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Quiz on Amyloidosis

Total questions: 20

Worksheet time: 10mins

Name
Class
Date
1.

Amyloidosis is defined as

a)

Intracellular lipid accumulation

b)

Extracellular deposition of misfolded protein fibrils

c)

Calcification of tissues

d)

Immune complex deposition

2.

Amyloid proteins share which common structural feature?

a)

Alpha-helix

b)

Random coil

c)

Beta-pleated sheet

d)

Triple helix

3.

Most common systemic amyloidosis is

a)

AL amyloidosis

b)

AA amyloidosis

c)

ATTR amyloidosis

d)

Aβ amyloidosis

4.

AA amyloidosis is associated with

a)

Plasma cell dyscrasia

b)

Chronic inflammatory conditions

c)

Alzheimer disease

d)

Aging

5.

AL amyloidosis is derived from

a)

Serum amyloid A

b)

Immunoglobulin light chains

c)

Transthyretin

d)

Beta-amyloid peptide

6.

Hereditary ATTR amyloidosis is due to deposition of

a)

Serum amyloid A

b)

Mutant transthyretin

c)

Immunoglobulin heavy chain

d)

Beta-amyloid peptide

7.

Aβ amyloid deposition is characteristic of

a)

Systemic amyloidosis

b)

Reactive amyloidosis

c)

Alzheimer disease

d)

Medullary carcinoma thyroid

8.

Pathogenesis of amyloidosis involves all EXCEPT

a)

Protein misfolding

b)

Failure of clearance

c)

Chronic inflammation

d)

Increased collagen synthesis

9.

Most commonly affected organ in systemic amyloidosis is

a)

Liver

b)

Spleen

c)

Kidney

d)

Heart

10.

Renal amyloidosis typically presents as

a)

Nephritic syndrome

b)

Nephrotic syndrome

c)

Acute kidney injury

d)

Renal colic

11.

Cardiac amyloidosis leads to

a)

Dilated cardiomyopathy

b)

Restrictive cardiomyopathy

c)

Hypertrophic cardiomyopathy

d)

Ischemic cardiomyopathy

12.

Congo red staining of amyloid shows which feature?

a)

Green fluorescence

b)

Apple-green birefringence under polarized light

c)

Blue granules

d)

Black deposits

13.

Which stain is also used to demonstrate amyloid?

a)

PAS

b)

Masson trichrome

c)

Thioflavin T

d)

Prussian blue

14.

Sago spleen refers to amyloid deposition mainly in

a)

Red pulp

b)

White pulp follicles

c)

Splenic capsule

d)

Trabeculae

15.

Lardaceous spleen refers to amyloid deposition mainly in

a)

White pulp only

b)

Red pulp sinusoids and cords

c)

Capsule only

d)

Trabeculae only

16.

Definitive diagnosis of amyloidosis is by

a)

Serum protein electrophoresis

b)

Imaging studies

c)

Tissue biopsy with special stains

d)

Urine routine exam

17.

Common site for biopsy to diagnose amyloidosis is

a)

Brain

b)

Heart

c)

Abdominal fat pad

d)

Spleen

18.

Autoimmune disease results from

a)

Immunodeficiency

b)

Loss of self-tolerance

c)

Allergic response

d)

Infection only

19.

Which of the following is an autoimmune disease?

a)

Hypertension

b)

Systemic lupus erythematosus

c)

Tuberculosis

d)

Diabetes insipidus

20.

Example of organ-specific autoimmune disease is

a)

Rheumatoid arthritis

b)

Systemic lupus erythematosus

c)

Type 1 diabetes mellitus

d)

Polyarteritis nodosa

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