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Neoplasia

Total questions: 20

Worksheet time: 10mins

Name
Class
Date
1.

Apoptosis is best defined as:

a)

Programmed cell death mediated by intrinsic enzymes

b)

Passive cell death due to ischemia

c)

Cell death due to inflammatory injury

d)

Cell death associated with necrosis

2.

Neoplasia is defined as:

a)

Abnormal mass persisting after removal of stimulus

b)

Reversible increase in cell number

c)

Growth coordinated with normal tissue

d)

Inflammatory proliferation

3.

Cancer cells most commonly evade apoptosis through which pathway?

a)

Lysosomal pathway

b)

Extrinsic pathway only

c)

Intrinsic mitochondrial pathway

d)

Autophagy pathway

4.

The intrinsic pathway of apoptosis is triggered by all EXCEPT:

a)

DNA damage

b)

Hypoxia

c)

Misfolded proteins

d)

Fas–FasL interaction

5.

Which of the following is a pro-apoptotic protein?

a)

BCL-2

b)

BCL-XL

c)

MCL-1

d)

BAX

6.

Anti-apoptotic members of the BCL-2 family include:

a)

BAX and BAK

b)

BAD and BID

c)

BCL-2 and BCL-XL

d)

BIM and PUMA

7.

Which proteins act as sensors in the intrinsic apoptotic pathway?

a)

BAX, BAK

b)

BAD, BID, BIM, PUMA

c)

Caspase-9

d)

Apaf-1

8.

Release of which molecule from mitochondria activates the caspase cascade?

a)

ATP

b)

Cytochrome C

c)

SMAC

d)

BCL-2

9.

Apaf-1 combines with cytochrome C to form:

a)

Death receptor complex

b)

Apoptosome

c)

Caspase-8 complex

d)

IAP complex

10.

Loss of function mutation of which gene is most important in evasion of apoptosis?

a)

RB

b)

p53

c)

MYC

d)

RAS

11.

Overexpression of MDM-2 leads to:

a)

Increased p53 synthesis

b)

Decreased degradation of p53

c)

Increased degradation of p53

d)

Activation of apoptosis

12.

Follicular lymphoma is associated with which translocation?

a)

t(9;22)

b)

t(15;17)

c)

t(14;18)

d)

t(8;14)

13.

In follicular lymphoma, tumor growth occurs mainly due to:

a)

Increased mitosis

b)

Increased angiogenesis

c)

Evasion of apoptosis

d)

Increased necrosis

14.

Cellular senescence is characterized by:

a)

Apoptosis

b)

Permanent cell cycle arrest

c)

Necrosis

d)

Autophagy

15.

Senescence is mediated by increased levels of:

a)

RAS and MYC

b)

p53 and p16 (INK4A)

c)

BCL-2 and MCL-1

d)

Caspase-3

16.

p53 and p16 maintain RB in which state to cause senescence?

a)

Hyperphosphorylated

b)

Mutated

c)

Hypophosphorylated

d)

Inactive

17.

Cells that escape senescence but are not immortal undergo:

a)

Differentiation

b)

Apoptosis immediately

c)

Mitotic crisis

d)

Autophagy

18.

Telomeres are best described as:

a)

RNA segments in nucleus

b)

Protein structures in cytoplasm

c)

DNA segments at chromosome ends

d)

Mitochondrial DNA

19.

Dysfunctional p53 during telomere shortening leads to:

a)

Apoptosis

b)

Senescence

c)

Non-homologous end joining

d)

Autophagy

20.

Cancer stem cells are characterized by:

a)

Limited replicative capacity

b)

Absence of telomerase

c)

Capacity for self-renewal

d)

Increased senescence