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WorksheetsTABLET PREPARATION
Total questions: 15
Worksheet time: 8mins
Which factor primarily explains why tablets vary widely in shape, size, and weight?
Availability of punch tooling at local plants
Colorants and coating selection during finishing
Manufacturer branding and market segmentation
Amount of medicinal substance and mode of administration
Which factor best explains why tablets tend to provide accurate dosing compared to many liquid formulations?
Compression increases mechanical strength of excipients
Coating reduces gastric degradation of drug
Higher bioavailability avoids first-pass metabolism
Uniform unit dose per tablet enables counting
Which classification correctly distinguishes the two main tablet manufacturing approaches shown: one formed by powder compression and the other by moist mass molded in a mold?
Compressed tablets and molded tablets
Enteric tablets and layered tablets
Sustained release and sugar coated
Effervescent tablets and lozenges
Which tablet type is designed for placement in the mouth to allow rapid absorption through the oral mucosa?
Buccal tablet placed between cheek and gum
Vaginal tablet inserted into the vagina
Implantation tablet placed under the skin
Enteric coated tablet swallowed intact
A patient needs a hormone released over months without daily dosing. Which dosage form best meets this requirement?
Plain tablet with conventional disintegration
Effervescent tablet to prepare an oral solution
Sublingual tablet for immediate systemic effect
Implantation tablet providing long-term release
In tablet formulation, which component defines therapeutic action and therefore requires detailed understanding of its physical and chemical properties, stability, and incompatibility?
Production method selected
Active pharmaceutical ingredient in the tablet
Excipients serving supportive functions
Polymeric coating materials
Manufacturing equipment used
In tablet formulation, which term best describes inert materials added to improve product qualities without direct pharmacological action?
Bioactive enhancers increasing potency
Excipients or formulation additives
Active substances with therapeutic effect
Solvents causing chemical reactions
A formulation diagram labels binder, disintegrant, lubricant/glidant/antiadherent, and filler/diluent. Which component primarily increases tablet bulk to achieve suitable size and weight?
Filler or diluent providing bulk
Binder ensuring particle cohesion
Lubricant reducing die friction
Disintegrant promoting tablet breakup
Which statement best describes the primary role of diluents in tablet formulation when the active drug dose is very small?
They increase bulk for easy compression
They improve dissolution by rapid disintegration
They enhance cohesion during granule formation
They reduce friction during tablet ejection
Where do lubricants assist granule movement within the press?
From tablet press to packaging line
From die cavity to blister pack sealing
From coating pan to drying oven
From hopper to die cavity during filling
Which excipient is chemically similar to magnesium stearate in function?
Stearic acid used as hydrophobic lubricant
Sodium starch glycolate as disintegrant
Citric acid used as flavoring agent
Hypromellose used as film former
What flow-related benefit do lubricants provide?
Elevate humidity to enhance cohesion
Generate electrostatic charge for faster drop
Increase particle size by agglomeration
Reduce interparticle friction for smooth filling
Which issue do lubricants help prevent on tooling surfaces?
Corrosion due to cleaning solutions
Microbial growth on machine parts
Oxidation of stainless steel under heat
Adhesion of powders onto dies and punches
Why might excessive lubricant cause formulation problems?
Creates sticky tablets that adhere to packaging
May reduce tablet hardness and slow dissolution
Will increase drug degradation via oxidation
Causes rapid disintegration and capping
Which substance can also aid flow besides lubrication?
Magnesium sulfate as drying agent
Mannitol as sweetening diluent
Sodium chloride as tonicity adjuster
Talc as a glidant and lubricant
