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WorksheetsDrugs A-M: How They Work (Mechanism of Action Only)
Total questions: 20
Worksheet time: 10mins
Albuterol primarily produces bronchodilation by which action?
Suppressing CNS activity during sedation
Enhancing GABA in central neurons
Blocking acetylcholine at muscarinic sites
Stimulating beta-2 receptors in the airways
Alcaine (proparacaine) provides ocular anesthesia via what mechanism?
Inhibiting platelet aggregation in vessels
Blocking sensory nerve impulses in the eye
Converting hemoglobin to methemoglobin
Binding cyanide to form vitamin B12
Amiodarone stabilizes cardiac rhythm primarily by:
Stimulating alpha receptors to raise pressure
Suppressing ventricular automaticity via GABA
Increasing calcium availability in myocardium
Blocking sodium, potassium, and calcium channels
Which statement best reflects ipratropium’s pulmonary effect?
Anticholinergic bronchodilator that reduces airway secretions
Beta-2 agonist producing rapid bronchodilation alone
Direct calcium channel blocker slowing AV conduction
Histamine receptor blocker preventing allergic bronchospasm
Aspirin’s antiplatelet action occurs through inhibition of:
Thromboxane A2–mediated platelet aggregation
Fibrin cross-linking via factor XIII activation
P2Y12 receptor–mediated ADP signaling
Antithrombin III–dependent thrombin inhibition
Which benzodiazepine mechanism is correctly matched?
Etomidate enhances GABA producing anxiolysis only
Lorazepam enhances GABA to depress CNS activity
Diazepam depresses CNS activity producing sedation and relaxation
Ketamine enhances GABA to induce dissociation
Midazolam enhances GABA causing sedation and amnesia
Dexamethasone’s therapeutic effect is best described as:
Opioid receptor agonist providing analgesia
Dose-dependent stimulation of adrenergic receptors
Blocks dopamine receptors in the basal ganglia
Suppresses inflammation and immune response
Dopamine exerts its effects through:
Anticholinergic inhibition reducing airway secretions
Enhancement of GABA leading to CNS depression
Direct blockade of sodium and calcium channels in myocardium
Dose-dependent stimulation of dopaminergic and adrenergic receptors
Epinephrine’s mixed receptor activity leads to:
Platelet inhibition by blocking thromboxane A2
Vasoconstriction and bronchodilation via alpha and beta stimulation
AV nodal slowing through calcium channel blockade
Sedation and amnesia through GABA enhancement
Etomidate is best characterized as an agent that:
Stimulates alpha receptors to raise blood pressure
Blocks sodium channels to treat dysrhythmias
Converts hemoglobin to methemoglobin
Suppresses CNS activity for sedation
Which statement about fentanyl is accurate?
Opioid receptor agonist providing analgesia
Dissociative anesthetic affecting catecholamines
Benzodiazepine enhancing GABA for amnesia
Antihistamine blocking H1 receptors centrally
Haloperidol affects the brain primarily by:
Blocking dopamine receptors in the brain
Enhancing GABA to produce sedation
Blocking histamine receptors peripherally
Stimulating alpha and beta receptors broadly
Heparin prevents thrombosis mainly by:
Blocking P2Y12 to prevent ADP-mediated aggregation
Inhibiting thromboxane A2 to limit platelet plug
Enhancing antithrombin III to inhibit clotting factors
Chelating calcium to reduce coagulation speed
Hydroxocobalamin counteracts cyanide toxicity by:
Converting hemoglobin to methemoglobin to sequester cyanide
Stimulating beta-2 receptors to improve delivery
Blocking sodium channels to reduce seizures
Binding cyanide to form vitamin B12 for renal excretion
Labetalol lowers both heart rate and blood pressure by:
Enhancing antithrombin III to reduce preload
Blocking alpha and beta receptors together
Stimulating beta-1 receptors in the myocardium
Blocking calcium channels in vascular smooth muscle
Furosemide increases urine output by which mechanism?
Inhibiting sodium and water reabsorption in the kidney
Blocking aldosterone receptors in the distal nephron
Enhancing ADH to concentrate tubular fluid
Osmotically drawing water into renal tubules
Magnesium sulfate’s pharmacologic class is best described as:
Alpha agonist vasoconstrictor and inotrope
Physiologic calcium channel blocker and CNS depressant
Direct beta-2 agonist bronchodilator and vasodilator
Anticholinergic secretion inhibitor and bronchodilator
Which corticosteroid statements are correct?
Atropine reduces inflammation by antimuscarinic action
Hydroxocobalamin suppresses immune cytokine production
Dexamethasone suppresses inflammation and immune response
Methylprednisolone reduces inflammation via immune suppression
Select the agents that enhance GABA signaling as their primary action.
Ketamine enhances GABA similar to benzodiazepines
Diazepam depresses CNS activity with GABA modulation
Midazolam enhances GABA causing sedation and amnesia
Lorazepam enhances GABA to depress CNS activity
Etomidate suppresses CNS without GABA enhancement
Morphine’s mechanism of action is:
Sodium channel blocker suppressing ventricular ectopy
Antihistamine reducing pruritus and secretions
Alpha agonist causing vasoconstriction and inotropy
Opioid agonist providing analgesia and vasodilation
