WorksheetsGraft Rejection Quiz
Total questions: 20
Worksheet time: 10mins
Graft rejection is defined as
Acceptance of graft by host
Immune-mediated destruction of graft
Infection of graft
Mechanical failure of graft
Most common cause of graft rejection is
Bacterial infection
Viral infection
Host immune response
Surgical error
Hyperacute graft rejection occurs due to
Cell-mediated immunity
Preformed antibodies
Delayed hypersensitivity
Immune tolerance
Hyperacute rejection occurs within
Weeks
Months
Minutes to hours
Years
Acute graft rejection is mainly mediated by
Antibodies only
T lymphocytes
Neutrophils
Eosinophils
Chronic graft rejection is characterized by
Acute inflammation
Fibrosis and vascular narrowing
Immediate necrosis
Antibody excess
Which graft rejection occurs months to years later?
Hyperacute
Acute
Chronic
Accelerated
Main mechanism of acute rejection is
Type I hypersensitivity
Type II hypersensitivity
Cell-mediated cytotoxicity
Immune complex deposition
Major histocompatibility complex responsible for graft rejection in humans is
HLA system
ABO system
Rh system
Complement system
Most important pretransplant investigation is
Chest X-ray
Blood sugar
HLA typing
Liver function test
Cross-matching before transplant is done to detect
ABO incompatibility
Preformed recipient antibodies
Infection risk
Organ function
ABO blood group compatibility is most important in
Corneal transplant
Bone marrow transplant
Kidney transplant
Skin graft
Graft rejection can be prevented by
Antibiotics
Immunosuppressive therapy
Analgesics
Antipyretics
Drug commonly used to prevent graft rejection
Cyclosporine
Penicillin
Paracetamol
Aspirin
Innate immunity is characterized by
Antigen specificity
Memory
Immediate response
Clonal expansion
Acquired immunity shows
No specificity
No memory
Antigen specificity and memory
Immediate response
Cells mainly involved in innate immunity are
Plasma cells
B lymphocytes
T lymphocytes
Neutrophils and macrophages
Humoral immunity is mediated by
Macrophages
T lymphocytes
B lymphocytes and antibodies
NK cells
Cell-mediated immunity is mediated by
B lymphocytes
Plasma cells
T lymphocytes
Complement
Example of graft rejection prevention method is
Plasmapheresis
Immunosuppressive drugs
Hormone therapy
Vaccination
