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WorksheetsPharmacology Week 3 Part 2
Total questions: 50
Worksheet time: 25mins
Which topical retinoid is specifically Pregnancy Category X in the slides?
Tazarotene
Benzoyl peroxide
Clindamycin topical
Azelaic acid
Which agent is also listed as Pregnancy Category X?
Trifarotene
Dapsone topical
Metronidazole topical
Doxycycline topical
Which medication can exacerbate acne?
Lithium
Acyclovir
Terbinafine
Brimonidine
Which set includes only medications listed as acne-exacerbating agents in the slides?
Androgens, corticosteroids, iodides, bromides
Valacyclovir, terbinafine, mupirocin, retapamulin
Brimonidine, oxymetazoline, ivermectin, metronidazole
Penicillin VK, cefazolin, ceftriaxone, piperacillin-tazobactam
Which acne-exacerbating medication is included in the slides?
Gold
Ivermectin
Azelaic acid
Dapsone
Which acne-exacerbating medication is included in the slides?
Dactinomycin
Clascoterone
Oxymetazoline
Terbinafine
Oral isotretinoin is indicated for:
Mild comedonal acne responsive to topical therapy only
Severe recalcitrant acne
Tinea pedis
Erysipelas
Oral isotretinoin is also used for:
Treatment-resistant moderate acne
Disseminated zoster
Non-purulent cellulitis
Cat bite infection
The REMS program required for isotretinoin is:
iPLEDGE
VAERS
REMS-ZosterNet
MedWatch only
Isotretinoin dispensing rules include:
Unlimited refills with one prescription
Maximum 30-day supply and no refills
Dispense 90-day supply at once
Dispense only as OTC
A pharmacy requirement for isotretinoin dispensing includes:
Daily stool cultures
Pharmacist obtains a “do not dispense after” date
Mandatory IV administration
Mandatory combination with benzoyl peroxide
Monitoring listed for isotretinoin includes:
Baseline and periodic CBC
Daily troponins
Monthly renal ultrasound
Weekly pulmonary function tests
Monitoring listed for isotretinoin includes:
Fasting lipid panel
Sweat chloride
INR
Serum lactate daily
Monitoring listed for isotretinoin includes:
Liver function tests
Serum amylase weekly for all
Urine eosinophils
D-dimer monthly
For females, isotretinoin monitoring includes:
Monthly pregnancy tests
Pregnancy test only once after treatment ends
No pregnancy testing required
Pregnancy tests only if symptoms occur
Which feature best supports acne vulgaris rather than rosacea?
Central facial erythema without comedones
Comedones present
Triggered flushing with alcohol
Vascular dysregulation only
Which feature best supports rosacea rather than acne vulgaris?
Comedones and pilosebaceous involvement
No comedones with central facial erythema
Nail involvement
Honey-colored crusts
The rosacea subtype list includes:
Erythematotelangiectatic
Bullous
Vesicular
Gangrenous
The rosacea subtype list includes:
Papulopustular
Necrotizing
Crusting
Follicular abscess subtype
The rosacea subtype list includes:
Phymatous
Ecthyma
Carbuncular
Dermatophytic subtype
The rosacea subtype list includes:
Ocular
Unguium
Capitis
Corporis
Common rosacea triggers listed include:
Spicy foods
Penicillin VK
Mupirocin
Terbinafine
Common rosacea triggers listed include:
Alcohol
Cefazolin
Vancomycin
Dapsone
Common rosacea triggers listed include:
Heat
Retapamulin
Clascoterone
TMP-SMX
Common rosacea triggers listed include:
Caffeine
Acyclovir
Doxycycline for tinea
Amoxicillin-clavulanate for acne
A recommended workup step for rosacea symptom control includes:
Avoiding all skincare forever
Identifying triggers and keeping a symptom diary
Monthly pregnancy tests for all patients
Using only antifungals
Persistent facial erythema in erythematotelangiectatic rosacea can be treated with:
Brimonidine
Terbinafine
Penicillin VK
TMP-SMX
Another option for persistent erythema in erythematotelangiectatic rosacea is:
Oxymetazoline
Retapamulin
Acyclovir
Ceftriaxone
Brimonidine and oxymetazoline help rosacea redness primarily by:
Vasoconstriction
Inhibiting viral DNA polymerase
Inhibiting bacterial cell wall synthesis
Increasing keratin plug formation
A key point about brimonidine and oxymetazoline in rosacea is:
They treat bumps and pustules best
They do not help papules or pustules
They are first-line for abscesses
They require iPLEDGE
First-line agents listed for papulopustular rosacea include:
Ivermectin
Penicillin VK
Terbinafine
Valacyclovir
Another listed option for papulopustular rosacea is:
Azelaic acid
Dicloxacillin
Piperacillin–tazobactam
Clascoterone
Another listed option for papulopustular rosacea is:
Metronidazole
Mupirocin
Acyclovir
Cefazolin
Another listed option for papulopustular rosacea is:
Minocycline foam
Oral amoxicillin–clavulanate
Oral terbinafine
Oral penicillin VK
Inflamed phymatous rosacea can be treated with:
Oral doxycycline or tetracycline
Topical retapamulin
Oral valacyclovir
IV cefazolin
Inflamed phymatous rosacea can also be treated with:
Oral isotretinoin
Oral terbinafine
Oral penicillin VK
IV acyclovir
Non-inflamed phymatous rosacea treatment options listed include:
Laser therapy or surgical intervention
Oral TMP–SMX only
Topical mupirocin only
IV vancomycin only
A patient with a moderate non-purulent infection (cellulitis) requires IV therapy. Which of the following is the most common pathogen targeted in this clinical scenario?
Staphylococcus aureus
Streptococcus pyogenes
Pseudomonas aeruginosa
Bacteroides fragilis
Which of the following medications is most likely to cause or worsen a patient’s acne through an androgenic mechanism?
Lithium
Phenytoin
Progestogens
Isoniazid
A patient is being treated for a severe necrotizing infection. Clindamycin is added to the regimen specifically for its ability to suppress toxins produced by which organisms?
Staphylococcus aureus and Escherichia coli
Streptococcus pyogenes and Clostridium species
Pseudomonas aeruginosa and Pasteurella multocida
Eikenella corrodens and Candida species
When treating a patient with oral terbinafine for tinea unguium, which laboratory assessment must be performed at baseline and periodically due to the risk of drug-induced organ toxicity?
Complete blood count (CBC)
Fasting lipid panel
Liver function tests (LFTs)
Thyroid-stimulating hormone (TSH)
Which of the following sets of medications are all documented in the objectives as agents that can exacerbate acne vulgaris?
Phenytoin, isoniazid, and cobalt
Acyclovir, valacyclovir, and famciclovir
Metronidazole, azelaic acid, and ivermectin
Cephalexin, dicloxacillin, and clindamycin
A patient is diagnosed with phymatous rosacea. If the lesions are currently non-inflamed, which management strategy is most appropriate according to the treatment objectives?
Oral doxycycline
Oral isotretinoin
Topical metronidazole
Laser therapy or surgical intervention
A 45-year-old male with a history of poorly controlled diabetes presents with a severe foot infection requiring hospitalization. Which pathogen must be empirically covered in this patient according to the treatment objectives?
Pasteurella multocida
Eikenella corrodens
Pseudomonas aeruginosa
Varicella-zoster virus
Which of the following is a strict contraindication for the use of oral terbinafine in a patient with tinea unguium?
Creatinine clearance (CrCl) of 45 mL/min
History of mild acne vulgaris
Concurrent use of topical mupirocin
Patient age under 30 years
In the management of severe non-purulent infections, why is the addition of IV clindamycin to the antimicrobial regimen considered critical?
It provides superior coverage against Pseudomonas
It is a cell wall synthesis inhibitor that works on dormant bacteria
It suppresses streptococcal cytokine and toxin production regardless of the bacterial growth phase
It is the only agent that effectively treats crystal-induced renal injury
A patient with moderate acne is starting a new regimen. Which of the following combination strategies is NOT listed as a first-line option for moderate disease?
Benzoyl peroxide + topical antibiotic
Retinoid + benzoyl peroxide
Retinoid + benzoyl peroxide + topical antibiotic
Oral antibiotic + oral isotretinoin
Which of the following statements regarding the iPLEDGE program and oral isotretinoin is correct?
A 90-day supply can be dispensed to improve compliance
Pharmacists must ensure the medication is not dispensed after a specific “do not dispense after” date
Refills are permitted as long as the patient has a negative pregnancy test
It is only required for female patients of childbearing age
A patient with severe non-purulent cellulitis is admitted for emergent surgical inspection and debridement. According to the objectives, which empiric IV antibiotic combination should be initiated?
IV penicillin + IV clindamycin
IV vancomycin + piperacillin–tazobactam
IV ceftriaxone + IV cefazolin
IV acyclovir + IV vancomycin
Which clinical finding is essential to confirm a diagnosis of acne vulgaris and differentiate it from rosacea?
Central facial erythema
Absence of telangiectasias
Presence of comedones
Vascular dysregulation
