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WorksheetsIntroduction to CNS Pharmacology
Total questions: 6
Worksheet time: 9mins
A 34-year-old woman comes to the physician because of a 6-week history of depressed mood, loss of interest, and difficulty sleeping. She also has had a 4.5-kg (10-lb) weight loss during this period. She has not been as productive as before at work due to difficulty concentrating. There is no evidence of suicidal ideation. Laboratory studies including thyroid-stimulating hormone are within the reference range. The physician prescribes treatment with escitalopram. This drug targets a neurotransmitter that is produced in which of the following brain structures?
Ventral tegmental area (VTA)
Locus coeruleus
Basal nucleus of Meynert
Raphe nucleus
Substantia nigra
Which of the following chemicals is most likely to function as a neurotransmitter in hierarchical systems?
Glutamate
Met-enkephalin
Nitric oxide
Norepinephrine
Substance P
Activation of metabotropic receptors located presynaptically causes inhibition by decreasing the inward flux of
Calcium
Chloride
Potassium
Sodium
An increase of chloride conductance is the most important result of activation of
GABA-B receptors
NMDA receptors
5-HT3 receptors
GABA-A receptors
M1 receptors
Which of the following receptors shares the same potassium channel as the 5-HT1A receptor?
D2 receptor
GABA-A receptor
GABA-B receptor
Mu receptor
Substance P receptor
One of the first neurotransmitter receptors to be identified in the CNS is located on the Renshaw cell in the spinal cord. Activation of this receptor results in excitation via an increase in cation (Na+, K+) conductance independently of G-protein coupled mechanisms. Which of the following compounds is most likely to activate this receptor?
Dopamine
Glycine
GABA
Nicotine
Serotonin
