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Acute Phase Reaction Quiz

Total questions: 20

Worksheet time: 10mins

Name
Class
Date
1.

Acute phase reaction is mainly mediated by which cytokine?

a)

IL-4

b)

IL-6

c)

IL-10

d)

IFN-γ

2.

Major site of synthesis of acute phase proteins is,

a)

Spleen

b)

Bone marrow

c)

Liver

d)

Lymph node

3.

Which of the following is a positive acute phase protein?

a)

Albumin

b)

Transferrin

c)

C-reactive protein

d)

Prealbumin

4.

Negative acute phase reactant among the following is,

a)

CRP

b)

Fibrinogen

c)

Serum amyloid A

d)

Albumin

5.

ESR is increased in acute phase reaction mainly due to increased,

a)

Albumin

b)

Globulins

c)

CRP

d)

Fibrinogen

6.

Virchow triad includes all EXCEPT,

a)

Endothelial injury

b)

Abnormal blood flow

c)

Hypercoagulability

d)

Platelet deficiency

7.

Most important factor in initiation of thrombosis is,

a)

Stasis

b)

Hypercoagulability

c)

Endothelial injury

d)

Age

8.

Stasis predisposes to thrombosis by,

a)

Increasing oxygenation

b)

Preventing clotting factor accumulation

c)

Disrupting laminar flow

d)

Reducing platelet contact

9.

Psammoma bodies are best described as,

a)

Irregular calcifications

b)

Concentric laminated calcifications

c)

Fat necrosis

d)

Cholesterol crystals

10.

Psammoma bodies are classically seen in all EXCEPT,

a)

Papillary carcinoma thyroid

b)

Serous carcinoma ovary

c)

Psammomatous meningioma

d)

Follicular carcinoma thyroid

11.

Fatty change (steatosis) most commonly affects,

a)

Heart

b)

Brain

c)

Liver

d)

Spleen

12.

Most common cause of fatty change in liver is,

a)

Ischemia

b)

Alcohol abuse

c)

Infection

d)

Trauma

13.

Fatty change is a form of,

a)

Irreversible cell injury

b)

Adaptive hyperplasia

c)

Reversible cell injury

d)

Cell death

14.

Accumulation of triglycerides in parenchymal cells is termed,

a)

Cholesterolosis

b)

Steatosis

c)

Glycogenosis

d)

Calcification

15.

Mechanism of fatty change includes all EXCEPT,

a)

Increased fatty acid delivery

b)

Decreased fatty acid oxidation

c)

Decreased apoprotein synthesis

d)

Increased lipoprotein secretion

16.

Acute phase proteins help in all EXCEPT,

a)

Opsonization

b)

Complement activation

c)

Coagulation inhibition

d)

Limiting tissue injury

17.

Serum amyloid A is associated with,

a)

Chronic inflammation

b)

Acute inflammation only

c)

Neoplasia

d)

Genetic disorders

18.

Hypercoagulable state may be inherited due to mutation of,

a)

Protein C

b)

Protein S

c)

Factor V Leiden

d)

Antithrombin III

19.

Fatty change in heart is commonly associated with,

a)

Alcoholism

b)

Severe anemia

c)

Dyslipidemia

d)

Diabetes mellitus

20.

Psammoma bodies represent a type of,

a)

Dystrophic calcification

b)

Metastatic calcification

c)

Fat necrosis

d)

Hyaline change