Patient V. consulted a doctor with complaints of weakness, drowsiness, fatigue, constipation, constant feeling of cold, significant weight gain, hearing loss, and a rough voice. Objectively: the thyroid gland is slightly enlarged, dense, and painful upon palpation. Laboratory data: TSH - 9 μIU/ml (N: 0.34–4.25 μIU/ml); T3 - 0.5 nmol/l (N: 1.2–2.1 nmol/l); T4 - 50 nmol/l (N: 70–151 nmol/l); Anti-thyroid antibodies to peroxidase - 55 IU/ml (N: ≤ 34 IU/ml).What disease is most likely in the patient, based on the symptoms and test results?

Patient A. complains of headache, muscle weakness in the calf muscles, paresthesia in the legs, polyuria, nocturia, polydipsia. Objectively: Pulse - 80 beats per minute, BP 160/120 mm Hg. The left border of the heart is 1.5 cm outward from the midclavicular line, the accent of the second tone over the aorta. The potassium content in the blood is 2.8 mmol / l. Adenoma of which gland leads to the development of this disease?

Patient V. came to the doctor with complaints of weakness, drowsiness, lethargy, constipation, chills, "unreasonable" weight gain, hearing loss, hoarse voice, facial swelling. Two years ago, she suffered from infectious thyroiditis. Laboratory data: TSH - 5 μIU/ml (N: 0.34–4.25 μIU/ml); T3 - 0.9 nmol/l (N: 1.2–2.1 nmol/l); T4 - 40 nmol/l (N: 70–151 nmol/l); Antithyroid antibodies to thyroglobulin - 155 IU/ml (N: ≤115 IU/ml). Which of the following could be the cause of facial swelling in the patient?

Patient S. complains of periodic attacks of headache, accompanied by cough, suffocation, tightness in the chest, palpitations, sharp increase in blood pressure. In the anamnesis: has been ill for about a year. Attacks occur during physical exertion (fast walking, lifting weights), last several minutes and pass on their own. At first they were observed rarely (once every 2-3 months), then they became more frequent and recently have been occurring several times a day. During the illness, she lost 6 kg. Objectively: BP - 200/120 mm Hg. Metanephrines and normetanephrine are elevated in daily urine. What change in hormone levels is characteristic of this pathology?

Patient B. complains of sudden weight loss, irritability, tearfulness, poor sleep, feeling of "heat", interruptions in the work of the heart, hand tremors and subfebrile temperature. On examination: the patient is exhausted, there is a tremor of the hands and eyelids, blood pressure 150/75 mm Hg, pulse 130 min, temperature 37.5 °C. Enlargement of the thyroid gland, shiny eyes, exophthalmos are noted. Laboratory data: TSH - 0.2 μIU/ml (N: 0.34–4.25 μIU/ml); T3 - 3.3 nmol/l (N: 1.2–2.1 nmol/l); Thyroxine - 250 nmol/l (N: 70–151 nmol/l); antibodies to TSH receptors were detected. What disease is most likely to affect the patient?

Patient A. complains of convulsive contractions of the muscles of the extremities, transient paresis of the muscles of the lower leg and forearm, rapid physical fatigue, attacks of pulsating headaches, thirst, profuse, frequent urination. Additional examination revealed: blood pressure 190/115 mm Hg. Computed tomography revealed a tumor of the adrenal gland. Laboratory data: Sodium - 158 mmol / l; Potassium - 2.9 mmol / l; Plasma renin is decreased; Serum 18-hydrocorticosterone - 110 ng / dl, (N: ≤ 100 ng / dl); Aldosterone-renin ratio - 60 pg / μIU (N: ≤ 12 pg / μIU). What disease is most likely in the patient?

The patient complains of weight gain, thirst, headaches, and lower back pain. Considers herself ill for 2 years after childbirth. She was treated for hypertension. Objectively: dysplastic obesity, pink-bluish striae on the abdominal skin. BP 160/100. Heart sounds are muffled. X-ray revealed vertebral osteoporosis. Laboratory data: Glucose - 9.5 mmol/l; Sodium - 150 mmol/l; Potassium - 3 mmol/l; ACTH - 22 pg/ml (N: ≤ 50 pg/ml); Cortisol - 850 nmol/l (N: 138–690 nmol/l). What disease is most likely in the patient?

Patient P., aged 32, suffers from suddenly beginning and suddenly ending attacks of severe headache with a sharp increase in blood pressure (up to 280-300 mm Hg), sweating, anxiety, a feeling of fear, rapid heartbeat, nausea, vomiting, abdominal pain. During an attack, the face is red, there is tremor, the hands and feet are cold, the heart rate is 100-140 per minute. Blood test: sodium - 143 mmol / l (N: 136-146 mmol / l); renin - 3.5 μIU / ml (N: 3.3-41 μIU / ml); aldosterone - 400 pmol / l (N: less then 443 pmol / l); diuresis - 1500 ml; venous blood glucose - 11.1 mmol / l; Glycated hemoglobin - 8%; Metanephrine in daily urine - 350 mcg/day (N: 30.00 – 180.00); Normetanephrine - 425 mcg/day (N: 111.00 – 419.00). Which disease is most likely in the patient based on clinical data?

Patient P. suffers from suddenly starting and suddenly ending attacks of severe headache with a sharp increase in blood pressure, sweating, anxiety, fear, rapid heartbeat, nausea, vomiting, abdominal pain. Blood test: sodium - 143 mmol / l (N: 136-146 mmol / l); renin - 3.5 μIU / ml (N: 3.3-41 μIU / ml); aldosterone - 400 pmol / l (N: less then 443 pmol / l); diuresis - 1500 ml; Metanephrine in daily urine - 350 mcg/day (N: 30.00 – 180.00); Normetanephrine - 425 mcg/day (N: 111.00 – 419.00). What complication can occur with untreated pheochromocytoma?

Central obesity, arterial hypertension, purple striae on the abdominal skin, moderate hyperpigmentation of the skin in a patient with moderately elevated ACTH levels may be a manifestation

Patient A. complains of muscle weakness, rapid physical fatigue, loss of appetite, nausea, muscle pain. Notes an addiction to salty food. History of pulmonary tuberculosis. On examination: the skin has a smoky-bronze color, pigmentation is more pronounced on exposed areas of the body, in places where clothing rubs and in the genital area, intense pigment deposition on the scar after appendectomy, there are dark spots on the oral mucosa. Laboratory data: Glucose - 3.1 mmol / l; Sodium - 130 mmol / l; Potassium - 6 mmol / l; ACTH - 22 pmol / L (N: 2-11 pmol / L); Cortisol - 110 nmol/L (N: 138–690 nmol/L). Which disease is most likely in this patient based on the data?

Patient A. was admitted to the hospital with complaints of abdominal pain, severe weakness, nausea, and vomiting. It is known that the patient was diagnosed with diabetes mellitus 8 years ago, is on constant intensified insulin therapy, a normocaloric diet, has self-control skills, regularly monitors glycemia, glycated hemoglobin, and undergoes outpatient examination once a year in a specialized diabetology department. The leading etiologic factor of this pathology is:

Patient B. consulted a cardiologist with complaints of persistent increase in blood pressure to 200/105 mm Hg over the past year, fatigue, muscle weakness, thirst. After taking diuretics (hypothiazide), the patient developed severe muscle weakness, interruptions in the work of the heart. Objectively: BP 140/90 mm Hg. Laboratory data: hypokalemia - 2.6 mmol / l, the aldosterone level was 950 pmol / l (N: 111-860 pmol / l). What is the secretion of renin in this pathology?

A woman was admitted to the clinic complaining of general weakness, irritability, sweating, increased appetite, weight loss, and palpitations. Examination revealed body temperature of 37.8°, finger tremors, diffuse enlargement of the thyroid gland, and slight exophthalmos. Graves' disease is suspected. What will a blood test reveal?