WorksheetsPathogenesis and Carcinogenesis Quiz
Total questions: 15
Worksheet time: 8mins
Knudson’s two-hit hypothesis explains the pathogenesis of
Colon carcinoma
Cervical carcinoma
Retinoblastoma
Hepatocellular carcinoma
In Knudson’s two-hit theory, both alleles of which gene are inactivated?
KRAS
TP53
RB1
MYC
A precancerous condition is best defined as
A benign tumor
A normal variant
A state associated with increased cancer risk
Acute inflammation
Example of a precancerous condition is
Acute appendicitis
Ulcerative colitis
Nephrotic syndrome
Pneumonia
PAP smear is primarily used for
Diagnosis of ovarian cancer
Screening for cervical cancer
Diagnosis of endometrial cancer
Detecting HPV DNA directly
PAP smear detects
Only invasive carcinoma
Cytological changes including dysplasia
Only HPV antigens
Only inflammation
Anaplasia refers to
Well-differentiated cells
Loss of differentiation
Encapsulation of tumor
Absence of mitosis
Feature of anaplasia includes
Low N:C ratio
Uniform nuclei
Pleomorphism
No mitoses
Radiation-induced carcinogenesis occurs due to
Protein denaturation
DNA damage causing mutations
Inhibition of apoptosis
Membrane damage only
Ionizing radiation induces cancer mainly by causing
Single-strand breaks only
Cross-links only
Double-strand DNA breaks
Mitochondrial damage
Radiation-induced thyroid carcinoma is associated with
Alcohol exposure
Tobacco smoking
Childhood irradiation
Obesity
Pleomorphic adenoma is a benign tumor commonly arising in
Thyroid gland
Parotid gland
Adrenal gland
Pancreas
Pleomorphic adenoma is also called
Monomorphic adenoma
Mixed tumor
Adenoid cystic carcinoma
Warthin tumor
Pleomorphic adenoma is composed of
Epithelial cells only
Mesenchymal cells only
Both epithelial and myoepithelial components
Neural cells
Precancerous lesion of cervix is termed
Leukoplakia
Cervical intraepithelial neoplasia (CIN)
Adenomyosis
Endometriosis
