In aerosol delivery, the inhaled particles ___________ in diameter are deposited on the tracheobronchial surface by _________.

Increase in tidal column results in _________ penetration of aerosol particles deeper into the _________ tracheobronchial and alveolar regions.

Valve discharge rate of an aerosol is the amount of the drug discharged per unit volume.

For pressurized metered dose inhalers (PMDIs), the momentum of aerosol particles generated depends on the device rather than the patient’s IFR.

Device must be kept vertical to ground to keep powder aerosolized.

Deposition by diffusion _________ with the increase in particle size.

The unit of the Valve Discharge Rate could be_____

Because of the large size of protein, they cannot be used for pulmonary delivery.

Pulmonary delivery usually has delayed onset of action compared to the oral dosage forms.

Pulmonary delivery dosage forms are inhaled through the mouth but not the nose.

For efficient deposition, breath-holding for a period less than than 5 seconds after inspiration recommended.

Deposition by diffusion increases with the increase in particle size.

Dissolution in the mucus is the rate limiting step for absorption of water soluble drugs in the aerosols.

The pleated steel is usually used for small volume aerosols.

If the drugs are suspended or emulsified in the propellant system, agitation during manufacture and use is required.

    Which one has the largest surface area?

Probability of deposition increases with each bifurcation

INCREASE in tidal volume results in less penetration of aerosol particles deeper into the distal tracheobronchial and alveolar regions.

Deposition by sedimentation mainly occurs in the lung periphery.

  Which statement is true about the nebulizers?

If the drugs are suspended or emulsified in the propellant system, agitation during manufacture and use is required.

Ideal Particle size for lung penetration is 1-5 um

  What is the difference between two-phase aerosol systems?

Device must be kept Parallel to ground to keep powder aerosolized.

  Which statement is true about the nebulizers?

If a drug has to enter blood circulation after pulmonary delivery, it must reach what part of the respiratory tract? 

An increased inspiratory flow rate causes:

Inertial impaction is a mechanism of particle deposition in the lungs, Inertial impaction is:

Particles and dissolved drug entrapped in the mucus are removed from the respiratory tract by

Which of the following statements about nebulizer is False?

As a pharmacist, how will you instruct a patient to breathe when using a nebulizer:

The form of the product and the amount of product expelled out of an aerosol system is controlled by the valve assembly

Which of these pMDI product produce aerosols without propellants?

  DPIs differ from pMDIs in which of the following ways?

Cristalization of drug may occur due to evaporation of solvent

Which of the following is TRUE about ultrasonic nebulizer disadvantage?

The function of the ______ is to permit the expulsion of the contents of the can in the desired form, at the desired rate, and, in the case of metered valves, in the proper amount or dose.

Lower water soluble drugs may dissolve at the very high relative humidity in the airways.

Brownian Diffusion, Deposition by diffusion increases with the decrease in particle size, and breath-holding following inhalation

For dry powder inhalers (DPI) and nebulizers, the aerosol droplet is carried by the inhaled air and thus aerosol velocity is controlled by IFR

Which one has the smallest surface area?

Surface area decreases with the increasing distance of the airway from the glottis.

Pulmonary delivered drugs may produce local side effects due to the oropharyngeal deposition

Pulmonary delivery dosage forms are inhaled through the nose.

Inertial impaction is the general mechanism for deposition of particles greater than 5 microns in diameter.

The macrophages engulfed particles will be eliminated via the lymphatic system or absorbed into the pulmonary circulation.

Propane cannot be used as propellant.

The actuator in the valve assembly prevents leakage of the formulation when the valve is in the closed position.

If the drugs are suspended or emulsified in the propellant system, constant agitation during manufacture and use is required.

The pharmacists are not allowed to put any label on an aerosol container because only the manufacturers can do that.

If multiple dosing is recommended in administering a pMDI, the patients need to wait for about 1 minute interval between actuations.