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WorksheetsViral Replication and Cell Lines Quiz
Total questions: 20
Worksheet time: 10mins
Positive-sense RNA viruses can act directly as
mRNA
rRNA
tRNA
Protein
Negative-sense RNA viruses require which enzyme for replication?
DNA polymerase
RNA-dependent RNA polymerase
Reverse transcriptase
RNA ligase
Replication of most RNA viruses occurs in
Nucleus
Endoplasmic reticulum
Golgi apparatus
Cytoplasm
Which virus replicates in the nucleus despite being an RNA virus?
Poliovirus
Influenza virus
Rabies virus
Rotavirus
Attachment of virus to host cell is mediated by
Viral genome
Capsid proteins only
Host enzymes
Viral surface proteins
Penetration of virus into host cell commonly occurs by
Exocytosis
Endocytosis
Fusion
Both endocytosis and fusion
Eclipse phase in viral replication represents
Release of virions
Assembly stage
No detectable infectious virus
Peak infectivity
Viral assembly usually occurs in
Nucleus only
Cytoplasm only
Cell membrane only
Nucleus or cytoplasm
Release of enveloped viruses mainly occurs by
Cell lysis
Budding
Pinocytosis
Autophagy
Negative-sense RNA viruses package which enzyme in the virion?
DNA polymerase
RNA-dependent RNA polymerase
Reverse transcriptase
Integrase
Primary cell lines are derived from
Immortal cells
Cancer cells
Normal tissue
Hybridoma cells
Primary cell lines have
Unlimited lifespan
High mutation rate
Limited lifespan
No diploid chromosomes
Diploid cell lines are derived from
HeLa cells
Cancer tissue
Fetal tissue
Bacterial cells
Continuous cell lines are characterized by
Diploid chromosomes
Limited divisions
Infinite growth
Normal karyotype
HeLa cell line originated from
Cervical carcinoma
Lung carcinoma
Breast carcinoma
Liver carcinoma
Interferons are produced mainly by
Bacteria
Viruses
Fungi
Host cells infected by viruses
Main action of interferons is to
Kill viruses directly
Enhance bacterial growth
Induce antiviral state in cells
Produce antibodies
Interferons act by inhibiting
Viral attachment
Viral protein synthesis
Viral entry only
Host cell division
Which interferon has immunomodulatory action?
IFN-α
IFN-β
IFN-γ
IFN-ε
Live attenuated viral vaccines produce
Short-lived immunity
No immune response
Strong and long-lasting immunity
Only humoral immunity
