillin

c)

Procaine benzyl penicillin is water insoluble and used for repository purposes

d)

Procaine benzyl penicillin is a beta lactamase resistant penicillin

8.

Which of the following statements about Methicillin is/are correct?

a)

Methicillin is an acid sensitive

penicillin

b)

Methicillin is a β lactamase resistant penicillin

c)

It contains lactam ring and thiazolidine ring

d)

The ortho-methoxy groups produced steric hindrance, reducing its affinity to β-lactamases

e)

Methicillin is a weak acid

9.

Which of the following statements about ampicillin is/are correct? (Select all correct answers that apply)

a)

Ampicillin is amphoteric substance

b)

Electron withdrawing character of the protonated primary amine group (NH3+), reducing participation in acid hydrolysis

c)

Ampicillin is a β lactamase sensitive penicillin

d)

Ampicillin is a weak acid

e)

Ampicillin is an acid resistant penicillin

10.

Which of the following statements about bacampicillin is/are correct?

a)

Bacampicillin is a β lactamase sensitive penicillin

b)

Bacampicillin is a pro-drug

c)

Bacampicillin is an acid resistant penicillin

d)

Bacampicillin is a neutral molecule

e)

Bacampicillin is a weak base

11.

The drug illustrated below is ampicillin. How many chiral centers are present?

a)

1

b)

5

c)

4

d)

3

e)

6

12.

Which of the following statements about dicloxacillin is/are correct? (Select all correct answers that apply)

a)

Dicloxacillin is a β lactamase resistant penicillin

b)

Dicloxacillin is a weak acid

c)

Dicloxacillin contains isoxazole ring

d)

Dicloxacillin is an acid resistant penicillin

e)

Dicloxacillin contains imidazole ring

13.

All of the following statements about Ampicillin is true except

a)

It contains lactam ring

b)

β lactamase sensitive penicillin

c)

Acid sensitive penicillin

d)

Ampicillin is an amphoteric substance

e)

It has 4 chiral centers

14.

Which of the following statements about Cefditoren pivoxil is/are correct? (Select all correct answers that apply)

a)

Cefditoren pivoxil is isolated from Amycolatopsis orientalis

b)

Cefditoren pivoxil is an orally active prodrug

c)

Cefditoren pivoxil is a β-lactam analog

d)

Bioavailability of cefditoren pivoxil is increased if taken with food

e)

Cefditoren pivoxil is a prodrug

15.

Which of the following are classified as protein synthesis inhibitors? (Select all that apply)


a)

Macrolides

b)

chloramphenicol

c)

Aminoglycosides

d)

macrolides

e)

Tetracyclines

16.

Which of the following statements about Cefuroxime axetil is/are correct? (Select all correct answers that apply)

a)

Cefuroxime axetil is a β-lactam analog

b)

Cefuroxime axetil has Z-oxime stereochemistry

c)

Cefuroxime axetil is a prodrug

d)

Cefuroxime axetil is a first-generation Cephalosporin

e)

Cefuroxime axetil is a second-generation Cephalosporin

17.

Which of the following statements about Cephalexin is/are correct? (Select all correct answers that apply)

a)

Cephalexin is an amphoteric compound

b)

Cephalexin is a β-lactam analog

c)

Cephalexin is a weak acid

d)

Cephalexin is a first-generation Cephalosporin

e)

Cephalexin contains 3 chiral centers.

18.

All are beta-lactamases resistant penicillins, Except:

a)

Nafcillin

b)

Oxacillin

c)

Methicillin

d)

Ampicillin

e)

Cloxacillin

19.

Which of the following statement is true regarding benzylpenicillin?

a)

Benzylpenicillin is a weak base

b)

Benzylpenicillin is a weak acid

c)

Benzylpenicillin is amphoteric substance

d)

Benzylpenicillin is a strong acid

e)

Benzylpenicillin is a neutral molecule

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