Sickle Cell Anemia and Gel Electrophoresis 21

Front

What is Sickle Cell Anemia?

Back

A genetic disorder that affects hemoglobin in red blood cells, causing them to become rigid and sickle-shaped.

Front

What is Gel Electrophoresis?

Back

A laboratory technique used to separate DNA, RNA, or proteins based on their size and charge.

Front

How do DNA fragments behave in Gel Electrophoresis?

Back

Larger DNA fragments move slower and remain closer to the starting wells, while smaller fragments move faster and travel farther.

Front

What is Hemoglobin?

Back

A protein in red blood cells that carries oxygen throughout the body.

Front

What is the significance of the sickle shape in Sickle Cell Anemia?

Back

The sickle shape of red blood cells can block blood flow and lead to pain and organ damage.

Front

What does it mean to be a carrier of Sickle Cell Anemia?

Back

A person who has one normal hemoglobin gene and one sickle cell gene, typically without symptoms.

Front

What is the inheritance pattern of Sickle Cell Anemia?

Back

It is inherited in an autosomal recessive pattern, meaning a child must inherit two copies of the sickle cell gene to have the disease.

Front

What are the symptoms of Sickle Cell Anemia?

Back

Symptoms include pain episodes, anemia, swelling, and increased risk of infections.

Front

What role does Gel Electrophoresis play in genetic testing?

Back

It helps to analyze DNA samples to identify genetic disorders, including Sickle Cell Anemia.

Front

What is the relationship between Sickle Cell Anemia and malaria?

Back

Individuals with one sickle cell gene (carriers) have some protection against malaria.