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Molecular Biology (19/1/2026)

Total questions: 10

Worksheet time: 7mins

Name
Class
Date
1.

Which feature best explains why DNA is more chemically stable than RNA?

a)

A. DNA has purine bases only

b)

B. DNA contains thymine instead of uracil

c)

C. DNA has deoxyribose lacking an –OH at the 2' carbon

d)

D. DNA is double-stranded

2.

A molecule made of adenine + ribose + phosphate would be classified as:

a)

A. A nucleoside

b)

B. A nucleotide

c)

C. A purine

d)

D. A pyrimidine

3.

If a nitrogenous base has a single six-membered ring, it must be:

a)

A. Adenine

b)

B. Guanine

c)

C. A purine

d)

D. A pyrimidine

4.

Glycosidic bonds link nucleotides to form DNA or RNA.

a)

True

b)

False

c)

Don't Know

5.

Which pairing rule ensures accurate DNA replication?

a)

A. Purine–purine pairing

b)

B. Pyrimidine–pyrimidine pairing

c)

C. Complementary base pairing (A–T, C–G)

d)

D. Random base pairing

6.

Which of the following correctly represents a nucleoside?

a)

A. Nitrogenous base + phosphate

b)

B. Nitrogenous base + ribose

c)

C. Ribose + phosphate

d)

D. Deoxyribose + phosphate

7.

What structural feature defines a polynucleotide?

a)

A. Multiple sugars bonded to each other

b)

B. A chain of nucleotides linked by phosphodiester bonds

c)

C. A single nitrogenous base repeated many times

d)

D. Two antiparallel strands

8.

Why must one DNA strand run 5' → 3' and the other 3' → 5'?

a)

To allow proper hydrogen bonding between bases

b)

To reduce repulsion between phosphates

c)

To make replication faster

d)

To increase base stacking forces

9.

The negative charge in DNA comes from its phosphate groups.

a)

True

b)

False

10.

A DNA molecule rich in guanine and cytosine would be expected to:

a)

A. Be less stable due to fewer hydrogen bonds

b)

B. Be more stable due to stronger base stacking and extra hydrogen bonds

c)

C. Replicate slower

d)

D. Be more flexible