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Pharmacology Quiz on Muscle Relaxants

Total questions: 20

Worksheet time: 10mins

Name
Class
Date
1.

Succinylcholine apnoea occurs due to

a)

Overdose of anesthetic agents

b)

Deficiency or atypical plasma pseudocholinesterase

c)

Central respiratory depression

d)

Renal failure

2.

Normal termination of action of succinylcholine depends on

a)

Acetylcholinesterase

b)

Plasma pseudocholinesterase

c)

Hepatic metabolism

d)

Renal excretion

3.

Management of succinylcholine apnoea includes

a)

Immediate antidote administration

b)

Mechanical ventilation and supportive care

c)

Neostigmine injection

d)

Atropine only

4.

Dantrolene acts by

a)

Blocking nicotinic receptors

b)

Inhibiting acetylcholinesterase

c)

Reducing Ca2+ release from sarcoplasmic reticulum

d)

Blocking sodium channels

5.

Primary therapeutic use of dantrolene is

a)

Myasthenia gravis

b)

Malignant hyperthermia

c)

Spasticity of spinal origin

d)

Parkinson disease

6.

Botulinum toxin produces paralysis by

a)

Blocking postsynaptic receptors

b)

Inhibiting acetylcholine release at neuromuscular junction

c)

Depolarizing end plate

d)

Blocking calcium channels in muscle

7.

Clinical use of botulinum toxin includes all EXCEPT

a)

Strabismus

b)

Spasticity

c)

Dystonia

d)

Myasthenia gravis

8.

Succinylcholine is a

a)

Non-depolarizing muscle relaxant

b)

Competitive antagonist

c)

Depolarizing muscle relaxant

d)

Central muscle relaxant

9.

d-Tubocurarine (d-TC) is classified as

a)

Depolarizing muscle relaxant

b)

Non-depolarizing muscle relaxant

c)

Central muscle relaxant

d)

Anticholinesterase

10.

Initial effect of succinylcholine at NMJ is

a)

Fasciculations

b)

Flaccid paralysis without twitching

c)

Spastic paralysis

d)

No visible effect

11.

Reversal of non-depolarizing block by neostigmine is due to

a)

Direct receptor activation

b)

Increased acetylcholine at NMJ

c)

Reduced acetylcholine release

d)

Depolarization block

12.

Succinylcholine block cannot be reversed by neostigmine because it

a)

Is irreversible

b)

Produces depolarization block

c)

Is centrally acting

d)

Is rapidly excreted

13.

Example of centrally acting muscle relaxant is

a)

Succinylcholine

b)

Pancuronium

c)

Baclofen

d)

d-Tubocurarine

14.

Centrally acting muscle relaxants act mainly at

a)

Neuromuscular junction

b)

Sarcolemma

c)

Spinal cord or brainstem

d)

Muscle fibers

15.

Rationale for adding adrenaline to lignocaine is to

a)

Increase toxicity

b)

Prolong duration and reduce systemic absorption

c)

Increase onset time

d)

Reduce analgesic effect

16.

Adrenaline with lignocaine is contraindicated in

a)

Minor procedures

b)

Finger and toe blocks

c)

Healthy adults

d)

Dental anesthesia

17.

Addition of adrenaline to lignocaine reduces

a)

Local blood flow

b)

Systemic toxicity

c)

Rate of absorption

d)

All of the above

18.

Botulinum toxin blocks release of which neurotransmitter?

a)

Dopamine

b)

GABA

c)

Acetylcholine

d)

Noradrenaline

19.

Dantrolene is useful in spasticity because it acts on

a)

Sodium channels of nerve

b)

Calcium channels of muscle

c)

GABA receptors

d)

Nicotinic receptors

20.

A major adverse effect of dantrolene is

a)

Hepatotoxicity

b)

Nephrotoxicity

c)

Ototoxicity

d)

Myelosuppression